DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11044 and Fbxl14

DIOPT Version :9

Sequence 1:NP_611456.1 Gene:CG11044 / 37281 FlyBaseID:FBgn0034484 Length:511 Species:Drosophila melanogaster
Sequence 2:NP_598701.2 Gene:Fbxl14 / 101358 MGIID:2141676 Length:400 Species:Mus musculus


Alignment Length:335 Identity:72/335 - (21%)
Similarity:110/335 - (32%) Gaps:128/335 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PDLVLEQIFTYLTPKERYYAGLVCRQWYRAFYLPTVWN--------------------------- 92
            |:| |..||.||..:::..|..||..|..|.|..:||.                           
Mouse    10 PEL-LAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRGVEAKLHLRRANPSLFPSLQARGIRRV 73

  Fly    93 NFLVDDRTLT---KPKFNYYS--------------GWQF-----CLDHMRTQFC-------LSRI 128
            ..|...|:|:   :...|..|              |..|     .|..:....|       |.||
Mouse    74 QILSLRRSLSYVIQGMANIESLNLSGCYNLTDNGLGHAFVQEIGSLRALNLSLCKQITDSSLGRI 138

  Fly   129 GRYVRGIEFRPWHSFNNIFQF-MTMLTWNIDKGREVN----PDTQFIGIGSRIRTLVYHFPCNMS 188
            .:|::|:|.......:||... :.::.|.:.:.:.:|    .....:|||        |.     
Mouse   139 AQYLKGLEVLELGGCSNITNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIG--------HL----- 190

  Fly   189 QPNDPEGIKLFGTGGQLLRVLKELLL----RLTDLHTLKLVDFVLERYEANHLLDEVVCSCCTKM 249
                 .|:......|.|  .|::|.|    :|||| :||.:...|                 |.:
Mouse   191 -----AGMTRSAAEGCL--GLEQLTLQDCQKLTDL-SLKHISRGL-----------------TGL 230

  Fly   250 RVLNL------VNVTTMHCPIMHVGLF--LNLQVLTISPQNIDDDVLSLLADTKLRHLHLLQNCY 306
            |:|||      .:...:|  :.|:|..  |||:    |..||.|..:          :||.....
Mouse   231 RLLNLSFCGGISDAGLLH--LSHMGSLRSLNLR----SCDNISDTGI----------MHLAMGSL 279

  Fly   307 TPSHLTISAC 316
            ..|.|.:|.|
Mouse   280 RLSGLDVSFC 289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11044NP_611456.1 F-box-like 51..94 CDD:289689 15/65 (23%)
Fbxl14NP_598701.2 Required for down-regulation of SNAI1. /evidence=ECO:0000250 2..48 15/38 (39%)
F-box-like 5..46 CDD:403981 14/36 (39%)
AMN1 90..296 CDD:187754 54/254 (21%)
leucine-rich repeat 92..118 CDD:275381 3/25 (12%)
leucine-rich repeat 119..142 CDD:275381 5/22 (23%)
LRR 1 144..163 4/18 (22%)
leucine-rich repeat 145..170 CDD:275381 4/24 (17%)
LRR 2 170..191 5/38 (13%)
leucine-rich repeat 171..203 CDD:275381 8/51 (16%)
LRR 3 203..225 9/22 (41%)
leucine-rich repeat 204..229 CDD:275381 10/42 (24%)
AMN1 228..395 CDD:187754 21/78 (27%)
LRR 4 229..250 5/22 (23%)
leucine-rich repeat 230..254 CDD:275381 6/25 (24%)
LRR 5 254..275 8/34 (24%)
leucine-rich repeat 255..280 CDD:275381 9/38 (24%)
leucine-rich repeat 281..306 CDD:275381 4/9 (44%)
leucine-rich repeat 307..331 CDD:275381
leucine-rich repeat 332..357 CDD:275381
leucine-rich repeat 358..382 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1947
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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