DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11044 and Fbxl13

DIOPT Version :9

Sequence 1:	NP_611456.1	Gene:	CG11044 / 37281	FlyBaseID:	FBgn0034484	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	XP_038962809.1	Gene:	Fbxl13 / 100125363	RGDID:	1642425	Length:	823	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	97/528 - (18%)
Similarity:	170/528 - (32%)	Gaps:	181/528 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LGLRRKSSAQLEVMQKAGWKIDGDEKACYIDVDEDEDQDTENMIE-SNWRY-------------- 53
            |.||.....|.:.:..|.||    |||.:.....::|..|::.:: ..|::
  Rat   168 LRLRHLFYTQKQRIILAKWK----EKARHKSKKREDDLITKHELQLKKWKFKLSLEKPINIEGSF 228

  Fly    54 ----------------LPDLVLEQIFTYLTPKERYYAGLVCRQWYRAFYLPTVWNNFLVDDRTLT 102
                            |||..:.|||.|||.|:......|.|.|.......::||:
  Rat   229 SDFGVTDKRIVFDISVLPDQAVVQIFVYLTFKDLVSCSQVNRSWMSMIQRGSLWNS--------- 284

  Fly   103 KPKFNYYSGWQFCLDHMRTQFCLSRIGRYVRGIEFRPWHSFNNIFQFMTMLTWNIDKGREVNPDT 167
                                            |:|....:..:.....|:..|.::..|     .
  Rat   285 --------------------------------IDFSTVKNIADRCVVTTLQKWRLNVLR-----L 312

  Fly   168 QFIGIGSRIRTLVYHFPCNMSQPNDPEGIKLFGTGGQLLRVLKELLLRLTDLHTLKLVDFVLERY 232
            .|.|...|.:||.....|.                            .|.:|:......|..|
  Rat   313 NFRGCVLRAKTLKSVSHCK----------------------------NLQELNVSDCPSFTDE-- 347

  Fly   233 EANHLLDEVVCSCCTKMRVLNLVNVT----TMHCPIMHVGLFLNLQVLTISPQNIDDDVLSLLAD 293
            ...|:.:.     |..:..|||.|.|    ||.   :....|.|||.|:::       ......|
  Rat   348 SMRHISEG-----CPGVLYLNLSNTTITNRTMR---LLPRYFHNLQNLSLA-------YCRKFTD 397

  Fly   294 TKLRHLHLLQNCYTPSHLTISAC---GVKAWRNVKKTNPRLRVHLRLEN---LTDGEV-VLQPEA 351
            ..|::|:|...|:...:|.:|.|   .|:.:||:..:...: :||.:.:   |||..| ||..:.
  Rat   398 KGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRNIANSCTGI-MHLTINDMPTLTDNCVKVLVEKC 461

  Fly   352 P-VHSITY--------CAPQT-------RIRAELLVRMVD--------HYKSTLAVYGHELLPRF 392
            | :.|:.:        ||.:.       :||.|...|:.|        :|.....:|..:.....
  Rat   462 PRISSVVFIGSPHISDCAFKALSACDLKKIRFEGNKRITDACFKSVDRNYPGISHIYMVDCKGLT 526

  Fly   393 SSPKPFHSRIDSLMLLMCRQCFNVDTLIIRE-------------------KVSTSTLLLIAKTAK 438
            .|.....|.:..|.:|....|..:..:.:|:                   .:..::::.:::...
  Rat   527 DSSLKSLSVLKQLTVLNLTNCVRIGDIGLRQFFDGPASVKLRELNLANCSLLGDTSVIRLSERCP 591

  Fly   439 NLQHLHVR 446
            ||.:|::|
  Rat   592 NLHYLNLR 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11044	NP_611456.1	F-box-like	51..94	CDD:289689	16/72 (22%)
Fbxl13	XP_038962809.1	Sfi1	<134..>214	CDD:400658	13/49 (27%)
		F-box-like	242..286	CDD:403981	15/84 (18%)
		leucine-rich repeat	257..270	CDD:275381	4/12 (33%)
		leucine-rich repeat	282..308	CDD:275381	6/66 (9%)
		AMN1	308..477	CDD:187754	46/219 (21%)
		leucine-rich repeat	309..332	CDD:275381	7/55 (13%)
		leucine-rich repeat	333..358	CDD:275381	6/31 (19%)
		leucine-rich repeat	359..383	CDD:275381	8/26 (31%)
		leucine-rich repeat	384..402	CDD:275381	5/24 (21%)
		leucine-rich repeat	412..437	CDD:275381	6/24 (25%)
		leucine-rich repeat	438..463	CDD:275381	8/25 (32%)
		leucine-rich repeat	464..486	CDD:275381	3/21 (14%)
		leucine-rich repeat	488..513	CDD:275381	6/24 (25%)
		leucine-rich repeat	514..534	CDD:275381	2/19 (11%)
		AMN1	525..733	CDD:187754	10/75 (13%)
		leucine-rich repeat	539..563	CDD:275381	4/23 (17%)
		leucine-rich repeat	567..592	CDD:275381	0/24 (0%)
		leucine-rich repeat	593..617	CDD:275381	3/7 (43%)
		leucine-rich repeat	618..641	CDD:275381
		leucine-rich repeat	642..667	CDD:275381
		leucine-rich repeat	668..693	CDD:275381
		leucine-rich repeat	694..719	CDD:275381
		leucine-rich repeat	720..745	CDD:275381
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900