Protein Alignment JUP and arm

DIOPT Version :10

• Sequence 1: XP_047291890.1
• Gene: JUP / 3728
• HGNCID: 6207
• Length: 762
• Species: Homo sapiens
• Sequence 2: NP_476665.2
• Gene: arm / 31151
• FlyBaseID: FBgn0000117
• Length: 843
• Species: Drosophila melanogaster
• Alignment Length: 726
• Identity: 459/726 - (63%)
• Similarity: 554/726 - (76%)
• Gaps: 27/726 - (3%)

Human     2 RTLRFCGERNCPSIATMEVMNLMEQPIKVTEWQQ-TYTYDSGIHSGANTCVPSVSSKGIMEEDEA 65
            ||:....:.|.|.:..|  ::..||.:.   ||| :|..||||||||.|.|||:|.|   |::|.
  Fly     9 RTMSHNNQYNPPDLPPM--VSAKEQTLM---WQQNSYLGDSGIHSGAVTQVPSLSGK---EDEEM 65

Human    66 CGRQYTLKKTTTYTQGVPPSQ-GDLEYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVE-GQAT 128
            .|........|.:.|.....| .|:..|:|.| |::|||.||.|... |:...:.:||.: .|.|
  Fly    66 EGDPLMFDLDTGFPQNFTQDQVDDMNQQLSQT-RSQRVRAAMFPETL-EEGIEIPSTQFDPQQPT 128

Human   129 NLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASR 193
            .:|||:||||:||.|:|:||||||||||||||:|||.|||||||.|||::|||:|:|||||||||
  Fly   129 AVQRLSEPSQMLKHAVVNLINYQDDAELATRAIPELIKLLNDEDQVVVSQAAMMVHQLSKKEASR 193

Human   194 RALMGSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVES 258
            .|:|.|||:|||:||.:.|::||::.:.....||||||||:|||||||||||||||::|||||||
  Fly   194 HAIMNSPQMVAALVRAISNSNDLESTKAAVGTLHNLSHHRQGLLAIFKSGGIPALVKLLSSPVES 258

Human   259 VLFYAITTLHNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLII 323
            ||||||||||||||:|:|:|||||||.||||||.||.:||.|||||.|||||:||||||||||||
  Fly   259 VLFYAITTLHNLLLHQDGSKMAVRLAGGLQKMVTLLQRNNVKFLAIVTDCLQILAYGNQESKLII 323

Human   324 LANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHLTSNSPRLVQN 388
            ||:|||..||:|||:|.||||||||||||||||||.|||||||:|||||||..||.:.|||||||
  Fly   324 LASGGPNELVRIMRSYDYEKLLWTTSRVLKVLSVCSSNKPAIVDAGGMQALAMHLGNMSPRLVQN 388

Human   389 CLWTLRNLSDVATKQEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVE 453
            ||||||||||.|||.||||::|:.||..|...||||:|||.|.||||||||.:||..|.|..||:
  Fly   389 CLWTLRNLSDAATKVEGLEALLQSLVQVLGSTDVNVVTCAAGILSNLTCNNQRNKATVCQVGGVD 453

Human   454 ALIHAILRAGDKDDITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKAT 518
            ||:..|:.|||:::||||||||||||||||.::|:|||:||||||:..|||||:.|::|||:||.
  Fly   454 ALVRTIINAGDREEITEPAVCALRHLTSRHVDSELAQNAVRLNYGLSVIVKLLHPPSRWPLIKAV 518

Human   519 IGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRH----VAAGTQQP--YTDGVRMEEIV 577
            |||||||||||||||||:|...|..||:||::|.||.:|.    ...|:|||  |.|||||||||
  Fly   519 IGLIRNLALCPANHAPLREHGAIHHLVRLLMRAFQDTERQRSSIATTGSQQPSAYADGVRMEEIV 583

Human   578 EGCTGALHILARDPMNRMEIFRLNTIPLFVQLLYSSVENIQRVAAGVLCELAQDKEAADAIDAEG 642
            ||..||||||||:..||..|.:.:.||:||:||::.:|||||||||||||||.|||.|:.|:.||
  Fly   584 EGTVGALHILARESHNRALIRQQSVIPIFVRLLFNEIENIQRVAAGVLCELAADKEGAEIIEQEG 648

Human   643 ASAPLMELLHSRNEGTATYAAAVLFRISEDKNPDYRKRVSVELTNSLFKHDPAAWEAA------- 700
            |:.||.:||||||||.||||||||||:||||..||:||:|:||||||.:.|...|..|
  Fly   649 ATGPLTDLLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSIELTNSLLREDNNIWANADLGMGPD 713

Human   701 -QSMIPINEPY 710
             |.|:...|.|
  Fly   714 LQDMLGPEEAY 724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
JUP	XP_047291890.1	CTNNAbd_CTNNG	90..159	CDD:439242	37/69 (54%)
		armadillo repeat	161..186	CDD:293788	17/24 (71%)
		armadillo repeat	203..229	CDD:293788	10/25 (40%)
		armadillo repeat	238..270	CDD:293788	29/31 (94%)
		Arm	238..270	CDD:425727	29/31 (94%)
		armadillo repeat	278..314	CDD:293788	28/35 (80%)
		armadillo repeat	322..355	CDD:293788	26/32 (81%)
		PLN03200	<345..>675	CDD:215629	230/335 (69%)
		ARM	358..398	CDD:214547	32/39 (82%)
		armadillo repeat	362..397	CDD:293788	28/34 (82%)
		armadillo repeat	410..435	CDD:293788	14/24 (58%)
		armadillo repeat	443..481	CDD:293788	23/37 (62%)
		armadillo repeat	487..525	CDD:293788	26/37 (70%)
		armadillo repeat	532..589	CDD:293788	36/62 (58%)
		armadillo repeat	594..628	CDD:293788	20/33 (61%)
		armadillo repeat	635..669	CDD:293788	24/33 (73%)
arm	NP_476665.2	CTNNAbd_dArm	85..159	CDD:439243	39/75 (52%)
		Adaptin_N	<150..>314	CDD:396262	124/163 (76%)
		armadillo repeat	161..186	CDD:293788	17/24 (71%)
		armadillo repeat	193..231	CDD:293788	18/37 (49%)
		armadillo repeat	238..270	CDD:293788	29/31 (94%)
		armadillo repeat	278..314	CDD:293788	28/35 (80%)
		armadillo repeat	320..355	CDD:293788	28/34 (82%)
		Arm	361..398	CDD:425727	30/36 (83%)
		armadillo repeat	362..397	CDD:293788	28/34 (82%)
		armadillo repeat	410..435	CDD:293788	14/24 (58%)
		Arm	439..481	CDD:425727	25/41 (61%)
		armadillo repeat	443..481	CDD:293788	23/37 (62%)
		armadillo repeat	490..525	CDD:293788	24/34 (71%)
		Arm	597..636	CDD:425727	23/38 (61%)
		armadillo repeat	600..636	CDD:293788	22/35 (63%)
		armadillo repeat	641..675	CDD:293788	24/33 (73%)