DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JUP and hmp-2

DIOPT Version :9

Sequence 1:	XP_016880077.1	Gene:	JUP / 3728	HGNCID:	6207	Length:	762	Species:	Homo sapiens
Sequence 2:	NP_001252425.1	Gene:	hmp-2 / 173338	WormBaseID:	WBGene00001979	Length:	704	Species:	Caenorhabditis elegans

Alignment Length:	673	Identity:	218/673 - (32%)
Similarity:	342/673 - (50%)	Gaps:	89/673 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    90 EYQMSTTARAKRVREAMCPGVSGEDSSLLLATQVEGQATN-----LQRLAEPSQLLKSAIVHLIN 149
            ::::.|  |..|:|.||.|......|:        .:|||     ::.:..|:|.||.:::.|:.
Worm    40 DHEVET--RTSRIRSAMFPDWIPPTSA--------AEATNSTTSIVEMMQMPTQQLKQSVMDLLT 94

Human   150 YQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALMGSP-----QLVAAVVRT 209
            |:...:::..:||:|.||:.|.|..||.:|......||:::.:   ...:|     ..|.|:: .
Worm    95 YEGSNDMSGLSLPDLVKLMCDHDESVVARAVHRAYMLSREDPN---FFNAPGFDHRSFVEALM-A 155

Human   210 MQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTLHNLLLYQ 274
            ...:|:::..|.....|.::|..|.|.|.||:|||:..::|||...:|||:.||:|||.|||::.
Worm   156 ASKSSNVNVRRNAIGALSHMSEQRGGPLLIFRSGGLAEIIRMLYDSLESVVHYAVTTLRNLLMHV 220

Human   275 EGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQESKLIILANGGPQALVQIMRNY 339
            ..::...|..:.::.:.|.|:|.|||.||...|.|..|...:..||:..|:..|||.||.|:|.|
Worm   221 SDSRAQARALNAVEALTPHLHKTNPKLLAQVADGLYFLLIDDAPSKITFLSLLGPQILVSILREY 285

Human   340 S-YEKLLWTTSRVLKVLSVCPSNKPAIVEAGGMQALGKHL-TSNSPRLVQNCLWTLRNLSDVATK 402
            | :.||::|..|.::.||||||||||::..|.:.||...| |:...|.....|..:|||||.||.
Worm   286 SDHRKLIYTVVRCIRSLSVCPSNKPALISLGCLPALYVELCTAKDERSQTAILVAMRNLSDSATN 350

Human   403 QEGLESVLKILVNQLSVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDD 467
            :|.|..::..|:..:.|.:..:..||.||||||||||::||..|..:.|::||:.||.|..:.::
Worm   351 EENLTQLIIKLLEIIRVANDGMTACACGTLSNLTCNNTRNKQTVCSHGGIDALVTAIRRLPEVEE 415

Human   468 ITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKATIGLIRNLALCPANH 532
            :||||:|||||.|:||..||.||:.:|.....|.|:..| :..:.|::||.:|:|||.||...|
Worm   416 VTEPALCALRHCTARHSLAEEAQSELRFCQAFPVILDQL-ETLRTPVIKAALGVIRNSALLQTN- 478

Human   533 APLQEAAVIPRLVQLLVKAHQDAQRHVA-------------AGTQQP--YTDGVRMEEIVEGCTG 582
                       |::|  ...|.|..|.|             |..:.|  ..|||.|..::||...
Worm   479 -----------LIEL--TQEQTANGHTAVSLTMDILRRAITAIEENPDIAVDGVPMWGVIEGAVS 530

Human   583 ALHILARDPMNRM----EIFRLNT--IPLFVQLLYSSV----------ENIQRVAAGVLCELAQD 631
            |||.||..|....    :|.::..  .|.|:.||:..:          |.::|...|:|.:|::.
Worm   531 ALHQLANHPAVAAACCDDIGQVGNPECPPFLDLLHRLLAHPRLGSMDDEVLEREILGLLYQLSKR 595

Human   632 KEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLFRISE---------DKNPDYRKRVSVELTN 687
            .:.|.|:::.|.||.|||...|:.:...|||..||..:..         ..:.||      |::.
Worm   596 PDGARAVESTGVSALLMESRGSQYKSVVTYANGVLSNLKRGDSAAIMNMSNSYDY------EMSG 654

Human   688 SL--FKHDPAAWEAAQSMIPINE 708
            |.  ::.|....|....|.|.|:
Worm   655 SAADWQRDGLERELFAEMYPTND 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JUP	XP_016880077.1	armadillo repeat	161..186	CDD:293788	10/24 (42%)
		armadillo repeat	203..229	CDD:293788	5/25 (20%)
		armadillo repeat	238..270	CDD:293788	16/31 (52%)
		ARM	238..270	CDD:214547	16/31 (52%)
		armadillo repeat	278..314	CDD:293788	12/35 (34%)
		armadillo repeat	322..355	CDD:293788	14/33 (42%)
		PLN03200	<345..>675	CDD:215629	125/370 (34%)
		ARM	358..398	CDD:214547	17/40 (43%)
		armadillo repeat	362..397	CDD:293788	12/35 (34%)
		armadillo repeat	410..435	CDD:293788	8/24 (33%)
		armadillo repeat	443..481	CDD:293788	17/37 (46%)
		armadillo repeat	487..525	CDD:293788	13/37 (35%)
		armadillo repeat	532..589	CDD:293788	18/71 (25%)
		armadillo repeat	594..628	CDD:293788	9/49 (18%)
		armadillo repeat	635..669	CDD:293788	14/33 (42%)
hmp-2	NP_001252425.1	ARM	106..216	CDD:237987	38/113 (34%)
		HEAT_2	106..>185	CDD:290374	22/82 (27%)
		HEAT repeat	106..137	CDD:293787	12/30 (40%)
		HEAT repeat	149..177	CDD:293787	5/28 (18%)
		ARM	183..303	CDD:237987	48/119 (40%)
		armadillo repeat	185..216	CDD:293788	16/30 (53%)
		armadillo repeat	224..260	CDD:293788	12/35 (34%)
		armadillo repeat	275..302	CDD:293788	12/26 (46%)
		Arm	305..346	CDD:278915	17/40 (43%)
		armadillo repeat	309..349	CDD:293788	15/39 (38%)
		ARM	357..473	CDD:237987	50/116 (43%)
		armadillo repeat	358..383	CDD:293788	8/24 (33%)
		armadillo repeat	391..429	CDD:293788	17/37 (46%)
		armadillo repeat	438..471	CDD:293788	10/33 (30%)
		ARM	518..633	CDD:237987	35/114 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161464682
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	313	1.000	Inparanoid score	I1756
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D163964at33208
OrthoFinder	1	1.000	-	-		FOG0002078
OrthoInspector	1	1.000	-	-		otm15811
orthoMCL	1	0.900	-	-		OOG6_103992
Panther	1	1.100	-	-	O	PTHR45976
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X1754
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.930