DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and RLP9

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001185260.1	Gene:	RLP9 / 842186	AraportID:	AT1G58190	Length:	1029	Species:	Arabidopsis thaliana

Alignment Length:	864	Identity:	201/864 - (23%)
Similarity:	325/864 - (37%)	Gaps:	253/864 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 EGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLP 226
            |.|.|...|.:::.|..|:.       ||:.:....:|.:                .|.|||:|.
plant    63 ERVECDRTSGRVIGLFLNQT-------FSDPILINLSLFH----------------PFEELRTLN 104

  Fly   227 ------DAW--------GASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSE 277
                  ..|        ...:|::|:.|.:.:|.::......|...||||.|.:..|::     |
plant   105 LYDFGCTGWFDDIHGYKSLGKLKKLEILDMGNNEVNNSVLPFLNAASSLRTLILHGNNM-----E 164

  Fly   278 AFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLI---RLIVLN 339
            .....|||::                  |..|.:||||||.|      |....||.   :|..|:
plant   165 GTFPMKELKD------------------LSNLELLDLSGNLL------NGPVPGLAVLHKLHALD 205

  Fly   340 LSNN----ALTRIGSKTFKELYFLQILDMRNNSI--------------------GHIEEGAF--- 377
            ||:|    :|.|.|.|:|:.|..|:|||:..|.:                    |:..||.|
plant   206 LSDNTFSGSLGREGYKSFERLKNLEILDISENGVNNTVLPFINTASSLKTLILHGNNMEGTFPMK 270

  Fly   378 --LPLYNLHTLNLAENR----------LHTL------DNRIFNGLYVLTKLTLNNNLVSIVESQA 424
              :.|.||..|:|::|:          .|.|      ||: |:|        .|..|..:
plant   271 ELINLRNLELLDLSKNQFVGPVPDLANFHNLQGLDMSDNK-FSG--------SNKGLCQL----- 321

  Fly   425 FRNCSDLKELDLSSNQLT-EVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRI 488
                .:|:|||||.|:.| :.|:....|:.|:.||:..|..:....:..|||:.:..|.|.||..
plant   322 ----KNLRELDLSQNKFTGQFPQCFDSLTQLQVLDISSNNFNGTVPSLIRNLDSVEYLALSDNEF 382

  Fly   489 -GNITVGMFQDLPRLSVLNLA--KNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLL 550
             |..::.:..:|.:|.|..|:  .|.::..:..:.....::..|.|....|.::.........|.
plant   383 KGFFSLELIANLSKLKVFKLSSRSNLLRLKKLSSLQPKFQLSVIELQNCNLENVPSFIQHQKDLH 447

  Fly   551 WLNLSENHLVW-FDYAFIPS--NLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASH--NRITEIG 610
            .:|||.|.|.. |.|..:..  ||:.|.:..|.:..|.....|...:::..|.|::  .|:.|..
plant   448 VINLSNNKLTGVFPYWLLEKYPNLRVLLLQNNSLTMLELPRLLNHTLQILDLSANNFDQRLPENI 512

  Fly   611 AMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFY 675
            ...:|| |..|.::||....|..::|.:...:..:||..|             ..|...|: :|.
plant   513 GKVLPN-IRHLNLSNNGFQWILPSSFGEMKDIKFLDLSHN-------------NFSGSLPM-KFL 562

  Fly   676 LGGNPFECDCSMEWLQRI--NNLTTRQHPHVVDLGNIECLMPHSR-----SAPLRPLASLSASDF 733
            :|       ||.....::  |....:..|...:.|::..|:.::.     :..||.:.||...|.
plant   563 IG-------CSSLHTLKLSYNKFFGQIFPKQTNFGSLVVLIANNNLFTGIADGLRNVQSLGVLDL 620

  Fly   734 VCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATW-----------ATNIVDCGRQDLAALP 787
            ...|.....|                          :|           :.|:::      ..||
plant   621 SNNYLQGVIP--------------------------SWFGGFFFAYLFLSNNLLE------GTLP 653

  Fly   788 NRI--PQDVSDLYLDGN----NMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQ--LVNLRV 844
            :.:  ......|.|.||    |:|    .|.|| .::..||||.:..    :|::..  :.::.|
plant   654 STLFSKPTFKILDLSGNKFSGNLP----SHFTG-MDMSLLYLNDNEF----SGTIPSTLIKDVLV 709

  Fly   845 LHLENNKLTALEGT--EFRSLGLLRELYLHNNMLT-HISNATFEP-----LVSLEVLRLDNNRL- 900
            |.|.||||:   ||  .|.....:..|.|..|.|| ||      |     |.|:.:|.|.||||
plant   710 LDLRNNKLS---GTIPHFVKNEFILSLLLRGNTLTGHI------PTDLCGLRSIRILDLANNRLK 765

  Fly   901 SSLPHLQYRHSLQGLTLGR 919
            .|:|     ..|..::.||
plant   766 GSIP-----TCLNNVSFGR 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	6/18 (33%)
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380	3/7 (43%)
		leucine-rich repeat	171..201	CDD:275380	5/29 (17%)
		LRR_RI	210..464	CDD:238064	81/316 (26%)
		leucine-rich repeat	212..236	CDD:275380	7/37 (19%)
		LRR_8	235..295	CDD:290566	14/59 (24%)
		leucine-rich repeat	237..260	CDD:275380	4/22 (18%)
		leucine-rich repeat	261..284	CDD:275380	5/22 (23%)
		LRR_8	283..345	CDD:290566	20/68 (29%)
		leucine-rich repeat	285..308	CDD:275380	2/22 (9%)
		leucine-rich repeat	309..334	CDD:275380	11/27 (41%)
		LRR_8	334..393	CDD:290566	26/97 (27%)
		leucine-rich repeat	335..358	CDD:275380	11/26 (42%)
		leucine-rich repeat	359..382	CDD:275380	10/47 (21%)
		LRR_8	382..441	CDD:290566	20/74 (27%)
		leucine-rich repeat	383..406	CDD:275380	10/38 (26%)
		leucine-rich repeat	407..430	CDD:275380	2/22 (9%)
		LRR_8	431..488	CDD:290566	21/57 (37%)
		leucine-rich repeat	431..451	CDD:275380	9/20 (45%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	18/84 (21%)
		leucine-rich repeat	478..499	CDD:275380	5/21 (24%)
		leucine-rich repeat	502..525	CDD:275380	4/24 (17%)
		leucine-rich repeat	526..548	CDD:275380	3/21 (14%)
		leucine-rich repeat	590..617	CDD:275380	6/28 (21%)
		leucine-rich repeat	618..641	CDD:275380	6/22 (27%)
		leucine-rich repeat	642..689	CDD:275380	9/46 (20%)
		LRRCT	679..736	CDD:214507	11/63 (17%)
		leucine-rich repeat	775..796	CDD:275380	2/22 (9%)
		LRR_8	797..852	CDD:290566	19/60 (32%)
		leucine-rich repeat	797..817	CDD:275380	9/23 (39%)
		leucine-rich repeat	818..841	CDD:275380	5/24 (21%)
		LRR_8	841..900	CDD:290566	24/66 (36%)
		leucine-rich repeat	842..865	CDD:275380	10/24 (42%)
		LRR_4	866..907	CDD:289563	18/47 (38%)
		leucine-rich repeat	866..889	CDD:275380	9/28 (32%)
		leucine-rich repeat	890..911	CDD:275380	8/21 (38%)
		TIR	1045..1183	CDD:214587
RLP9	NP_001185260.1	LRRNT_2	32..68	CDD:285463	2/4 (50%)
		LRR_RI	<92..240	CDD:238064	50/192 (26%)
		LRR	<120..>333	CDD:227223	67/259 (26%)
		leucine-rich repeat	129..152	CDD:275380	4/22 (18%)
		leucine-rich repeat	153..177	CDD:275380	9/46 (20%)
		LRR_RI	170..383	CDD:238064	70/254 (28%)
		leucine-rich repeat	178..200	CDD:275380	11/27 (41%)
		leucine-rich repeat	201..228	CDD:275380	11/26 (42%)
		leucine-rich repeat	229..277	CDD:275380	10/47 (21%)
		leucine-rich repeat	278..300	CDD:275380	4/21 (19%)
		leucine-rich repeat	301..323	CDD:275380	7/39 (18%)
		LRR_8	322..380	CDD:290566	19/57 (33%)
		leucine-rich repeat	324..347	CDD:275380	10/22 (45%)
		leucine-rich repeat	348..371	CDD:275380	7/22 (32%)
		leucine-rich repeat	372..396	CDD:275380	6/23 (26%)
		LRR_RI	422..673	CDD:238064	57/304 (19%)
		LRR_8	422..481	CDD:290566	15/58 (26%)
		leucine-rich repeat	423..445	CDD:275380	3/21 (14%)
		leucine-rich repeat	446..470	CDD:275380	8/23 (35%)
		leucine-rich repeat	471..493	CDD:275380	5/21 (24%)
		LRR_8	493..553	CDD:290566	15/73 (21%)
		leucine-rich repeat	494..518	CDD:275380	4/23 (17%)
		leucine-rich repeat	519..542	CDD:275380	6/22 (27%)
		leucine-rich repeat	543..567	CDD:275380	8/44 (18%)
		leucine-rich repeat	568..591	CDD:275380	2/22 (9%)
		leucine-rich repeat	592..614	CDD:275380	3/21 (14%)
		leucine-rich repeat	615..637	CDD:275380	5/47 (11%)
		leucine-rich repeat	638..661	CDD:275380	3/28 (11%)
		leucine-rich repeat	662..684	CDD:275380	9/26 (35%)
		leucine-rich repeat	685..707	CDD:275380	5/25 (20%)
		leucine-rich repeat	730..753	CDD:275380	9/28 (32%)
		leucine-rich repeat	754..780	CDD:275380	11/31 (35%)
		leucine-rich repeat	781..867	CDD:275380
		LRR_8	847..902	CDD:290566
		leucine-rich repeat	868..891	CDD:275380
		leucine-rich repeat	892..912	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	126	1.000	Inparanoid score	I1925
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050