DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and RLP47

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001190722.1	Gene:	RLP47 / 827015	AraportID:	AT4G13810	Length:	706	Species:	Arabidopsis thaliana

Alignment Length:	621	Identity:	142/621 - (22%)
Similarity:	228/621 - (36%)	Gaps:	163/621 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRL-------DLQCSQELL----HASELAP 83
            |:|.      .:.|..:   :|....||||.:...|.|       .||..|:|:    |.|.:.|
plant    71 CSWD------GVSCDPK---TGVVVELDLQYSHLNGPLRSNSSLFRLQHLQKLVLGSNHLSGILP 126

  Fly    84 GLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELS 148
            .....|::|..|.:..|.|....|::...|..|..|.| |:|.....|.      .|...|..|:
plant   127 DSIGNLKRLKVLVLVNCNLFGKIPSSLGNLSYLTHLDL-SYNDFTSEGP------DSMGNLNRLT 184

  Fly   149 E----------LHLGDNNIR--------------------------------------------- 158
            :          :.||||.::
plant   185 DMLLKLSSVTWIDLGDNQLKGINLKISSTVSLPSPIEYLGLLSCNISEFPKFLRNQTSLEYLDIS 249

  Fly   159 ------QLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDV 217
                  |:||.:| |:|.|:.:|::.|     .|.||.     |.|     ..:.||.||..||:
plant   250 ANQIEGQVPEWLW-SLPELRYVNISHN-----SFNGFE-----GPA-----DVIQGGRELLVLDI 298

  Fly   218 SFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGN 282
            |.|..:   |.:....:..:..|...:|..|...|..:..|.:||:|.:|.|:........|. |
plant   299 SSNIFQ---DPFPLLPVVSMNYLFSSNNRFSGEIPKTICELDNLRILVLSNNNFSGSIPRCFE-N 359

  Fly   283 KELRELHLQGNDLYEL--PKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIR---LIVLNLSN 342
            ..|..|||:.|:|..:  .:.:.|.|:...|    |:.|.|..:..|    ||.   :..||:.:
plant   360 LHLYVLHLRNNNLSGIFPEEAISHHLQSFDV----GHNLFSGELPKS----LINCSDIEFLNVED 416

  Fly   343 NALTRIGSKTFKELYFLQILDMRNNSI-GHI-EEGAFLPLYNLHTLNLAENR------------- 392
            |.:........:.|..||||.:|:|.. |.| ..|..|....|...:::|||
plant   417 NRINDTFPSWLELLPNLQILVLRSNEFYGPIFSPGDSLSFSRLRIFDISENRFTGVLPSDYFVGW 481

  Fly   393 -----LHTLDNRIFNGLYVLTKL----------TLNNNLVSIVESQAFRNCSDLKELDLSSNQLT 442
                 :..:|.||..  |.:|.:          .:|..|...:....|   :..|.:|:|.|:|.
plant   482 SVMSSVVDIDGRIIQ--YTVTGIDRDFYHKSVALINKGLKMELVGSGF---TIYKTIDVSGNRLE 541

  Fly   443 -EVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLN 506
             ::||::..|..:..|.:..|..:.....:..||:.|..|.|..||:.....|....|..|..:|
plant   542 GDIPESIGLLKEVIVLSMSNNAFTGHIPPSLSNLSNLQSLDLSQNRLSGSIPGELGKLTFLEWMN 606

  Fly   507 LAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGI 542
            .:.||::    |...:.|:|:.  .|.:..|:..|:
plant   607 FSHNRLE----GPIPETTQIQT--QDSSSFTENPGL 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	9/35 (26%)
		leucine-rich repeat	92..115	CDD:275380	6/22 (27%)
		LRR_8	115..181	CDD:290566	22/126 (17%)
		leucine-rich repeat	116..146	CDD:275380	8/29 (28%)
		leucine-rich repeat	147..170	CDD:275380	10/83 (12%)
		leucine-rich repeat	171..201	CDD:275380	8/29 (28%)
		LRR_RI	210..464	CDD:238064	70/289 (24%)
		leucine-rich repeat	212..236	CDD:275380	6/23 (26%)
		LRR_8	235..295	CDD:290566	17/59 (29%)
		leucine-rich repeat	237..260	CDD:275380	5/22 (23%)
		leucine-rich repeat	261..284	CDD:275380	7/22 (32%)
		LRR_8	283..345	CDD:290566	18/66 (27%)
		leucine-rich repeat	285..308	CDD:275380	8/24 (33%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		LRR_8	334..393	CDD:290566	18/81 (22%)
		leucine-rich repeat	335..358	CDD:275380	4/22 (18%)
		leucine-rich repeat	359..382	CDD:275380	10/24 (42%)
		LRR_8	382..441	CDD:290566	16/86 (19%)
		leucine-rich repeat	383..406	CDD:275380	7/40 (18%)
		leucine-rich repeat	407..430	CDD:275380	4/32 (13%)
		LRR_8	431..488	CDD:290566	16/57 (28%)
		leucine-rich repeat	431..451	CDD:275380	7/20 (35%)
		leucine-rich repeat	454..477	CDD:275380	4/22 (18%)
		LRR_8	477..559	CDD:290566	17/66 (26%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		leucine-rich repeat	526..548	CDD:275380	4/17 (24%)
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
RLP47	NP_001190722.1	LRR_RI	263..>443	CDD:238064	56/206 (27%)
		leucine-rich repeat	267..292	CDD:275380	10/39 (26%)
		leucine-rich repeat	293..338	CDD:275380	11/47 (23%)
		LRR_8	338..395	CDD:290566	17/61 (28%)
		leucine-rich repeat	339..360	CDD:275380	6/21 (29%)
		leucine-rich repeat	385..408	CDD:275380	8/30 (27%)
		leucine-rich repeat	409..432	CDD:275380	4/22 (18%)
		leucine-rich repeat	459..529	CDD:275380	12/74 (16%)
		leucine-rich repeat	513..553	CDD:275380	11/42 (26%)
		leucine-rich repeat	554..577	CDD:275380	4/22 (18%)
		LRR_8	556..612	CDD:290566	14/55 (25%)
		leucine-rich repeat	578..599	CDD:275380	6/20 (30%)
		LRRNT_2	36..79	CDD:285463	2/13 (15%)
		leucine-rich repeat	87..110	CDD:275380	7/22 (32%)
		LRR_8	110..169	CDD:290566	17/59 (29%)
		leucine-rich repeat	111..134	CDD:275380	6/22 (27%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		LRR_RI	<150..>301	CDD:238064	36/173 (21%)
		leucine-rich repeat	159..182	CDD:275380	8/29 (28%)
		leucine-rich repeat	183..219	CDD:275380	5/35 (14%)
		leucine-rich repeat	220..242	CDD:275380	0/21 (0%)
		LRR_8	221..277	CDD:290566	9/61 (15%)
		leucine-rich repeat	243..266	CDD:275380	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000