DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and RLP42

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_189138.1	Gene:	RLP42 / 822093	AraportID:	AT3G25020	Length:	890	Species:	Arabidopsis thaliana

Alignment Length:	874	Identity:	208/874 - (23%)
Similarity:	327/874 - (37%)	Gaps:	248/874 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 LRIDACKLQRVPPNA----FEGLMSL----KRLTLESHNAVWGPGKTLELHGQSFQGLKELSELH 151
            |::.||....:.||:    |..|.||    ...|..|.::.:|....||:...|..|.
plant    78 LQLRACLSGTLKPNSSLFQFHHLRSLLLPHNNFTSSSISSKFGMLNNLEVLSLSSSGF------- 135

  Fly   152 LGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLD 216
                 :.|:|.. :.::..|..|:|::|.:..:  |.|...|                .:|:.||
plant   136 -----LAQVPFS-FSNLSMLSALDLSKNELTGS--LSFVRNL----------------RKLRVLD 176

  Fly   217 VSFNELRSL--PDAWGASRLRRLQTLSLQHNNI-STLAPNALAGLSSLRVLNISYNHLVSLPSEA 278
            ||:|....:  |:: ....|..|..|:|::||. |:..|.....|:.|.||::|.|.........
plant   177 VSYNHFSGILNPNS-SLFELHHLIYLNLRYNNFTSSSLPYEFGNLNKLEVLDVSSNSFFGQVPPT 240

  Fly   279 FAGNKELRELHLQGNDLY-ELPKGLLHRLEQLLVLDLSGNQ--------------LTSHHVDNST 328
            .:...:|.||:|..||.. .||  |:..|.:|.:|.|.||.              |:|.:::.:.
plant   241 ISNLTQLTELYLPLNDFTGSLP--LVQNLTKLSILHLFGNHFSGTIPSSLFTMPFLSSIYLNKNN 303

  Fly   329 FAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLA-ENR 392
            .:|.|.  |.|.|:       |...:.||      :..|.:|.|.| ....|.||..|:|: .|.
plant   304 LSGSIE--VPNSSS-------SSRLEHLY------LGKNHLGKILE-PIAKLVNLKELDLSFLNT 352

  Fly   393 LHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTL 457
            .|.:|..:|:.|..|..|.|:.:.:|            ...|.|.|    .:|      |.|:.|
plant   353 SHPIDLSLFSSLKSLLLLDLSGDWIS------------KASLTLDS----YIP------STLEVL 395

  Fly   458 DLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQD----LPRLSVLNLAKNRIQSIERG 518
            .|....||||. |.|:.|:.|..:.|.:|||.    |.|.:    |||||.:.:..|.:...| |
plant   396 RLEHCDISEFP-NVFKTLHNLEYIALSNNRIS----GKFPEWLWSLPRLSSVFITDNLLTGFE-G 454

  Fly   519 AFD--KNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAF---IP---SNLKWLD 575
            :.:  .|:.::.:.||.|.|.         .:|..|.||.|:....|..|   ||   .|...||
plant   455 SSEVLVNSSVQILSLDTNSLE---------GALPHLPLSINYFSAIDNRFGGDIPLSICNRSSLD 510

  Fly   576 IHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKT 640
            :                      ||.|:|..:......:.|.:.|....||:.|.|....:|| |
plant   511 V----------------------LDLSYNNFSGQIPPCLSNLLYLKLRKNNLEGSIPDKYYVD-T 552

  Fly   641 RLARVDL-YANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHV 704
            .|...|: |..:..|:..:.:                       :||.  ||.::
plant   553 PLRSFDVGYNRLTGKLPRSLI-----------------------NCSA--LQFLS---------- 582

  Fly   705 VDLGNIECLMP-HSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHD 768
            ||...|:...| :.::.|...:..||:::|   |....||
plant   583 VDHNGIKDTFPFYLKALPKLQVLLLSSNEF---YGPLSPP------------------------- 619

  Fly   769 ATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLR---ALYLNASNLMT 830
                 |....|..:|..|      :::...|.|:..|:..|........:.   .||:..|.::
plant   620 -----NQGPLGFPELRIL------EIAGNKLTGSLPPDFFVNWKASSHTMNEDLGLYMVYSKVI- 672

  Fly   831 LQNGSLA--QLVNLRVLHL---ENNKLTA----------LEGTEFRSLGLLRELY---LHNNMLT 877
            ..|..|.  :.::||...|   :.|.||:          |||....|||||:.|.   |.||..|
plant   673 FGNYHLTYYETIDLRYKGLSMEQENVLTSSATIDLSGNRLEGEIPESLGLLKALIALNLSNNAFT 737

  Fly   878 HISNATFEPLVSLEVLRLDNNRLS-SLPH 905
            .....:...|..:|.|.|.:|:|| ::|:
plant   738 GHIPLSLANLKKIESLDLSSNQLSGTIPN 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380	7/23 (30%)
		LRR_8	115..181	CDD:290566	15/69 (22%)
		leucine-rich repeat	116..146	CDD:275380	8/33 (24%)
		leucine-rich repeat	147..170	CDD:275380	2/22 (9%)
		leucine-rich repeat	171..201	CDD:275380	7/29 (24%)
		LRR_RI	210..464	CDD:238064	72/272 (26%)
		leucine-rich repeat	212..236	CDD:275380	8/25 (32%)
		LRR_8	235..295	CDD:290566	18/60 (30%)
		leucine-rich repeat	237..260	CDD:275380	8/23 (35%)
		leucine-rich repeat	261..284	CDD:275380	5/22 (23%)
		LRR_8	283..345	CDD:290566	22/76 (29%)
		leucine-rich repeat	285..308	CDD:275380	10/23 (43%)
		leucine-rich repeat	309..334	CDD:275380	8/38 (21%)
		LRR_8	334..393	CDD:290566	16/59 (27%)
		leucine-rich repeat	335..358	CDD:275380	5/22 (23%)
		leucine-rich repeat	359..382	CDD:275380	5/22 (23%)
		LRR_8	382..441	CDD:290566	16/59 (27%)
		leucine-rich repeat	383..406	CDD:275380	8/23 (35%)
		leucine-rich repeat	407..430	CDD:275380	4/22 (18%)
		LRR_8	431..488	CDD:290566	18/56 (32%)
		leucine-rich repeat	431..451	CDD:275380	4/19 (21%)
		leucine-rich repeat	454..477	CDD:275380	10/22 (45%)
		LRR_8	477..559	CDD:290566	25/87 (29%)
		leucine-rich repeat	478..499	CDD:275380	7/24 (29%)
		leucine-rich repeat	502..525	CDD:275380	6/24 (25%)
		leucine-rich repeat	526..548	CDD:275380	4/21 (19%)
		leucine-rich repeat	590..617	CDD:275380	4/26 (15%)
		leucine-rich repeat	618..641	CDD:275380	7/22 (32%)
		leucine-rich repeat	642..689	CDD:275380	6/47 (13%)
		LRRCT	679..736	CDD:214507	12/57 (21%)
		leucine-rich repeat	775..796	CDD:275380	3/20 (15%)
		LRR_8	797..852	CDD:290566	13/62 (21%)
		leucine-rich repeat	797..817	CDD:275380	4/19 (21%)
		leucine-rich repeat	818..841	CDD:275380	5/27 (19%)
		LRR_8	841..900	CDD:290566	24/74 (32%)
		leucine-rich repeat	842..865	CDD:275380	11/35 (31%)
		LRR_4	866..907	CDD:289563	14/44 (32%)
		leucine-rich repeat	866..889	CDD:275380	7/25 (28%)
		leucine-rich repeat	890..911	CDD:275380	7/17 (41%)
		TIR	1045..1183	CDD:214587
RLP42	NP_189138.1	leucine-rich repeat	100..124	CDD:275380	6/23 (26%)
		PLN00113	113..>810	CDD:331614	198/839 (24%)
		leucine-rich repeat	125..148	CDD:275380	6/35 (17%)
		leucine-rich repeat	149..171	CDD:275380	7/39 (18%)
		leucine-rich repeat	172..197	CDD:275380	8/25 (32%)
		leucine-rich repeat	198..222	CDD:275380	8/23 (35%)
		leucine-rich repeat	223..246	CDD:275380	5/22 (23%)
		leucine-rich repeat	247..269	CDD:275380	10/23 (43%)
		leucine-rich repeat	270..293	CDD:275380	5/22 (23%)
		leucine-rich repeat	294..318	CDD:275380	8/32 (25%)
		leucine-rich repeat	319..341	CDD:275380	7/28 (25%)
		leucine-rich repeat	342..391	CDD:275380	16/70 (23%)
		leucine-rich repeat	392..414	CDD:275380	10/22 (45%)
		leucine-rich repeat	415..436	CDD:275380	7/24 (29%)
		leucine-rich repeat	439..463	CDD:275380	6/24 (25%)
		leucine-rich repeat	464..508	CDD:275380	14/52 (27%)
		leucine-rich repeat	511..553	CDD:275380	12/64 (19%)
		leucine-rich repeat	554..577	CDD:275380	5/45 (11%)
		leucine-rich repeat	578..601	CDD:275380	6/32 (19%)
		leucine-rich repeat	602..628	CDD:275380	8/58 (14%)
		leucine-rich repeat	629..701	CDD:275380	16/78 (21%)
		leucine-rich repeat	702..725	CDD:275380	8/22 (36%)
		leucine-rich repeat	726..749	CDD:275380	6/22 (27%)
		leucine-rich repeat	750..773	CDD:275380	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000