DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and RLP39

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001327089.1	Gene:	RLP39 / 822088	AraportID:	AT3G24900	Length:	915	Species:	Arabidopsis thaliana

Alignment Length:	902	Identity:	213/902 - (23%)
Similarity:	331/902 - (36%)	Gaps:	240/902 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 QSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNAN 203
            |:|...|...:.| ..|:...| .||||...:..::.|   |:|:          |....| .:|
plant    75 QAFTQFKNEFDTH-ACNHSDSL-NGVWCDNSTGAVMKL---RLRA----------CLSGTL-KSN 123

  Fly   204 GAVSGGSELQTLDVSFNEL--RSLPDAWGA----------------------SRLRRLQTLSLQH 244
            .::....:|:.|.:|:|..  .|:|..:|.                      |.|..|..|.|.|
plant   124 SSLFQFHQLRHLYLSYNNFTPSSIPSEFGMLNKLEVLFMSTGGFLGQVPSSFSNLSMLSALLLHH 188

  Fly   245 NNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAG----NKELRELH------LQGNDL---- 295
            |.: |.:.:.:..|..|.:|::|:||        |:|    |..|.|||      |..|:.
plant   189 NEL-TGSLSFVRNLRKLTILDVSHNH--------FSGTLNPNSSLFELHNLAYLDLGSNNFTSSS 244

  Fly   296 --YELPKGLLHRLEQLLVLDLSGN--------------QLTSHHVDNSTFAG-------LIRLIV 337
              ||.  |.|::||   :||:|.|              |||..::..:.|.|       |.:|.:
plant   245 LPYEF--GNLNKLE---LLDVSSNSFFGQVPPTISNLTQLTELYLPLNDFTGSLPLVQNLTKLSI 304

  Fly   338 LNLSNNALTRIGSKTFKELYFLQILDMRNNSI-GHIEEGAFLPLYNLHTLNLAENRLHTLDNRIF 401
            |:||:|..:.....:...:.||..||:..|:: |.||.........|..|||.||.   .:.:|.
plant   305 LHLSDNHFSGTIPSSLFTMPFLSYLDLGGNNLSGSIEVPNSSLSSRLENLNLGENH---FEGKII 366

  Fly   402 NGLYVLTKLT------LNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDL--SMLKTLD 458
            ..:..|..|.      ||.:..  :..:.|.:...|..||||...:::...::...  |.|:.|.
plant   367 EPISKLINLKELHLSFLNTSYP--INLKLFSSLKYLLLLDLSGGWISQASLSLDSYIPSTLEALL 429

  Fly   459 LGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKN 523
            |....||.|. |..:.|..|..:.|..|:|..........|||||
plant   430 LKHCNISVFP-NILKTLPNLEFIALSTNKISGKIPEWLWSLPRLS-------------------- 473

  Fly   524 TEIEAIRLDKNFLTDINGIFATL--ASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGN 586
                ::.:::|..|...|....|  :|:..|||..|:|        ...|..|.:..||..|..|
plant   474 ----SVFIEENLFTGFEGSSEILVNSSVRILNLLSNNL--------EGALPHLPLSVNYFSARNN 526

  Fly   587 YY------KLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFIN---NNIIGQIQANTFVDKTRL 642
            .|      .:.....:..||.|:|..|  |.:. |.....|.:|   ||:.|.| .:|:.....|
plant   527 RYGGDIPLSICSRRSLVFLDLSYNNFT--GPIP-PCPSNFLILNLRKNNLEGSI-PDTYYADAPL 587

  Fly   643 ARVDL-YANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCS-MEWLQRINNLTTRQHPHVV 705
            ..:|: |..:..|:..:.|                       :|| :::|...:|......|..:
plant   588 RSLDVGYNRLTGKLPRSLL-----------------------NCSALQFLSVDHNGIKDTFPFSL 629

  Fly   706 D-LGNIECLMPHSRS--APLRP--LASLSASDFVC------KYESHCPPTCHCCEYEQCECEVIC 759
            . |..::.|:.||.:  .||.|  ..||...:...      |:....||..    :|..:...:.
plant   630 KALPKLQVLILHSNNFYGPLSPPNQGSLGFPELRILEIAGNKFTGSLPPDF----FENWKASSLT 690

  Fly   760 ----PGNCSCFHDATWAT------NIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTG 814
                .|....::...:.|      ..:|...:.|:...||:....:.:...||.: |.|:....|
plant   691 MNEDQGLYMVYNKVVYGTYYFTSLEAIDLQYKGLSMEQNRVLSSSATIDFSGNRL-EGEIPESIG 754

  Fly   815 RRNLRALY-LNASNLMTLQNG-------SLAQLVNLRVLHLENNKLTALEGTEFRSLGLLREL-Y 870
            .  |:||. ||.||     |.       |||.|..:..|.|.:|:|:   ||....:|.|..| |
plant   755 L--LKALIALNLSN-----NAFTGHIPLSLANLKKIESLDLSSNQLS---GTIPNGIGTLSFLAY 809

  Fly   871 L---HNNMLTHI---SNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNA 921
            :   ||.:...|   :..|.:|..|.|    .|..|..||       ||....|.||
plant   810 MNVSHNQLNGEIPQGTQITGQPKSSFE----GNAGLCGLP-------LQESCFGTNA 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	11/41 (27%)
		leucine-rich repeat	116..146	CDD:275380	2/6 (33%)
		leucine-rich repeat	147..170	CDD:275380	7/22 (32%)
		leucine-rich repeat	171..201	CDD:275380	5/29 (17%)
		LRR_RI	210..464	CDD:238064	80/323 (25%)
		leucine-rich repeat	212..236	CDD:275380	9/47 (19%)
		LRR_8	235..295	CDD:290566	21/69 (30%)
		leucine-rich repeat	237..260	CDD:275380	7/22 (32%)
		leucine-rich repeat	261..284	CDD:275380	8/26 (31%)
		LRR_8	283..345	CDD:290566	27/94 (29%)
		leucine-rich repeat	285..308	CDD:275380	11/34 (32%)
		leucine-rich repeat	309..334	CDD:275380	10/45 (22%)
		LRR_8	334..393	CDD:290566	19/59 (32%)
		leucine-rich repeat	335..358	CDD:275380	5/22 (23%)
		leucine-rich repeat	359..382	CDD:275380	7/23 (30%)
		LRR_8	382..441	CDD:290566	17/64 (27%)
		leucine-rich repeat	383..406	CDD:275380	7/22 (32%)
		leucine-rich repeat	407..430	CDD:275380	5/28 (18%)
		LRR_8	431..488	CDD:290566	17/58 (29%)
		leucine-rich repeat	431..451	CDD:275380	5/19 (26%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..559	CDD:290566	18/83 (22%)
		leucine-rich repeat	478..499	CDD:275380	4/20 (20%)
		leucine-rich repeat	502..525	CDD:275380	2/22 (9%)
		leucine-rich repeat	526..548	CDD:275380	4/23 (17%)
		leucine-rich repeat	590..617	CDD:275380	7/26 (27%)
		leucine-rich repeat	618..641	CDD:275380	7/25 (28%)
		leucine-rich repeat	642..689	CDD:275380	7/48 (15%)
		LRRCT	679..736	CDD:214507	14/68 (21%)
		leucine-rich repeat	775..796	CDD:275380	4/20 (20%)
		LRR_8	797..852	CDD:290566	20/62 (32%)
		leucine-rich repeat	797..817	CDD:275380	5/19 (26%)
		leucine-rich repeat	818..841	CDD:275380	12/30 (40%)
		LRR_8	841..900	CDD:290566	18/65 (28%)
		leucine-rich repeat	842..865	CDD:275380	6/22 (27%)
		LRR_4	866..907	CDD:289563	14/47 (30%)
		leucine-rich repeat	866..889	CDD:275380	8/29 (28%)
		leucine-rich repeat	890..911	CDD:275380	5/20 (25%)
		TIR	1045..1183	CDD:214587
RLP39	NP_001327089.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000