DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and RLP34

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001326087.1	Gene:	RLP34 / 820272	AraportID:	AT3G11010	Length:	957	Species:	Arabidopsis thaliana

Alignment Length:	1012	Identity:	234/1012 - (23%)
Similarity:	361/1012 - (35%)	Gaps:	301/1012 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSE 94
            |||: |:|     |:.:   ||       :|.|    |:|.||.  ||....:....|.|..|:.
plant    83 CNWE-GVT-----CNAK---SG-------EVIE----LNLSCSS--LHGRFHSNSSIRNLHFLTT 125

  Fly    95 LRIDACKLQRVPPNAFEG-----LMSLKRLTLESHNAVWGPGKTLELHGQSFQG--------LKE 146
            |  |...      |.|||     :.:|..||            :|:|....|.|        |..
plant   126 L--DRSH------NDFEGQITSSIENLSHLT------------SLDLSYNRFSGQILNSIGNLSR 170

  Fly   147 LSELHLGDNNIR-QLPEGVWCSMPSLQLLNLTQNR-----------IRSAEFLGFSEKLCAGSAL 199
            |:.|.|..|... |:|..:. ::..|..|.|:.||           :....|||.|.....|...
plant   171 LTSLDLSFNQFSGQIPSSIG-NLSHLTFLGLSGNRFFGQIPSSIGNLSHLTFLGLSGNRFFGQFP 234

  Fly   200 SNANGAVSGGSELQTLDVSFNELR-SLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRV 263
            |    ::.|.|.|..|.:|:|:.. .:|.:.|  .|.:|..|.|..||.....|::...|:.|..
plant   235 S----SIGGLSNLTNLHLSYNKYSGQIPSSIG--NLSQLIVLYLSVNNFYGEIPSSFGNLNQLTR 293

  Fly   264 LNISYNHL----------------VSLPSEAFAGN--------KELRELHLQGNDLYELPKGLLH 304
            |::|:|.|                |||.:..|.|.        ..|...:...|.........|.
plant   294 LDVSFNKLGGNFPNVLLNLTGLSVVSLSNNKFTGTLPPNITSLSNLMAFYASDNAFTGTFPSFLF 358

  Fly   305 RLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNL-SNNALTRIGSKTFKELYFLQILDMRNNS 368
            .:..|..|.||||||.. .::....:....|..||: |||.:..|.|...|      :::::...
plant   359 IIPSLTYLGLSGNQLKG-TLEFGNISSPSNLQYLNIGSNNFIGPIPSSISK------LINLQELG 416

  Fly   369 IGH-------IEEGAFLPLYNLHTLNLAENRLHTLD-NRIFNGLYVLTKLTLNNNLVSIVESQAF 425
            |.|       ::...|..|.:|..|.|:.....|:| |.|......|..|.|:.||||.....:.
plant   417 ISHLNTQCRPVDFSIFSHLKSLDDLRLSYLTTTTIDLNDILPYFKTLRSLDLSGNLVSATNKSSV 481

  Fly   426 RN---CSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNR 487
            .:   ...::.|.||...:|:.||.::....|..||:..|:|.
plant   482 SSDPPSQSIQSLYLSGCGITDFPEILRTQHELGFLDVSNNKIK---------------------- 524

  Fly   488 IGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWL 552
             |.:. |....||.|..|||:.|.....:|....:.:....:..:.||...|......|.||..|
plant   525 -GQVP-GWLWTLPNLFYLNLSNNTFIGFQRPTKPEPSMAYLLGSNNNFTGKIPSFICELRSLYTL 587

  Fly   553 NLSENHLVWFDYAFIP-------SNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIG 610
            :||:|:.    ...||       |||..|::..|.:.. |....:.|.:|  :||..||::  :|
plant   588 DLSDNNF----SGSIPRCMENLKSNLSELNLRQNNLSG-GFPEHIFESLR--SLDVGHNQL--VG 643

  Fly   611 AMSVPNSIELLFINNNIIGQIQANTFVDKTRLARV-DLYANVLSKISLNALRVAPVSAEKPVPEF 674
              .:|.|  |.|.:|..:..:::|         |: |::...||  ||..|:|           .
plant   644 --KLPRS--LRFFSNLEVLNVESN---------RINDMFPFWLS--SLQKLQV-----------L 682

  Fly   675 YLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNI-ECLMPHSRSAPLRPLASLSASDFVCKYE 738
            .|..|.|.                         |.| :.|.|..|      :..:|.:.|
plant   683 VLRSNAFH-------------------------GPINQALFPKLR------IIDISHNHF----- 711

  Fly   739 SHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDL--YLDG 801
            :...||.:..|:.:                                         :|.|  |.||
plant   712 NGSLPTEYFVEWSR-----------------------------------------MSSLGTYEDG 735

  Fly   802 NNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLH----LENNKLTALEGTEFRS 862
            :|:..|..|:.            ..:::.:..|..::||.:..::    ...||   .||...:|
plant   736 SNVNYLGSGYY------------QDSMVLMNKGVESELVRILTIYTAVDFSGNK---FEGEIPKS 785

  Fly   863 LGLLRELY---LHNNMLTHISNATFEPLVSLEVLRLDNNR-----------LSSLPHLQYRHS-L 912
            :|||:||:   |.||..|....::...|.:||.|.:..|:           ||.|.::.:.|: |
plant   786 IGLLKELHVLNLSNNAFTGHIPSSIGNLTALESLDVSQNKLYGEIPQEIGNLSLLSYMNFSHNQL 850

  Fly   913 QGLTLGRNAW-SCRCQQLR-ELAQFVSDNAMVVRDAH 947
            .||..|...: :.||.... .|..|.|....|.||.|
plant   851 TGLVPGGQQFLTQRCSSFEGNLGLFGSSLEEVCRDIH 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	8/24 (33%)
		leucine-rich repeat	92..115	CDD:275380	7/27 (26%)
		LRR_8	115..181	CDD:290566	19/85 (22%)
		leucine-rich repeat	116..146	CDD:275380	8/37 (22%)
		leucine-rich repeat	147..170	CDD:275380	6/23 (26%)
		leucine-rich repeat	171..201	CDD:275380	10/40 (25%)
		LRR_RI	210..464	CDD:238064	73/290 (25%)
		leucine-rich repeat	212..236	CDD:275380	7/24 (29%)
		LRR_8	235..295	CDD:290566	19/83 (23%)
		leucine-rich repeat	237..260	CDD:275380	7/22 (32%)
		leucine-rich repeat	261..284	CDD:275380	10/46 (22%)
		LRR_8	283..345	CDD:290566	17/62 (27%)
		leucine-rich repeat	285..308	CDD:275380	3/22 (14%)
		leucine-rich repeat	309..334	CDD:275380	8/24 (33%)
		LRR_8	334..393	CDD:290566	16/66 (24%)
		leucine-rich repeat	335..358	CDD:275380	9/23 (39%)
		leucine-rich repeat	359..382	CDD:275380	4/29 (14%)
		LRR_8	382..441	CDD:290566	17/62 (27%)
		leucine-rich repeat	383..406	CDD:275380	7/23 (30%)
		leucine-rich repeat	407..430	CDD:275380	7/25 (28%)
		LRR_8	431..488	CDD:290566	11/56 (20%)
		leucine-rich repeat	431..451	CDD:275380	6/19 (32%)
		leucine-rich repeat	454..477	CDD:275380	5/22 (23%)
		LRR_8	477..559	CDD:290566	20/81 (25%)
		leucine-rich repeat	478..499	CDD:275380	2/20 (10%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		leucine-rich repeat	526..548	CDD:275380	4/21 (19%)
		leucine-rich repeat	590..617	CDD:275380	8/26 (31%)
		leucine-rich repeat	618..641	CDD:275380	4/22 (18%)
		leucine-rich repeat	642..689	CDD:275380	11/47 (23%)
		LRRCT	679..736	CDD:214507	9/57 (16%)
		leucine-rich repeat	775..796	CDD:275380	0/20 (0%)
		LRR_8	797..852	CDD:290566	11/60 (18%)
		leucine-rich repeat	797..817	CDD:275380	7/21 (33%)
		leucine-rich repeat	818..841	CDD:275380	2/22 (9%)
		LRR_8	841..900	CDD:290566	19/76 (25%)
		leucine-rich repeat	842..865	CDD:275380	5/26 (19%)
		LRR_4	866..907	CDD:289563	15/54 (28%)
		leucine-rich repeat	866..889	CDD:275380	8/25 (32%)
		leucine-rich repeat	890..911	CDD:275380	7/31 (23%)
		TIR	1045..1183	CDD:214587
RLP34	NP_001326087.1	LRRNT_2	40..91	CDD:311940	5/13 (38%)
		PLN00113	75..>717	CDD:331614	184/784 (23%)
		leucine-rich repeat	123..146	CDD:275380	8/30 (27%)
		leucine-rich repeat	147..170	CDD:275380	7/34 (21%)
		leucine-rich repeat	171..194	CDD:275380	6/23 (26%)
		leucine-rich repeat	195..218	CDD:275380	5/22 (23%)
		leucine-rich repeat	219..242	CDD:275380	7/26 (27%)
		leucine-rich repeat	243..266	CDD:275380	7/24 (29%)
		leucine-rich repeat	267..290	CDD:275380	7/22 (32%)
		leucine-rich repeat	291..314	CDD:275380	5/22 (23%)
		leucine-rich repeat	315..362	CDD:275380	8/46 (17%)
		leucine-rich repeat	388..411	CDD:275380	9/28 (32%)
		leucine-rich repeat	412..437	CDD:275380	4/24 (17%)
		leucine-rich repeat	463..489	CDD:275380	7/25 (28%)
		leucine-rich repeat	490..512	CDD:275380	6/21 (29%)
		leucine-rich repeat	513..536	CDD:275380	8/46 (17%)
		leucine-rich repeat	560..583	CDD:275380	4/22 (18%)
		PLN00113	566..>880	CDD:331614	95/440 (22%)
		leucine-rich repeat	584..608	CDD:275380	7/27 (26%)
		leucine-rich repeat	609..630	CDD:275380	4/21 (19%)
		leucine-rich repeat	631..654	CDD:275380	10/30 (33%)
		leucine-rich repeat	655..678	CDD:275380	7/33 (21%)
		leucine-rich repeat	679..700	CDD:275380	8/56 (14%)
		leucine-rich repeat	701..737	CDD:275380	11/87 (13%)
		leucine-rich repeat	738..791	CDD:275380	13/67 (19%)
		leucine-rich repeat	792..815	CDD:275380	6/22 (27%)
		leucine-rich repeat	816..839	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910