DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and TLR10

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_112218.2 Gene:TLR10 / 81793 HGNCID:15634 Length:811 Species:Homo sapiens


Alignment Length:1038 Identity:208/1038 - (20%)
Similarity:346/1038 - (33%) Gaps:333/1038 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 ELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLP 275
            ||.| :.|...||.:|    |.......||.|.:|.:..|..:....:|.||||.:.:|.:..|.
Human    29 ELMT-NCSNMSLRKVP----ADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLD 88

  Fly   276 SEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNL 340
            .:.|..|||||.|.|..|.|..:...||..|.   .||||.|...:..:.... ..:..|.:|.|
Human    89 LKTFEFNKELRYLDLSNNRLKSVTWYLLAGLR---YLDLSFNDFDTMPICEEA-GNMSHLEILGL 149

  Fly   341 SNNALTRIGSKTFKELYFLQI----LDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIF 401
            |.   .:|....|:::..|.:    |..|  ::.|.|||: ||:.|       ..:||.:     
Human   150 SG---AKIQKSDFQKIAHLHLNTVFLGFR--TLPHYEEGS-LPILN-------TTKLHIV----- 196

  Fly   402 NGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDL-GENQIS 465
                                            |.:.:|....:.:.::...:|:..:: |::|..
Human   197 --------------------------------LPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFV 229

  Fly   466 EFKNNTFRNL---NQLTGLRLIDNRIGNITVGMF--------QDLPRLSVLNLAKNRIQSIERGA 519
            .::..  |||   |..|.:.|: |::..:...:|        ..:....:.|:.......::..:
Human   230 SYEMQ--RNLSLENAKTSVLLL-NKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNS 291

  Fly   520 FD-KNTEIEAIRLD----KNFLTDINGIFATLASLLWLNLSEN-----HLVWFDYAFIPSNLKWL 574
            || .||.:..|:|:    :.|....:.|:..|..:...||:.:     |:::.:|   |:..::|
Human   292 FDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNY---PTKFQYL 353

  Fly   575 DIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQ-ANTFVD 638
            :...|.         |.:|:...|:...|              ::.|.:|.|.:..:. .:.|.:
Human   354 NFANNI---------LTDELFKRTIQLPH--------------LKTLILNGNKLETLSLVSCFAN 395

  Fly   639 KTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPH 703
            .|.|..:||..|:|                                               ||. 
Human   396 NTPLEHLDLSQNLL-----------------------------------------------QHK- 412

  Fly   704 VVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHD 768
                 |.|                                                  |||    
Human   413 -----NDE--------------------------------------------------NCS---- 418

  Fly   769 ATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQN 833
              |                   |:.|.::.|..|.:.:.....|.  ::::.|.||.:.:.|:..
Human   419 --W-------------------PETVVNMNLSYNKLSDSVFRCLP--KSIQILDLNNNQIQTVPK 460

  Fly   834 GSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNN 898
            .:: .|:.||.|::..|.||.|.|                  .:|.|.        |.||.::.|
Human   461 ETI-HLMALRELNIAFNFLTDLPG------------------CSHFSR--------LSVLNIEMN 498

  Fly   899 RLSSLPHLQYRHSLQ---GLTLGRNAWSCRCQQLRELAQFVS----DNAMVVRDAHDIYCLDAGI 956
            .:.| |.|.:..|.|   .|..|||.:.|.|    ||..|:.    ...|:|..:....|     
Human   499 FILS-PSLDFVQSCQEVKTLNAGRNPFRCTC----ELKNFIQLETYSEVMMVGWSDSYTC----- 553

  Fly   957 KRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESV 1021
            :..|.|.|        :.|.|.....:|.:        ..||...:|:|.||:.|.:.|......
Human   554 EYPLNLRG--------TRLKDVHLHELSCN--------TALLIVTIVVIMLVLGLAVAFCCLHFD 602

  Fly  1022 RMWLFAHYGVRVCEPRFEDAGKL----------YDAIILHSEKDYEFVCRNIAAELEHGRPPFRL 1076
            ..|.....|  .|...:....|.          :.|.|.:||.|..:|...:...||.......:
Human   603 LPWYLRMLG--QCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILI 665

  Fly  1077 CIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLATEWNRIEF----RNAFHESLRGLAQKLV 1136
            |:.:....|..|..: :|.....|.|.|.||:.|.:..||...||    .|.|||:...:.  |:
Human   666 CLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHII--LI 728

  Fly  1137 IIEETSVSA------EAEDVAELSPYLKSVPSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTL 1193
            ::|......      :.:.:.|...||:.....|  .|. .||..||.||.:.:......|.|
Human   729 LLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRR--KCG-LFWANLRAAINVNVLATREMYEL 788

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR 210..592 CDD:443914 87/406 (21%)
leucine-rich repeat 212..236 CDD:275380 7/23 (30%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
leucine-rich repeat 285..308 CDD:275380 9/22 (41%)
leucine-rich repeat 309..334 CDD:275380 5/24 (21%)
leucine-rich repeat 335..358 CDD:275380 6/22 (27%)
leucine-rich repeat 359..382 CDD:275380 9/26 (35%)
leucine-rich repeat 383..406 CDD:275380 2/22 (9%)
leucine-rich repeat 407..430 CDD:275380 0/22 (0%)
leucine-rich repeat 431..451 CDD:275380 2/19 (11%)
leucine-rich repeat 454..477 CDD:275380 6/26 (23%)
leucine-rich repeat 478..499 CDD:275380 4/28 (14%)
leucine-rich repeat 502..525 CDD:275380 4/23 (17%)
leucine-rich repeat 526..548 CDD:275380 5/25 (20%)
leucine-rich repeat 590..617 CDD:275380 4/26 (15%)
leucine-rich repeat 618..641 CDD:275380 4/23 (17%)
leucine-rich repeat 642..689 CDD:275380 5/46 (11%)
LRRCT 679..736 CDD:214507 4/56 (7%)
LRR <775..>920 CDD:443914 31/147 (21%)
leucine-rich repeat 775..796 CDD:275380 2/20 (10%)
leucine-rich repeat 797..817 CDD:275380 3/19 (16%)
leucine-rich repeat 818..841 CDD:275380 5/22 (23%)
leucine-rich repeat 842..865 CDD:275380 8/22 (36%)
leucine-rich repeat 866..889 CDD:275380 2/22 (9%)
leucine-rich repeat 890..911 CDD:275380 7/20 (35%)
TIR 1045..1183 CDD:214587 39/148 (26%)
TLR10NP_112218.2 LRR 1 24..46 8/21 (38%)
LRR <33..267 CDD:443914 66/294 (22%)
LRR 2 49..70 5/20 (25%)
leucine-rich repeat 50..73 CDD:275378 5/22 (23%)
LRR_8 72..129 CDD:404697 25/59 (42%)
LRR 3 73..94 7/20 (35%)
leucine-rich repeat 74..97 CDD:275378 8/22 (36%)
LRR 4 97..118 9/20 (45%)
leucine-rich repeat 98..112 CDD:275378 6/13 (46%)
leucine-rich repeat 119..143 CDD:275378 6/27 (22%)
LRR 5 119..139 6/23 (26%)
LRR 6 143..166 6/25 (24%)
leucine-rich repeat 144..155 CDD:275378 4/13 (31%)
LRR 7 296..321 6/24 (25%)
LRR 8 325..348 4/25 (16%)
LRR <348..>524 CDD:443914 57/356 (16%)
LRR 9 349..368 4/27 (15%)
LRR 10 373..394 4/34 (12%)
leucine-rich repeat 374..398 CDD:275378 4/23 (17%)
LRR 11 398..419 12/129 (9%)
leucine-rich repeat 399..444 CDD:275378 18/174 (10%)
LRR 12 422..442 3/19 (16%)
LRR 13 444..465 4/21 (19%)
leucine-rich repeat 445..467 CDD:275378 5/22 (23%)
LRR 14 467..488 9/38 (24%)
leucine-rich repeat 468..481 CDD:275378 6/12 (50%)
LRR 15 489..509 7/28 (25%)
leucine-rich repeat 491..513 CDD:275380 7/22 (32%)
LRRCT 522..574 CDD:214507 14/68 (21%)
TIR 633..775 CDD:214587 37/146 (25%)
Blue background indicates that the domain is not in the aligned region.

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