DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and RLP27

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_180865.2	Gene:	RLP27 / 817868	AraportID:	AT2G33060	Length:	808	Species:	Arabidopsis thaliana

Alignment Length:	636	Identity:	172/636 - (27%)
Similarity:	249/636 - (39%)	Gaps:	157/636 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 LHG-----QSFQGLKELSELHLGDNNI--RQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKL 193
            |||     .|..||:.|..|:|.:||.  ..||.| :.::..|::|.|:.|        ||
plant    83 LHGSMKPNSSLFGLQHLRYLNLSNNNFTSASLPSG-FGNLNRLEVLYLSSN--------GF---- 134

  Fly   194 CAGSALSNANGAVSGGSELQTLDVSFNELR-SLPDAWGASRLRRLQTLSLQHNNISTLAPNALAG 257
                 |.....:.|..|:|..||:|.|||. |.|   ....|.:|..|.|.:|:.|...|::|..
plant   135 -----LGQVPSSFSNLSQLNILDLSHNELTGSFP---FVQNLTKLSILVLSYNHFSGTIPSSLLT 191

  Fly   258 LSSLRVLNISYNHL---VSLPSEAFAGNKELREL---HLQGNDLYELPKGLLHRLEQLLVLDLSG 316
            |..|..|::..|:|   :..|:.:.:...|...|   |.:|..|..:.|     |..|..||||.
plant   192 LPFLSSLDLRENYLTGSIEAPNSSTSSRLEFMYLGNNHFEGQILEPISK-----LINLKHLDLSF 251

  Fly   317 NQLTSHHVD---NSTFAGLIRLIV-----------------LNLSNNALTRIGSKTF----KELY 357
            .: ||:.:|   .|:|..|:||::                 |||.|..|...|...|    |.|.
plant   252 LK-TSYPIDLNLFSSFKSLVRLVLSGNSLLATSITSDSKIPLNLENLVLLSCGLIEFPTILKNLT 315

  Fly   358 FLQILDMRNNSI-GHIEEGAFLPLYNLHTLNLAEN-----------------RLHTLDNRIFNGL 404
            .|:.:|:.||.| |.:.|. |..|..|..:||..|                 ||..|....|.|.
plant   316 KLEHIDLSNNKIKGKVPEW-FWNLPRLRRVNLFNNLFTDLEGSEEVLVNSSVRLLDLAYNHFRGP 379

  Fly   405 YVLTKLTLN-----NNLVSIVESQAFRNC--SDLKELDLSSNQLT-------------------- 442
            :....|::|     ||  |...:.....|  |.|..||||.|.||
plant   380 FPKPPLSINLLSAWNN--SFTGNIPLETCNRSSLAILDLSYNNLTGPIPRCLSDFQESLIVVNLR 442

  Fly   443 ------EVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPR 501
                  .:|:...|.::|:|||:|.||::.....:..|.:.|..:.:..|:|.:......:.||.
plant   443 KNNLEGSLPDIFSDGALLRTLDVGYNQLTGKLPRSLLNCSMLRFVSVDHNKIKDTFPFWLKALPD 507

  Fly   502 LSVLNLAKNR----IQSIERG--AFDKNTEIEAIRLDKNFLTDI--NGIFATLASLLWLNLSENH 558
            |..|.|..|:    |...:||  ||.|...:|.  .|.||...:  |......||.|.:| .:..
plant   508 LQALTLRSNKFHGPISPPDRGPLAFPKLRILEI--SDNNFTGSLPPNYFVNWEASSLQMN-EDGR 569

  Fly   559 LVWFDY---AFIPSNLKWLDIHGNYIE---ALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNS 617
            :...||   .:|..:...|...|.::|   .|.:|         .|:|.|.|::..    .:|.|
plant   570 IYMGDYNNPYYIYEDTVDLQYKGLFMEQGKVLTSY---------ATIDFSGNKLEG----QIPES 621

  Fly   618 IELL-------FINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALR 661
            |.||       ..||...|.|.. :..:.|.|..:||..|.||....|.|:
plant   622 IGLLKALIALNLSNNAFTGHIPL-SLANVTELESLDLSRNQLSGTIPNGLK 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	18/51 (35%)
		leucine-rich repeat	116..146	CDD:275380	6/14 (43%)
		leucine-rich repeat	147..170	CDD:275380	8/24 (33%)
		leucine-rich repeat	171..201	CDD:275380	7/29 (24%)
		LRR_RI	210..464	CDD:238064	94/335 (28%)
		leucine-rich repeat	212..236	CDD:275380	10/24 (42%)
		LRR_8	235..295	CDD:290566	17/65 (26%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	5/25 (20%)
		LRR_8	283..345	CDD:290566	24/84 (29%)
		leucine-rich repeat	285..308	CDD:275380	6/25 (24%)
		leucine-rich repeat	309..334	CDD:275380	11/27 (41%)
		LRR_8	334..393	CDD:290566	24/97 (25%)
		leucine-rich repeat	335..358	CDD:275380	10/43 (23%)
		leucine-rich repeat	359..382	CDD:275380	9/23 (39%)
		LRR_8	382..441	CDD:290566	22/82 (27%)
		leucine-rich repeat	383..406	CDD:275380	9/39 (23%)
		leucine-rich repeat	407..430	CDD:275380	6/29 (21%)
		LRR_8	431..488	CDD:290566	20/82 (24%)
		leucine-rich repeat	431..451	CDD:275380	9/45 (20%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..559	CDD:290566	24/89 (27%)
		leucine-rich repeat	478..499	CDD:275380	3/20 (15%)
		leucine-rich repeat	502..525	CDD:275380	10/28 (36%)
		leucine-rich repeat	526..548	CDD:275380	5/23 (22%)
		leucine-rich repeat	590..617	CDD:275380	5/26 (19%)
		leucine-rich repeat	618..641	CDD:275380	7/29 (24%)
		leucine-rich repeat	642..689	CDD:275380	8/20 (40%)
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
RLP27	NP_180865.2	PLN00113	15..>712	CDD:215061	172/636 (27%)
		leucine-rich repeat	99..123	CDD:275380	8/24 (33%)
		leucine-rich repeat	124..147	CDD:275380	8/39 (21%)
		leucine-rich repeat	171..194	CDD:275380	8/22 (36%)
		leucine-rich repeat	195..219	CDD:275380	5/23 (22%)
		leucine-rich repeat	220..243	CDD:275380	7/27 (26%)
		leucine-rich repeat	244..268	CDD:275380	10/24 (42%)
		leucine-rich repeat	269..316	CDD:275380	12/46 (26%)
		leucine-rich repeat	317..338	CDD:275380	8/21 (38%)
		leucine-rich repeat	341..365	CDD:275380	4/23 (17%)
		leucine-rich repeat	387..410	CDD:275380	5/24 (21%)
		leucine-rich repeat	411..435	CDD:275380	8/23 (35%)
		leucine-rich repeat	436..459	CDD:275380	2/22 (9%)
		leucine-rich repeat	460..483	CDD:275380	8/22 (36%)
		leucine-rich repeat	484..507	CDD:275380	4/22 (18%)
		leucine-rich repeat	535..561	CDD:275380	6/27 (22%)
		leucine-rich repeat	562..603	CDD:275380	9/41 (22%)
		leucine-rich repeat	604..627	CDD:275380	10/35 (29%)
		leucine-rich repeat	628..651	CDD:275380	4/23 (17%)
		leucine-rich repeat	652..673	CDD:275380	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000