Protein Alignment 18w and PODNL1

DIOPT Version :10

• Sequence 1: NP_476814.1
• Gene: 18w / 37277
• FlyBaseID: FBgn0287775
• Length: 1385
• Species: Drosophila melanogaster
• Sequence 2: XP_011526610.1
• Gene: PODNL1 / 79883
• HGNCID: 26275
• Length: 579
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 83/406 - (20%)
• Similarity: 128/406 - (31%)
• Gaps: 141/406 - (34%)

  Fly   219 HFDEHAPRLKEHLNYLLKYLPPSPPEKKNLRVEPIEKSLPRSACPSPTPIFQQLYLAVAHWERYL 283
            |..|...||||.|..|.:.:..:.||         :.:..:..|.:.|.         |...:.|
Human   433 HLYEQGGRLKEPLQKLKEAIGRAMPE---------QMAKYQDECQAHTQ---------AKVAKML 479

  Fly   284 RDSPDFFRCRSVDVGGPLRRRMPSSSGTVSPAGADGDEEEDEEVFRCGGR------------DDG 336
            .:..|          ...|.|:.|            |||||||.   |||            |:.
Human   480 EEEKD----------KEQRDRICS------------DEEEDEEK---GGRRIMGPRKKFQWNDEI 519

  Fly   337 TMLMAGGRRRNSYQVGTAAETGDTGKLMAVNGSEKLRRRSSPAD----FSQGHHGITIRISDDQY 397
            ..|....||.:.:.....|:.    |:||.: ..|::..|:..|    ...|..|..|.:..|..
Human   520 RTLFKESRRGHGHLTSILAKK----KVMAPS-KIKVKESSTKPDKKVSVPSGQIGGPIALPSDHQ 579

  Fly   398 LDIDSQLDQGTMVSAGESDSESDLGEGM------DVEEFPETPYVHSP-------EEEFG----- 444
            ..       |..:.|...:..|....|:      ::|:..:...:.:|       .:|..
Human   580 TG-------GLSIGASSRELPSQASGGLANPPPVNLEDSLDEDLIRNPASSVEAVSKELAALNSR 637

  Fly   445 AAGEQVEELPEEHKSLIWFLVKQVRPGMDLSKVVLPTFILEPRSF-----------------LDK 492
            |||.....||...|:          |...:..|:...   |.|:|                 |:.
Human   638 AAGNSEFTLPAPSKA----------PAEKVGGVLCTE---EKRNFAKPSPSAPPPASSLQSPLNF 689

  Fly   493 LADSYYHADILSKAVLEDDPFTRMKTVVQWYLSGFYKKPKGLKKPYNPILGETFRCYWQHENGSR 557
            ||:   .|..|.::..|..|.:          ||:  |....:.|.|..|.|..:...:|.:..|
Human   690 LAE---QALALGQSSQEKKPES----------SGY--KELSCQAPLNKGLPEVHQSKAKHHSLPR 739

  Fly   558 TFYIAEQVSHHPPVSV 573
            |       ||.|.|:|
Human   740 T-------SHGPQVAV 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:404697
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR	210..592	CDD:443914	83/406 (20%)
		leucine-rich repeat	212..236	CDD:275380	8/16 (50%)
		leucine-rich repeat	237..260	CDD:275380	2/22 (9%)
		leucine-rich repeat	261..284	CDD:275380	3/22 (14%)
		leucine-rich repeat	285..308	CDD:275380	3/22 (14%)
		leucine-rich repeat	309..334	CDD:275380	10/36 (28%)
		leucine-rich repeat	335..358	CDD:275380	4/22 (18%)
		leucine-rich repeat	359..382	CDD:275380	6/26 (23%)
		leucine-rich repeat	383..406	CDD:275380	4/22 (18%)
		leucine-rich repeat	407..430	CDD:275380	5/28 (18%)
		leucine-rich repeat	431..451	CDD:275380	5/31 (16%)
		leucine-rich repeat	454..477	CDD:275380	3/22 (14%)
		leucine-rich repeat	478..499	CDD:275380	6/37 (16%)
		leucine-rich repeat	502..525	CDD:275380	3/22 (14%)
		leucine-rich repeat	526..548	CDD:275380	6/21 (29%)
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		LRR	<775..>920	CDD:443914
		leucine-rich repeat	775..796	CDD:275380
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		leucine-rich repeat	842..865	CDD:275380
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
PODNL1	XP_011526610.1	LRR	<75..321	CDD:443914
		leucine-rich repeat	75..97	CDD:275380
		leucine-rich repeat	98..123	CDD:275380
		leucine-rich repeat	124..168	CDD:275380
		PLN00113	157..>534	CDD:215061	32/143 (22%)
		leucine-rich repeat	169..194	CDD:275380
		leucine-rich repeat	195..215	CDD:275380
		leucine-rich repeat	216..239	CDD:275380
		leucine-rich repeat	240..265	CDD:275380
		leucine-rich repeat	266..287	CDD:275380
		leucine-rich repeat	289..310	CDD:275380
		leucine-rich repeat	311..336	CDD:275380
		leucine-rich repeat	337..358	CDD:275380
		leucine-rich repeat	361..428	CDD:275380
		leucine-rich repeat	429..452	CDD:275380	8/18 (44%)
		leucine-rich repeat	453..478	CDD:275380	5/42 (12%)
		leucine-rich repeat	500..523	CDD:275380	5/25 (20%)
		leucine-rich repeat	524..547	CDD:275380	6/27 (22%)