DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr4al

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001315534.1 Gene:tlr4al / 795671 ZFINID:ZDB-GENE-090507-2 Length:816 Species:Danio rerio


Alignment Length:1065 Identity:233/1065 - (21%)
Similarity:382/1065 - (35%) Gaps:361/1065 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 CAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGL 258
            |.|..||.....:.  |.:||||.|||:|:     |                    |........
Zfish    32 CMGRNLSYIPSRIP--SSVQTLDFSFNDLK-----W--------------------LKKTVFPVF 69

  Fly   259 SSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKG---LLHRLEQLLVLDLSGNQLT 320
            :.||||::|..|:..:.::||...|.|..|.|.||.:.....|   .|:.|::|:::|: |.:..
Zfish    70 TFLRVLDLSRCHIRQIENDAFYNVKNLTTLFLTGNPIIYFAPGCLNTLYNLQRLVLVDI-GLESL 133

  Fly   321 SHHVDNSTFAGLIRLIVLNLSNNALTRIG----SKTFKELYFLQILDMRNNSIGHIEEGAFLPLY 381
            ..:::|     |.:|..||:..|.:..:.    ..|||:   ..:||:..|:|..|.....:.|.
Zfish   134 QLNINN-----LTKLQELNVGTNYIQSMTLPPFMSTFKD---FSLLDLHANNISIIRTNHTVVLR 190

  Fly   382 NL---HTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTE 443
            .:   .||.|:.|.|..::...|.|:: |.:|.:.:..||....:                    
Zfish   191 EIGKNMTLILSRNPLLHIEPGSFKGVH-LVELDIRSTFVSFASKK-------------------- 234

  Fly   444 VPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLA 508
                                         :.||.|.||     .:..:..||::|.|:|      
Zfish   235 -----------------------------QGLNGLHGL-----NVTRLMFGMYKDDPKL------ 259

  Fly   509 KNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKW 573
                                      :.:|:: .|..|.|:.:...         |.::...|.|
Zfish   260 --------------------------YPSDLD-YFDGLCSIHFYEA---------YYYMKERLDW 288

  Fly   574 -------------LDIHGNYIEALG--NYYKLQEEIRVTT-------LDASHNRITEIGAMSVPN 616
                         :.:.|..|..:|  .::|::|...:.|       ...||.|..|        
Zfish   289 KMNIFRCMINATVVVVKGGVIRVIGYVPFHKIKELYLINTQLYTVPGKQLSHIRTLE-------- 345

  Fly   617 SIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNP- 680
              :.:|.:|:   ..|...|:|..:|..|||.:|   :|:|.:..:..:|....:....|..|| 
Zfish   346 --KFVFTHNS---ATQVEKFLDMPKLQYVDLNSN---QITLQSCCIDVLSGTPQIRYLNLSLNPQ 402

  Fly   681 -------FECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPL-ASLSASDFVCKY 737
                   ||...|:|.|.       ..|..::.:|:...|   |....||.| .|.|:..||   
Zfish   403 ISLDKGGFEGLESLEILD-------FHHTKLLGIGSFTLL---SNLKNLRYLDISYSSVTFV--- 454

  Fly   738 ESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALP---NRIPQDVSDLYL 799
                                    |..||:           |...|..|.   |....||:: ||
Zfish   455 ------------------------NVYCFY-----------GLSSLKVLKMAGNSFQGDVAN-YL 483

  Fly   800 DGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLG 864
             .||:..||  ||.         ::..:::.:...|...|..||.|:|..|.|.:::.....:|.
Zfish   484 -FNNLTFLE--HLD---------ISYCHVIEIHLTSFKNLQRLRHLNLRGNNLMSIDFLTDPNLK 536

  Fly   865 LLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQL 929
            .|...|::.|.:|.|      ||..|:.|.:               :|....|..|...|.|.| 
Zfish   537 QLTTFYVNKNSITTI------PLDILQKLPM---------------NLSEFDLSFNPIDCSCSQ- 579

  Fly   930 RELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGG-- 992
            .:...::.:|..|::...:|.|                             ..||.:.|....  
Zfish   580 TDFMLWIINNQRVLKQPENILC-----------------------------KTISPNSDFRVTDF 615

  Fly   993 ------YRLPLLAAVLV--LIFLVVVLIIVFVFRESVR-MWL----FAHYGVRVCEPRFEDAGKL 1044
                  |:..|:.|:||  ::|:||:.|:|:.|:..:| .|:    :...|.:.|.         
Zfish   616 DIDHCVYKKKLIIALLVFCVVFIVVLSILVYRFQFYLRYCWILLRGYRSPGQQECS--------- 671

  Fly  1045 YDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQ---ASHLQLVEGARASRKIILVL 1106
            |||.::.|..|..:|...:...||:|.||.:||:..||....   ||:: :.||...|||||:|:
Zfish   672 YDAFVIFSSYDEAWVMNELMENLENGVPPIQLCLHMRDFQAGKSIASNI-IDEGIMGSRKIIVVV 735

  Fly  1107 TRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETS--VSAEAEDVAE--------LSPYLKSVP 1161
            :::.:.:.|.|.||.         |||...::|..:  :....|||||        |..:||   
Zfish   736 SQHFIDSAWCRFEFE---------LAQSRFVVERNANIIIIILEDVAERKTKKVLGLHKHLK--- 788

  Fly  1162 SNRLLTCDR------YFWEKLRYAI 1180
            .|..|...|      .||.:||.||
Zfish   789 KNTYLKWSRDPLSNMRFWIRLRKAI 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 3/6 (50%)
LRR 210..592 CDD:443914 78/406 (19%)
leucine-rich repeat 212..236 CDD:275380 9/23 (39%)
leucine-rich repeat 237..260 CDD:275380 1/22 (5%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
leucine-rich repeat 285..308 CDD:275380 8/25 (32%)
leucine-rich repeat 309..334 CDD:275380 5/24 (21%)
leucine-rich repeat 335..358 CDD:275380 7/26 (27%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
leucine-rich repeat 383..406 CDD:275380 7/25 (28%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
leucine-rich repeat 431..451 CDD:275380 0/19 (0%)
leucine-rich repeat 454..477 CDD:275380 1/22 (5%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 1/22 (5%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 6/33 (18%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 14/54 (26%)
LRRCT 679..736 CDD:214507 18/65 (28%)
LRR <775..>920 CDD:443914 34/147 (23%)
leucine-rich repeat 775..796 CDD:275380 6/23 (26%)
leucine-rich repeat 797..817 CDD:275380 8/19 (42%)
leucine-rich repeat 818..841 CDD:275380 2/22 (9%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
leucine-rich repeat 866..889 CDD:275380 7/22 (32%)
leucine-rich repeat 890..911 CDD:275380 2/20 (10%)
TIR 1045..1183 CDD:214587 50/155 (32%)
tlr4alNP_001315534.1 leucine-rich repeat 28..47 CDD:275380 4/16 (25%)
LRR <36..>205 CDD:443914 52/204 (25%)
leucine-rich repeat 48..71 CDD:275380 10/47 (21%)
leucine-rich repeat 72..95 CDD:275380 8/22 (36%)
leucine-rich repeat 96..119 CDD:275380 7/22 (32%)
leucine-rich repeat 120..142 CDD:275380 6/27 (22%)
leucine-rich repeat 143..168 CDD:275380 7/27 (26%)
leucine-rich repeat 170..196 CDD:275380 6/25 (24%)
leucine-rich repeat 321..343 CDD:275380 4/21 (19%)
LRR <328..617 CDD:443914 85/416 (20%)
leucine-rich repeat 366..391 CDD:275380 8/27 (30%)
leucine-rich repeat 392..415 CDD:275380 5/22 (23%)
leucine-rich repeat 416..440 CDD:275380 6/33 (18%)
leucine-rich repeat 441..464 CDD:275380 11/60 (18%)
leucine-rich repeat 465..489 CDD:275380 9/25 (36%)
leucine-rich repeat 490..513 CDD:275380 6/33 (18%)
leucine-rich repeat 514..537 CDD:275380 7/22 (32%)
leucine-rich repeat 538..562 CDD:275380 9/44 (20%)
TIR 672..813 CDD:214587 48/153 (31%)
Blue background indicates that the domain is not in the aligned region.

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