Protein Alignment 18w and Lrrc15

DIOPT Version :10

• Sequence 1: NP_476814.1
• Gene: 18w / 37277
• FlyBaseID: FBgn0287775
• Length: 1385
• Species: Drosophila melanogaster
• Sequence 2: NP_083249.1
• Gene: Lrrc15 / 74488
• MGIID: 1921738
• Length: 579
• Species: Mus musculus
• Alignment Length: 470
• Identity: 130/470 - (27%)
• Similarity: 198/470 - (42%)
• Gaps: 53/470 - (11%)

  Fly   190 SEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPD--AWGASRLRRLQT------------- 239
            ||..|:.::.....||               ::.::|.  .|.|..|:.|.|
Mouse    27 SECTCSRASQVECTGA---------------QIVAMPSPLPWNAMSLQILNTHITELPEDKFLNI 76

  Fly   240 -----LSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELP 299
                 |.::.|.::.:.|.|...|.|||.|:::.|.|.:||...|.....|..|.|..|.|.::.
Mouse    77 SALIALKMEKNELANIMPGAFRNLGSLRHLSLANNKLKNLPVRLFQDVNNLETLLLSNNQLVQIQ 141

  Fly   300 KGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDM 364
            .....:...|..|.|.||.|  .::....|..|:.|..|||.||..|.:..:.|:.|..||:|.:
Mouse   142 PAQFSQFSNLKELQLYGNNL--EYIPEGVFDHLVGLTKLNLGNNGFTHLSPRVFQHLGNLQVLRL 204

  Fly   365 RNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCS 429
            ..|.:..|..|.|..|.||..|.|.||::.||...:|:....|.:|.|:||.:|.:....|....
Mouse   205 YENRLSDIPMGTFDALGNLQELALQENQIGTLSPGLFHNNRNLQRLYLSNNHISHLPPGIFMQLP 269

  Fly   430 DLKELDLSSNQLTEV-PEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITV 493
            .|.:|.|..|.|.|: |.....:..|:.|.|..|.|:...:|.|.:||||..|.|..|::..|:.
Mouse   270 HLNKLTLFGNSLKELSPGVFGPMPNLRELWLYNNHITSLPDNAFSHLNQLQVLILSHNQLSYISP 334

  Fly   494 GMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDING-IFATLASLLWLNLSEN 557
            |.|..|..|..|:|..|.:|.::...|.....:..:.|..|.|..:.| |||.:..|:.:.|..|
Mouse   335 GAFNGLTNLRELSLHTNALQDLDGNVFRSLANLRNVSLQNNRLRQLPGSIFANVNGLMTIQLQNN 399

  Fly   558 HLV-----WFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNS 617
            :|.     .||:.   .||..|.::.|......|...|.:.:   .|:.:......:...|.|.|
Mouse   400 NLENLPLGIFDHL---GNLCELRLYDNPWRCDSNILPLHDWL---ILNRARLGTDTLPVCSSPAS 458

  Fly   618 I---ELLFINNNIIG 629
            :   .|:.||.|..|
Mouse   459 VRGQSLVIINVNFPG 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:404697
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380	3/10 (30%)
		LRR	210..592	CDD:443914	116/408 (28%)
		leucine-rich repeat	212..236	CDD:275380	4/25 (16%)
		leucine-rich repeat	237..260	CDD:275380	7/40 (18%)
		leucine-rich repeat	261..284	CDD:275380	8/22 (36%)
		leucine-rich repeat	285..308	CDD:275380	5/22 (23%)
		leucine-rich repeat	309..334	CDD:275380	8/24 (33%)
		leucine-rich repeat	335..358	CDD:275380	9/22 (41%)
		leucine-rich repeat	359..382	CDD:275380	8/22 (36%)
		leucine-rich repeat	383..406	CDD:275380	8/22 (36%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		leucine-rich repeat	431..451	CDD:275380	7/20 (35%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		leucine-rich repeat	478..499	CDD:275380	7/20 (35%)
		leucine-rich repeat	502..525	CDD:275380	6/22 (27%)
		leucine-rich repeat	526..548	CDD:275380	7/22 (32%)
		leucine-rich repeat	590..617	CDD:275380	4/26 (15%)
		leucine-rich repeat	618..641	CDD:275380	5/15 (33%)
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		LRR	<775..>920	CDD:443914
		leucine-rich repeat	775..796	CDD:275380
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		leucine-rich repeat	842..865	CDD:275380
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Lrrc15	NP_083249.1	LRR_8	54..113	CDD:404697	14/58 (24%)
		LRR 1	54..75		4/20 (20%)
		leucine-rich repeat	58..78	CDD:275380	3/19 (16%)
		LRR 2	78..99		4/20 (20%)
		LRR 3	102..123		9/20 (45%)
		LRR	103..>441	CDD:443914	104/345 (30%)
		leucine-rich repeat	103..126	CDD:275380	8/22 (36%)
		LRR 4	126..147		5/20 (25%)
		leucine-rich repeat	127..150	CDD:275380	5/22 (23%)
		LRR 5	150..171		7/22 (32%)
		leucine-rich repeat	151..174	CDD:275380	8/24 (33%)
		LRR 6	174..195		8/20 (40%)
		leucine-rich repeat	175..198	CDD:275380	9/22 (41%)
		LRR 7	198..219		7/20 (35%)
		leucine-rich repeat	199..222	CDD:275380	8/22 (36%)
		LRR 8	222..243		9/20 (45%)
		leucine-rich repeat	223..246	CDD:275380	8/22 (36%)
		LRR 9	246..267		7/20 (35%)
		leucine-rich repeat	247..270	CDD:275380	7/22 (32%)
		LRR 10	270..291		7/20 (35%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		LRR 11	294..315		7/20 (35%)
		leucine-rich repeat	295..318	CDD:275380	8/22 (36%)
		LRR 12	318..339		8/20 (40%)
		leucine-rich repeat	319..342	CDD:275380	8/22 (36%)
		LRR 13	342..363		6/20 (30%)
		leucine-rich repeat	343..364	CDD:275380	6/20 (30%)
		LRR 14	366..387		6/20 (30%)
		leucine-rich repeat	367..387	CDD:275380	6/19 (32%)
		LRR 15	390..411		5/20 (25%)
		leucine-rich repeat	391..412	CDD:275380	6/20 (30%)
		LRRCT	423..>462	CDD:214507	7/41 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	476..509