DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 18w and Lrrtm1

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001349038.1	Gene:	Lrrtm1 / 74342	MGIID:	2389173	Length:	522	Species:	Mus musculus

Alignment Length:	417	Identity:	113/417 - (27%)
Similarity:	164/417 - (39%)	Gaps:	129/417 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ITIIAVAACLLLLVADAHAQQQCNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCS 72
            :.:..:.||..:|.|   |...|..|       .||.                    ||| |.|
Mouse    20 VVLCLLGACFQMLPA---APSGCPGQ-------CRCE--------------------GRL-LYC- 52

  Fly    73 QELLHASELAP-------GLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGP 130
             |.|:.:| ||       ||..:...|||||          ...|.|||.|..|.|: ||.:
Mouse    53 -EALNLTE-APHNLSGLLGLSLRYNSLSELR----------AGQFTGLMQLTWLYLD-HNHI--- 101

  Fly   131 GKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCA 195
               ..:.|.:||.|:.:.||.|..|.|.:|....:..||:
Mouse   102 ---CSVQGDAFQKLRRVKELTLSSNQITELANTTFRPMPN------------------------- 138

  Fly   196 GSALSNANGAVSGGSELQTLDVSFNELRSL-PDAWGASRLRRLQTLSLQHNNISTLAPNALAGLS 259
                            |:::|:|:|:|::| ||.:..  ||:|.||.::.|.|..:.........
Mouse   139 ----------------LRSVDLSYNKLQALAPDLFHG--LRKLTTLHMRANAIQFVPVRIFQDCR 185

  Fly   260 SLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHV 324
            ||:.|:|.||.|.||...:|||..:|.||||:.|||.:                          |
Mouse   186 SLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLIK--------------------------V 224

  Fly   325 DNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLA 389
            :.:.|..||.|..|.|..|.:..:.| :...::.|:.:|:..|.|.::|...|..:..|.||.|.
Mouse   225 NFAHFPRLISLHSLCLRRNKVAIVVS-SLDWVWNLEKMDLSGNEIEYMEPHVFETVPYLQTLQLD 288

  Fly   390 ENRLHTLDNRIFNGLYVLTKLTLNNNL 416
            .|||..::.||.|....||.:||..||
Mouse   289 SNRLTYIEPRILNSWKSLTSITLAGNL 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	11/31 (35%)
		leucine-rich repeat	92..115	CDD:275380	8/22 (36%)
		LRR_8	115..181	CDD:290566	17/65 (26%)
		leucine-rich repeat	116..146	CDD:275380	9/29 (31%)
		leucine-rich repeat	147..170	CDD:275380	7/22 (32%)
		leucine-rich repeat	171..201	CDD:275380	0/29 (0%)
		LRR_RI	210..464	CDD:238064	66/208 (32%)
		leucine-rich repeat	212..236	CDD:275380	9/24 (38%)
		LRR_8	235..295	CDD:290566	24/59 (41%)
		leucine-rich repeat	237..260	CDD:275380	5/22 (23%)
		leucine-rich repeat	261..284	CDD:275380	11/22 (50%)
		LRR_8	283..345	CDD:290566	16/61 (26%)
		leucine-rich repeat	285..308	CDD:275380	8/22 (36%)
		leucine-rich repeat	309..334	CDD:275380	3/24 (13%)
		LRR_8	334..393	CDD:290566	16/58 (28%)
		leucine-rich repeat	335..358	CDD:275380	5/22 (23%)
		leucine-rich repeat	359..382	CDD:275380	6/22 (27%)
		LRR_8	382..441	CDD:290566	16/35 (46%)
		leucine-rich repeat	383..406	CDD:275380	10/22 (45%)
		leucine-rich repeat	407..430	CDD:275380	6/10 (60%)
		LRR_8	431..488	CDD:290566
		leucine-rich repeat	431..451	CDD:275380
		leucine-rich repeat	454..477	CDD:275380
		LRR_8	477..559	CDD:290566
		leucine-rich repeat	478..499	CDD:275380
		leucine-rich repeat	502..525	CDD:275380
		leucine-rich repeat	526..548	CDD:275380
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Lrrtm1	NP_001349038.1	LRR 1	64..87		8/32 (25%)
		LRR	<75..>315	CDD:227223	90/326 (28%)
		LRR 2	89..111		8/28 (29%)
		leucine-rich repeat	91..114	CDD:275380	9/29 (31%)
		LRR 3	112..135		7/22 (32%)
		leucine-rich repeat	115..138	CDD:275380	7/22 (32%)
		LRR 4	136..159		10/63 (16%)
		leucine-rich repeat	139..162	CDD:275380	9/24 (38%)
		LRR 5	161..183		6/21 (29%)
		leucine-rich repeat	163..186	CDD:275380	5/22 (23%)
		LRR 6	184..207		10/22 (45%)
		leucine-rich repeat	187..210	CDD:275380	11/22 (50%)
		LRR 7	209..231		10/47 (21%)
		leucine-rich repeat	211..234	CDD:275380	11/48 (23%)
		LRR 8	233..255		6/22 (27%)
		leucine-rich repeat	235..257	CDD:275380	5/22 (23%)
		LRR 9	256..278		6/21 (29%)
		leucine-rich repeat	258..281	CDD:275380	6/22 (27%)
		LRR 10	280..302		9/21 (43%)
		leucine-rich repeat	282..300	CDD:275380	8/17 (47%)
		leucine-rich repeat	306..318	CDD:275378	6/10 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000