DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and TLR4

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_612564.1 Gene:TLR4 / 7099 HGNCID:11850 Length:839 Species:Homo sapiens


Alignment Length:1006 Identity:238/1006 - (23%)
Similarity:385/1006 - (38%) Gaps:250/1006 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   231 ASRLRRLQTLSLQHNNISTLAPNALAGLSSLR----------VLNISYNHLVSLPSEAFAGNKEL 285
            ||||            ..||.| |:|.||.:|          |.||:|               :.
Human     4 ASRL------------AGTLIP-AMAFLSCVRPESWEPCVEVVPNITY---------------QC 40

  Fly   286 RELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGS 350
            .||     :.|::|                         ||..|:    ...|:||.|.|..:||
Human    41 MEL-----NFYKIP-------------------------DNLPFS----TKNLDLSFNPLRHLGS 71

  Fly   351 KTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKL-TLNN 414
            .:|.....||:||:....|..||:||:..|.:|.||.|..|.:.:|....|:||..|.|| .:..
Human    72 YSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTLILTGNPIQSLALGAFSGLSSLQKLVAVET 136

  Fly   415 NLVSIVESQAFRNCSDLKELDLSSN--QLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQ 477
            ||.|: |:....:...||||:::.|  |..::||...:|:.|:.|||..|:|........|.|:|
Human   137 NLASL-ENFPIGHLKTLKELNVAHNLIQSFKLPEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQ 200

  Fly   478 LTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNF------L 536
            :..|.|                    .|:|:.|.:..|:.||| |...:..:.|..||      .
Human   201 MPLLNL--------------------SLDLSLNPMNFIQPGAF-KEIRLHKLTLRNNFDSLNVMK 244

  Fly   537 TDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDA 601
            |.|.|:.......|.|....|.          .||:..|  .:.:|.|.|.  ..||.|:..||.
Human   245 TCIQGLAGLEVHRLVLGEFRNE----------GNLEKFD--KSALEGLCNL--TIEEFRLAYLDY 295

  Fly   602 SHNRITEI-GAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPV 665
            ..:.|.:: ..::..:|..|:.:....:.....|  .....|..|:........:.|.:|:....
Human   296 YLDDIIDLFNCLTNVSSFSLVSVTIERVKDFSYN--FGWQHLELVNCKFGQFPTLKLKSLKRLTF 358

  Fly   666 SAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSA 730
            ::.|       |||.|.                     .|||.::|.|             .||.
Human   359 TSNK-------GGNAFS---------------------EVDLPSLEFL-------------DLSR 382

  Fly   731 SDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAAL----PNRIP 791
            :....|         .||.........:...:.|.....|.::|.:  |.:.|..|    .|...
Human   383 NGLSFK---------GCCSQSDFGTTSLKYLDLSFNGVITMSSNFL--GLEQLEHLDFQHSNLKQ 436

  Fly   792 QDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGS-----------LAQLVNLRVL 845
            .....::|...|:..|::.|...|.....::...|:|..|:...           ..:|.||..|
Human   437 MSEFSVFLSLRNLIYLDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFL 501

  Fly   846 HLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRH 910
            .|...:|..|..|.|.||..|:.|.:.:|....:....::.|.||:||....|.:.:....:.:|
Human   502 DLSQCQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQH 566

  Fly   911 ---SLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDC 972
               ||..|.|.:|.::|.|:. :...|::.|...::.:...:.|.....|:.:.::         
Human   567 FPSSLAFLNLTQNDFACTCEH-QSFLQWIKDQRQLLVEVERMECATPSDKQGMPVL--------- 621

  Fly   973 SDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFA---HYGVRVC 1034
                   :.||:...:       ..:..|.||..|||.::.|.|::....:.|.|   .||    
Human   622 -------SLNITCQMN-------KTIIGVSVLSVLVVSVVAVLVYKFYFHLMLLAGCIKYG---- 668

  Fly  1035 EPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRD-LPPQASHLQLV-EGAR 1097
              |.|:   :|||.:::|.:|.::|...:...||.|.|||:||:..|| :|..|....:: ||..
Human   669 --RGEN---IYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEGFH 728

  Fly  1098 ASRKIILVLTRNLLATEWNRIEFRNA----FHESLRGL----AQKLVIIEETSVSAEAEDVAELS 1154
            .|||:|:|::::.:.:.|...|:..|    |..|..|:    .||   :|:|.:..:.|....||
Human   729 KSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQK---VEKTLLRQQVELYRLLS 790

  Fly  1155 --PYLK---SVPSNRLLTCDRYFWEKLRYAI 1180
              .||:   ||....:      ||.:||.|:
Human   791 RNTYLEWEDSVLGRHI------FWRRLRKAL 815

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR 210..592 CDD:443914 100/379 (26%)
leucine-rich repeat 212..236 CDD:275380 4/4 (100%)
leucine-rich repeat 237..260 CDD:275380 6/22 (27%)
leucine-rich repeat 261..284 CDD:275380 5/32 (16%)
leucine-rich repeat 285..308 CDD:275380 4/22 (18%)
leucine-rich repeat 309..334 CDD:275380 3/24 (13%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 10/22 (45%)
leucine-rich repeat 383..406 CDD:275380 9/22 (41%)
leucine-rich repeat 407..430 CDD:275380 7/23 (30%)
leucine-rich repeat 431..451 CDD:275380 8/21 (38%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
leucine-rich repeat 478..499 CDD:275380 2/20 (10%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
leucine-rich repeat 526..548 CDD:275380 6/27 (22%)
leucine-rich repeat 590..617 CDD:275380 6/27 (22%)
leucine-rich repeat 618..641 CDD:275380 2/22 (9%)
leucine-rich repeat 642..689 CDD:275380 9/46 (20%)
LRRCT 679..736 CDD:214507 9/56 (16%)
LRR <775..>920 CDD:443914 37/162 (23%)
leucine-rich repeat 775..796 CDD:275380 4/24 (17%)
leucine-rich repeat 797..817 CDD:275380 5/19 (26%)
leucine-rich repeat 818..841 CDD:275380 4/33 (12%)
leucine-rich repeat 842..865 CDD:275380 9/22 (41%)
leucine-rich repeat 866..889 CDD:275380 4/22 (18%)
leucine-rich repeat 890..911 CDD:275380 5/23 (22%)
TIR 1045..1183 CDD:214587 47/151 (31%)
TLR4NP_612564.1 LRR 1 55..76 8/24 (33%)
leucine-rich repeat 56..79 CDD:275378 8/22 (36%)
LRR_8 57..114 CDD:404697 23/56 (41%)
PPP1R42 76..>190 CDD:455733 41/114 (36%)
LRR 2 79..100 9/20 (45%)
leucine-rich repeat 80..103 CDD:275378 10/22 (45%)
LRR 3 103..124 7/20 (35%)
leucine-rich repeat 104..127 CDD:275378 9/22 (41%)
LRR 4 127..148 7/21 (33%)
leucine-rich repeat 128..176 CDD:275378 16/48 (33%)
leucine-rich repeat 130..151 CDD:275380 6/21 (29%)
LRR 5 151..172 8/20 (40%)
LRR 6 176..199 7/22 (32%)
leucine-rich repeat 177..190 CDD:275378 6/12 (50%)
leucine-rich repeat 195..224 CDD:275380 12/49 (24%)
LRR 7 205..225 8/40 (20%)
LRR 8 227..247 4/19 (21%)
LRR 290..>581 CDD:443914 66/344 (19%)
LRR 9 331..351 2/19 (11%)
LRR 10 352..373 8/48 (17%)
leucine-rich repeat 353..374 CDD:275380 9/48 (19%)
LRR 11 374..394 7/41 (17%)
LRR 12 400..422 4/23 (17%)
leucine-rich repeat 401..423 CDD:275380 4/23 (17%)
LRR 13 423..444 3/20 (15%)
leucine-rich repeat 424..448 CDD:275380 4/23 (17%)
LRR 14 448..456 2/7 (29%)
leucine-rich repeat 449..472 CDD:275380 3/22 (14%)
LRR 15 472..495 2/22 (9%)
leucine-rich repeat 473..497 CDD:275380 3/23 (13%)
LRR 16 497..518 8/20 (40%)
leucine-rich repeat 498..521 CDD:275380 9/22 (41%)
LRR 17 521..542 3/20 (15%)
LRR 18 545..565 5/19 (26%)
leucine-rich repeat 546..570 CDD:275380 5/23 (22%)
LRRCT 579..625 CDD:214507 7/62 (11%)
TIR 674..815 CDD:214587 46/149 (31%)
Blue background indicates that the domain is not in the aligned region.

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