DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and TLR3

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_003256.1 Gene:TLR3 / 7098 HGNCID:11849 Length:904 Species:Homo sapiens


Alignment Length:1007 Identity:220/1007 - (21%)
Similarity:378/1007 - (37%) Gaps:248/1007 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   210 SELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSL 274
            :.:..|:::.|:||.||.| ..:|..:|.:|.:..|.||.|.|.....|..|:|||:.:|.|..|
Human    51 TNITVLNLTHNQLRRLPAA-NFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQL 114

  Fly   275 PSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLN 339
            ..:.||....|.||||..|.:.::......:.:.|:.||||.|.|:|..:  .|...|..|..|.
Human   115 SDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKL--GTQVQLENLQELL 177

  Fly   340 LSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGL 404
            ||||.:..:.|:.         ||:..||             :|..|.|:.|::.......|:.:
Human   178 LSNNKIQALKSEE---------LDIFANS-------------SLKKLELSSNQIKEFSPGCFHAI 220

  Fly   405 YVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKN 469
            ..|..|.|||  |.:..|...:.|.:|..                  :.::.|.|..:|:|...|
Human   221 GRLFGLFLNN--VQLGPSLTEKLCLELAN------------------TSIRNLSLSNSQLSTTSN 265

  Fly   470 NTFRNLNQLTGLRLIDNRIGNITV---GMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRL 531
            .||..| :.|.|.::|....|:.|   ..|..||:|....|..|.||.:...:......:..:.|
Human   266 TTFLGL-KWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNL 329

  Fly   532 DKNF------------LTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL 584
            .::|            :.|.:  |..|..|..||:.:|     |...|.||:....|:..|:...
Human   330 KRSFTKQSISLASLPKIDDFS--FQWLKCLEHLNMEDN-----DIPGIKSNMFTGLINLKYLSLS 387

  Fly   585 GNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYA 649
            .::..|:.....|.:..:|            :.:.:|.:..|.|.:|:::.|.....|..:||  
Human   388 NSFTSLRTLTNETFVSLAH------------SPLHILNLTKNKISKIESDAFSWLGHLEVLDL-- 438

  Fly   650 NVLSKISLNALRVAPVSAE----KPVPEFYLGGNPFECDCSMEWLQRINN----------LTTRQ 700
                  .||.:.......|    :.:.|.||..|        ::||...|          |..|:
Human   439 ------GLNEIGQELTGQEWRGLENIFEIYLSYN--------KYLQLTRNSFALVPSLQRLMLRR 489

  Fly   701 HPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSC 765
                |.|.|::     |..:|.:||.:|:..|                                 
Human   490 ----VALKNVD-----SSPSPFQPLRNLTILD--------------------------------- 512

  Fly   766 FHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMT 830
                                             |..||:..:....|.|...|..|.|..:||..
Human   513 ---------------------------------LSNNNIANINDDMLEGLEKLEILDLQHNNLAR 544

  Fly   831 LQNGS--------LAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPL 887
            |...:        |..|.:|.:|:||:|....:....|:.|..|:.:.|..|.|..:..:.|...
Human   545 LWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQ 609

  Fly   888 VSLEVLRLDNNRLSSLPHLQYRHSLQGLT---LGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDI 949
            |||:.|.|..|.::|:....:..:.:.||   :..|.:.|.|:.:.....::::....:.:....
Human   610 VSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSH 674

  Fly   950 YCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIV 1014
            |               |.|.|...........:.||.:|.|......::...::|||:.:||:|.
Human   675 Y---------------LCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIH 724

  Fly  1015 FVFRESVRMWLFAHYGV-RVC--------EPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHG 1070
            |   |..|:..:.:..| ||.        ..:||     |.|.|:|:.||.::|..:.:: :|..
Human   725 F---EGWRISFYWNVSVHRVLGFKEIDRQTEQFE-----YAAYIIHAYKDKDWVWEHFSS-MEKE 780

  Fly  1071 RPPFRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLATE-WNRIEFRNAFHESLRGLAQ 1133
            ....:.|:::||.......|: :|...:.|||||.|:|.:||... ..|.:..:|..:::.....
Human   781 DQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLD 845

  Fly  1134 KLVIIEETSVSAEAEDVAELSPYLKSVPSNRL 1165
            .::::                 :|:.:|..:|
Human   846 SIILV-----------------FLEEIPDYKL 860

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 68/253 (27%)
leucine-rich repeat 212..236 CDD:275380 8/23 (35%)
LRR_8 235..295 CDD:290566 23/59 (39%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 9/22 (41%)
LRR_8 283..345 CDD:290566 22/61 (36%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 10/24 (42%)
LRR_8 334..393 CDD:290566 15/58 (26%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 4/22 (18%)
LRR_8 382..441 CDD:290566 14/58 (24%)
leucine-rich repeat 383..406 CDD:275380 5/22 (23%)
leucine-rich repeat 407..430 CDD:275380 8/22 (36%)
LRR_8 431..488 CDD:290566 12/56 (21%)
leucine-rich repeat 431..451 CDD:275380 1/19 (5%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
LRR_8 477..559 CDD:290566 22/96 (23%)
leucine-rich repeat 478..499 CDD:275380 6/23 (26%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 5/33 (15%)
leucine-rich repeat 590..617 CDD:275380 3/26 (12%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 10/50 (20%)
LRRCT 679..736 CDD:214507 15/66 (23%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 18/62 (29%)
leucine-rich repeat 797..817 CDD:275380 5/19 (26%)
leucine-rich repeat 818..841 CDD:275380 8/30 (27%)
LRR_8 841..900 CDD:290566 18/58 (31%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
LRR_4 866..907 CDD:289563 12/40 (30%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 5/20 (25%)
TIR 1045..1183 CDD:214587 27/123 (22%)
TLR3NP_003256.1 LRRNT 28..50 CDD:396168