DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and TLR2

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001305716.1 Gene:TLR2 / 7097 HGNCID:11848 Length:784 Species:Homo sapiens


Alignment Length:1064 Identity:233/1064 - (21%)
Similarity:385/1064 - (36%) Gaps:325/1064 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   160 LPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEK-LCAGSALSNANGAVSGGSE-LQTLDVSFNEL 222
            :|..:|.......:::|::....:...|..... :|.||: .:.|...||.:| :::||:|.|.:
Human     1 MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSS-GSLNSIPSGLTEAVKSLDLSNNRI 64

  Fly   223 RSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRE 287
            ..:.:: ...|...||.|.|..|.|:|:..::.:.|.||..|::|||:|.:|.|..|.....|..
Human    65 TYISNS-DLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTF 128

  Fly   288 LHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSN-NALTRIGSK 351
            |:|.||....|.                         :.|.|:.|.:|.:|.:.| :..|:|..|
Human   129 LNLLGNPYKTLG-------------------------ETSLFSHLTKLQILRVGNMDTFTKIQRK 168

  Fly   352 TFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNL 416
            .|..|.||:.|::         :.:.|..|...:|...:|..|.:       |::...:.|....
Human   169 DFAGLTFLEELEI---------DASDLQSYEPKSLKSIQNVSHLI-------LHMKQHILLLEIF 217

  Fly   417 VSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGL 481
            |.:..|.   .|.:|::.||.:...:|             |..||.. |..|..||||      :
Human   218 VDVTSSV---ECLELRDTDLDTFHFSE-------------LSTGETN-SLIKKFTFRN------V 259

  Fly   482 RLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATL 546
            ::.|.       .:||.:..|       |:|..:....||..|              :||:....
Human   260 KITDE-------SLFQVMKLL-------NQISGLLELEFDDCT--------------LNGVGNFR 296

  Fly   547 ASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGA 611
            |       |:|     |....|..::.|.|...:|.....:|.|      :||.:...|:..|  
Human   297 A-------SDN-----DRVIDPGKVETLTIRRLHIPRFYLFYDL------STLYSLTERVKRI-- 341

  Fly   612 MSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYL 676
             :|.||                          :|.|...:||: .|.:|....:| |..:.|.||
Human   342 -TVENS--------------------------KVFLVPCLLSQ-HLKSLEYLDLS-ENLMVEEYL 377

  Fly   677 GGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHC 741
            ..:.    |...| ..:..|..||: |:..|        ......|..|.:|:..| :.|...|.
Human   378 KNSA----CEDAW-PSLQTLILRQN-HLASL--------EKTGETLLTLKNLTNID-ISKNSFHS 427

  Fly   742 PPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPE 806
            .|       |.|:                |                                 ||
Human   428 MP-------ETCQ----------------W---------------------------------PE 436

  Fly   807 LEVGHLTGRRNLRALYLN-ASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGL--LRE 868
                        :..||| :|..:....|.:.:  .|.:|.:.||.|...      ||.|  |:|
Human   437 ------------KMKYLNLSSTRIHSVTGCIPK--TLEILDVSNNNLNLF------SLNLPQLKE 481

  Fly   869 LYLHNNMLTHISNATFEPLVSLEVLRLDNNRLS--SLPHLQYRHSLQGLTLGRNAWSCRCQQLRE 931
            ||:..|.|..:.:|:..|:  |.||::..|.::  |...|...|:|:.|..|.|.:.|.|    |
Human   482 LYISRNKLMTLPDASLLPM--LLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSC----E 540

  Fly   932 LAQFVSDN---AMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQ------ 987
            ...|..:.   |.|:.|....|..|                         |.|::...|      
Human   541 FLSFTQEQQALAKVLIDWPANYLCD-------------------------SPSHVRGQQVQDVRL 580

  Fly   988 DLAGGYRLPLLAAVLVLIFLVVVLIIVFVFR-------ESVRMWLFAHYGVRVCEPRFEDAGKL- 1044
            .::..:|..|::.:...:||:::|..|...|       :.:..||.|..     :||...:..: 
Human   581 SVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKR-----KPRKAPSRNIC 640

  Fly  1045 YDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL-QLVEGARASRKIILVLTR 1108
            |||.:.:||:|..:|...:..|||:..|||:||:.:||..|....: .:::....|.|.:.||:.
Human   641 YDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSE 705

  Fly  1109 NLLATEWNRIE-----FRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTC 1168
            |.:.:||.:.|     || .|.|:  ..|..|:::|.....|..:...:|         .:::..
Human   706 NFVKSEWCKYELDFSHFR-LFDEN--NDAAILILLEPIEKKAIPQRFCKL---------RKIMNT 758

  Fly  1169 DRY------------FWEKLRYAI 1180
            ..|            ||..||.||
Human   759 KTYLEWPMDEAQREGFWVNLRAAI 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566 3/20 (15%)
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380 2/9 (22%)
leucine-rich repeat 171..201 CDD:275380 5/30 (17%)
LRR_RI 210..464 CDD:238064 61/255 (24%)
leucine-rich repeat 212..236 CDD:275380 5/23 (22%)
LRR_8 235..295 CDD:290566 23/59 (39%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 9/22 (41%)
LRR_8 283..345 CDD:290566 12/62 (19%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 3/24 (13%)
LRR_8 334..393 CDD:290566 15/59 (25%)
leucine-rich repeat 335..358 CDD:275380 8/23 (35%)
leucine-rich repeat 359..382 CDD:275380 3/22 (14%)
LRR_8 382..441 CDD:290566 11/58 (19%)
leucine-rich repeat 383..406 CDD:275380 4/22 (18%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
LRR_8 431..488 CDD:290566 14/56 (25%)
leucine-rich repeat 431..451 CDD:275380 4/19 (21%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
LRR_8 477..559 CDD:290566 14/81 (17%)
leucine-rich repeat 478..499 CDD:275380 3/20 (15%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 2/21 (10%)
leucine-rich repeat 590..617 CDD:275380 6/26 (23%)
leucine-rich repeat 618..641 CDD:275380 0/22 (0%)
leucine-rich repeat 642..689 CDD:275380 12/46 (26%)
LRRCT 679..736 CDD:214507 11/56 (20%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 11/55 (20%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 5/23 (22%)
LRR_8 841..900 CDD:290566 20/60 (33%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
LRR_4 866..907 CDD:289563 13/42 (31%)
leucine-rich repeat 866..889 CDD:275380 8/22 (36%)
leucine-rich repeat 890..911 CDD:275380 6/22 (27%)
TIR 1045..1183 CDD:214587 42/154 (27%)
TLR2NP_001305716.1 PLN00113 <40..>206 CDD:331614 52/208 (25%)
leucine-rich repeat 54..77 CDD:275380 5/23 (22%)
LRR 1 54..77 5/23 (22%)
LRR_8 77..135 CDD:316378 22/57 (39%)
leucine-rich repeat 78..101 CDD:275380 8/22 (36%)
LRR 2 78..101 8/22 (36%)
leucine-rich repeat 102..125 CDD:275380 9/22 (41%)
LRR 3 102..125 9/22 (41%)
leucine-rich repeat 126..150 CDD:275380 9/48 (19%)
LRR 4 126..150 9/48 (19%)
leucine-rich repeat 151..175 CDD:275380 8/23 (35%)
LRR 5 151..175 8/23 (35%)
LRR 6 176..199 5/31 (16%)
leucine-rich repeat 176..196 CDD:275380 5/28 (18%)
LRR 7 200..223 4/29 (14%)
LRR 8 224..250 8/42 (19%)
LRR 9 251..278 11/46 (24%)
LRR 10 279..308 10/54 (19%)
LRR 11 309..337 7/33 (21%)
NEL <324..>558 CDD:330839 77/367 (21%)
LRR 12 338..361 9/52 (17%)
leucine-rich repeat 362..388 CDD:275380 8/31 (26%)
LRR 13 362..388 8/31 (26%)
leucine-rich repeat 389..414 CDD:275380 7/33 (21%)
LRR 14 389..414 7/33 (21%)
leucine-rich repeat 415..437 CDD:275380 10/90 (11%)
LRR 15 415..437 10/90 (11%)
leucine-rich repeat 438..478 CDD:275380 13/47 (28%)
LRR 16 438..457 5/18 (28%)
LRR 17 458..478 8/25 (32%)
leucine-rich repeat 479..500 CDD:275380 7/20 (35%)
LRR 18 479..500 7/20 (35%)
leucine-rich repeat 501..524 CDD:275380 6/22 (27%)
LRR 19 501..524 6/22 (27%)
LRRCT 533..586 CDD:214507 13/81 (16%)
TIR 640..784 CDD:214587 42/155 (27%)
ATG16L1-binding motif 761..778 3/16 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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