DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and TLR1

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_003254.2 Gene:TLR1 / 7096 HGNCID:11847 Length:786 Species:Homo sapiens


Alignment Length:1044 Identity:208/1044 - (19%)
Similarity:349/1044 - (33%) Gaps:364/1044 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 LDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAF 279
            :|.|.|.|..:|    ....::...|::..|.||.|..:.:..||.||:|.||:|.:..|....|
Human    29 VDRSKNGLIHVP----KDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQYLDISVF 89

  Fly   280 AGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNA 344
            ..|:||..|.|..|.|.::.   .|....|..||||.|...:..:... |..:.:|..|.||.. 
Human    90 KFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAFDALPICKE-FGNMSQLKFLGLSTT- 149

  Fly   345 LTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTK 409
                                      |:|:.:.||:.:                           
Human   150 --------------------------HLEKSSVLPIAH--------------------------- 161

  Fly   410 LTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEF------K 468
              ||.:.|.:|..:.:....|              ||.:||.: .::|.:......||      .
Human   162 --LNISKVLLVLGETYGEKED--------------PEGLQDFN-TESLHIVFPTNKEFHFILDVS 209

  Fly   469 NNTFRNLNQLTGLRLI--DNRIGNI--TVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAI 529
            ..|..|| :|:.::.:  ||:....  .:...|..|:||  ||..|.|:                
Human   210 VKTVANL-ELSNIKCVLEDNKCSYFLSILAKLQTNPKLS--NLTLNNIE---------------- 255

  Fly   530 RLDKNFLTDINGIFATLASLLWLNLSENHLVWF---------------DYAFIPSNLKWLDIHGN 579
                   |..|. |..:..|:|     :..||:               |:.:..::||.|.||..
Human   256 -------TTWNS-FIRILQLVW-----HTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSIHQV 307

  Fly   580 YIEALG---NY-YKLQEEIRVTTLDASHNRITEIGAMSVPNSIE---LLFINNNIIGQIQANTFV 637
            ..:..|   :| |::...:.:.....|..|:..   |..|:.|.   .|..:||::.........
Human   308 VSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVH---MLCPSKISPFLHLDFSNNLLTDTVFENCG 369

  Fly   638 DKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHP 702
            ..|.|..:.|..|.|.::|                                   :|..:||:   
Human   370 HLTELETLILQMNQLKELS-----------------------------------KIAEMTTQ--- 396

  Fly   703 HVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFH 767
                               ::.|..|..|.....|:..                   .|:||   
Human   397 -------------------MKSLQQLDISQNSVSYDEK-------------------KGDCS--- 420

  Fly   768 DATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQ 832
               |..:::..                        ||                    :||::|  
Human   421 ---WTKSLLSL------------------------NM--------------------SSNILT-- 436

  Fly   833 NGSLAQLV--NLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISN-ATFEPLVSLEVLR 894
             .::.:.:  .::||.|.:||:.::. .:...|..|:||.:..|.||.:.. .:|.   ||.||.
Human   437 -DTIFRCLPPRIKVLDLHSNKIKSIP-KQVVKLEALQELNVAFNSLTDLPGCGSFS---SLSVLI 496

  Fly   895 LDNNRLS--SLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIK 957
            :|:|.:|  |....|....::.:..|.|.:.|.|    ||.:||.:...|..:.           
Human   497 IDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTC----ELGEFVKNIDQVSSEV----------- 546

  Fly   958 RELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLA----------AVLVLIFLVVVLI 1012
                    |...||            |...|....||..||.          ..|:::.:|..::
Human   547 --------LEGWPD------------SYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATML 591

  Fly  1013 IVFVFRESVRMWLFAHYGVR-VCE-----------PRFEDAGKL-YDAIILHSEKDYEFVCRNIA 1064
            ::.|...|:..:|...:.:| ||:           |..|....| :.|.|.:|..|..:|...:.
Human   592 VLAVTVTSLCSYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELL 656

  Fly  1065 AELEHGRPPFRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNLLATEWNRIEF----RNAF 1124
            ..||  :...::|:.:|:..|..|.:: ::.....|.|.|.||:.|.:.:||...|.    .|.|
Human   657 PNLE--KEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLF 719

  Fly  1125 HESLRGLAQKLVIIE---ETSVSAEAEDVAEL---SPYLK--SVPSNRLLTCDRYFWEKLRYAIP 1181
            ||....|.  |:::|   :.|:.:....:..|   ..||:  ...|.|.|     ||..||.||.
Human   720 HEGSNSLI--LILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGL-----FWANLRAAIN 777

  Fly  1182 IELS 1185
            |:|:
Human   778 IKLT 781

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR 210..592 CDD:443914 85/405 (21%)
leucine-rich repeat 212..236 CDD:275380 5/20 (25%)
leucine-rich repeat 237..260 CDD:275380 6/22 (27%)
leucine-rich repeat 261..284 CDD:275380 9/22 (41%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
leucine-rich repeat 335..358 CDD:275380 4/22 (18%)
leucine-rich repeat 359..382 CDD:275380 4/22 (18%)
leucine-rich repeat 383..406 CDD:275380 0/22 (0%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
leucine-rich repeat 431..451 CDD:275380 3/19 (16%)
leucine-rich repeat 454..477 CDD:275380 6/28 (21%)
leucine-rich repeat 478..499 CDD:275380 4/24 (17%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 4/26 (15%)
leucine-rich repeat 618..641 CDD:275380 4/25 (16%)
leucine-rich repeat 642..689 CDD:275380 5/46 (11%)
LRRCT 679..736 CDD:214507 6/56 (11%)
LRR <775..>920 CDD:443914 28/149 (19%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 3/24 (13%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
leucine-rich repeat 866..889 CDD:275380 7/23 (30%)
leucine-rich repeat 890..911 CDD:275380 8/22 (36%)
TIR 1045..1183 CDD:214587 40/150 (27%)
TLR1NP_003254.2 LRR <29..>152 CDD:443914 40/157 (25%)
leucine-rich repeat 47..70 CDD:275378 6/22 (27%)
LRR 1 54..77 9/22 (41%)
leucine-rich repeat 71..94 CDD:275378 9/22 (41%)
LRR 2 78..101 7/22 (32%)
leucine-rich repeat 95..115 CDD:275378 6/22 (27%)
LRR 3 102..125 8/25 (32%)
leucine-rich repeat 116..140 CDD:275378 7/24 (29%)
LRR 4 126..150 5/51 (10%)
leucine-rich repeat 141..152 CDD:275378 5/37 (14%)
LRR 5 151..175 7/52 (13%)
LRR 6 176..199 6/37 (16%)
LRR 7 200..223 6/23 (26%)
LRR 215..>526 CDD:443914 83/478 (17%)
LRR 8 224..250 7/27 (26%)
LRR 9 251..278 9/55 (16%)
LRR 10 279..308 6/28 (21%)
LRR 11 309..337 4/27 (15%)
Interaction with bacterial lipopeptide 313..316 1/2 (50%)
LRR 12 338..361 6/25 (24%)
leucine-rich repeat 352..373 CDD:275380 3/20 (15%)
LRR 13 362..388 5/25 (20%)
leucine-rich repeat 374..399 CDD:275380 8/81 (10%)
LRR 14 389..414 7/46 (15%)
leucine-rich repeat 400..424 CDD:275380 8/48 (17%)
LRR 15 415..437 9/93 (10%)
leucine-rich repeat 425..446 CDD:275380 5/67 (7%)
LRR 16 438..457 4/18 (22%)
leucine-rich repeat 447..469 CDD:275380 6/22 (27%)
LRR 17 458..478 4/20 (20%)
leucine-rich repeat 470..492 CDD:275380 7/24 (29%)
LRR 18 479..500 8/23 (35%)
leucine-rich repeat 494..515 CDD:275380 7/20 (35%)
LRR 19 501..524 4/22 (18%)
LRRCT 524..577 CDD:214507 17/87 (20%)
TIR 636..779 CDD:214587 40/151 (26%)
Blue background indicates that the domain is not in the aligned region.

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