DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Tlr8

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001094479.1	Gene:	Tlr8 / 684440	RGDID:	1590327	Length:	1029	Species:	Rattus norvegicus

Alignment Length:	1288	Identity:	271/1288 - (21%)
Similarity:	444/1288 - (34%)	Gaps:	418/1288 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LESGTGT-----------PLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLSELRIDACK 101
            |.|||..           |.|.:...|.  :..:|:...||......|.:     ::::.:....
  Rat    14 LSSGTSAVFLKGNFSRSYPCDEKRHNAL--VTAECNHRQLHEVPQTIGKY-----VTDVDLSDNT 71

  Fly   102 LQRVPPNAFEGLMSLKRLTLESHNA-VWGPGKT---LELHGQSFQGLKELSELHLGDNNIRQLPE 162
            :..:...:|:...:|.::.| :||| ...|.:.   :.:...:|..|:.|:||.|.||.:..:|.
  Rat    72 IMHITNESFQKFRNLTKINL-NHNAKQQHPNENKNGMNITEGAFLSLRNLTELLLEDNQLYTIPA 135

  Fly   163 GVWCSMP-SLQLLNLTQNRI-----------RSAE--FLGFSEKLCAGSALSNANGAVSGGSELQ 213
            |    :| ||:.|:|.||.|           |:.|  :||::............:||.:....|:
  Rat   136 G----LPESLKELSLIQNNIFQVTKNNTFGLRNLERLYLGWNCYFKCNQIFKVEDGAFNNLINLK 196

  Fly   214 TLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLA--------------------------- 251
            .|.:|||.|.|:|....:|    |..|.|.:..|||:.
  Rat   197 LLSLSFNNLFSVPPKLPSS----LSKLFLSNAKISTITQEDFKGLEHLILLDLSGNCPRCFNAPF 257

  Fly   252 --------------PNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDL-YELPKG 301
                          |.|...|:.||.||:|...|.::||..|.....|:||||:.|.| .|:..|
  Rat   258 PCESCNLSASIRIHPLAFQNLTQLRFLNLSSTSLRTIPSTWFDNLTNLKELHLEFNYLVQEIASG 322

  Fly   302 -LLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMR 365
             .|.:|..|..||||.|.:...::...|.                    |..|..|..|:.|.::
  Rat   323 AFLTKLPSLQTLDLSFNFIHKEYLQYITI--------------------SPNFSMLRSLRKLHLK 367

  Fly   366 NNSIGHIEEGAFLPLY---NLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIV----ESQ 423
            ......:::..|.||.   ||.|:||..|.:..:|.:.|.....|..:.|:.|.::.|    :..
  Rat   368 GYVFRELKKEHFKPLQNLPNLTTINLGINFIEKIDFKAFQDFPNLKVIYLSGNRIASVIDGTDHS 432

  Fly   424 AFRN------CSDLKELDLSSN--QLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTG 480
            ::||      .:|..|.|...|  ..||.....|..:..|.|||..|.|.....:.|.....:..
  Rat   433 SWRNRLRKPLSTDYDEFDPHMNFYHSTEPLIKPQCTTYGKALDLSLNNIFVIGKSQFEGFQDIAC 497

  Fly   481 LRLIDNRIGNITVGM-FQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNF-------LT 537
            |.|..|..|.:..|. |..:|.:..|:|..||:...:...|....::|.:.|..|.       :|
  Rat   498 LNLSFNANGQVLNGTEFSSMPHIKYLDLTNNRLDFDDNQTFSDLHDLEVLDLSHNAHYFSIAGVT 562

  Fly   538 DINGIFATLASLLWLNLSEN--HLVWFDYAFIPSNLKWLDIHGNYIEAL-----GNYYKLQEEIR 595
            ...|....|..|..||||.|  :.:..:|.....:||.|...||.::.|     |.|:.:...:.
  Rat   563 HRLGFIQNLIKLKVLNLSHNGIYTLTDEYKLQSKSLKELVFSGNRLDRLWNANDGKYWSIFTSLE 627

  Fly   596 -VTTLDASHNRITEI---GAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKIS 656
             :|.||.|:|.:.:|   ..:::|.|::.|.||:|              ||
  Rat   628 TLTRLDLSYNNLQQIPNEAFLNLPQSLQELHINDN--------------RL-------------- 664

  Fly   657 LNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQH-PHVVDLGNIECLMPHSRSA 720
                                               |..|.|..|: ||:
  Rat   665 -----------------------------------RFFNWTLLQYFPHL---------------- 678

  Fly   721 PLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAA 785
                                                                 :::|.||.:|..
  Rat   679 -----------------------------------------------------HVLDLGRNELYF 690

  Fly   786 LPN---RIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNAS-NLMTLQNGSLAQL---VNLR 843
            |.|   :....:..|.|:.|:...|..|.|:..|||  :||:.| |.:.:.|.|..|.   .||.
  Rat   691 LTNCLSKFTHSLKTLLLNHNHFSHLPAGFLSEARNL--VYLDLSFNTIKMINKSSLQTETKTNLS 753

  Fly   844 VLHLENNKL-TALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQ 907
            ||.|:.|.. ...:.::|||       :|..|                             ||::
  Rat   754 VLDLQGNHFDCTCDISDFRS-------WLEEN-----------------------------PHVR 782

  Fly   908 YRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDC 972
                                    :.:.|           |:.|.:.|.:|...::.
  Rat   783 ------------------------IPRLV-----------DVICSNPGDQRWKSVMS-------- 804

  Fly   973 SDLLDASASNISSSQDLAGGYRLPLLAAVLVLI-FLVVVLIIVFVFRESV---RMWLFAHYGVRV 1033
               ||.:.. :|.:           .||:|... ||....:::......:   .:|...|    :
  Rat   805 ---LDLTTC-VSDT-----------TAAILFFFTFLTTSTVLLAALVHHLFYWDVWFIYH----M 850

  Fly  1034 CEPRF------EDAGKLYDAIILHSEKD---YEFVCRNIAAELEHGR-PPFRLCIQQRDLPPQAS 1088
            |..:.      ..:...|||.|.:..||   .::|...:...||... ....||:::||..|...
  Rat   851 CSAKLRGYRSSSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESEDKSVLLCLEERDWDPGLP 915

  Fly  1089 HL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAE 1152
            .: .|::....|:|.|.|||:. .|..||   |:.||:.:|:.|..:.:   :..:....|.|.:
  Rat   916 IIDNLMQSINQSKKTIFVLTKK-YAKSWN---FKTAFYLALQRLMDENM---DVIIFILLEPVLQ 973

  Fly  1153 LSPYLK--------SV---PSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLD 1194
            .|.||:        |:   |:|.  ..:..||:.|:..:..|...|.:|..:|
  Rat   974 YSQYLRLRQRICKSSILQWPNNP--KAENLFWQSLKNVVLTENDSRYDNLYID 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	4/24 (17%)
		leucine-rich repeat	92..115	CDD:275380	1/22 (5%)
		LRR_8	115..181	CDD:290566	23/70 (33%)
		leucine-rich repeat	116..146	CDD:275380	8/33 (24%)
		leucine-rich repeat	147..170	CDD:275380	9/23 (39%)
		leucine-rich repeat	171..201	CDD:275380	10/42 (24%)
		LRR_RI	210..464	CDD:238064	79/311 (25%)
		leucine-rich repeat	212..236	CDD:275380	9/23 (39%)
		LRR_8	235..295	CDD:290566	24/100 (24%)
		leucine-rich repeat	237..260	CDD:275380	9/63 (14%)
		leucine-rich repeat	261..284	CDD:275380	9/22 (41%)
		LRR_8	283..345	CDD:290566	18/63 (29%)
		leucine-rich repeat	285..308	CDD:275380	11/24 (46%)
		leucine-rich repeat	309..334	CDD:275380	7/24 (29%)
		LRR_8	334..393	CDD:290566	14/61 (23%)
		leucine-rich repeat	335..358	CDD:275380	3/22 (14%)
		leucine-rich repeat	359..382	CDD:275380	5/25 (20%)
		LRR_8	382..441	CDD:290566	18/70 (26%)
		leucine-rich repeat	383..406	CDD:275380	7/22 (32%)
		leucine-rich repeat	407..430	CDD:275380	6/32 (19%)
		LRR_8	431..488	CDD:290566	16/58 (28%)
		leucine-rich repeat	431..451	CDD:275380	6/21 (29%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	24/91 (26%)
		leucine-rich repeat	478..499	CDD:275380	6/21 (29%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		leucine-rich repeat	526..548	CDD:275380	6/28 (21%)
		leucine-rich repeat	590..617	CDD:275380	7/30 (23%)
		leucine-rich repeat	618..641	CDD:275380	4/22 (18%)
		leucine-rich repeat	642..689	CDD:275380	1/46 (2%)
		LRRCT	679..736	CDD:214507	6/57 (11%)
		leucine-rich repeat	775..796	CDD:275380	6/23 (26%)
		LRR_8	797..852	CDD:290566	22/58 (38%)
		leucine-rich repeat	797..817	CDD:275380	6/19 (32%)
		leucine-rich repeat	818..841	CDD:275380	8/26 (31%)
		LRR_8	841..900	CDD:290566	11/59 (19%)
		leucine-rich repeat	842..865	CDD:275380	8/23 (35%)
		LRR_4	866..907	CDD:289563	4/40 (10%)
		leucine-rich repeat	866..889	CDD:275380	2/22 (9%)
		leucine-rich repeat	890..911	CDD:275380	2/20 (10%)
		TIR	1045..1183	CDD:214587	40/153 (26%)
Tlr8	NP_001094479.1	PRK15370	<21..>218	CDD:185268	48/212 (23%)
		leucine-rich repeat	62..85	CDD:275380	1/22 (5%)
		leucine-rich repeat	86..119	CDD:275380	8/33 (24%)
		leucine-rich repeat	120..140	CDD:275380	9/23 (39%)
		PLN00113	141..>664	CDD:215061	138/560 (25%)
		leucine-rich repeat	141..164	CDD:275380	6/22 (27%)
		leucine-rich repeat	165..194	CDD:275380	5/28 (18%)
		leucine-rich repeat	195..215	CDD:275380	8/19 (42%)
		leucine-rich repeat	216..239	CDD:275380	6/22 (27%)
		leucine-rich repeat	240..280	CDD:275380	3/39 (8%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		leucine-rich repeat	305..324	CDD:275380	9/18 (50%)
		leucine-rich repeat	331..387	CDD:275380	15/75 (20%)
		leucine-rich repeat	388..411	CDD:275380	7/22 (32%)
		leucine-rich repeat	467..494	CDD:275380	7/26 (27%)
		leucine-rich repeat	495..510	CDD:275380	4/14 (29%)
		leucine-rich repeat	520..543	CDD:275380	5/22 (23%)
		leucine-rich repeat	544..573	CDD:275380	6/28 (21%)
		leucine-rich repeat	574..597	CDD:275380	7/22 (32%)
		leucine-rich repeat	598..628	CDD:275380	8/29 (28%)
		PRK15370	<629..>739	CDD:185268	39/243 (16%)
		leucine-rich repeat	629..653	CDD:275380	7/23 (30%)
		leucine-rich repeat	654..677	CDD:275380	10/85 (12%)
		leucine-rich repeat	678..701	CDD:275380	6/91 (7%)
		leucine-rich repeat	702..725	CDD:275380	6/22 (27%)
		leucine-rich repeat	726..745	CDD:275380	7/20 (35%)
		PCC	730..>813	CDD:188093	25/165 (15%)
		TIR	868..1004	CDD:214587	38/144 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820