DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and TLR8

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_057694.2 Gene:TLR8 / 51311 HGNCID:15632 Length:1059 Species:Homo sapiens


Alignment Length:1309 Identity:276/1309 - (21%)
Similarity:468/1309 - (35%) Gaps:389/1309 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SSIITIIAVAACLLLLVADAHAQQQCNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDL 69
            ||::|      |:.||::.:                  |.:.|.|:.:.:              .
Human    26 SSMLT------CIFLLISGS------------------CELCAEENFSRS--------------Y 52

  Fly    70 QCSQELLHASELAPGLFRQLQK--------LSELRIDACKLQRVPPNAFEGLMSLKRLTLESHN- 125
            .|.::..:.|.:|....|:||:        ::||.:....:..:...:|:||.:|.::.| :|| 
Human    53 PCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINL-NHNP 116

  Fly   126 ----AVWGPG---KTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMP-SLQLLNLTQNRIR 182
                ....||   ..|.:...:|..||.|.||.|.||.:.|:|.|    :| ||..|:|.||.|.
Human   117 NVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSG----LPESLTELSLIQNNIY 177

  Fly   183 SAEFLGFS----------------EKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGA 231
            :....|.|                .|:|..:.:.  :|.....:.|:.|.:|||.|..:|....:
Human   178 NITKEGISRLINLKNLYLAWNCYFNKVCEKTNIE--DGVFETLTNLELLSLSFNSLSHVPPKLPS 240

  Fly   232 SRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYN-----------------HLVSLPSEAF 279
            |    |:.|.|.:..|..::.....||.:|.:|::|.|                 ..:::...||
Human   241 S----LRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAF 301

  Fly   280 AGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNA 344
            ....:||.|:|....|.::.......:..|.||||..|.|.......:....|.||.:|:||.|.
Human   302 QNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNY 366

  Fly   345 L-----TRIG-SKTFKELYFLQILDMRNNSIGHIEEGAFLPLY---NLHTLNLAENRLHTLDNRI 400
            :     ..|. |:.|.:|..|:.|.:|......:.|..|.||.   ||.|:||..|.:..:|.::
Human   367 IKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKL 431

  Fly   401 FNGLYVLTKLTLNNNLVS-IVES--QAFRNCSDLK-----------ELDLSSN--QLTEVPEAVQ 449
            |.....|..:.|:.|.:| :|:.  |::.|.|..:           |.|..||  ..|......|
Human   432 FQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQ 496

  Fly   450 DLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGM-FQDLPRLSVLNLAKNRIQ 513
            ..:..|.|||..|.|.....|.|.||..:..|.|..|....:..|. |..:|.:..|:|..||:.
Human   497 CAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD 561

  Fly   514 SIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHG 578
            .....|..:.:::|.:.|      ..|..:..:|.:       .|.:.|...|  :|||.|::..
Human   562 FDNASALTELSDLEVLDL------SYNSHYFRIAGV-------THHLEFIQNF--TNLKVLNLSH 611

  Fly   579 NYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINN--NIIGQIQANTFVD--- 638
            |.|..|.:.|.|:.:                      :.:||:|..|  :|:.....|.::.   
Human   612 NNIYTLTDKYNLESK----------------------SLVELVFSGNRLDILWNDDDNRYISIFK 654

  Fly   639 -KTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHP 702
             ...|.|:||        |||.|:                                         
Human   655 GLKNLTRLDL--------SLNRLK----------------------------------------- 670

  Fly   703 HVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFH 767
                                                 |.|                         
Human   671 -------------------------------------HIP------------------------- 673

  Fly   768 DATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQ 832
                                       ::.:|   |:|          .:|..|::| .|::...
Human   674 ---------------------------NEAFL---NLP----------ASLTELHIN-DNMLKFF 697

  Fly   833 NGS-LAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLD 896
            |.: |.|...|.:|.|..|||..|..:.......||.|.|.:|.::|:.:.....:.||:.|.|.
Human   698 NWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLS 762

  Fly   897 NNRLSSLP----HLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMV-VRDAHDIYCLDAGI 956
            :|.|.::.    ..:....|..|.|..|.:.|.| .:.:..:::.::..| :....|:.|...|.
Human   763 SNLLKTINKSALETKTTTKLSMLELHGNPFECTC-DIGDFRRWMDEHLNVKIPRLVDVICASPGD 826

  Fly   957 KRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESV 1021
            :|...::         |..|....|::::                 |::|.....|...|...::
Human   827 QRGKSIV---------SLELTTCVSDVTA-----------------VILFFFTFFITTMVMLAAL 865

  Fly  1022 RMWLFAHYGV----RVCEPRFEDAGKL------YDAIILHSEKD---YEFVCRNIAAELEHGRPP 1073
            ...|| ::.|    .||..:.:....|      |||.|.:..||   .::|...:...||..|..
Human   866 AHHLF-YWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDK 929

  Fly  1074 -FRLCIQQRDLPPQASHL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLV 1136
             ..||:::||..|..:.: .|::....|:|.:.|||:. .|..||   |:.||:.:|:.|..:.:
Human   930 NVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKK-YAKSWN---FKTAFYLALQRLMDENM 990

  Fly  1137 IIEETSVSAEAEDVAELSPYLK--------SV---PSNRLLTCDRYFWEKLRYAIPIELSPRGNN 1190
               :..:....|.|.:.|.||:        |:   |.|.  ..:..||:.||..:..|...|.||
Human   991 ---DVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNP--KAEGLFWQTLRNVVLTENDSRYNN 1050

  Fly  1191 YTLDHHERF 1199
            ..:|..:::
Human  1051 MYVDSIKQY 1059

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 5/24 (21%)
leucine-rich repeat 92..115 CDD:275380 5/22 (23%)
LRR_8 115..181 CDD:290566 26/74 (35%)
leucine-rich repeat 116..146 CDD:275380 9/37 (24%)
leucine-rich repeat 147..170 CDD:275380 10/23 (43%)
leucine-rich repeat 171..201 CDD:275380 10/45 (22%)
LRR_RI 210..464 CDD:238064 77/295 (26%)
leucine-rich repeat 212..236 CDD:275380 8/23 (35%)
LRR_8 235..295 CDD:290566 16/76 (21%)
leucine-rich repeat 237..260 CDD:275380 6/22 (27%)
leucine-rich repeat 261..284 CDD:275380 6/39 (15%)
LRR_8 283..345 CDD:290566 19/61 (31%)
leucine-rich repeat 285..308 CDD:275380 5/22 (23%)
leucine-rich repeat 309..334 CDD:275380 8/24 (33%)
LRR_8 334..393 CDD:290566 23/67 (34%)
leucine-rich repeat 335..358 CDD:275380 9/28 (32%)
leucine-rich repeat 359..382 CDD:275380 7/25 (28%)
LRR_8 382..441 CDD:290566 20/74 (27%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 7/25 (28%)
LRR_8 431..488 CDD:290566 19/69 (28%)
leucine-rich repeat 431..451 CDD:275380 6/32 (19%)
leucine-rich repeat 454..477 CDD:275380 10/22 (45%)
LRR_8 477..559 CDD:290566 15/82 (18%)
leucine-rich repeat 478..499 CDD:275380 5/21 (24%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 1/26 (4%)
leucine-rich repeat 618..641 CDD:275380 6/28 (21%)
leucine-rich repeat 642..689 CDD:275380 8/46 (17%)
LRRCT 679..736 CDD:214507 0/56 (0%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 14/55 (25%)
leucine-rich repeat 797..817 CDD:275380 3/19 (16%)
leucine-rich repeat 818..841 CDD:275380 7/23 (30%)
LRR_8 841..900 CDD:290566 18/58 (31%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
LRR_4 866..907 CDD:289563 12/44 (27%)
leucine-rich repeat 866..889 CDD:275380 6/22 (27%)
leucine-rich repeat 890..911 CDD:275380 5/24 (21%)
TIR 1045..1183 CDD:214587 41/153 (27%)
TLR8NP_057694.2 LRR_8 83..155 CDD:290566 21/72 (29%)
leucine-rich repeat 83..106 CDD:275380 5/22 (23%)
leucine-rich repeat 107..144 CDD:275380 9/37 (24%)
leucine-rich repeat 145..165 CDD:275380 10/23 (43%)
leucine-rich repeat 166..189 CDD:275380 8/22 (36%)
leucine-rich repeat 190..220 CDD:275380 3/31 (10%)
leucine-rich repeat 221..241 CDD:275380 7/19 (37%)
LRR_8 240..317 CDD:290566 17/80 (21%)
leucine-rich repeat 242..265 CDD:275380 6/22 (27%)
leucine-rich repeat 266..306 CDD:275380 6/39 (15%)
LRR_8 305..367 CDD:290566 19/61 (31%)
leucine-rich repeat 307..330 CDD:275380 5/22 (23%)
leucine-rich repeat 331..356 CDD:275380 8/24 (33%)
leucine-rich repeat 387..413 CDD:275380 7/25 (28%)
LRR_8 412..>449 CDD:290566 11/36 (31%)
leucine-rich repeat 414..437 CDD:275380 7/22 (32%)
LRR_8 502..560 CDD:290566 19/57 (33%)
LRR_RI <504..719 CDD:238064 67/403 (17%)
leucine-rich repeat 504..524 CDD:275380 9/19 (47%)
leucine-rich repeat 525..549 CDD:275380 5/23 (22%)
LRR_8 548..614 CDD:290566 18/80 (23%)
leucine-rich repeat 550..573 CDD:275380 5/22 (23%)
leucine-rich repeat 574..603 CDD:275380 7/43 (16%)
leucine-rich repeat 604..658 CDD:275380 14/75 (19%)
LRR_8 657..718 CDD:290566 24/212 (11%)
leucine-rich repeat 659..683 CDD:275380 13/174 (7%)
leucine-rich repeat 684..707 CDD:275380 7/23 (30%)
LRR_8 706..766 CDD:290566 18/59 (31%)
leucine-rich repeat 708..730 CDD:275380 7/21 (33%)
leucine-rich repeat 732..755 CDD:275380 6/22 (27%)
leucine-rich repeat 756..775 CDD:275380 5/18 (28%)
LRRCT 790..835 CDD:214507 8/54 (15%)
TIR 898..1040 CDD:214587 41/150 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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