DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and TLR7

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:1251 Identity:269/1251 - (21%)
Similarity:466/1251 - (37%) Gaps:352/1251 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 DLQVAEAAGRLDLQCSQELL---HASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKR 118
            |..:.|..|.:....:...|   |..:::|..|.:|..|.|:.. .|....:|..: :..|.:||
Human    53 DKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDF-RCNCVPIPLGS-KNNMCIKR 115

  Fly   119 LTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRS 183
                           |::..:||.||..|..|:|..|.:.::|:|:   .||||||:|..|.|.|
Human   116 ---------------LQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFS 162

  Fly   184 AEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHN--- 245
            ..    .|.|                                      :.|..::.|.|..|   
Human   163 IR----KENL--------------------------------------TELANIEILYLGQNCYY 185

  Fly   246 ----NIS-TLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHR 305
                .:| ::..:|...|:.|:||::..|::.::|:..   ...|.||:|..|.:.::.:...:.
Human   186 RNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVL---PSTLTELYLYNNMIAKIQEDDFNN 247

  Fly   306 LEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIG 370
            |.||.:||||||....:   |:.|.      .....||:..:|....|..|..|::|.:.:||:.
Human   248 LNQLQILDLSGNCPRCY---NAPFP------CAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQ 303

  Fly   371 HIEEGAFLPLYNLHTLNLAENRL--HTLDNRIFNGLYVLTKLTLNNNL------VSIVESQAFRN 427
            |:....|..:..|..|:|::|.|  ...|.:..:.|..|.:|.|:.|.      .|:..||||.:
Human   304 HVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSS 368

  Fly   428 CSDLKELDLSSNQLTEVP----EAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRI 488
            ...||.|.:......|:.    ..:.:|..|:.||||.|.|                      :|
Human   369 LKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFI----------------------KI 411

  Fly   489 GNITVGMFQDLPRLSVLNLAKNRI----QSIERGAFDKN--TEIEA-----------IRLDK--- 533
            .|::  ||:...||.|::|:.|:|    .|.|.| |..|  |.:|:           .|.||   
Human   412 ANLS--MFKQFKRLKVIDLSVNKISPSGDSSEVG-FCSNARTSVESYEPQVLEQLHYFRYDKYAR 473

  Fly   534 ---------NFLTDINGIFATLASLLWLNLSENHLVWF---DYAFIPSNLKWLDIHGNYIEALGN 586
                     :|::.....:....:   |:||:|.:.:.   |:..: |.||.|::.||.|....|
Human   474 SCRFKNKEASFMSVNESCYKYGQT---LDLSKNSIFFVKSSDFQHL-SFLKCLNLSGNLISQTLN 534

  Fly   587 YYKLQEEIRVTTLDASHNRITEI--GAMSVPNSIELLFINNNIIGQIQANTFVDK--TRLARVDL 647
            ..:.|....:..||.|:||:..:  .|....:.:|:|.|::|      ::.|..:  |.:.....
Human   535 GSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN------SHYFQSEGITHMLNFTK 593

  Fly   648 YANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIEC 712
            ...||.|:.:|...::..::.....|            |:..|:...|             :::.
Human   594 NLKVLQKLMMNDNDISSSTSRTMESE------------SLRTLEFRGN-------------HLDV 633

  Fly   713 LMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVD 777
            |.....:..|:...:|      .|.|.                                    :|
Human   634 LWREGDNRYLQLFKNL------LKLEE------------------------------------LD 656

  Fly   778 CGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNL 842
            ..:..|:.||:.:        .||  ||.          ||:.|.|..:.|.:.....|..|.||
Human   657 ISKNSLSFLPSGV--------FDG--MPP----------NLKNLSLAKNGLKSFSWKKLQCLKNL 701

  Fly   843 RVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQ 907
            ..|.|.:|:||.:..........|:.|.|.||.:..::....:....|..|.|.:|::..:....
Human   702 ETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTS 766

  Fly   908 Y----RHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLAN 968
            :    .::|:.|.|..|.:.|.|..:..:.........:...|.|:.|:..|..:...:|.    
Human   767 FPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVIS---- 827

  Fly   969 GPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHYGVRV 1033
                   ||.....:    ||.......|  ::.|.:||:|::....::...|  |...|:    
Human   828 -------LDLYTCEL----DLTNLILFSL--SISVSLFLMVMMTASHLYFWDV--WYIYHF---- 873

  Fly  1034 CEPRFEDAGKL------YDAIILHSEKD---YEFVCRNIAAELEHGRPP-FRLCIQQRD-LPPQA 1087
            |:.:.:...:|      |||.|::..||   .|:|...:.|:||..|.. |.||:::|| ||.|.
Human   874 CKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQP 938

  Fly  1088 SHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQK------LVIIEETSVSAE 1146
            ....|.:..:.|:|.:.|:|.....||    .|:.||:.|.:.|..:      |:.:|:      
Human   939 VLENLSQSIQLSKKTVFVMTDKYAKTE----NFKIAFYLSHQRLMDEKVDVIILIFLEK------ 993

  Fly  1147 AEDVAELSPYLKSV----------------PSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLDH 1195
                    |:.||.                |:|.  ....|||:.|:.|:           ..|:
Human   994 --------PFQKSKFLQLRKRLCGSSVLEWPTNP--QAHPYFWQCLKNAL-----------ATDN 1037

  Fly  1196 HERFKQPVSPGMIFRQ 1211
            |..:.|      :|::
Human  1038 HVAYSQ------VFKE 1047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 5/27 (19%)
leucine-rich repeat 92..115 CDD:275380 4/22 (18%)
LRR_8 115..181 CDD:404697 21/65 (32%)
leucine-rich repeat 116..146 CDD:275380 7/29 (24%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 10/29 (34%)
LRR 210..592 CDD:443914 101/433 (23%)
leucine-rich repeat 212..236 CDD:275380 1/23 (4%)
leucine-rich repeat 237..260 CDD:275380 6/30 (20%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 9/24 (38%)
leucine-rich repeat 335..358 CDD:275380 5/22 (23%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
leucine-rich repeat 383..406 CDD:275380 7/24 (29%)
leucine-rich repeat 407..430 CDD:275380 9/28 (32%)
leucine-rich repeat 431..451 CDD:275380 4/23 (17%)
leucine-rich repeat 454..477 CDD:275380 7/22 (32%)
leucine-rich repeat 478..499 CDD:275380 4/20 (20%)
leucine-rich repeat 502..525 CDD:275380 10/28 (36%)
leucine-rich repeat 526..548 CDD:275380 5/44 (11%)
leucine-rich repeat 590..617 CDD:275380 7/28 (25%)
leucine-rich repeat 618..641 CDD:275380 5/24 (21%)
leucine-rich repeat 642..689 CDD:275380 6/46 (13%)
LRRCT 679..736 CDD:214507 6/56 (11%)
LRR <775..>920 CDD:443914 34/148 (23%)
leucine-rich repeat 775..796 CDD:275380 4/20 (20%)
leucine-rich repeat 797..817 CDD:275380 4/19 (21%)
leucine-rich repeat 818..841 CDD:275380 6/22 (27%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 4/24 (17%)
TIR 1045..1183 CDD:214587 44/164 (27%)
TLR7NP_057646.1 PCC 753..>837 CDD:188093 15/98 (15%)
LRR 27 772..795 6/22 (27%)
TIR 890..>993 CDD:214587 33/106 (31%)
LRR 1 43..64 3/10 (30%)
leucine-rich repeat 48..69 CDD:275380 3/15 (20%)
LRR 2 65..87 4/21 (19%)
LRR_8 75..139 CDD:404697 20/80 (25%)
leucine-rich repeat 91..128 CDD:275380 12/53 (23%)
LRR 109..>434 CDD:443914 102/420 (24%)
LRR 3 110..126 6/30 (20%)
LRR 4 127..149 6/24 (25%)
leucine-rich repeat 129..173 CDD:275380 19/88 (22%)
LRR 5 151..170 9/60 (15%)
LRR 6 171..195 5/23 (22%)
LRR 7 203..226 6/25 (24%)
leucine-rich repeat 206..225 CDD:275380 5/21 (24%)
leucine-rich repeat 227..250 CDD:275380 6/22 (27%)
LRR 8 228..247 4/18 (22%)
LRR 9 248..275 11/35 (31%)
leucine-rich repeat 251..291 CDD:275380 14/48 (29%)
LRR 10 289..312 7/22 (32%)
leucine-rich repeat 292..315 CDD:275380 6/22 (27%)
LRR 11 314..337 6/22 (27%)
leucine-rich repeat 316..341 CDD:275380 7/24 (29%)
LRR 12 339..368 10/28 (36%)
leucine-rich repeat 342..371 CDD:275380 9/28 (32%)
LRR 13 369..392 4/22 (18%)
leucine-rich repeat 372..398 CDD:275380 5/25 (20%)
LRR 14 396..419 12/46 (26%)
leucine-rich repeat 399..422 CDD:275380 11/46 (24%)
LRR 15 421..443 8/21 (38%)
LRR 478..>785 CDD:443914 75/403 (19%)
LRR 16 492..515 5/25 (20%)
leucine-rich repeat 496..518 CDD:275380 5/25 (20%)
LRR 17 516..540 8/24 (33%)
leucine-rich repeat 519..543 CDD:275380 8/23 (35%)
LRR 18 541..564 6/22 (27%)
leucine-rich repeat 544..567 CDD:275380 6/22 (27%)
LRR 19 566..588 6/27 (22%)
leucine-rich repeat 568..597 CDD:275380 6/34 (18%)
LRR 20 595..618 4/22 (18%)
leucine-rich repeat 598..651 CDD:275380 10/83 (12%)
LRR 21 619..644 5/49 (10%)
leucine-rich repeat 621..643 CDD:275380 3/34 (9%)
LRR 22 649..672 7/72 (10%)
leucine-rich repeat 652..676 CDD:275380 9/79 (11%)
LRR 23 674..697 7/32 (22%)
leucine-rich repeat 677..700 CDD:275380 6/22 (27%)
LRR 24 698..721 8/22 (36%)
leucine-rich repeat 701..724 CDD:275380 6/22 (27%)
LRR 25 723..745 5/21 (24%)
leucine-rich repeat 725..748 CDD:275380 5/22 (23%)
LRR 26 746..769 4/22 (18%)
leucine-rich repeat 749..767 CDD:275380 4/17 (24%)

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