DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and TLR7

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_057646.1 Gene:TLR7 / 51284 HGNCID:15631 Length:1049 Species:Homo sapiens


Alignment Length:1251 Identity:269/1251 - (21%)
Similarity:466/1251 - (37%) Gaps:352/1251 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 DLQVAEAAGRLDLQCSQELL---HASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKR 118
            |..:.|..|.:....:...|   |..:::|..|.:|..|.|:.. .|....:|..: :..|.:||
Human    53 DKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDF-RCNCVPIPLGS-KNNMCIKR 115

  Fly   119 LTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRS 183
                           |::..:||.||..|..|:|..|.:.::|:|:   .||||||:|..|.|.|
Human   116 ---------------LQIKPRSFSGLTYLKSLYLDGNQLLEIPQGL---PPSLQLLSLEANNIFS 162

  Fly   184 AEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHN--- 245
            ..    .|.|                                      :.|..::.|.|..|   
Human   163 IR----KENL--------------------------------------TELANIEILYLGQNCYY 185

  Fly   246 ----NIS-TLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHR 305
                .:| ::..:|...|:.|:||::..|::.::|:..   ...|.||:|..|.:.::.:...:.
Human   186 RNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVL---PSTLTELYLYNNMIAKIQEDDFNN 247

  Fly   306 LEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIG 370
            |.||.:||||||....:   |:.|.      .....||:..:|....|..|..|::|.:.:||:.
Human   248 LNQLQILDLSGNCPRCY---NAPFP------CAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQ 303

  Fly   371 HIEEGAFLPLYNLHTLNLAENRL--HTLDNRIFNGLYVLTKLTLNNNL------VSIVESQAFRN 427
            |:....|..:..|..|:|::|.|  ...|.:..:.|..|.:|.|:.|.      .|:..||||.:
Human   304 HVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSS 368

  Fly   428 CSDLKELDLSSNQLTEVP----EAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRI 488
            ...||.|.:......|:.    ..:.:|..|:.||||.|.|                      :|
Human   369 LKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFI----------------------KI 411

  Fly   489 GNITVGMFQDLPRLSVLNLAKNRI----QSIERGAFDKN--TEIEA-----------IRLDK--- 533
            .|::  ||:...||.|::|:.|:|    .|.|.| |..|  |.:|:           .|.||   
Human   412 ANLS--MFKQFKRLKVIDLSVNKISPSGDSSEVG-FCSNARTSVESYEPQVLEQLHYFRYDKYAR 473

  Fly   534 ---------NFLTDINGIFATLASLLWLNLSENHLVWF---DYAFIPSNLKWLDIHGNYIEALGN 586
                     :|::.....:....:   |:||:|.:.:.   |:..: |.||.|::.||.|....|
Human   474 SCRFKNKEASFMSVNESCYKYGQT---LDLSKNSIFFVKSSDFQHL-SFLKCLNLSGNLISQTLN 534

  Fly   587 YYKLQEEIRVTTLDASHNRITEI--GAMSVPNSIELLFINNNIIGQIQANTFVDK--TRLARVDL 647
            ..:.|....:..||.|:||:..:  .|....:.:|:|.|::|      ::.|..:  |.:.....
Human   535 GSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN------SHYFQSEGITHMLNFTK 593

  Fly   648 YANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIEC 712
            ...||.|:.:|...::..::.....|            |:..|:...|             :::.
Human   594 NLKVLQKLMMNDNDISSSTSRTMESE------------SLRTLEFRGN-------------HLDV 633

  Fly   713 LMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVD 777
            |.....:..|:...:|      .|.|.                                    :|
Human   634 LWREGDNRYLQLFKNL------LKLEE------------------------------------LD 656

  Fly   778 CGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNL 842
            ..:..|:.||:.:        .||  ||.          ||:.|.|..:.|.:.....|..|.||
Human   657 ISKNSLSFLPSGV--------FDG--MPP----------NLKNLSLAKNGLKSFSWKKLQCLKNL 701

  Fly   843 RVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQ 907
            ..|.|.:|:||.:..........|:.|.|.||.:..::....:....|..|.|.:|::..:....
Human   702 ETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTS 766

  Fly   908 Y----RHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLAN 968
            :    .::|:.|.|..|.:.|.|..:..:.........:...|.|:.|:..|..:...:|.    
Human   767 FPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVIS---- 827

  Fly   969 GPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHYGVRV 1033
                   ||.....:    ||.......|  ::.|.:||:|::....::...|  |...|:    
Human   828 -------LDLYTCEL----DLTNLILFSL--SISVSLFLMVMMTASHLYFWDV--WYIYHF---- 873

  Fly  1034 CEPRFEDAGKL------YDAIILHSEKD---YEFVCRNIAAELEHGRPP-FRLCIQQRD-LPPQA 1087
            |:.:.:...:|      |||.|::..||   .|:|...:.|:||..|.. |.||:::|| ||.|.
Human   874 CKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQP 938

  Fly  1088 SHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQK------LVIIEETSVSAE 1146
            ....|.:..:.|:|.:.|:|.....||    .|:.||:.|.:.|..:      |:.:|:      
Human   939 VLENLSQSIQLSKKTVFVMTDKYAKTE----NFKIAFYLSHQRLMDEKVDVIILIFLEK------ 993

  Fly  1147 AEDVAELSPYLKSV----------------PSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLDH 1195
                    |:.||.                |:|.  ....|||:.|:.|:           ..|:
Human   994 --------PFQKSKFLQLRKRLCGSSVLEWPTNP--QAHPYFWQCLKNAL-----------ATDN 1037

  Fly  1196 HERFKQPVSPGMIFRQ 1211
            |..:.|      :|::
Human  1038 HVAYSQ------VFKE 1047

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 5/27 (19%)
leucine-rich repeat 92..115 CDD:275380 4/22 (18%)
LRR_8 115..181 CDD:290566 21/65 (32%)
leucine-rich repeat 116..146 CDD:275380 7/29 (24%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 10/29 (34%)
LRR_RI 210..464 CDD:238064 66/273 (24%)
leucine-rich repeat 212..236 CDD:275380 1/23 (4%)
LRR_8 235..295 CDD:290566 16/67 (24%)
leucine-rich repeat 237..260 CDD:275380 6/30 (20%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
LRR_8 283..345 CDD:290566 18/61 (30%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 9/24 (38%)
LRR_8 334..393 CDD:290566 15/58 (26%)
leucine-rich repeat 335..358 CDD:275380 5/22 (23%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
LRR_8 382..441 CDD:290566 19/66 (29%)
leucine-rich repeat 383..406 CDD:275380 7/24 (29%)
leucine-rich repeat 407..430 CDD:275380 9/28 (32%)
LRR_8 431..488 CDD:290566 12/60 (20%)
leucine-rich repeat 431..451 CDD:275380 4/23 (17%)
leucine-rich repeat 454..477 CDD:275380 7/22 (32%)
LRR_8 477..559 CDD:290566 25/110 (23%)
leucine-rich repeat 478..499 CDD:275380 4/20 (20%)
leucine-rich repeat 502..525 CDD:275380 10/28 (36%)
leucine-rich repeat 526..548 CDD:275380 5/44 (11%)
leucine-rich repeat 590..617 CDD:275380 7/28 (25%)
leucine-rich repeat 618..641 CDD:275380 5/24 (21%)
leucine-rich repeat 642..689 CDD:275380 6/46 (13%)
LRRCT 679..736 CDD:214507 6/56 (11%)
leucine-rich repeat 775..796 CDD:275380 4/20 (20%)
LRR_8 797..852 CDD:290566 16/54 (30%)
leucine-rich repeat 797..817 CDD:275380 4/19 (21%)
leucine-rich repeat 818..841 CDD:275380 6/22 (27%)
LRR_8 841..900 CDD:290566 16/58 (28%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
LRR_4 866..907 CDD:289563 9/40 (23%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 4/24 (17%)
TIR 1045..1183 CDD:214587 44/164 (27%)
TLR7NP_057646.1 leucine-rich repeat 598..651 CDD:275380 10/83 (12%)
LRR 21 619..644 5/49 (10%)
leucine-rich repeat 621..643 CDD:275380 3/34 (9%)
LRR 22 649..672 7/72 (10%)
leucine-rich repeat 652..676 CDD:275380 9/79 (11%)
LRR 23 674..697 7/32 (22%)
leucine-rich repeat 677..700 CDD:275380 6/22 (27%)
LRR 24 698..721 8/22 (36%)
leucine-rich repeat 701..724 CDD:275380 6/22 (27%)
LRR 25 723..745 5/21 (24%)
leucine-rich repeat 725..748 CDD:275380 5/22 (23%)
LRR 26 746..769 4/22 (18%)
leucine-rich repeat 749..767 CDD:275380 4/17 (24%)
PCC 753..>837 CDD:188093 15/98 (15%)
LRR 27 772..795 6/22 (27%)
TIR 890..>993 CDD:214587 33/106 (31%)
LRR 1 43..64 3/10 (30%)
leucine-rich repeat 48..69 CDD:275380 3/15 (20%)
LRR 2 65..87 4/21 (19%)
LRR_8 75..139 CDD:404697 20/80 (25%)
leucine-rich repeat 91..128 CDD:275380 12/53 (23%)
LRR 3 110..126 6/30 (20%)
LRR 4 127..149 6/24 (25%)
leucine-rich repeat 129..173 CDD:275380 19/88 (22%)
LRR 5 151..170 9/60 (15%)
LRR 6 171..195 5/23 (22%)
PLN00113 191..>711 CDD:215061 143/653 (22%)
LRR 7 203..226 6/25 (24%)
leucine-rich repeat 206..225 CDD:275380 5/21 (24%)
leucine-rich repeat 227..250 CDD:275380 6/22 (27%)
LRR 8 228..247 4/18 (22%)
LRR 9 248..275 11/35 (31%)
leucine-rich repeat 251..291 CDD:275380 14/48 (29%)
LRR 10 289..312 7/22 (32%)
leucine-rich repeat 292..315 CDD:275380 6/22 (27%)
LRR 11 314..337 6/22 (27%)
leucine-rich repeat 316..341 CDD:275380 7/24 (29%)
LRR 12 339..368 10/28 (36%)
leucine-rich repeat 342..371 CDD:275380 9/28 (32%)
LRR 13 369..392 4/22 (18%)
leucine-rich repeat 372..398 CDD:275380 5/25 (20%)
LRR 14 396..419 12/46 (26%)
leucine-rich repeat 399..422 CDD:275380 11/46 (24%)
LRR 15 421..443 8/21 (38%)
LRR <488..775 CDD:227223 70/383 (18%)
LRR 16 492..515 5/25 (20%)
leucine-rich repeat 496..518 CDD:275380 5/25 (20%)
LRR 17 516..540 8/24 (33%)
leucine-rich repeat 519..543 CDD:275380 8/23 (35%)
LRR 18 541..564 6/22 (27%)
leucine-rich repeat 544..567 CDD:275380 6/22 (27%)
LRR 19 566..588 6/27 (22%)
leucine-rich repeat 568..597 CDD:275380 6/34 (18%)
LRR 20 595..618 4/22 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.780

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