DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Tlr11

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001138251.2 Gene:Tlr11 / 498491 RGDID:1564460 Length:932 Species:Rattus norvegicus


Alignment Length:1111 Identity:253/1111 - (22%)
Similarity:388/1111 - (34%) Gaps:365/1111 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   105 VPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDN-----NIRQLPEGV 164
            :|.|||:|..||:.|.|:.        .|..:..::||||.:|..|....:     ::...|:  
  Rat   100 LPANAFDGFYSLQLLRLQL--------GTTNITSRTFQGLDQLQYLFFEHHAPCCLSLFLPPD-- 154

  Fly   165 WCSMPSLQLLNLTQNRIRSAEFLG----FSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSL 225
              |:.||:.|:       |..|.|    :|..:...:.|.:.....|..::||.|.      |..
  Rat   155 --SLESLRSLS-------SLSFQGYCLTYSHSIYLPTTLRHLTMRNSCLTKLQELQ------RLF 204

  Fly   226 PD-AWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELH 289
            || ..|||               ||  ||.......|.||::||             |.:|::..
  Rat   205 PDLLLGAS---------------ST--PNTKPRTPFLEVLDLSY-------------NLQLKQAG 239

  Fly   290 LQGNDLYELPKGLLHRLEQLLVLD---LSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSK 351
            ::  |||.|   .||.    |:||   |....|||        :||:.|..|:|....:.::.:.
  Rat   240 IR--DLYGL---TLHS----LILDGTPLRALDLTS--------SGLLHLHFLSLVGTGIEKLPAS 287

  Fly   352 T--FKELYFLQILDMRNNSIGHI-EEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLN 413
            .  |.||.   .||:..|.|.:| ..|..|.|..|..|:|.:|.|.:|..|....|..|.||.|:
  Rat   288 VTGFSELC---ALDLGKNQIQNILGNGDILGLKALKFLSLHDNHLQSLPVRFLRTLPQLQKLNLS 349

  Fly   414 -NNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEA-VQDLSMLKTLDLGENQISEFKNNTFRNLN 476
             |.|..|:|.......::|..||||.|||.|:|.. ...||.|:.|.|..|.||...|.:.:.|.
  Rat   350 MNKLGPILELPEGLFSTNLTVLDLSHNQLCEIPRGNFSFLSQLQELWLSGNNISSLSNESLQGLR 414

  Fly   477 QLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDING 541
            .|..|.|..|:|..:..|....||.|:.|||....::.|      ..|:::..::.::...   |
  Rat   415 WLRTLDLSWNQIKVLKPGWLSHLPALTTLNLLGTYLEHI------SGTQLQGPKMLRHLQL---G 470

  Fly   542 IFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHG-NYIEALGNYYKLQEEIRVTTLDASHNR 605
            .|.||         |.:.:||     |..|. |:|.. .||:.:                     
  Rat   471 SFPTL---------EIYRLWF-----PMLLS-LEIQAETYIQFM--------------------- 499

  Fly   606 ITEIGAMSVPNSIELLFINN------NIIGQIQANTFVDKTRLARVDL--YANVLSKISLNALRV 662
                    ||:....||:.|      |::.:.:..| :....|.|:.|  |:..||...|.:.  
  Rat   500 --------VPSGEPFLFLENLTLETSNLLLEPKTTT-IHFPSLRRLTLRGYSIFLSTSQLQSF-- 553

  Fly   663 APVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLAS 727
              ...:.|:.|::           ..|.         ::...|||...|  ||..|...|     
  Rat   554 --FPPQLPLLEYF-----------FVWC---------RNDDAVDLHLFE--MPRLRVLEL----- 589

  Fly   728 LSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQ 792
                                             ||.:.|::::..         .|..|.|.:||
  Rat   590 ---------------------------------GNLNFFYESSTV---------KLEMLLNEVPQ 612

  Fly   793 DVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEG 857
             :..|.|...|:..|.|....|.::|:.|.||:.                |.|.:.:|       
  Rat   613 -LQVLALSHLNLKNLSVSSFKGLQSLKLLLLNSE----------------RALEMNSN------- 653

  Fly   858 TEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAW 922
                    |:||........:.|:.||                          :.|..|....:|
  Rat   654 --------LQELIPQIPQYVYFSDVTF--------------------------ACQCETSWLESW 684

  Fly   923 SCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDAS--ASNISS 985
            :.|           :.|..|.           |:::.:    .:||..|.|..|..|  |:|...
  Rat   685 ATR-----------APNTFVY-----------GLEKPI----CMANASDYSKTLLFSFLATNCPH 723

  Fly   986 SQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHY------------GVRVCEPRF 1038
            ..:..|     .|.:..:|:.|:::.:|      |...|.:.|:            |......:|
  Rat   724 GTEFWG-----FLTSFSLLLLLIILPLI------SCHKWSWLHHLWTLFHTCWWKLGGHRLRGQF 777

  Fly  1039 EDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPP---FRLCIQQRDLPPQASHLQ-LVEGARAS 1099
            .     ||..|.:.|:|.::|...:...||...|.   .|||:..||.......:: ::.....|
  Rat   778 N-----YDVFISYCEEDQDWVLEELVPVLEKAPPEGEGLRLCLPARDFGIGNDRMESMIASMGKS 837

  Fly  1100 RKIILVLTRNLLATEWNRIEFRNA----------------FHESLRGLAQKLVIIEETSVSAEAE 1148
            |.|:.|||...||:.|..:|.|.|                |.|.|.  .|||......|...:.|
  Rat   838 RAILCVLTGQALASPWCNLELRLATYHLIARPGTTCLLLLFLEPLD--RQKLHSYHRLSRWLQKE 900

  Fly  1149 DVAELS 1154
            |..:||
  Rat   901 DYFDLS 906

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380 5/9 (56%)
LRR_8 115..181 CDD:404697 16/70 (23%)
leucine-rich repeat 116..146 CDD:275380 8/29 (28%)
leucine-rich repeat 147..170 CDD:275380 4/27 (15%)
leucine-rich repeat 171..201 CDD:275380 7/33 (21%)
LRR 210..592 CDD:443914 112/391 (29%)
leucine-rich repeat 212..236 CDD:275380 9/24 (38%)
leucine-rich repeat 237..260 CDD:275380 4/22 (18%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 9/27 (33%)
leucine-rich repeat 335..358 CDD:275380 6/24 (25%)
leucine-rich repeat 359..382 CDD:275380 8/23 (35%)
leucine-rich repeat 383..406 CDD:275380 8/22 (36%)
leucine-rich repeat 407..430 CDD:275380 8/23 (35%)
leucine-rich repeat 431..451 CDD:275380 10/20 (50%)
leucine-rich repeat 454..477 CDD:275380 8/22 (36%)
leucine-rich repeat 478..499 CDD:275380 6/20 (30%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 4/21 (19%)
leucine-rich repeat 590..617 CDD:275380 2/26 (8%)
leucine-rich repeat 618..641 CDD:275380 5/28 (18%)
leucine-rich repeat 642..689 CDD:275380 9/48 (19%)
LRRCT 679..736 CDD:214507 9/56 (16%)
LRR <775..>920 CDD:443914 26/144 (18%)
leucine-rich repeat 775..796 CDD:275380 5/20 (25%)
leucine-rich repeat 797..817 CDD:275380 6/19 (32%)
leucine-rich repeat 818..841 CDD:275380 4/22 (18%)
leucine-rich repeat 842..865 CDD:275380 3/22 (14%)
leucine-rich repeat 866..889 CDD:275380 6/22 (27%)
leucine-rich repeat 890..911 CDD:275380 0/20 (0%)
TIR 1045..1183 CDD:214587 37/130 (28%)
Tlr11NP_001138251.2 leucine-rich repeat 111..133 CDD:275380 8/29 (28%)
LRR 171..576 CDD:443914 133/538 (25%)
leucine-rich repeat 224..246 CDD:275380 10/36 (28%)
leucine-rich repeat 248..270 CDD:275380 11/33 (33%)
leucine-rich repeat 271..293 CDD:275380 4/21 (19%)
leucine-rich repeat 294..318 CDD:275380 9/26 (35%)
leucine-rich repeat 319..342 CDD:275380 8/22 (36%)
leucine-rich repeat 343..367 CDD:275380 8/23 (35%)
leucine-rich repeat 368..391 CDD:275380 11/22 (50%)
leucine-rich repeat 392..415 CDD:275380 8/22 (36%)
leucine-rich repeat 416..437 CDD:275380 6/20 (30%)
leucine-rich repeat 440..463 CDD:275380 6/28 (21%)
leucine-rich repeat 533..583 CDD:275380 15/75 (20%)
leucine-rich repeat 584..612 CDD:275380 8/74 (11%)
leucine-rich repeat 613..633 CDD:275380 5/19 (26%)
TIR_2 781..>861 CDD:463954 23/79 (29%)
Blue background indicates that the domain is not in the aligned region.

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