Protein Alignment 18w and kek6

DIOPT Version :10

• Sequence 1: NP_476814.1
• Gene: 18w / 37277
• FlyBaseID: FBgn0287775
• Length: 1385
• Species: Drosophila melanogaster
• Sequence 2: NP_001263151.1
• Gene: kek6 / 43729
• FlyBaseID: FBgn0039862
• Length: 843
• Species: Drosophila melanogaster
• Alignment Length: 780
• Identity: 146/780 - (18%)
• Similarity: 253/780 - (32%)
• Gaps: 306/780 - (39%)

  Fly   739 SHCPPTCHCCEYEQC--------ECEVICPGNCSCFHDATWATN---IVDCGRQDLAALPNRIPQ 792
            |..|.|...|....|        :..:.|..||:|    .| ||   ...|....|..:||.:..
  Fly    10 SRTPRTLPVCWILLCLVAWTVADDWSLSCASNCTC----KW-TNGKKSAICSSLQLTTIPNTLST 69

  Fly   793 DVSDLYLDGNNMPEL--EVGHLTGRRNLRALYLNASNLMTLQNGSLAQLV--------------- 840
            ::..|.|:.|::|.|  |.....|..||:.:||..|.:..:...|...|.
  Fly    70 ELQVLVLNDNHIPYLNREEFSTLGLLNLQRIYLKKSEVQYIHKESFRNLKILVEIDLSDNKLEML 134

  Fly   841 ---------NLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLD 896
                     .||:|:|..|.|..|...:|..|..||.|.:|:.::::|...:...|..||.|.|.
  Fly   135 DKDTFMGNDRLRILYLNGNPLKRLAAYQFPILPHLRTLDMHDCLISYIDPMSLANLNLLEFLNLK 199

  Fly   897 NNRLSSLPHLQYRH--SLQGLTLGRNAWSCRCQQLRELAQF-----VSDNAMVVR---------- 944
            ||.|.||....::|  :|:.|:|..|.|.|.| :||:...:     :|..::|.:
  Fly   200 NNLLESLSEYVFQHMANLKTLSLEENPWQCNC-KLRKFRGWYVNSRLSSVSLVCKGPPAQKDRTW 263

  Fly   945 -----------------DAHDIYCLDAGIKREL--------------ELIGNLANGPD------- 971
                             :..::..:|.|.....              ||.|.:.:..:
  Fly   264 DSVDDELFGCPPRVEIFNNEEVQNIDIGSNTTFSCLVYGDPLPEVAWELNGKILDNDNVLFESES 328

  Fly   972 -CSDLL--DASASNISSSQDLAGGY----------------------------RLP-------LL 998
             .||.|  :.:..|::|..  ||.|                            :.|       |:
  Fly   329 IASDKLWSNLTVFNVTSLD--AGTYACTGSNSIGSMTQNISIYLSEIVQHVLEKTPETFWYFGLI 391

  Fly   999 AAVLVLIFLVV-VLIIVFVFRESVRMWLFAH--------------------------------YG 1030
            ..:...:||:: :..:|.:.:.:.|....|:                                ||
  Fly   392 MGIFGTVFLLISISFVVCLCKRTTRQHRHANKAGVKSSVSFNDQEKKLLDSSVTTTTNDRGDSYG 456

  Fly  1031 V-----RVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL 1090
            :     .:...:.:.||..::.|.:|:.:.:           .||    .:.:||:   ||.
  Fly   457 IDNQPTSIGMNKGDSAGMGFNQIEIHAVESH-----------RHG----SMLVQQQ---PQQ--- 500

  Fly  1091 QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSP 1155
            |.|.|.                                .|:.|:|:.::::
  Fly   501 QQVAGG--------------------------------GGMRQQLMQVKDS-------------- 519

  Fly  1156 YLKSVPSNRLLTCDRYFWEKLRYAIPIELSPRGNNYTLDHHERFKQPVSPGMIFRQAPPPPAYYC 1220
                       ||.       ..::|..::...:::.....|.|  |::.|:.     |||..:|
  Fly   520 -----------TCG-------MMSVPTSMAGHAHSHPAQISEEF--PLNVGVF-----PPPPEFC 559

  Fly  1221 TEEMEANYSSATTATPSPRPTRPGG-------AARIVDSMPMPMRPPSEHIYHSI---------- 1268
            :..:             |.|...|.       ...::|...:.|.|...:|...:
  Fly   560 SNIV-------------PNPAFGGNIFIRVSVTQDMLDGADLNMYPDLLNIPKRMQDVQESGAGA 611

  Fly  1269 ----ESEYSAYDQHEALSMI---PTGLMHQHQQQQLRLHQQQQQQQQQRLLQPQFRAMPQQAIPA 1326
                |.:::...:|.|...|   .|.|..|.||.| :.||.|||||||::.|.|.:.:.||..|:
  Fly   612 VAVPEGQFATLPRHTARRGILKKDTSLQQQQQQHQ-QQHQHQQQQQQQQIQQQQHQQLQQQHQPS 675

  Fly  1327  1326
              Fly   676  675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:404697
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR	210..592	CDD:443914
		leucine-rich repeat	212..236	CDD:275380
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		leucine-rich repeat	335..358	CDD:275380
		leucine-rich repeat	359..382	CDD:275380
		leucine-rich repeat	383..406	CDD:275380
		leucine-rich repeat	407..430	CDD:275380
		leucine-rich repeat	431..451	CDD:275380
		leucine-rich repeat	454..477	CDD:275380
		leucine-rich repeat	478..499	CDD:275380
		leucine-rich repeat	502..525	CDD:275380
		leucine-rich repeat	526..548	CDD:275380
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		LRR	<775..>920	CDD:443914	46/172 (27%)
		leucine-rich repeat	775..796	CDD:275380	4/20 (20%)
		leucine-rich repeat	797..817	CDD:275380	7/21 (33%)
		leucine-rich repeat	818..841	CDD:275380	6/46 (13%)
		leucine-rich repeat	842..865	CDD:275380	9/22 (41%)
		leucine-rich repeat	866..889	CDD:275380	6/22 (27%)
		leucine-rich repeat	890..911	CDD:275380	10/22 (45%)
		TIR	1045..1183	CDD:214587	17/137 (12%)
kek6	NP_001263151.1	LRR	<56..>226	CDD:443914	45/169 (27%)
		leucine-rich repeat	71..96	CDD:275380	7/24 (29%)
		LRR_8	96..155	CDD:404697	12/58 (21%)
		leucine-rich repeat	97..120	CDD:275380	6/22 (27%)
		leucine-rich repeat	121..144	CDD:275380	0/22 (0%)
		leucine-rich repeat	145..168	CDD:275380	9/22 (41%)
		leucine-rich repeat	169..216	CDD:275380	16/46 (35%)
		LRRCT	225..274	CDD:214507	8/49 (16%)
		Ig	286..360	CDD:472250	13/75 (17%)
		Ig strand B	294..298	CDD:409353	0/3 (0%)
		Ig strand C	307..310	CDD:409353	0/2 (0%)
		Ig strand E	336..340	CDD:409353	0/3 (0%)
		Ig strand F	350..355	CDD:409353	1/4 (25%)