DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tl

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001262995.1 Gene:Tl / 43222 FlyBaseID:FBgn0262473 Length:1117 Species:Drosophila melanogaster


Alignment Length:1222 Identity:278/1222 - (22%)
Similarity:454/1222 - (37%) Gaps:364/1222 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 LLHASELAPGLFRQ----LQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLE 135
            :..:..|...:.||    |..|...|....:|..:|.|....:.:|..|.|.::        ..|
  Fly   131 IFESDNLGMNITRQHLDRLHGLKRFRFTTRRLTHIPANLLTDMRNLSHLELRAN--------IEE 187

  Fly   136 LHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALS 200
            :....|..|:.|..:..|.|.:||:|.|::..||.|:.|||..|::.:.....|           
  Fly   188 MPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNLTKHDF----------- 241

  Fly   201 NANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLN 265
                  .|.:.:..:|:..|.:..||.                         :..|.|:::..:|
  Fly   242 ------EGATSVLGIDIHDNGIEQLPH-------------------------DVFAHLTNVTDIN 275

  Fly   266 ISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFA 330
            :|.|...|||...|..||.|.|:.|..|   .:|                               
  Fly   276 LSANLFRSLPQGLFDHNKHLNEVRLMNN---RVP------------------------------- 306

  Fly   331 GLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHT 395
                          |..:.|:.|.....||||.:|                       ||  |.:
  Fly   307 --------------LATLPSRLFANQPELQILRLR-----------------------AE--LQS 332

  Fly   396 LDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLG 460
            |...:|.....:|.::|.:||:..:.:....:..:|..||||:|:||.:|:::            
  Fly   333 LPGDLFEHSTQITNISLGDNLLKTLPATLLEHQVNLLSLDLSNNRLTHLPDSL------------ 385

  Fly   461 ENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTE 525
                       |.:...||.|||.||.:..|:..:|.:|..|..|.:::||:::|:..||.....
  Fly   386 -----------FAHTTNLTDLRLEDNLLTGISGDIFSNLGNLVTLVMSRNRLRTIDSRAFVSTNG 439

  Fly   526 IEAIRLDKNFL------------TDINGIFATLASLLWLNLSENHL--VWFDYAFIPSNLKWLDI 576
            :..:.||.|.:            |.||..|..:..||.|||..|.:  |:.|:......|:.||:
  Fly   440 LRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSIIFVYNDWKNTMLQLRELDL 504

  Fly   577 HGNYIEALGNYYKL----QEEIRVTTLDASHNRITEIGAMSVPNSIEL-LFINNNIIGQIQANTF 636
            ..|.|.:|| |..|    |..:.|   :.:||:|..|   ::|..:.| ...|||::        
  Fly   505 SYNNISSLG-YEDLAFLSQNRLHV---NMTHNKIRRI---ALPEDVHLGEGYNNNLV-------- 554

  Fly   637 VDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEW-LQRINNLTTRQ 700
                   .||                             |..||..|||::.| :|.:..:...|
  Fly   555 -------HVD-----------------------------LNDNPLVCDCTILWFIQLVRGVHKPQ 583

  Fly   701 HPHVVDL--GNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNC 763
            :.....|  ..:.|..|:....  .|:..:.....:|..:....|.           |..||..|
  Fly   584 YSRQFKLRTDRLVCSQPNVLEG--TPVRQIEPQTLICPLDFSDDPR-----------ERKCPRGC 635

  Fly   764 SCFHDATW-ATNIVDCGRQDLAALPNRIP-----QDVSDLYLDGNNMPELEVGHLTGRRNLRALY 822
            :| |..|: ...:::|...:|..:| |:|     ..:.:|:|:.|.:..|...:..|..::.:|:
  Fly   636 NC-HVRTYDKALVINCHSGNLTHVP-RLPNLHKNMQLMELHLENNTLLRLPSANTPGYESVTSLH 698

  Fly   823 LNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPL 887
            |..:||.::....|.  .||..|.:..|.|..|..|   .||.|                     
  Fly   699 LAGNNLTSIDVDQLP--TNLTHLDISWNHLQMLNAT---VLGFL--------------------- 737

  Fly   888 VSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCL 952
                      ||.     :::|    .:.|..|.|.|.| ..:.|..|..||...:.|.:::.|:
  Fly   738 ----------NRT-----MKWR----SVKLSGNPWMCDC-TAKPLLLFTQDNFERIGDRNEMMCV 782

  Fly   953 DAGI-KRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVL----- 1011
            :|.: .|.:||                      |:.|:.     |....|.:.:.:|:.|     
  Fly   783 NAEMPTRMVEL----------------------STNDIC-----PAEKGVFIALAVVIALTGLLA 820

  Fly  1012 ----IIVFVFRESVRMWLFAHYGVR--VCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHG 1070
                .:.:.|:..:::||:||..:.  |.|... |..|.:||.|.:|.||..|:...:..:||||
  Fly   821 GFTAALYYKFQTEIKIWLYAHNLLLWFVTEEDL-DKDKKFDAFISYSHKDQSFIEDYLVPQLEHG 884

  Fly  1071 RPPFRLCIQQRD------LPPQASHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESL- 1128
            ...|:||:.:||      :|.     .::.....||:.|:||::|.:.:||.|:|||.|...:| 
  Fly   885 PQKFQLCVHERDWLVGGHIPE-----NIMRSVADSRRTIIVLSQNFIKSEWARLEFRAAHRSALN 944

  Fly  1129 RGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTCDRYFWEKLRYAIPIELSPRGN---- 1189
            .|.::.:|||.......|..| .||..|||.  :..|...|.:||:|||:|:| ...|.||    
  Fly   945 EGRSRIIVIIYSDIGDVEKLD-EELKAYLKM--NTYLKWGDPWFWDKLRFALP-HRRPVGNIGNG 1005

  Fly  1190 --------NYTLDHHERFK-QPVSPGMIFRQAPPPPAYYCTEEMEANYSSAT 1232
                    ..|.|..|..| .||:|.:     ..|||......:.|..:..|
  Fly  1006 ALIKTALKGSTDDKLELIKPSPVTPPL-----TTPPAEATKNPLVAQLNGVT 1052

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 4/19 (21%)
leucine-rich repeat 92..115 CDD:275380 5/22 (23%)
LRR_8 115..181 CDD:290566 20/65 (31%)
leucine-rich repeat 116..146 CDD:275380 6/29 (21%)
leucine-rich repeat 147..170 CDD:275380 8/22 (36%)
leucine-rich repeat 171..201 CDD:275380 6/29 (21%)
LRR_RI 210..464 CDD:238064 46/253 (18%)
leucine-rich repeat 212..236 CDD:275380 4/23 (17%)
LRR_8 235..295 CDD:290566 15/59 (25%)
leucine-rich repeat 237..260 CDD:275380 2/22 (9%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
LRR_8 283..345 CDD:290566 6/61 (10%)
leucine-rich repeat 285..308 CDD:275380 5/22 (23%)
leucine-rich repeat 309..334 CDD:275380 0/24 (0%)
LRR_8 334..393 CDD:290566 10/58 (17%)
leucine-rich repeat 335..358 CDD:275380 3/22 (14%)
leucine-rich repeat 359..382 CDD:275380 5/22 (23%)
LRR_8 382..441 CDD:290566 15/58 (26%)
leucine-rich repeat 383..406 CDD:275380 5/22 (23%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
LRR_8 431..488 CDD:290566 17/56 (30%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 1/22 (5%)
LRR_8 477..559 CDD:290566 30/93 (32%)
leucine-rich repeat 478..499 CDD:275380 9/20 (45%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 7/33 (21%)
leucine-rich repeat 590..617 CDD:275380 8/30 (27%)
leucine-rich repeat 618..641 CDD:275380 4/23 (17%)
leucine-rich repeat 642..689 CDD:275380 8/46 (17%)
LRRCT 679..736 CDD:214507 12/59 (20%)
leucine-rich repeat 775..796 CDD:275380 5/25 (20%)
LRR_8 797..852 CDD:290566 14/54 (26%)
leucine-rich repeat 797..817 CDD:275380 5/19 (26%)
leucine-rich repeat 818..841 CDD:275380 5/22 (23%)
LRR_8 841..900 CDD:290566 11/58 (19%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
LRR_4 866..907 CDD:289563 3/40 (8%)
leucine-rich repeat 866..889 CDD:275380 1/22 (5%)
leucine-rich repeat 890..911 CDD:275380 3/20 (15%)
TIR 1045..1183 CDD:214587 51/144 (35%)
TlNP_001262995.1 LRR_8 174..233 CDD:290566 20/66 (30%)
leucine-rich repeat 176..198 CDD:275380 6/29 (21%)
leucine-rich repeat 199..222 CDD:275380 8/22 (36%)
LRR_RI 216..542 CDD:238064 104/470 (22%)
LRR_8 221..281 CDD:290566 17/101 (17%)
leucine-rich repeat 223..270 CDD:275380 13/88 (15%)
leucine-rich repeat 271..294 CDD:275380 8/22 (36%)
leucine-rich repeat 295..320 CDD:275380 8/72 (11%)
leucine-rich repeat 321..343 CDD:275380 10/46 (22%)
LRR_8 342..402 CDD:290566 21/82 (26%)
leucine-rich repeat 344..367 CDD:275380 4/22 (18%)
leucine-rich repeat 368..391 CDD:275380 10/45 (22%)
LRR_8 390..450 CDD:290566 20/59 (34%)
leucine-rich repeat 392..415 CDD:275380 10/22 (45%)
leucine-rich repeat 416..439 CDD:275380 7/22 (32%)
leucine-rich repeat 440..474 CDD:275380 7/33 (21%)
leucine-rich repeat 475..498 CDD:275380 8/22 (36%)
LRR_8 477..534 CDD:290566 19/60 (32%)
leucine-rich repeat 499..520 CDD:275380 9/21 (43%)
leucine-rich repeat 523..552 CDD:275380 8/34 (24%)
LRRCT 561..619 CDD:214507 12/59 (20%)
LRRNT 631..667 CDD:214470 11/37 (30%)
leucine-rich repeat 664..693 CDD:275380 5/28 (18%)
LRR_8 669..726 CDD:290566 14/58 (24%)
leucine-rich repeat 694..715 CDD:275380 5/22 (23%)
leucine-rich repeat 716..737 CDD:275380 8/23 (35%)
LRRCT 751..800 CDD:214507 16/76 (21%)
TIR 858..996 CDD:214587 51/146 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453767
Domainoid 1 1.000 44 1.000 Domainoid score I4673
eggNOG 1 0.900 - - E2759_KOG4641
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24216
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
76.750

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