DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and cDIP

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_650951.1 Gene:cDIP / 42512 FlyBaseID:FBgn0038865 Length:554 Species:Drosophila melanogaster


Alignment Length:679 Identity:148/679 - (21%)
Similarity:232/679 - (34%) Gaps:266/679 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 TMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELLHA----SELAPGLFRQLQKLSELRID 98
            |.|:...||..|.||...:.          |.:.|:.|:..    :.....||..|: :|||.:.
  Fly    71 TFDLPTEVRIAEDGTTYEVG----------DEEHSRTLIFENCTFTNFPLRLFYTLE-VSELDMR 124

  Fly    99 ACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQ-GLKELSELHLGDNNIRQLPE 162
            .|.::.:                     .|          ::|. |..:|..|.|.||:|..||.
  Fly   125 GCGIRFI---------------------YW----------ENFSIGADKLVILLLSDNHIEVLPT 158

  Fly   163 GVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPD 227
            ..:....:|:.:.|.:|:      ||   ||.|| |..|                          
  Fly   159 KTFRGAGNLEFIFLNRNK------LG---KLQAG-AFDN-------------------------- 187

  Fly   228 AWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQG 292
                  |.:||.|.|..|.:..||.:..|||.|||.:.::.|.|.::.|:.||.|.:|..:.:|.
  Fly   188 ------LLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQN 246

  Fly   293 NDLYEL------PKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSK 351
            |.|.|:      .:|..|   |:..:|||.|.               .|:||.|:.||..     
  Fly   247 NRLREVGEYAFRSRGRHH---QMQYVDLSNNP---------------ELVVLLLNINATN----- 288

  Fly   352 TFKELYFLQILDMRNNSIGHIEEGAFLPLY-NLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNN 415
                      |..||.|:..:.      || ::..::|::||:..|   .|.....|..|.|.||
  Fly   289 ----------LTARNCSLDRVN------LYGSVTNVDLSDNRVREL---YFPASEALEHLVLRNN 334

  Fly   416 LVSIVESQAFRNCSDLKELDLSSN-QLTEVP-----------------------EAVQDLSMLKT 456
              |:|:..:......|:.||::.| .|.::|                       ||:|.:..|:.
  Fly   335 --SLVQLASLSRVPRLRHLDVADNPNLGQLPDGWRTPHLEMLVLRNTGQMELPLEALQGMQNLQK 397

  Fly   457 LDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFD 521
            ||:..|.::|...:.|..|.|||...:..|                                   
  Fly   398 LDISGNNLTEIDPSAFPTLTQLTHFYIHGN----------------------------------- 427

  Fly   522 KNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGN 586
             |....::|...:.|...|||..|:.:                 :.|      |..|.|...:..
  Fly   428 -NWNCFSLRNIMDVLIRANGIAYTVDN-----------------YDP------DFPGEYFHGIAC 468

  Fly   587 YYKLQEEIRVTTLDASHNRITEIGAMSVPNS----------------------------IELLF- 622
            .|:|.|:..|.:..:|     ||.| ||.:|                            .:|:| 
  Fly   469 MYRLPEKEGVDSSSSS-----EISA-SVESSPITSSSDPSEVDKLRDELKAVVQHFDSKFDLIFS 527

  Fly   623 ----INNNIIGQIQANTFVDKTRLARVDL 647
                :|.    ||||...::||..::|.|
  Fly   528 KLAQLNE----QIQAFEVLNKTVWSQVTL 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 6/28 (21%)
leucine-rich repeat 92..115 CDD:275380 4/22 (18%)
LRR_8 115..181 CDD:290566 14/66 (21%)
leucine-rich repeat 116..146 CDD:275380 3/30 (10%)
leucine-rich repeat 147..170 CDD:275380 8/22 (36%)
leucine-rich repeat 171..201 CDD:275380 10/29 (34%)
LRR_RI 210..464 CDD:238064 69/284 (24%)
leucine-rich repeat 212..236 CDD:275380 1/23 (4%)
LRR_8 235..295 CDD:290566 22/59 (37%)
leucine-rich repeat 237..260 CDD:275380 10/22 (45%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
LRR_8 283..345 CDD:290566 17/67 (25%)
leucine-rich repeat 285..308 CDD:275380 7/28 (25%)
leucine-rich repeat 309..334 CDD:275380 4/24 (17%)
LRR_8 334..393 CDD:290566 14/59 (24%)
leucine-rich repeat 335..358 CDD:275380 6/22 (27%)
leucine-rich repeat 359..382 CDD:275380 6/23 (26%)
LRR_8 382..441 CDD:290566 16/59 (27%)
leucine-rich repeat 383..406 CDD:275380 5/22 (23%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
LRR_8 431..488 CDD:290566 20/80 (25%)
leucine-rich repeat 431..451 CDD:275380 9/43 (21%)
leucine-rich repeat 454..477 CDD:275380 7/22 (32%)
LRR_8 477..559 CDD:290566 11/81 (14%)
leucine-rich repeat 478..499 CDD:275380 3/20 (15%)
leucine-rich repeat 502..525 CDD:275380 1/22 (5%)
leucine-rich repeat 526..548 CDD:275380 6/21 (29%)
leucine-rich repeat 590..617 CDD:275380 9/26 (35%)
leucine-rich repeat 618..641 CDD:275380 8/27 (30%)
leucine-rich repeat 642..689 CDD:275380 2/6 (33%)
LRRCT 679..736 CDD:214507
leucine-rich repeat 775..796 CDD:275380
LRR_8 797..852 CDD:290566
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
LRR_8 841..900 CDD:290566
leucine-rich repeat 842..865 CDD:275380
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
cDIPNP_650951.1 leucine-rich repeat 118..142 CDD:275380 7/54 (13%)
LRR_RI 143..407 CDD:238064 88/349 (25%)
leucine-rich repeat 143..166 CDD:275380 8/22 (36%)
LRR_8 166..225 CDD:290566 26/100 (26%)
leucine-rich repeat 167..190 CDD:275380 12/64 (19%)
leucine-rich repeat 191..214 CDD:275380 10/22 (45%)
leucine-rich repeat 215..238 CDD:275380 8/22 (36%)
leucine-rich repeat 239..265 CDD:275380 7/28 (25%)
leucine-rich repeat 266..325 CDD:275380 21/97 (22%)
LRR_8 304..357 CDD:290566 15/57 (26%)
leucine-rich repeat 326..347 CDD:275380 7/22 (32%)
leucine-rich repeat 348..394 CDD:275380 9/45 (20%)
LRR_8 369..428 CDD:290566 14/94 (15%)
LRR_4 393..433 CDD:289563 12/75 (16%)
leucine-rich repeat 395..418 CDD:275380 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453795
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.940

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