DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and CD180

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_005573.2 Gene:CD180 / 4064 HGNCID:6726 Length:661 Species:Homo sapiens


Alignment Length:867 Identity:189/867 - (21%)
Similarity:313/867 - (36%) Gaps:257/867 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   179 NRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQ 243
            |:..:.|.||.||   ....|.|..         :.|:.|||.|.::.:. ..|||..|..|.|.
Human    34 NKTYNCENLGLSE---IPDTLPNTT---------EFLEFSFNFLPTIHNR-TFSRLMNLTFLDLT 85

  Fly   244 HNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQ 308
            ...|:.:..:.......|..|.::.|.|:.:...:..|.|.|:.|.|....:..|....:|.||.
Human    86 RCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETSLNGPKSLKHLFLIQTGISNLEFIPVHNLEN 150

  Fly   309 LLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKEL-YFLQI-LDMRNNSIGH 371
            |..|.|..|.::|........|.  .|.||:..|||:..|..:..:.| ..:.: |:...|::..
Human   151 LESLYLGSNHISSIKFPKDFPAR--NLKVLDFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKG 213

  Fly   372 IEEGAF--LPLYNLH---TLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDL 431
            ||.|||  ....:|:   |.||:.         |||||         .|  |..:|.......|:
Human   214 IELGAFDSTIFQSLNFGGTPNLSV---------IFNGL---------QN--STTQSLWLGTFEDI 258

  Fly   432 KELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMF 496
            .:.|:||..|..:.|     ..:::|:|.|::.|:..:.||:...||..|.|....:..:..|| 
Human   259 DDEDISSAMLKGLCE-----MSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKGLPSGM- 317

  Fly   497 QDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVW 561
                  ..|||.|..:.|:..  ||:..:|.|               |...||       .||  
Human   318 ------KGLNLLKKLVLSVNH--FDQLCQISA---------------ANFPSL-------THL-- 350

  Fly   562 FDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRI--TEIGAMSVPNSIELLFIN 624
                :|..|:|.|.:....:|.|||         :.|||.|||.|  ::..::.:.|...|..:|
Human   351 ----YIRGNVKKLHLGVGCLEKLGN---------LQTLDLSHNDIEASDCCSLQLKNLSHLQTLN 402

  Fly   625 ---NNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCS 686
               |..:| :|:..|.:..:|..:||   ..:::.:||            |:     :||:   :
Human   403 LSHNEPLG-LQSQAFKECPQLELLDL---AFTRLHINA------------PQ-----SPFQ---N 443

  Fly   687 MEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYE 751
            :.:|| :.|||                                                      
Human   444 LHFLQ-VLNLT------------------------------------------------------ 453

  Fly   752 QCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRR 816
                        .||.|.:        .:..||.||     .:..|.|.||:..:   |.:| :.
Human   454 ------------YCFLDTS--------NQHLLAGLP-----VLRHLNLKGNHFQD---GTIT-KT 489

  Fly   817 NLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISN 881
            ||                 |..:.:|.||.|.:..|.:::...|.|||.:..:.|.:|.||..|.
Human   490 NL-----------------LQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSI 537

  Fly   882 ATFEPLVSLEVLRLDNNRLS-----SLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAM 941
            .:...|..: .|.|..|.::     .||.|..:.:   :.|..|...|.|..:..|..: .:|..
Human   538 DSLSHLKGI-YLNLAANSINIISPRLLPILSQQST---INLSHNPLDCTCSNIHFLTWY-KENLH 597

  Fly   942 VVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIF 1006
            .:..:.:..|               ||.|   .|.....|::..|..:..      :....:::|
Human   598 KLEGSEETTC---------------ANPP---SLRGVKLSDVKLSCGITA------IGIFFLIVF 638

  Fly  1007 LVVVLIIVFVFRESVRMWLFAH 1028
            |:::.|::|...:.:..|.:.|
Human   639 LLLLAILLFFAVKYLLRWKYQH 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566 1/1 (100%)
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 7/21 (33%)
LRR_RI 210..464 CDD:238064 67/260 (26%)
leucine-rich repeat 212..236 CDD:275380 8/23 (35%)
LRR_8 235..295 CDD:290566 13/59 (22%)
leucine-rich repeat 237..260 CDD:275380 4/22 (18%)
leucine-rich repeat 261..284 CDD:275380 5/22 (23%)
LRR_8 283..345 CDD:290566 19/61 (31%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 6/24 (25%)
LRR_8 334..393 CDD:290566 19/65 (29%)
leucine-rich repeat 335..358 CDD:275380 8/23 (35%)
leucine-rich repeat 359..382 CDD:275380 7/25 (28%)
LRR_8 382..441 CDD:290566 16/61 (26%)
leucine-rich repeat 383..406 CDD:275380 9/25 (36%)
leucine-rich repeat 407..430 CDD:275380 3/22 (14%)
LRR_8 431..488 CDD:290566 15/56 (27%)
leucine-rich repeat 431..451 CDD:275380 5/19 (26%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..559 CDD:290566 18/81 (22%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 7/28 (25%)
leucine-rich repeat 618..641 CDD:275380 6/25 (24%)
leucine-rich repeat 642..689 CDD:275380 8/46 (17%)
LRRCT 679..736 CDD:214507 7/56 (13%)
leucine-rich repeat 775..796 CDD:275380 4/20 (20%)
LRR_8 797..852 CDD:290566 13/54 (24%)
leucine-rich repeat 797..817 CDD:275380 6/19 (32%)
leucine-rich repeat 818..841 CDD:275380 2/22 (9%)
LRR_8 841..900 CDD:290566 18/58 (31%)
leucine-rich repeat 842..865 CDD:275380 8/22 (36%)
LRR_4 866..907 CDD:289563 11/45 (24%)
leucine-rich repeat 866..889 CDD:275380 6/22 (27%)
leucine-rich repeat 890..911 CDD:275380 6/25 (24%)
TIR 1045..1183 CDD:214587
CD180NP_005573.2 leucine-rich repeat 38..57 CDD:275380 7/30 (23%)
LRR 1 54..75 5/30 (17%)
leucine-rich repeat 58..78 CDD:275380 8/20 (40%)
LRR 2 78..99 4/20 (20%)
leucine-rich repeat 79..102 CDD:275380 4/22 (18%)
LRR_8 102..161 CDD:290566 17/58 (29%)
LRR 3 102..123 4/20 (20%)
leucine-rich repeat 103..126 CDD:275380 5/22 (23%)
LRR 4 126..147 4/20 (20%)
leucine-rich repeat 127..150 CDD:275380 6/22 (27%)
LRR 5 150..171 5/20 (25%)
leucine-rich repeat 151..174 CDD:275380 6/24 (25%)
LRR 6 174..195 7/20 (35%)
leucine-rich repeat 175..195 CDD:275380 7/19 (37%)
leucine-rich repeat 196..234 CDD:275380 10/37 (27%)
LRR 7 201..221 7/19 (37%)
leucine-rich repeat 235..275 CDD:275380 15/64 (23%)
LRR 8 275..296 6/20 (30%)
leucine-rich repeat 276..299 CDD:275380 6/22 (27%)
LRR 9 299..320 6/27 (22%)
leucine-rich repeat 300..322 CDD:275380 6/28 (21%)
LRR 10 322..343 7/37 (19%)
LRR_8 323..382 CDD:290566 25/97 (26%)
leucine-rich repeat 323..371 CDD:275380 17/77 (22%)
LRR_RI 327..541 CDD:238064 75/377 (20%)
LRR 11 346..366 8/32 (25%)
LRR_8 371..432 CDD:290566 18/73 (25%)
LRR 12 371..391 8/28 (29%)
leucine-rich repeat 372..397 CDD:275380 8/24 (33%)
LRR 13 397..418 6/21 (29%)
leucine-rich repeat 398..421 CDD:275380 6/23 (26%)
LRR_8 420..481 CDD:290566 24/163 (15%)
LRR 14 421..442 7/40 (18%)
leucine-rich repeat 422..446 CDD:275380 8/46 (17%)
LRR 15 446..466 8/94 (9%)
leucine-rich repeat 447..470 CDD:275380 12/102 (12%)
LRR 16 470..493 8/43 (19%)
leucine-rich repeat 471..497 CDD:275380 9/46 (20%)
LRR_8 497..555 CDD:290566 18/58 (31%)
LRR 17 497..518 6/20 (30%)
leucine-rich repeat 498..521 CDD:275380 8/22 (36%)
LRR 18 521..544 5/22 (23%)
leucine-rich repeat 522..543 CDD:275380 5/20 (25%)
LRR 19 546..564 3/18 (17%)
TPKR_C2 577..626 CDD:301599 12/67 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.