DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and tlr20.2

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001170914.2	Gene:	tlr20.2 / 403140	ZFINID:	ZDB-GENE-040220-6	Length:	950	Species:	Danio rerio

Alignment Length:	1281	Identity:	264/1281 - (20%)
Similarity:	416/1281 - (32%)	Gaps:	500/1281 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 CNW------------QYGLTTMDIR------C-SVRAL-ESGTGTPLDLQVAEAAGRLDLQCSQE 74
            |:|            ::..:|...|      | ||..: |...|.|.:||        :|....:
Zfish    26 CSWLAGKCHIESDGEEFSFSTSSPRKRNTTVCRSVTDMKEDLRGLPANLQ--------NLIVQTD 82

  Fly    75 LLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQ 139
            |.:...|||..|.:...|..|.|..| |..|||.||.||.::..|||....      :..|: ..
Zfish    83 LGYHGVLAPNSFLRFGSLENLEIVGC-LSEVPPEAFNGLTNVTTLTLSCSQ------QCTEV-AF 139

  Fly   140 SFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQ-------------NRIRSAEFLGFSE 191
            .|..|..|:.|.|.|.::..||..|:..:|.|:.|:|..             ..::|.::||...
Zfish   140 DFSRLTSLTSLSLSDYSLSLLPSNVFEKIPQLRWLHLCSECLKDLSEVLCRLKNVKSLKYLGLGN 204

  Fly   192 KLCAGSALSNANGAVSGGSELQT------LDVSFNELRSLPDAWGASR----------------- 233
            .:.  :.|...|.:|...||:.|      .|:...:|..:.:  ||.:
Zfish   205 TML--TRLQYPNCSVFNVSEISTKFNIERADLLLGKLEHVDE--GALKVFGKLSRLYFTVSSKNF 265

  Fly   234 LRRLQTLSLQHNNISTLAPNAL--------AGLSSLRVLNISYNHL-VSLPSEAFAGNKELRELH 289
            ||.|..:.:...::.....:.|        |.|.|::.:::.|:.: :||.|:...|.|::..:.
Zfish   266 LRDLSLIGVHQISVIIATVDVLNVDDLCVAAKLYSVKSVDVDYDTINLSLTSKISDGCKQIGYIM 330

  Fly   290 LQGNDLYELPKGLL--HRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGS-- 350
            |: |:::.....||  :.|.|:.      :.|||..:|.....          ||:..:...|
Zfish   331 LE-NNIFGKTVNLLDVNSLFQIF------SNLTSVTIDKHVLR----------SNDFQSLCASFP 378

  Fly   351 KTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNN 415
            :|.|::..:.:..:|   |..|....|:...||.||.||.::...:::..|.||..|.:|.|::|
Zfish   379 QTVKKISDMVLRIIR---IDKIVSHQFMCFVNLKTLKLAMSKFSVIEDFAFIGLNKLKELNLHSN 440

  Fly   416 LVSIVESQAFRNCSDLKELDLSSNQLTEV-PEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLT 479
            .:|.:....|....:|:.|||:.|.|..: ||:.:.|..|:||.||:             ||...
Zfish   441 KISSIHQHTFSGLHELRVLDLNENPLFHIEPESFRHLINLRTLLLGD-------------LNFPP 492

  Fly   480 GLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFA 544
            .:.||...:.:|    |:::||    ||:...|.|
Zfish   493 NMSLIKLHLSDI----FREIPR----NLSNVFISS------------------------------ 519

  Fly   545 TLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEI 609
                    .|...|||......:.:.|. |.|.|.|               |...|.:...:|.:
Zfish   520 --------GLRPMHLVIGSNTTLNNGLN-LHIKGQY---------------VIVEDCNSLLLTSV 560

  Fly   610 GAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEF 674
            ..:.:           |....|..|.|:.|
Zfish   561 VTLQI-----------NAAYMICENEFIGK----------------------------------- 579

  Fly   675 YLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYES 739
            |:                         |.||.|                            |:|
Zfish   580 YV-------------------------PSVVSL----------------------------KFE- 590

  Fly   740 HCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNM 804
                                    |.|.|                                  |:
Zfish   591 ------------------------SMFSD----------------------------------NI 597

  Fly   805 PELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLT--ALEGTEFRSLGLLR 867
            .:|.|                          :.|||:|:.|.|||..||  ...|..|.:|..|.
Zfish   598 GDLSV--------------------------INQLVHLKTLKLENIDLTNQPNTGIMFHNLTKLE 636

  Fly   868 ELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLP------------HLQYRHSLQGLTLG-- 918
            .|.|.|..|..:..:..:.|.:|..|.|       ||            ||.....:....||
Zfish   637 TLILANCRLLFLDGSLTKDLKALTTLVL-------LPKDTVNILQTFAVHLIQLEFVCFYRLGLY 694

  Fly   919 ---RNAWSCRCQQLRELAQFVSDNAMVVRD-----AHDIYCLDAGIKRELELIGNLANGPDCSDL 975
               .|||         |..::.||..|..|     .||:.|.             ..|..|..:.
Zfish   695 CSCDNAW---------LVSWIRDNRKVEVDMSNPSMHDLQCF-------------FGNEFDQLNF 737

  Fly   976 LDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFV--------------FRESVRMWLF 1026
            :..:..|.|...|    :.....::|.:.||:||||:..||              |||::||...
Zfish   738 VSYAKENCSFDLD----FVFFACSSVFLCIFIVVVLMYKFVGQYFKPFYHIANGWFREALRMKEK 798

  Fly  1027 AHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPF-RLCIQQRDLPPQASHL 1090
            ..|              .|||.:.:|.||..:|...:...||...||| |||:..||.  |..|
Zfish   799 QQY--------------RYDAFVSYSGKDEHWVIEELLPNLEQRGPPFLRLCLHSRDF--QLGH- 846

  Fly  1091 QLVEGAR----ASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVA 1151
            .:||...    |||:.:.:::||.|.:.|..:|.:.|.:.                :..|..|:.
Zfish   847 DIVENITDSIYASRRTLCLVSRNYLNSNWCSLEMQLATYR----------------LQVEHRDIL 895

  Fly  1152 ELSPYLKSVPSN---------RLLTCDRY------------FWEKL 1176
            .| .:|:::||.         ||:....|            ||::|
Zfish   896 IL-VFLENIPSRLLSSHHRLARLVKTRTYLDWPQEPEMHDAFWDRL 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	6/24 (25%)
		leucine-rich repeat	92..115	CDD:275380	12/22 (55%)
		LRR_8	115..181	CDD:290566	17/78 (22%)
		leucine-rich repeat	116..146	CDD:275380	6/29 (21%)
		leucine-rich repeat	147..170	CDD:275380	7/22 (32%)
		leucine-rich repeat	171..201	CDD:275380	7/42 (17%)
		LRR_RI	210..464	CDD:238064	68/290 (23%)
		leucine-rich repeat	212..236	CDD:275380	6/46 (13%)
		LRR_8	235..295	CDD:290566	14/68 (21%)
		leucine-rich repeat	237..260	CDD:275380	4/30 (13%)
		leucine-rich repeat	261..284	CDD:275380	5/23 (22%)
		LRR_8	283..345	CDD:290566	13/63 (21%)
		leucine-rich repeat	285..308	CDD:275380	5/24 (21%)
		leucine-rich repeat	309..334	CDD:275380	4/24 (17%)
		LRR_8	334..393	CDD:290566	15/60 (25%)
		leucine-rich repeat	335..358	CDD:275380	5/24 (21%)
		leucine-rich repeat	359..382	CDD:275380	4/22 (18%)
		LRR_8	382..441	CDD:290566	20/58 (34%)
		leucine-rich repeat	383..406	CDD:275380	8/22 (36%)
		leucine-rich repeat	407..430	CDD:275380	6/22 (27%)
		LRR_8	431..488	CDD:290566	18/57 (32%)
		leucine-rich repeat	431..451	CDD:275380	8/20 (40%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..559	CDD:290566	11/81 (14%)
		leucine-rich repeat	478..499	CDD:275380	4/20 (20%)
		leucine-rich repeat	502..525	CDD:275380	4/22 (18%)
		leucine-rich repeat	526..548	CDD:275380	0/21 (0%)
		leucine-rich repeat	590..617	CDD:275380	3/26 (12%)
		leucine-rich repeat	618..641	CDD:275380	5/22 (23%)
		leucine-rich repeat	642..689	CDD:275380	1/46 (2%)
		LRRCT	679..736	CDD:214507	4/56 (7%)
		leucine-rich repeat	775..796	CDD:275380	0/20 (0%)
		LRR_8	797..852	CDD:290566	11/54 (20%)
		leucine-rich repeat	797..817	CDD:275380	3/19 (16%)
		leucine-rich repeat	818..841	CDD:275380	2/22 (9%)
		LRR_8	841..900	CDD:290566	19/60 (32%)
		leucine-rich repeat	842..865	CDD:275380	10/24 (42%)
		LRR_4	866..907	CDD:289563	12/52 (23%)
		leucine-rich repeat	866..889	CDD:275380	6/22 (27%)
		leucine-rich repeat	890..911	CDD:275380	7/32 (22%)
		TIR	1045..1183	CDD:214587	42/158 (27%)
tlr20.2	NP_001170914.2	leucine-rich repeat	358..383	CDD:275380	5/34 (15%)
		LRR_8	407..466	CDD:290566	20/58 (34%)
		leucine-rich repeat	408..431	CDD:275380	8/22 (36%)
		LRR_4	431..471	CDD:289563	12/39 (31%)
		leucine-rich repeat	432..455	CDD:275380	6/22 (27%)
		leucine-rich repeat	456..479	CDD:275380	9/22 (41%)
		leucine-rich repeat	496..539	CDD:275380	14/88 (16%)
		leucine-rich repeat	540..583	CDD:275380	13/128 (10%)
		leucine-rich repeat	584..608	CDD:275380	13/136 (10%)
		leucine-rich repeat	609..634	CDD:275380	10/24 (42%)
		leucine-rich repeat	635..658	CDD:275380	6/22 (27%)
		TIR	802..940	CDD:214587	41/157 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3549
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.870