DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and tlr8a

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	XP_001920594.5	Gene:	tlr8a / 403137	ZFINID:	ZDB-GENE-040219-13	Length:	1019	Species:	Danio rerio

Alignment Length:	1224	Identity:	263/1224 - (21%)
Similarity:	436/1224 - (35%)	Gaps:	380/1224 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 GLMSLKRLTL---------------ESHNAVWGPGKTLELHGQSF----QGLKELSELHLGDNNI 157
            ||:.:.:|||               :.|..:......:...|:..    |.|...:.:.|.:|.|
Zfish     8 GLILILKLTLALSELNVRILKTQPCDIHENITAETVVVNCRGRKLKVLPQFLANTTYIDLSENYI 72

  Fly   158 RQLPEGVWCSMPSLQLLN---LTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSF 219
            :.|....:..:.:|.|||   |.|||          |.:.|....||.       ::|:.||::.
Zfish    73 KNLTVQSFHGLENLTLLNLNWLNQNR----------EVVIAKGVFSNL-------TKLRVLDLNG 120

  Fly   220 NELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYN----------HLVSL 274
            .:|:.:|    ....:.|:.|||..|.|:.:.......:.:|.||.:|.|          :.:..
Zfish   121 IKLKYIP----KDIPKNLEKLSLVENKITWINLTTFEHVKNLSVLYLSNNCYYWNPCSRRYRIEK 181

  Fly   275 PSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLN 339
            .|.::..|  |:.|.|..|:|.::|.||...||:   |:|..|.||  ::....|.||..|.||.
Zfish   182 GSLSYLVN--LKRLTLSFNNLTQVPIGLPVSLER---LELGSNSLT--YIGEHDFRGLFNLTVLK 239

  Fly   340 LS----------------NNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNL 388
            :.                .|....|..:.|.:|..|.||.:..|||..|....|..|.||..|.|
Zfish   240 IQGNCPRCHTAPYPCIPCKNTSIEIHPQAFSDLRNLHILHLAGNSIKSINPAWFANLSNLQQLFL 304

  Fly   389 AENRLHT-----LDNRIFNGLYVLTKLTLNNNL------VSIVESQAFRNCSDLKELDLSSNQLT 442
            :.|.|.:     .|......|.:||||.|:.|.      :::|.|..|.|.:.|:.|.|......
Zfish   305 SFNLLFSAITDPADTVFLGNLPLLTKLDLSYNFAFKTYPLTVVLSPGFANLTSLRSLHLRGLVFR 369

  Fly   443 EVP----EAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVG--------- 494
            ::.    :::.||..|..||:|.|.|....:..|:::..   |.|.:||:..:||.
Zfish   370 KIQKDTFKSLFDLQHLNVLDVGVNFIVFATSYIFQHVRL---LYLAENRLYPVTVNGELSKATFV 431

  Fly   495 ----------MFQDLPRLS---------------VLNLAKNRIQSIERGAFDKNTEIEAIRLDKN 534
                      |.:.|....               ||:|::|.:..|....||....|..:.|.:|
Zfish   432 GSNHRSIMPLMAEPLDTFDAPKNLVKSECYNAGRVLDLSRNNLFLISPEQFDTYGNISCLNLSRN 496

  Fly   535 -FLTDINGI-FATLASLLWLNLSENHL-VWFDYAFIP-SNLKWLDIHGNYIEALGNYYKLQEEIR 595
             |.|..||. |.:|.:|.:|:||.|.: :.:|.||.. .:|:.|||..|     .:|:
Zfish   497 GFSTAPNGSEFTSLPNLKYLDLSFNKVDLAYDNAFRELQSLEVLDISYN-----SHYF------- 549

  Fly   596 VTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNAL 660
             |....:||.:    .:....|:::|.::.|.|     ||...||              :|..:|
Zfish   550 -TVAGVTHNMM----FLQYLPSLKVLNMSFNSI-----NTLTTKT--------------MSSKSL 590

  Fly   661 RVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPL 725
            |           |....||..    ...|..:.|.       :|:...|.
Zfish   591 R-----------ELQFRGNKL----GRMWRDKDNT-------YVMIFKNF--------------- 618

  Fly   726 ASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIV--DCGRQDLAALP- 787
                                                           ||::  |.....:..:|
Zfish   619 -----------------------------------------------TNLIHLDISNNSIGKIPY 636

  Fly   788 ---NRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLEN 849
               .::|..:..|.:..|.:..:....|...:|||.|.|:.:|::.:.:.....:.:|.:|:|::
Zfish   637 TVYTQLPITIQRLQMSHNQLANINWTMLRRFQNLRELILHDNNIIEIASNLSVDVPSLELLNLQH 701

  Fly   850 NKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQG 914
            |:::.|.....:.:..|:||.|..|.|..::.:||.....|::|.|..
Zfish   702 NRISKLAIGFLQGVVNLKELDLSYNYLITVNQSTFPTESDLKMLWLHG----------------- 749

  Fly   915 LTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCS------ 973
                 |.:.|.|    .|.:||            ::.||..:|     |..|..|..|:
Zfish   750 -----NPFHCTC----NLLEFV------------LWILDTNVK-----IPRLVTGVTCTMPEERK 788

  Fly   974 -------DLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLF---AH 1028
                   |:.:.....::                 .|..|:....||...| .::.|.||   ..
Zfish   789 GLAVIKFDIQECIDDQLA-----------------FVAYFISAACIICTTF-AAITMHLFYWDVS 835

  Fly  1029 YGVRVCEPRFEDAGKL------YDAIILHSEKD---YEFVCRNIAAELEHGRPPF-RLCIQQRDL 1083
            |.....:.||....:|      |||.|.:..||   .::|..::..:||.....| .:|:::||.
Zfish   836 YLYYYLKARFTGYQQLSSESCIYDAFITYDTKDPQVSDWVLNHLRVQLEERSELFLPICLEERDW 900

  Fly  1084 PPQASHL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEA 1147
            .|.:..| .|.:..:.|||.:.|||...:    |...|:.|            |.:....:..|.
Zfish   901 IPGSPVLDSLTQSIQNSRKTVFVLTEGYV----NSGSFKLA------------VFLAHQRLLEEN 949

  Fly  1148 EDVAE---LSPYLKSVPSNRL---------------LTCDRYFWEKLRYAIPIE 1183
            |||..   |.|.|:.....||               .:.:.:||:.||.||.::
Zfish   950 EDVIVLLLLEPVLQHSHFVRLRRRLCARSILEWPHSSSAEAWFWQSLRNAIRVD 1003

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380	2/2 (100%)
		LRR_8	115..181	CDD:290566	18/87 (21%)
		leucine-rich repeat	116..146	CDD:275380	7/48 (15%)
		leucine-rich repeat	147..170	CDD:275380	4/22 (18%)
		leucine-rich repeat	171..201	CDD:275380	10/32 (31%)
		LRR_RI	210..464	CDD:238064	80/294 (27%)
		leucine-rich repeat	212..236	CDD:275380	5/23 (22%)
		LRR_8	235..295	CDD:290566	17/69 (25%)
		leucine-rich repeat	237..260	CDD:275380	6/22 (27%)
		leucine-rich repeat	261..284	CDD:275380	7/32 (22%)
		LRR_8	283..345	CDD:290566	22/77 (29%)
		leucine-rich repeat	285..308	CDD:275380	9/22 (41%)
		leucine-rich repeat	309..334	CDD:275380	8/24 (33%)
		LRR_8	334..393	CDD:290566	21/74 (28%)
		leucine-rich repeat	335..358	CDD:275380	7/38 (18%)
		leucine-rich repeat	359..382	CDD:275380	9/22 (41%)
		LRR_8	382..441	CDD:290566	21/69 (30%)
		leucine-rich repeat	383..406	CDD:275380	7/27 (26%)
		leucine-rich repeat	407..430	CDD:275380	10/28 (36%)
		LRR_8	431..488	CDD:290566	15/60 (25%)
		leucine-rich repeat	431..451	CDD:275380	3/23 (13%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	29/117 (25%)
		leucine-rich repeat	478..499	CDD:275380	7/39 (18%)
		leucine-rich repeat	502..525	CDD:275380	7/37 (19%)
		leucine-rich repeat	526..548	CDD:275380	9/23 (39%)
		leucine-rich repeat	590..617	CDD:275380	3/26 (12%)
		leucine-rich repeat	618..641	CDD:275380	6/22 (27%)
		leucine-rich repeat	642..689	CDD:275380	6/46 (13%)
		LRRCT	679..736	CDD:214507	5/56 (9%)
		leucine-rich repeat	775..796	CDD:275380	3/26 (12%)
		LRR_8	797..852	CDD:290566	13/54 (24%)
		leucine-rich repeat	797..817	CDD:275380	3/19 (16%)
		leucine-rich repeat	818..841	CDD:275380	5/22 (23%)
		LRR_8	841..900	CDD:290566	16/58 (28%)
		leucine-rich repeat	842..865	CDD:275380	5/22 (23%)
		LRR_4	866..907	CDD:289563	11/40 (28%)
		leucine-rich repeat	866..889	CDD:275380	8/22 (36%)
		leucine-rich repeat	890..911	CDD:275380	3/20 (15%)
		TIR	1045..1183	CDD:214587	41/160 (26%)
tlr8a	XP_001920594.5	NEL	<15..>226	CDD:330839	56/238 (24%)
		leucine-rich repeat	62..112	CDD:275380	16/66 (24%)
		leucine-rich repeat	113..133	CDD:275380	5/23 (22%)
		LRR_8	133..200	CDD:316378	17/68 (25%)
		leucine-rich repeat	134..157	CDD:275380	6/22 (27%)
		leucine-rich repeat	158..189	CDD:275380	6/30 (20%)
		PLN00113	189..>702	CDD:331614	141/642 (22%)
		leucine-rich repeat	190..234	CDD:275380	18/48 (38%)
		leucine-rich repeat	235..274	CDD:275380	7/38 (18%)
		leucine-rich repeat	275..298	CDD:275380	9/22 (41%)
		leucine-rich repeat	299..327	CDD:275380	7/27 (26%)
		leucine-rich repeat	328..357	CDD:275380	10/28 (36%)
		leucine-rich repeat	358..381	CDD:275380	3/22 (14%)
		leucine-rich repeat	465..487	CDD:275380	7/21 (33%)
		leucine-rich repeat	488..512	CDD:275380	9/23 (39%)
		leucine-rich repeat	513..536	CDD:275380	8/22 (36%)
		leucine-rich repeat	537..566	CDD:275380	9/45 (20%)
		leucine-rich repeat	567..620	CDD:275380	17/155 (11%)
		leucine-rich repeat	621..645	CDD:275380	3/23 (13%)
		leucine-rich repeat	646..669	CDD:275380	3/22 (14%)
		leucine-rich repeat	670..693	CDD:275380	5/22 (23%)
		LRR_8	692..752	CDD:316378	17/81 (21%)
		leucine-rich repeat	694..717	CDD:275380	5/22 (23%)
		leucine-rich repeat	718..736	CDD:275380	6/17 (35%)
		TPKR_C2	750..>789	CDD:326558	13/59 (22%)
		TIR	858..1000	CDD:214587	39/157 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820