DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr8b

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001373638.1 Gene:tlr8b / 403136 ZFINID:ZDB-GENE-040219-12 Length:1015 Species:Danio rerio


Alignment Length:1277 Identity:276/1277 - (21%)
Similarity:467/1277 - (36%) Gaps:396/1277 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LVADAHAQQQCNWQYGLTTMDIRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELLHASELAPG 84
            |:...|:.:..||.:           |.|      |.|:.::..:..||  ||:           
Zfish     7 LLCTVHSSEGYNWAW-----------RKL------PCDVNLSNTSVTLD--CSE----------- 41

  Fly    85 LFRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSE 149
              |.|:|:.:                              |.:|                 ..:.
Zfish    42 --RYLKKIPK------------------------------NLIW-----------------NTTN 57

  Fly   150 LHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQT 214
            |:|.:|.|..:.:..:.::.::..::|.:|:|....     ||         .||..|..:.|:|
Zfish    58 LNLANNKIHNISKDAFWNLNNVTWIDLRRNQIEKCH-----EK---------DNGVFSRLTNLKT 108

  Fly   215 LDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYN--HLVS---- 273
            |.:..|::..||....|.    ||.|||..|:|.::..:...|::.|.||.::.|  |.:|    
Zfish   109 LLLDNNKISVLPKNLPAG----LQWLSLNSNHIKSIEQSDFKGMTKLTVLKLNKNCYHNISAELT 169

  Fly   274 LPSEAFAGNKELRELHLQGNDLYELPKGL---LHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRL 335
            :.:|.|. :.:|.||.|..|.|:.:|..|   ||.|..||      |::  .||..|....|.||
Zfish   170 IQNETFQ-HLQLTELQLSKNGLHNVPFALPRTLHNLSLLL------NRI--DHVHESDLNHLTRL 225

  Fly   336 IVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRI 400
            .||:||.|.     ...|...:........||:: .|...||..|..|..|.|:.|.|.::::..
Zfish   226 KVLDLSGNC-----PICFTTPFPCTSCQTNNNAL-QIHPNAFSKLSQLQDLRLSGNSLQSINSMW 284

  Fly   401 FNGLYVLTKLTLN-NNLVSIVES-QAFRNCSDLKELDLSSNQLTE-------VPEAVQDLSMLKT 456
            |..|..|..|.|: |:|:|..|| |.|.....::.:|:|.|..:|       :.|....|..|:|
Zfish   285 FQNLTNLKYLYLSFNSLISEFESGQFFSVLPQVEVVDISYNNPSERIYPRLKLSEGFSRLESLQT 349

  Fly   457 LDLGE---NQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRI------ 512
            |.|..   :::||.......:|..|:.|.|..|.:..:.:.:|::...||:::|..||:      
Zfish   350 LHLEGYIFHKLSEDDLRPLFSLRNLSVLNLAVNFLQQVNLSVFRNFHNLSLISLIDNRLTFSSPI 414

  Fly   513 -----QSIERGAFDKN----------------------TEIEAIR------LDKNFLTDIN-GIF 543
                 || :.|..|.|                      |:.|.:.      |.:|.:..:| .:|
Zfish   415 RRWEGQS-KSGFKDDNQGDHREGPYIHTNEEFRHYPPFTKAECLATGPVLDLSRNNIYHVNPPLF 478

  Fly   544 ATLASLLWLNLSENHLVWF----DYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHN 604
            ....::..||||.|.:|.:    ::|..| .||:||:                         |||
Zfish   479 TGAENITCLNLSSNFIVSYFNGTEFAHFP-KLKYLDL-------------------------SHN 517

  Fly   605 RI--TEIGAMSVPNSIELLFINNN-----IIGQIQANTFVDKTRLARV-DLYANVLSKISLNALR 661
            ||  ....|:|...::|:|.:::|     :.|.....||::..:..:| :|..|.::.::...|:
Zfish   518 RIYMHSDSALSELKALEVLDLSHNQHYFEVAGVRNCLTFLENLQFLKVLNLSWNEINMLTNKTLQ 582

  Fly   662 VAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLA 726
                  ...:.|....||            |::.:..:|..:               .:..:.|:
Zfish   583 ------SDSLNELQFQGN------------RLDIMWKKQRGY---------------QSLFKSLS 614

  Fly   727 SLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIP 791
            :|:..|.               .|.:.                                  :.||
Zfish   615 NLTYLDI---------------SYNKL----------------------------------SEIP 630

  Fly   792 QDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALE 856
            .|:.|.:                .:.||.:.::.:.|.......|..|..|..|.|..|||..:.
Zfish   631 DDIFDYF----------------PKTLRYISMSRNTLTDFAWEQLQSLPQLETLDLSKNKLRVVP 679

  Fly   857 GTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQY----RHSLQGLTL 917
            ....:....|:.|.|.:|.::.:..:..|.:.||::|...||:|..|....:    .|.||.|.|
Zfish   680 RKLSKHTRSLKVLDLSHNQISKLRYSFLENVKSLQILNFANNKLKHLGASSFTTGSNHQLQILDL 744

  Fly   918 GRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASN 982
            .||...|.|..|..:......:.::.|.|.|:.|.....||...::.           ||...:.
Zfish   745 QRNPIHCTCNLLDFILWLEKSDTILPRLATDVLCDLPESKRGHPMVS-----------LDFKNAC 798

  Fly   983 ISSSQDLAGGYRLPLLAAVL-VLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFE------- 1039
            |::|           :|.:| :|...|:.|::.......|..|..: |....|..||:       
Zfish   799 INNS-----------IAEILYILTSSVITLVMCTTIGIHVFYWDIS-YAYNFCMARFKSYYLKTN 851

  Fly  1040 DAGKLYDAIILHSEKD---YEFVCRNIAAELE----HGRPPFRLCIQQRDLPPQ---ASHLQLVE 1094
            |.  :|||.:::..||   .|:|..::..|||    |.||   ||:::||..|.   ..:|.|  
Zfish   852 DC--IYDAFVMYDTKDPMVAEWVLNHLRLELEDRGRHVRP---LCLEERDWTPGIPIMDNLNL-- 909

  Fly  1095 GARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKS 1159
            ....|||.|.|||...:         .:...:....|||:.::.|...|..    :..|.|.|: 
Zfish   910 SVHRSRKTIFVLTEGFV---------HSGIFKMAAFLAQQRLLEEGVDVMV----LVLLEPVLR- 960

  Fly  1160 VPSNRLLTCDR------------------YFWEKLRYAIPIE 1183
              .:|:|...|                  :||:.||.|:..|
Zfish   961 --QSRILNLRRCLCGHSVLEWPRNPAAEGWFWQSLRNAVRFE 1000

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 6/24 (25%)
leucine-rich repeat 92..115 CDD:275380 0/22 (0%)
LRR_8 115..181 CDD:290566 8/65 (12%)
leucine-rich repeat 116..146 CDD:275380 2/29 (7%)
leucine-rich repeat 147..170 CDD:275380 4/22 (18%)
leucine-rich repeat 171..201 CDD:275380 5/29 (17%)
LRR_RI 210..464 CDD:238064 82/274 (30%)
leucine-rich repeat 212..236 CDD:275380 7/23 (30%)
LRR_8 235..295 CDD:290566 21/65 (32%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 8/28 (29%)
LRR_8 283..345 CDD:290566 25/64 (39%)
leucine-rich repeat 285..308 CDD:275380 11/25 (44%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
LRR_8 334..393 CDD:290566 18/58 (31%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
LRR_8 382..441 CDD:290566 20/60 (33%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 10/24 (42%)
LRR_8 431..488 CDD:290566 17/66 (26%)
leucine-rich repeat 431..451 CDD:275380 5/26 (19%)
leucine-rich repeat 454..477 CDD:275380 7/25 (28%)
LRR_8 477..559 CDD:290566 26/121 (21%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 10/55 (18%)
leucine-rich repeat 526..548 CDD:275380 5/28 (18%)
leucine-rich repeat 590..617 CDD:275380 7/28 (25%)
leucine-rich repeat 618..641 CDD:275380 6/27 (22%)
leucine-rich repeat 642..689 CDD:275380 7/47 (15%)
LRRCT 679..736 CDD:214507 6/56 (11%)
leucine-rich repeat 775..796 CDD:275380 3/20 (15%)
LRR_8 797..852 CDD:290566 9/54 (17%)
leucine-rich repeat 797..817 CDD:275380 0/19 (0%)
leucine-rich repeat 818..841 CDD:275380 5/22 (23%)
LRR_8 841..900 CDD:290566 16/58 (28%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
LRR_4 866..907 CDD:289563 12/40 (30%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 6/24 (25%)
TIR 1045..1183 CDD:214587 43/165 (26%)
tlr8bNP_001373638.1 leucine-rich repeat 36..57 CDD:275380 9/82 (11%)
leucine-rich repeat 58..78 CDD:275380 4/19 (21%)
LRR_8 64..116 CDD:404697 13/65 (20%)
leucine-rich repeat 79..105 CDD:275380 8/39 (21%)
leucine-rich repeat 106..121 CDD:275380 5/14 (36%)
LRR_8 126..190 CDD:404697 21/68 (31%)
leucine-rich repeat 127..150 CDD:275380 8/22 (36%)
leucine-rich repeat 151..179 CDD:275380 8/28 (29%)
PLN00113 180..>735 CDD:215061 148/693 (21%)
leucine-rich repeat 180..224 CDD:275380 18/51 (35%)
leucine-rich repeat 225..266 CDD:275380 13/46 (28%)
leucine-rich repeat 267..290 CDD:275380 7/22 (32%)
leucine-rich repeat 347..373 CDD:275380 7/25 (28%)
leucine-rich repeat 374..397 CDD:275380 5/22 (23%)
leucine-rich repeat 462..483 CDD:275380 4/20 (20%)
leucine-rich repeat 484..508 CDD:275380 8/24 (33%)
leucine-rich repeat 509..532 CDD:275380 11/47 (23%)
leucine-rich repeat 563..615 CDD:275380 10/84 (12%)
leucine-rich repeat 586..607 CDD:275380 5/47 (11%)
leucine-rich repeat 616..640 CDD:275380 7/88 (8%)
leucine-rich repeat 641..664 CDD:275380 5/22 (23%)
leucine-rich repeat 665..688 CDD:275380 6/22 (27%)
leucine-rich repeat 689..712 CDD:275380 5/22 (23%)
leucine-rich repeat 713..732 CDD:275380 6/18 (33%)
LRRCT 747..795 CDD:214507 12/58 (21%)
TIR 855..997 CDD:214587 42/162 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.920

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