DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and tlr22

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001122147.2 Gene:tlr22 / 403135 ZFINID:ZDB-GENE-040220-5 Length:955 Species:Danio rerio


Alignment Length:1168 Identity:254/1168 - (21%)
Similarity:406/1168 - (34%) Gaps:349/1168 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   102 LQRVPPNAF---EGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSELHLGDNNIRQLPEG 163
            :.|||.|.:   ....|..::.:|..|.                 |..|..|::.:|.|.::.:|
Zfish    61 IPRVPNNTWILDISFNSFAQIQIEDLNI-----------------LLNLQYLNVSNNKISKIQDG 108

  Fly   164 VWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDA 228
            .:.|:.:|..|||..||:.:.                 :||.:.|                    
Zfish   109 AFGSLFNLTDLNLASNRLNAV-----------------SNGMLRG-------------------- 136

  Fly   229 WGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPS-EAFAGNKELRELHLQG 292
                 |..|..|.|..|.||.:..:|.:.|.||:|||:|.|||..:.. :....:..|.||::..
Zfish   137 -----LTNLLVLRLDRNYISVIKESAFSTLHSLQVLNLSKNHLRHIDDVKPVLASLYLEELYIGS 196

  Fly   293 N--------DLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALT--R 347
            |        :|...|..|..       ||||.|:..:..:.|:.|..|..|.:....:|...  .
Zfish   197 NYFNVFNSSELSTKPLSLKR-------LDLSNNRFAAFQLTNNIFPTLNHLDLSYCGHNGTMAWN 254

  Fly   348 IGSKTF----KELYFL----------QILDMRNNSIGHIEEGAFLPLYN-----------LHTLN 387
            :..|::    |.|||:          .:|...||::..|.....:.|..           |..|.
Zfish   255 VTEKSYLASVKTLYFMDVNMSIQTADNVLQSFNNTLNKIRLNGNVRLNKTSLLLSVCSPMLRVLR 319

  Fly   388 LAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLS 452
            |...::..|.|.:|:....|::|.|..|.:|.:....||....||:|.|..|:||.|..:.|.|:
Zfish   320 LIATKIKHLTNHMFDPCSELSELDLGGNEISNLSQSMFRGFKQLKKLQLQINKLTRVTNSFQILT 384

  Fly   453 MLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIER 517
            .|:.:||..|.|.:...|.|.||.|:..|.|..|:|.:|...:|:||..|.||.|..|.:..|:.
Zfish   385 SLEFIDLSRNHIHKLSCNDFANLTQVKTLYLYSNKISSIRSCLFKDLKSLEVLRLGTNNLLKIDD 449

  Fly   518 GAFDKNTEIEAIRLDKNFLTDING-IFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYI 581
            ...:....::.::|..|.|:.|.. .|..|..|..|:|.:|.:              .:|.|...
Zfish   450 VFSNGPYFLKELQLSYNKLSLIKSHTFGNLPQLNNLSLEDNQI--------------SEIEGYAF 500

  Fly   582 EALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVD 646
            ..|.|         :|:|..|.|:||.....:.|                  |.|.....|..:|
Zfish   501 GGLEN---------LTSLFLSSNKITGKTLTTHP------------------NVFSGMPNLQNLD 538

  Fly   647 LYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIE 711
            |:||.:|                           |..|             ..::|...||.|:.
Zfish   539 LFANSIS---------------------------FAYD-------------KLKYPLFKDLKNLR 563

  Fly   712 CLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIV 776
            .|..:|:                                                          
Zfish   564 ELSLYSQ---------------------------------------------------------- 570

  Fly   777 DCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVN 841
               |:.:..||:.:                     |.|..:|:..|:..:||..|..........
Zfish   571 ---RRGIGQLPSNL---------------------LEGLSSLQMFYIGNTNLNQLNPNLFNFTPQ 611

  Fly   842 LRVLHLENNKL---TALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNR---- 899
            |..|.|..|.|   .|:....|..:..|.:|.:....|..::......|..|..||...|.    
Zfish   612 LWFLDLSKNALREDDAIPPELFHPIPNLTKLIISRTQLRSLNFLLGANLNKLSTLRASGNEIDSV 676

  Fly   900 ----LSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKREL 960
                :.|||.|..      |.|..|.::|.|           :||         :.:|...|.|.
Zfish   677 NETLIKSLPRLAV------LDLQNNTFTCDC-----------NNA---------FFIDWAKKNES 715

  Fly   961 ELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWL 1025
            ..:..|:. ..||.......::::.....:..:....:..|...|.:::.|::.|:       |.
Zfish   716 TQVYYLSR-YTCSYPRTLRGTSLAEFNTDSCTFNWDYICFVCSSILVILTLLLSFI-------WN 772

  Fly  1026 FAHYGV---------RVCEPRFEDAGKL--YDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQ 1079
            |..|.|         .:.:.|...:|:.  |||.|.::..|..:|...:..:|| |...:|||:.
Zfish   773 FLRYQVVYTYYLFLAFLYDSRRNQSGQTFQYDAFISYNTLDEAWVMEELIPKLE-GEQGWRLCLH 836

  Fly  1080 QRDLPPQASHL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNA----FHESLRGLAQKLVIIE 1139
            .||..|....: .:|:|..:|||.|.::|||.|.:.|...|.:.|    |.|      ||.|:| 
Zfish   837 HRDFEPGRPIIDNIVDGIYSSRKTICLITRNYLKSNWCSSEVQVASFRLFDE------QKDVLI- 894

  Fly  1140 ETSVSAEAEDVAELSPY--LKSVPSNRLL-------TCDRYFWEKLRYAIPIELSPRGNNYTL 1193
              .|..|.....:||||  |:.:...|..       ..::.||:||:.|:..:.|.:..|..|
Zfish   895 --LVFLEDIPTHQLSPYHRLRKLVKKRTYIRWPKPGEDNKIFWQKLKMALETKDSHKSENCIL 955

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380 4/15 (27%)
LRR_8 115..181 CDD:404697 15/65 (23%)
leucine-rich repeat 116..146 CDD:275380 3/29 (10%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 6/29 (21%)
LRR 210..592 CDD:443914 106/418 (25%)
leucine-rich repeat 212..236 CDD:275380 1/23 (4%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 8/23 (35%)
leucine-rich repeat 285..308 CDD:275380 7/30 (23%)
leucine-rich repeat 309..334 CDD:275380 8/24 (33%)
leucine-rich repeat 335..358 CDD:275380 5/28 (18%)
leucine-rich repeat 359..382 CDD:275380 5/32 (16%)
leucine-rich repeat 383..406 CDD:275380 6/22 (27%)
leucine-rich repeat 407..430 CDD:275380 7/22 (32%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
leucine-rich repeat 478..499 CDD:275380 6/20 (30%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
leucine-rich repeat 526..548 CDD:275380 6/22 (27%)
leucine-rich repeat 590..617 CDD:275380 7/26 (27%)
leucine-rich repeat 618..641 CDD:275380 2/22 (9%)
leucine-rich repeat 642..689 CDD:275380 8/46 (17%)
LRRCT 679..736 CDD:214507 8/56 (14%)
LRR <775..>920 CDD:443914 31/155 (20%)
leucine-rich repeat 775..796 CDD:275380 3/20 (15%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 5/22 (23%)
leucine-rich repeat 842..865 CDD:275380 7/25 (28%)
leucine-rich repeat 866..889 CDD:275380 4/22 (18%)
leucine-rich repeat 890..911 CDD:275380 8/28 (29%)
TIR 1045..1183 CDD:214587 47/151 (31%)
tlr22NP_001122147.2 LRR <70..>242 CDD:443914 53/237 (22%)
leucine-rich repeat 71..91 CDD:275380 4/36 (11%)
leucine-rich repeat 92..115 CDD:275380 6/22 (27%)
leucine-rich repeat 116..139 CDD:275380 10/64 (16%)
leucine-rich repeat 140..163 CDD:275380 8/22 (36%)
leucine-rich repeat 164..213 CDD:275380 14/48 (29%)
leucine-rich repeat 214..338 CDD:275380 27/130 (21%)
LRR 283..698 CDD:443914 121/583 (21%)
leucine-rich repeat 339..362 CDD:275380 7/22 (32%)
leucine-rich repeat 363..385 CDD:275380 10/21 (48%)
leucine-rich repeat 386..409 CDD:275380 9/22 (41%)
leucine-rich repeat 410..433 CDD:275380 8/22 (36%)
leucine-rich repeat 434..457 CDD:275380 6/22 (27%)
leucine-rich repeat 458..481 CDD:275380 6/22 (27%)
leucine-rich repeat 482..505 CDD:275380 7/36 (19%)
leucine-rich repeat 506..533 CDD:275380 9/44 (20%)
leucine-rich repeat 534..561 CDD:275380 11/66 (17%)
leucine-rich repeat 562..587 CDD:275380 7/106 (7%)
leucine-rich repeat 588..606 CDD:275380 5/17 (29%)
leucine-rich repeat 612..638 CDD:275380 7/25 (28%)
leucine-rich repeat 639..662 CDD:275380 4/22 (18%)
leucine-rich repeat 663..686 CDD:275380 6/22 (27%)
PCC 669..>737 CDD:188093 18/94 (19%)
leucine-rich repeat 687..705 CDD:275380 8/43 (19%)
TIR 802..945 CDD:214587 47/152 (31%)
Blue background indicates that the domain is not in the aligned region.

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