DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and tlr19.1

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001352353.1	Gene:	tlr19.1 / 403134	ZFINID:	ZDB-GENE-040220-3	Length:	958	Species:	Danio rerio

Alignment Length:	1138	Identity:	249/1138 - (21%)
Similarity:	412/1138 - (36%)	Gaps:	332/1138 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 FRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSEL 150
            |..|..|..|.||..:|:||...|||||.:||.|::...:.::   :.:.:..:||.||..|.||
Zfish    97 FSHLPSLEVLHIDGIRLERVQAGAFEGLPNLKYLSMLFSDELY---RLVRIDNRSFAGLNNLEEL 158

  Fly   151 HLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTL 215
            .|....:.....|::..:.||..|::.:.   .|:.||  |..|   .:||      |.:.|:.|
Zfish   159 SLTGLMLLNGSSGIFDPLVSLIRLDIVRT---CAQDLG--EIFC---CISN------GMTRLRHL 209

  Fly   216 DVSFNELRSLPD--------AWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLV 272
            :|..:|:.::.:        .|..:.|..:|.|.|..|||..:..|:|....:|..|.:.:.. .
Zfish   210 NVEDSEISTIENKGCPGGSMTWPLTALSGVQNLYLIGNNIKYIQANSLIIFQNLSSLFLEFEG-K 273

  Fly   273 SLPSEAFAGNKELRELHLQGNDLYELP---KGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGL-- 332
            ||.|...:|..::.:|.|:|..|.:..   |.|.|.:..|....||   |....:|..|...|
Zfish   274 SLGSIWESGVGKVNDLTLKGKVLKKYSTNFKDLCHLVSSLYSQSLS---LVYTSIDRLTAEDLKD 335

  Fly   333 --IRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHT 395
              .:|..|.:.|:.:..:..:.:.....:|.|.|           |::.|.:.....:|.:.
Zfish   336 CGTKLTKLLIQNSKIDNLDFRFWTSKLEMQALQM-----------AYMKLTDAPFCFVANST--- 386

  Fly   396 LDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLG 460
                    ::.||.|.|..|.::.:|...|.....|::|.||.|             .:|||.|
Zfish   387 --------MWSLTSLDLTGNSITNIEGDQFACMPFLEQLYLSQN-------------AIKTLQL- 429

  Fly   461 ENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTE 525
                     :.||.|.:|..|:|..|:|..::...|::|..|.||.:..|.|::||.|.|
Zfish   430 ---------HAFRGLPRLKILQLDSNKIWQLSANDFKNLRALEVLLINDNIIETIETGTF----- 480

  Fly   526 IEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALG-NYYK 589
                 .|:..|.:::  |..|..:..|:| ||  ::|::   |..|:.|.|..:|    | |.|
Zfish   481 -----WDQRELCELS--FGRLEYVYELHL-EN--IFFEF---PPKLQRLSIDAHY----GTNIY- 527

  Fly   590 LQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSK 654
                               ||..|.||....|.:|...:|
Zfish   528 -------------------IGNASPPNGTFALELNGERLG------------------------- 548

  Fly   655 ISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRS 719
                                ::|       |..:.|..:..|            .:.|
Zfish   549 --------------------FVG-------CDSDVLMAVREL------------KVNC------- 567

  Fly   720 APLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLA 784
                       :.|:||                               |:..|...::....:::
Zfish   568 -----------TYFLCK-------------------------------DSFMAPYFLNLESLEIS 590

  Fly   785 ALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLEN 849
            ....|.|.:    |...||:..|        ::|:...||..| .|....:...|..|:.|.:.|
Zfish   591 GGAERAPLN----YATINNLHHL--------KHLKLARLNFPN-YTESRSAFWNLTQLQTLVVVN 642

  Fly   850 NKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLD---------NNRLSSLPH 905
            ..|:.|..:.||.|..|:.|.|:::....:::..|..|..|:...||         |..|  |..
Zfish   643 CHLSFLTKSMFRDLTSLQLLRLYSDSPLILTDGVFGVLPVLKAFILDRVDFQCSCENGWL--LDW 705

  Fly   906 LQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGP 970
            ......:|.:.|.:.......|:|..||..   ..:...||..|..:
Zfish   706 ADSTEKVQVIYLQKQQCVWHYQKLNFLATM---EKLCQTDAQYICYV------------------ 749

  Fly   971 DCSDLLDASASNISSSQDLAGGY---RLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHYGVR 1032
                   |:||:||.....|.||   |.|.|     ::||            .::.|:...:|.|
Zfish   750 -------ATASSISLLLSAAVGYQFARWPSL-----VLFL------------RLKGWMERRFGRR 790

  Fly  1033 VCEPR---FEDAGKL----YDAIILHSEKDYEFVCRNIAAEL-EHGRPPFRLCIQQRDLPPQASH 1089
            ....|   .:|.|::    |||.:....:|..:|...:|:.| |.|.|..|||:..||.......
Zfish   791 WNRRRRRMEDDYGEIEEMQYDAFVSFCSQDEAWVLGEMASRLEEQGNPRLRLCLHNRDFEVGKDI 855

  Fly  1090 L-QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAEL 1153
            : .:.:....|:..:.:::|..|.::|..:|.|.|.|..|.....:|::|....:|.     .||
Zfish   856 MDNITDSIHNSQCTVCLISRRYLRSDWCGLEMRVATHRQLEEQKHRLILIFLQHISP-----FEL 915

  Fly  1154 SPY---LKSVPSNRLLTC-----DR-YFWEKLR 1177
            |.:   .|.|.|...|..     || :||::||
Zfish   916 SAFHRLAKLVRSRTYLDWPEEEGDREHFWDRLR 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380	2/4 (50%)
		leucine-rich repeat	92..115	CDD:275380	12/22 (55%)
		LRR_8	115..181	CDD:290566	15/65 (23%)
		leucine-rich repeat	116..146	CDD:275380	7/29 (24%)
		leucine-rich repeat	147..170	CDD:275380	5/22 (23%)
		leucine-rich repeat	171..201	CDD:275380	7/29 (24%)
		LRR_RI	210..464	CDD:238064	59/268 (22%)
		leucine-rich repeat	212..236	CDD:275380	6/31 (19%)
		LRR_8	235..295	CDD:290566	17/59 (29%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	6/22 (27%)
		LRR_8	283..345	CDD:290566	17/68 (25%)
		leucine-rich repeat	285..308	CDD:275380	7/25 (28%)
		leucine-rich repeat	309..334	CDD:275380	7/28 (25%)
		LRR_8	334..393	CDD:290566	9/58 (16%)
		leucine-rich repeat	335..358	CDD:275380	3/22 (14%)
		leucine-rich repeat	359..382	CDD:275380	5/22 (23%)
		LRR_8	382..441	CDD:290566	13/58 (22%)
		leucine-rich repeat	383..406	CDD:275380	1/22 (5%)
		leucine-rich repeat	407..430	CDD:275380	7/22 (32%)
		LRR_8	431..488	CDD:290566	16/56 (29%)
		leucine-rich repeat	431..451	CDD:275380	5/19 (26%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	24/81 (30%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	9/22 (41%)
		leucine-rich repeat	526..548	CDD:275380	4/21 (19%)
		leucine-rich repeat	590..617	CDD:275380	4/26 (15%)
		leucine-rich repeat	618..641	CDD:275380	3/22 (14%)
		leucine-rich repeat	642..689	CDD:275380	2/46 (4%)
		LRRCT	679..736	CDD:214507	5/56 (9%)
		leucine-rich repeat	775..796	CDD:275380	2/20 (10%)
		LRR_8	797..852	CDD:290566	13/54 (24%)
		leucine-rich repeat	797..817	CDD:275380	4/19 (21%)
		leucine-rich repeat	818..841	CDD:275380	6/22 (27%)
		LRR_8	841..900	CDD:290566	17/67 (25%)
		leucine-rich repeat	842..865	CDD:275380	8/22 (36%)
		LRR_4	866..907	CDD:289563	11/49 (22%)
		leucine-rich repeat	866..889	CDD:275380	5/22 (23%)
		leucine-rich repeat	890..911	CDD:275380	6/29 (21%)
		TIR	1045..1183	CDD:214587	40/144 (28%)
tlr19.1	NP_001352353.1	LRR_8	101..162	CDD:316378	23/63 (37%)
		leucine-rich repeat	103..126	CDD:275380	12/22 (55%)
		leucine-rich repeat	127..154	CDD:275380	7/29 (24%)
		leucine-rich repeat	155..178	CDD:275380	5/22 (23%)
		leucine-rich repeat	179..238	CDD:275380	16/72 (22%)
		leucine-rich repeat	207..219	CDD:275378	3/11 (27%)
		leucine-rich repeat	239..265	CDD:275380	9/25 (36%)
		leucine-rich repeat	340..363	CDD:275380	3/22 (14%)
		leucine-rich repeat	364..389	CDD:275380	6/46 (13%)
		LRR_8	389..448	CDD:316378	23/81 (28%)
		leucine-rich repeat	390..413	CDD:275378	7/22 (32%)
		leucine-rich repeat	414..437	CDD:275378	12/45 (27%)
		LRR_8	436..>482	CDD:316378	16/55 (29%)
		leucine-rich repeat	438..461	CDD:275378	7/22 (32%)
		leucine-rich repeat	462..485	CDD:275378	10/32 (31%)
		leucine-rich repeat	540..562	CDD:275380	6/73 (8%)
		leucine-rich repeat	563..608	CDD:275380	12/109 (11%)
		leucine-rich repeat	609..634	CDD:275380	7/33 (21%)
		leucine-rich repeat	635..658	CDD:275380	8/22 (36%)
		TIR	809..952	CDD:214587	40/145 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910