DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr4bb

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_997978.2 Gene:tlr4bb / 403132 ZFINID:ZDB-GENE-040219-9 Length:819 Species:Danio rerio


Alignment Length:990 Identity:229/990 - (23%)
Similarity:356/990 - (35%) Gaps:296/990 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   291 QGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIV--LNLSNNALTRIGSKTF 353
            ||.:..||.|...:        ..||..||       ...|.:...|  |:.|.|.||.:..:.|
Zfish    23 QGQECTELIKNKEY--------SCSGRNLT-------CIPGSLPFSVASLDFSFNFLTSLHKRVF 72

  Fly   354 KELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVS 418
            ..:..||:||:....|..||:.||..:.||.||.|..|.:..|.....|.||.|.:|.    ||.
Zfish    73 PVMLNLQLLDLTRCYIRQIEKDAFYNVKNLMTLILTGNPITYLAPECLNSLYKLQRLV----LVD 133

  Fly   419 IVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRL 483
            :          .|:.|.|..|.||:          |:.|.:|.|.|......:|  ::......|
Zfish   134 V----------RLESLQLQINNLTK----------LQDLKVGTNCIQSMTLPSF--MSTFKDFSL 176

  Fly   484 IDNRIGNITV------GMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGI 542
            :|....||::      .:.:::.|...|.|::|.:..||.|||            |:.:      
Zfish   177 LDLHANNISIIRMDHTAVLREIGRNMTLILSRNPLIHIEPGAF------------KDVI------ 223

  Fly   543 FATLASLLWLNLSENHLVWFDYAFIPSN--------LKWLDIHGNYIEALGNYYKLQEEIRVTTL 599
                       |.|.||:   .|||..|        |..|.:...::    ..|::.|:|:|   
Zfish   224 -----------LRELHLL---AAFISFNAQKECHKALTGLTVDKLFV----GRYRMDEKIKV--- 267

  Fly   600 DASHNRITEIGAMSVPNSIE-LLFINNNIIGQIQANTFVDKTRLARVDLYAN--VLSKISLNALR 661
                         |||:.:| |..||.|.|..:|......:..|.|..:.|.  .:.|..:|:::
Zfish   268 -------------SVPDYLEGLCSINFNEIYLVQKEWSDSEMHLFRCMVNATKITIKKAYMNSMK 319

  Fly   662 VAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLA 726
            ..|....|   |.||..........:..:..:..|..:. |..:....:..|       ||....
Zfish   320 HIPFHRLK---ELYLSDTGLSVVPFISHIPSLEKLVMKS-PFPITFTGVSDL-------PLLQYV 373

  Fly   727 SLSASDFVCKYESHCPPTCHCCEYEQCECEVICPG-------NCSCFHDATWATNIVDCGRQDLA 784
            .||.:..:          .|.|      |.::.|.       |.|...:.|:...          
Zfish   374 DLSGNMLI----------LHEC------CSILFPRTPNIQYLNLSQNSEITFVNE---------- 412

  Fly   785 ALPNRIPQDVSDL--YLDGNNMPELEV---GHLTGRRNLRALYLNAS------NLMTLQNGSLAQ 838
                  |....||  .||.::...:.|   |.....|||:  ||:.|      |.:|.|:     
Zfish   413 ------PFSALDLLEVLDFHHTKLVIVFYFGFFKHLRNLK--YLDISYTRVHFNTLTFQD----- 464

  Fly   839 LVNLRVLHLENN------------KLTALEGTEFRSLGL-------------LRELYLHNNMLTH 878
            |.||.||.:..|            .||:||..:....|:             ||.|||..|.|..
Zfish   465 LHNLTVLKMAGNSFSGDKLSYFLQNLTSLEVLDISQCGIEKVSMRSFTGTQKLRHLYLSRNKLMV 529

  Fly   879 ISNATFEPLVSLEVLRLDNNRLSSLP--HLQ-YRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNA 940
            :...|...|..|..:.:|.|.::::|  .|| ...:|....|..|:..|.|.| .:...::....
Zfish   530 LDFLTQPELTHLTSVYIDKNSITTIPLDVLQKLPMNLSEFDLSSNSIDCSCSQ-TDFILWIIQKQ 593

  Fly   941 MVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGY-----RLPLLAA 1000
            .:::...:|.|.......:.:.|                        |....|     ||.::.:
Zfish   594 NILKQLENIRCKTFSANTDFKAI------------------------DFDIDYCVHKKRLTIVLS 634

  Fly  1001 VLVLIFLVVVLIIVFVFRESVRMWLFAHY-----------GVRVCEPRFEDAGKLYDAIILHSEK 1054
            |:.:.|:||:.|:::.|      |.:..|           |.:.|.         |||.::.|..
Zfish   635 VICVTFVVVLAILLYKF------WFYVQYCFILFSGYRSPGQQECS---------YDAFVIFSSY 684

  Fly  1055 DYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQ---ASHLQLVEGARASRKIILVLTRNLLATEWN 1116
            |..:|...:...||:|.||.:||:..||....   ||:: :.||...|||||:|::::.:.:.|.
Zfish   685 DEAWVMNELMENLENGVPPIQLCLHMRDFQAGKSIASNI-IDEGIMGSRKIIVVVSQHFIDSSWC 748

  Fly  1117 RIEFRNAFHESLRGLAQKLVIIEETS--VSAEAEDVAE--------LSPYLKSVPSNRLLTCDR- 1170
            |.||.         |||...::|..:  :....|||||        |..:||   .|..|...| 
Zfish   749 RFEFE---------LAQSRFLMERNANIIIIILEDVAERKTKKVFGLHKHLK---KNTYLKWSRD 801

  Fly  1171 -----YFWEKLRYAI 1180
                 .||.:||.||
Zfish   802 PLSNMRFWIRLRKAI 816

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 50/174 (29%)
leucine-rich repeat 212..236 CDD:275380
LRR_8 235..295 CDD:290566 2/3 (67%)
leucine-rich repeat 237..260 CDD:275380
leucine-rich repeat 261..284 CDD:275380
LRR_8 283..345 CDD:290566 14/55 (25%)
leucine-rich repeat 285..308 CDD:275380 5/16 (31%)
leucine-rich repeat 309..334 CDD:275380 5/24 (21%)
LRR_8 334..393 CDD:290566 22/60 (37%)
leucine-rich repeat 335..358 CDD:275380 7/24 (29%)
leucine-rich repeat 359..382 CDD:275380 9/22 (41%)
LRR_8 382..441 CDD:290566 18/58 (31%)
leucine-rich repeat 383..406 CDD:275380 8/22 (36%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
LRR_8 431..488 CDD:290566 14/56 (25%)
leucine-rich repeat 431..451 CDD:275380 6/19 (32%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..559 CDD:290566 16/87 (18%)
leucine-rich repeat 478..499 CDD:275380 4/26 (15%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
leucine-rich repeat 526..548 CDD:275380 1/21 (5%)
leucine-rich repeat 590..617 CDD:275380 6/26 (23%)
leucine-rich repeat 618..641 CDD:275380 7/23 (30%)
leucine-rich repeat 642..689 CDD:275380 10/48 (21%)
LRRCT 679..736 CDD:214507 7/56 (13%)
leucine-rich repeat 775..796 CDD:275380 1/20 (5%)
LRR_8 797..852 CDD:290566 20/77 (26%)
leucine-rich repeat 797..817 CDD:275380 5/24 (21%)
leucine-rich repeat 818..841 CDD:275380 8/28 (29%)
LRR_8 841..900 CDD:290566 22/83 (27%)
leucine-rich repeat 842..865 CDD:275380 8/34 (24%)
LRR_4 866..907 CDD:289563 13/42 (31%)
leucine-rich repeat 866..889 CDD:275380 9/22 (41%)
leucine-rich repeat 890..911 CDD:275380 6/23 (26%)
TIR 1045..1183 CDD:214587 50/155 (32%)
tlr4bbNP_997978.2 leucine-rich repeat 56..77 CDD:275380 6/20 (30%)
LRR_8 77..133 CDD:290566 22/59 (37%)
leucine-rich repeat 78..101 CDD:275380 9/22 (41%)
leucine-rich repeat 102..125 CDD:275380 8/22 (36%)
leucine-rich repeat 126..148 CDD:275380 9/35 (26%)
leucine-rich repeat 149..173 CDD:275380 6/25 (24%)
leucine-rich repeat 174..200 CDD:275380 4/25 (16%)
leucine-rich repeat 201..222 CDD:275380 9/32 (28%)
LRR_RI <325..531 CDD:238064 52/255 (20%)
leucine-rich repeat 326..369 CDD:275380 7/53 (13%)
leucine-rich repeat 370..395 CDD:275380 6/40 (15%)
LRR_8 394..455 CDD:290566 16/78 (21%)
leucine-rich repeat 396..419 CDD:275380 4/38 (11%)
leucine-rich repeat 420..444 CDD:275380 4/23 (17%)
LRR_8 443..527 CDD:290566 26/90 (29%)
leucine-rich repeat 445..467 CDD:275380 8/28 (29%)
leucine-rich repeat 468..492 CDD:275380 5/23 (22%)
LRR_8 491..576 CDD:290566 22/84 (26%)
leucine-rich repeat 493..516 CDD:275380 3/22 (14%)
leucine-rich repeat 517..540 CDD:275380 9/22 (41%)
leucine-rich repeat 541..565 CDD:275380 6/23 (26%)
TIR 675..816 CDD:214587 48/153 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24216
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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