DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr2

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:XP_005170910.1 Gene:tlr2 / 403125 ZFINID:ZDB-GENE-040219-6 Length:818 Species:Danio rerio


Alignment Length:957 Identity:207/957 - (21%)
Similarity:346/957 - (36%) Gaps:282/957 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   293 NDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELY 357
            |:|:::|.    ....:|.||||.||:.|  ::.:..:....||:|||..|.|..|....||..:
Zfish    70 NNLHQVPT----VPSDVLGLDLSFNQIES--INMTDLSSYNELIILNLHKNKLRHIHRDAFKSQH 128

  Fly   358 FLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVES 422
            .|::||:..|::.::....|..|.:|..|||..|...|                       :..:
Zfish   129 NLEVLDLSLNNLNNLSPSWFHKLKSLQQLNLVGNPYST-----------------------VGPA 170

  Fly   423 QAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLD----LGENQISEFKNNTFRNLNQLTGLRL 483
            ..|::..:|:.|.|.|..|.|:.:  ..|.:|..||    .|.| :..::|.:.:....      
Zfish   171 PIFKSLVNLRTLHLGSPSLRELHK--NGLDVLTHLDEMTFFGSN-LRSYENGSLKAARP------ 226

  Fly   484 IDNRIGNITV---GMFQDLPRL--SVLNLAKN--RIQSIERGAFDKNTEIEAIRLDKNFLTDING 541
                ||::::   .:|:..|.|  .||....:  .:..|:......||..|..::.|...|    
Zfish   227 ----IGSVSLSLQNLFESDPELVSKVLQDVSHPETLLIIKDVTMKTNTSTEPFKMVKEGGT---- 283

  Fly   542 IFATLASLLWLNLS--ENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQ----EEIRVTTLD 600
                 .||.:.|.|  :..|..|......|.|.::.:.......:|.:.|.:    :.:|...| 
Zfish   284 -----KSLTFQNSSTTDQALTSFLEFMDGSPLSFIGLEDIQFVGIGEWQKAKYTHHDSLRTAYL- 342

  Fly   601 ASHNRITEI-GAMSVPNSIELLFINNNI--IGQIQANTFV---DKTRLAR----VDLYANVLSKI 655
                |..|| |.....:.|||.|:..:.  :..|.|..||   :.|.|.:    :||..|:|:.:
Zfish   343 ----RNIEIEGFFGFSSMIELGFLLKHFHNVSVINATVFVIPKETTFLLKNLEYMDLSQNLLTDL 403

  Fly   656 SLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSA 720
            ::.             |..|.|...:         |.:|.|...|:. :..||.:..|:.:.:. 
Zfish   404 TIQ-------------PTLYTGSGAY---------QNLNMLNVSQNV-LKSLGLMSRLVTNLKK- 444

  Fly   721 PLRPLASLSASDFVCKYESHC--PPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDL 783
             |:.| .||.:.||...|. |  |.|.........:...:.|    |...   :..::|....||
Zfish   445 -LKYL-DLSYNSFVSMPEK-CSWPVTLRFLNLSSTKLSTLTP----CLPS---SLTVLDLSENDL 499

  Fly   784 AALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLE 848
            .|...|.|                   |||      .|.|..:.||.|.:|.|  ..:|..|.::
Zfish   500 KAFKQRFP-------------------HLT------TLILTGNRLMKLPDGKL--FPSLNTLLIQ 537

  Fly   849 NNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYRHSLQ 913
            .|.|.....:..||                     |:.|:.||.                     
Zfish   538 RNALRMFNQSSLRS---------------------FKTLLYLEA--------------------- 560

  Fly   914 GLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDA 978
                |.|.:.|.|       :|||   ...:|..|:..|..|.:..:           |:.....
Zfish   561 ----GANNFVCSC-------KFVS---FFKKDVEDLITLQDGRQNYV-----------CNTPFTL 600

  Fly   979 SASNISSSQ-DLAGGYRLPLLAAVLVLIFLVVV---LII-------VFVFRESVRMWLFAHYGVR 1032
            ..:.|.|.: .:...|.:|   ||.||.|.::.   |::       |..:.:..:.|:.|     
Zfish   601 RGNAIDSVRLSVFECYMIP---AVSVLCFGIITALGLVVLTCHKLHVIWYLQMTKAWIQA----- 657

  Fly  1033 VCEPRFEDAGKL-----YDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL-Q 1091
               .|....|:|     |||.:.:|:.|.|:|...:.||||..:|.|.||:.:||..|....: .
Zfish   658 ---KRKPAVGRLPEELRYDAFVSYSQHDAEWVEEILVAELEDTQPSFSLCLHKRDFRPGRWIVDN 719

  Fly  1092 LVEGARASRKIILVLTRNLLATEWNRIE-----FRNAFHESLRGLAQKLVIIEETSVSAEAEDVA 1151
            :::....|.:.:.||:.:.:::||.|.|     ||               |::|.:.||.   :.
Zfish   720 IIDSIEKSYRTLFVLSEHFVSSEWCRYELDFSHFR---------------IMDEHNDSAV---LV 766

  Fly  1152 ELSPYLK-SVPS-----NRLLTCDRY------------FWEKLRYAI 1180
            .|.|..| ::|.     .:::....|            ||..||.|:
Zfish   767 LLEPIKKETIPKRFCKLRKIMNSRTYLEWPEDEDKRDEFWSNLRAAL 813

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 46/174 (26%)
leucine-rich repeat 212..236 CDD:275380
LRR_8 235..295 CDD:290566 1/1 (100%)
leucine-rich repeat 237..260 CDD:275380
leucine-rich repeat 261..284 CDD:275380
LRR_8 283..345 CDD:290566 17/51 (33%)
leucine-rich repeat 285..308 CDD:275380 3/14 (21%)
leucine-rich repeat 309..334 CDD:275380 8/24 (33%)
LRR_8 334..393 CDD:290566 21/58 (36%)
leucine-rich repeat 335..358 CDD:275380 10/22 (45%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
LRR_8 382..441 CDD:290566 11/58 (19%)
leucine-rich repeat 383..406 CDD:275380 6/22 (27%)
leucine-rich repeat 407..430 CDD:275380 1/22 (5%)
LRR_8 431..488 CDD:290566 13/60 (22%)
leucine-rich repeat 431..451 CDD:275380 6/19 (32%)
leucine-rich repeat 454..477 CDD:275380 6/26 (23%)
LRR_8 477..559 CDD:290566 17/90 (19%)
leucine-rich repeat 478..499 CDD:275380 3/23 (13%)
leucine-rich repeat 502..525 CDD:275380 5/26 (19%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 6/31 (19%)
leucine-rich repeat 618..641 CDD:275380 8/27 (30%)
leucine-rich repeat 642..689 CDD:275380 8/50 (16%)
LRRCT 679..736 CDD:214507 13/56 (23%)
leucine-rich repeat 775..796 CDD:275380 6/20 (30%)
LRR_8 797..852 CDD:290566 13/54 (24%)
leucine-rich repeat 797..817 CDD:275380 3/19 (16%)
leucine-rich repeat 818..841 CDD:275380 7/22 (32%)
LRR_8 841..900 CDD:290566 10/58 (17%)
leucine-rich repeat 842..865 CDD:275380 6/22 (27%)
LRR_4 866..907 CDD:289563 4/40 (10%)
leucine-rich repeat 866..889 CDD:275380 2/22 (9%)
leucine-rich repeat 890..911 CDD:275380 2/20 (10%)
TIR 1045..1183 CDD:214587 41/160 (26%)
tlr2XP_005170910.1 leucine-rich repeat 85..105 CDD:275378 7/21 (33%)
leucine-rich repeat 106..129 CDD:275378 10/22 (45%)
LRR_8 108..163 CDD:290566 18/54 (33%)
leucine-rich repeat 130..153 CDD:275378 6/22 (27%)
leucine-rich repeat 154..178 CDD:275378 7/46 (15%)
leucine-rich repeat 179..192 CDD:275378 5/12 (42%)
LRR_RI <390..501 CDD:238064 29/144 (20%)
leucine-rich repeat 390..418 CDD:275380 7/49 (14%)
LRR_8 418..478 CDD:290566 16/64 (25%)
leucine-rich repeat 419..444 CDD:275380 6/25 (24%)
leucine-rich repeat 445..467 CDD:275380 9/23 (39%)
leucine-rich repeat 468..488 CDD:275380 2/26 (8%)
leucine-rich repeat 489..508 CDD:275380 6/37 (16%)
leucine-rich repeat 509..530 CDD:275380 9/28 (32%)
leucine-rich repeat 531..554 CDD:275380 7/43 (16%)
TIR 671..814 CDD:214587 41/161 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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