DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and tlr21

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001186264.1 Gene:tlr21 / 402884 ZFINID:ZDB-GENE-040220-4 Length:989 Species:Danio rerio


Alignment Length:1201 Identity:266/1201 - (22%)
Similarity:447/1201 - (37%) Gaps:351/1201 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 FRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSEL 150
            |..|..|:.|.:||..:..:..:||..|..|:.|.|..:|..:       ||...|..|..|::|
Zfish    80 FDHLPNLTALILDANHITNIDKDAFNNLHHLQTLNLSCNNISF-------LHRDVFSDLHNLTQL 137

  Fly   151 HLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTL 215
            .||.|.:....:.::.|:.:|::|:|.:|.:.:               .|:...:::..:.|..|
Zfish   138 LLGSNKLTNPDKYLFSSLTNLKILDLRRNHLYN---------------FSSVVESITNLTSLIKL 187

  Fly   216 DVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFA 280
            |:|||:|                 .:|||   ||..|.:||.|                    :.
Zfish   188 DLSFNKL-----------------TTLQH---STHLPESLALL--------------------YL 212

  Fly   281 GNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNAL 345
            |:.:|:.|....:.|..:.|           ||||.|:    ::.:.:|.|      |.|.|...
Zfish   213 GDNKLKTLGCDKSFLMNVKK-----------LDLSDNK----NLASKSFLG------LKLENITY 256

  Fly   346 TRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLN----LAENRLHTLDNRIFNGLYV 406
            .|:   .|..:...::|...|....||:... |.|.|.|.|:    |..|..|.        ...
Zfish   257 LRL---RFTNISIFKLLTYPNVHPWHIDFSG-LKLKNSHALSSLCVLMRNHSHK--------HLQ 309

  Fly   407 LTKLTLNNNLVSIVESQAFRNCSDL-KELDLSSNQLTEVP--EAVQDLSMLKTLDLGENQISEFK 468
            :.|:.|.:|.:..:::..||.|..: :|:|||.|:|....  :.:.:.:.||:|.:..|.:::..
Zfish   310 IPKMLLQSNSIGALKNNTFRYCPSITREMDLSRNELKSAGCLQFLHNQTQLKSLKMEHNHLTKLT 374

  Fly   469 N-NTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLD 532
            : |.....|.||.|....|||..|:...|.:.|:|.:|.|..|.|..::..|.....:::.:|||
Zfish   375 SCNKAEIHNSLTNLSYRYNRILQISGYAFSNTPKLEILELNINIIAYMDHKALSGLKDLKTLRLD 439

  Fly   533 KNFLTDI-NGIFATLASLLWLNLSENHL-VWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIR 595
            .|.|:|| |..|..|.:|..|||..|.: |.|:|.|  .||..|||                   
Zfish   440 NNLLSDIYNDSFEDLTNLKTLNLRNNEIAVIFNYTF--QNLSKLDI------------------- 483

  Fly   596 VTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNAL 660
               ||...|:|:::    .|::.:.|:...|:        ::|:..|..:|:.  :..|:| ..|
Zfish   484 ---LDLGGNKISQL----KPHAFDGLYSLTNL--------YLDRNHLKMIDVV--LFGKLS-GTL 530

  Fly   661 RVAPVSAEKPVPEFYLGGN-----------PFECDCSMEWLQRINNLTTR-QHPHVVDLGNIECL 713
            :|..           |.||           ||:.      :.|:.:|... |.|:.::      |
Zfish   531 QVLD-----------LQGNMIMYFTEHTHSPFKN------MSRLYDLKLNGQQPNGIN------L 572

  Fly   714 MPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDC 778
            :|.   |..|.|.||.:                                                
Zfish   573 LPR---AFFRGLTSLKS------------------------------------------------ 586

  Fly   779 GRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTG--------RRNLRALYLNAS--NLMTLQN 833
                              |||..|        |:.|        .:||..|.|:.|  .:..||:
Zfish   587 ------------------LYLTNN--------HIIGFGDETFDDLKNLDYLTLDNSCAGVAQLQS 625

  Fly   834 GSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNN 898
            |....|..||.|.|||..:.:.....|.:|..|:.|:|:.|           |::||::..||| 
Zfish   626 GIFKSLQKLRTLSLENMGIKSFSKDVFGNLTGLKTLHLNRN-----------PMMSLDISLLDN- 678

  Fly   899 RLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELI 963
             |::|.::..|..         ..||.|.........:.:..:......:|.|.|..        
Zfish   679 -LTNLIYIDMRSC---------PLSCGCHNSDLQNWTIMNKRLQFPHLFNITCPDHP-------- 725

  Fly   964 GNLANGPD---CSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWL 1025
            |:..:..|   |  .||......||:..|.            :|:.|:.:|.:...::.....::
Zfish   726 GSYFHNFDTKVC--YLDIELYFFSSTSTLT------------ILLTLIPLLYVKLYWKFKYGYYV 776

  Fly  1026 F-AHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASH 1089
            | :.:|.:....|.::....|||.:.::..|.::|...:...||..  .||||:..||.......
Zfish   777 FRSWFGEQWRRLRDQEEKYNYDAFVSYNSADEDWVMEQLLPNLEGS--SFRLCLHHRDFELGRDI 839

  Fly  1090 L-QLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVI-----IEETSVSA--E 1146
            : .:|.....|||.|.|::::.|.:||..:|.:.|.:...:.:...|::     |.|..:||  .
Zfish   840 VDNIVAAVYGSRKTICVVSQSFLRSEWCSLEIQLASYRLFQEMQDVLLLVFLEPIPERQLSAYHR 904

  Fly  1147 AEDVAELSPYLKSVPSNRLLTCD------RYFWEKLRYAIPIELSPRGNNYTLDHHE-RFKQPVS 1204
            ...|.....||:...||    |.      ..||.:|:.|:....|...:...:|.:| |.|:.| 
Zfish   905 MRKVMLKKTYLQWPGSN----CSDPNSAKELFWNQLKRALRSSNSGSQDEQKMDDNELRRKEKV- 964

  Fly  1205 PGMIFRQAPPPPAYYCTEEMEANYSSATTAT 1235
                           |.::.|..|....|.|
Zfish   965 ---------------CADKEEREYFVNQTPT 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 2/4 (50%)
leucine-rich repeat 92..115 CDD:275380 7/22 (32%)
LRR_8 115..181 CDD:290566 18/65 (28%)
leucine-rich repeat 116..146 CDD:275380 8/29 (28%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 4/29 (14%)
LRR_RI 210..464 CDD:238064 61/260 (23%)
leucine-rich repeat 212..236 CDD:275380 7/23 (30%)
LRR_8 235..295 CDD:290566 12/59 (20%)
leucine-rich repeat 237..260 CDD:275380 9/22 (41%)
leucine-rich repeat 261..284 CDD:275380 1/22 (5%)
LRR_8 283..345 CDD:290566 14/61 (23%)
leucine-rich repeat 285..308 CDD:275380 4/22 (18%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
LRR_8 334..393 CDD:290566 16/62 (26%)
leucine-rich repeat 335..358 CDD:275380 5/22 (23%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
LRR_8 382..441 CDD:290566 17/63 (27%)
leucine-rich repeat 383..406 CDD:275380 5/26 (19%)
leucine-rich repeat 407..430 CDD:275380 6/22 (27%)
LRR_8 431..488 CDD:290566 16/60 (27%)
leucine-rich repeat 431..451 CDD:275380 6/22 (27%)
leucine-rich repeat 454..477 CDD:275380 5/23 (22%)
LRR_8 477..559 CDD:290566 30/82 (37%)
leucine-rich repeat 478..499 CDD:275380 8/20 (40%)
leucine-rich repeat 502..525 CDD:275380 6/22 (27%)
leucine-rich repeat 526..548 CDD:275380 10/22 (45%)
leucine-rich repeat 590..617 CDD:275380 5/26 (19%)
leucine-rich repeat 618..641 CDD:275380 3/22 (14%)
leucine-rich repeat 642..689 CDD:275380 11/57 (19%)
LRRCT 679..736 CDD:214507 14/68 (21%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 21/64 (33%)
leucine-rich repeat 797..817 CDD:275380 6/27 (22%)
leucine-rich repeat 818..841 CDD:275380 8/24 (33%)
LRR_8 841..900 CDD:290566 18/58 (31%)
leucine-rich repeat 842..865 CDD:275380 8/22 (36%)
LRR_4 866..907 CDD:289563 12/40 (30%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 7/20 (35%)
TIR 1045..1183 CDD:214587 39/151 (26%)
tlr21NP_001186264.1 leucine-rich repeat 65..85 CDD:275380 2/4 (50%)
LRR_8 84..144 CDD:290566 20/66 (30%)
leucine-rich repeat 86..109 CDD:275380 7/22 (32%)
LRR_RI 107..350 CDD:238064 77/337 (23%)
leucine-rich repeat 110..133 CDD:275380 8/29 (28%)
leucine-rich repeat 134..157 CDD:275380 6/22 (27%)
LRR_8 156..217 CDD:290566 22/115 (19%)
leucine-rich repeat 158..183 CDD:275380 5/39 (13%)
leucine-rich repeat 184..206 CDD:275380 13/41 (32%)
leucine-rich repeat 207..229 CDD:275380 7/41 (17%)
leucine-rich repeat 230..253 CDD:275380 10/43 (23%)
LRR_RI <336..540 CDD:238064 68/253 (27%)
leucine-rich repeat 360..383 CDD:275380 5/22 (23%)
leucine-rich repeat 385..408 CDD:275380 8/22 (36%)
LRR_8 407..467 CDD:290566 22/59 (37%)
leucine-rich repeat 409..432 CDD:275380 6/22 (27%)
leucine-rich repeat 433..456 CDD:275380 10/22 (45%)
LRR_8 455..515 CDD:290566 22/95 (23%)
leucine-rich repeat 457..480 CDD:275380 11/24 (46%)
leucine-rich repeat 481..504 CDD:275380 9/48 (19%)
leucine-rich repeat 505..529 CDD:275380 6/34 (18%)
leucine-rich repeat 530..556 CDD:275380 7/42 (17%)
LRR_8 555..615 CDD:290566 21/142 (15%)
leucine-rich repeat 557..583 CDD:275380 8/34 (24%)
LRR_8 582..668 CDD:290566 29/170 (17%)
leucine-rich repeat 584..607 CDD:275380 7/96 (7%)
leucine-rich repeat 608..633 CDD:275380 8/24 (33%)
leucine-rich repeat 634..657 CDD:275380 8/22 (36%)
leucine-rich repeat 658..679 CDD:275380 10/33 (30%)
leucine-rich repeat 682..694 CDD:275378 2/20 (10%)
TIR 797..942 CDD:214587 39/150 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 219 1.000 Inparanoid score I3549
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm24216
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.870

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