DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Toll-9

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	1144	Identity:	210/1144 - (18%)
Similarity:	371/1144 - (32%)	Gaps:	404/1144 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 KTLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAG 196
            |:|.|..:|..|...|.:|      |:.  |.:|...|:..|.:.|:.         ::.||
  Fly    58 KSLMLKYESDDGNSCLLDL------IKD--EVIWWQFPNGTLRDSTKK---------YAHKL--- 102

  Fly   197 SALSNANGAVSGGSEL---------------QTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNN 246
             .|..::|.:...|:|               :....:||.|.:.|.....|....|:.|||:.||
  Fly   103 -YLDLSHGNLKDDSDLFREAKLSRKVTIWRTEVFSAAFNTLTAAPFRTLYSMRESLKLLSLRGNN 166

  Fly   247 ISTLAPNA-----LAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRL 306
            .:.|.|:|     ....|.|...|       |:|...     ||..|| ...|||:        .
  Fly   167 FAELIPDAEDFARFVNESRLEASN-------SVPHHC-----ELLLLH-NTTDLYD--------R 210

  Fly   307 EQLLVLDLS---GNQLTSHHVDNSTFAGLIRLIV--LNLSNNALTRIGSKTFKELYFLQILDMRN 366
            |..|..:.:   |..:|:    ...:...|:::.  .:...::...|...||.::..|..||:.|
  Fly   211 ECYLYFNNNTNMGQSITT----GRNYTNFIKVLKDRFDQHGSSSQSIAWATFPKMPRLVELDISN 271

  Fly   367 NSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDL 431
            .||.::.:.||..:.||..|.:::|::.|:.:..|  .||                      ..:
  Fly   272 CSIEYVSKEAFRNVSNLRRLFMSDNKIMTISHDTF--YYV----------------------QGV 312

  Fly   432 KELDLS-SNQLT-----EVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGN 490
            :.|||| :|.||     ::|.....||::..|        :.:.|.|:.|.:|..|.|..:::..
  Fly   313 QYLDLSFTNFLTYSYQLQLPTLEMALSLIYGL--------KIQQNVFKYLPELIYLDLSHSKMTR 369

  Fly   491 ITVGMFQDL-PRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDIN-------GIFATLA 547
            .:...|..| .:|..|:|....|..:....| |||.:|.:.|..|.....|       ||..||.
  Fly   370 NSAVAFAHLGDKLKFLSLCYTAIPMVSSTIF-KNTVLEGLDLSGNPYLSYNIIDDAFDGIANTLK 433

  Fly   548 SLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEAL--GNYYKLQEEIRVTTLDASHNRITEIG 610
            .|.:...:...|.|....   .||:.|.:.||.|.||  ..:..|:
  Fly   434 YLYFERSNIKDLEWSKSL---KNLQVLGLAGNNINALTPAMFQSLE------------------- 476

  Fly   611 AMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFY 675
                  |:|:|.:::|.:|....:.|.:.:.|..::|.:|.::.:|...|:    ..|: :....
  Fly   477 ------SLEILDLSSNHVGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLK----DFER-LDYLS 530

  Fly   676 LGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESH 740
            ||.|.|.|||                              |.|:  :..:|:.:..|..|.|
  Fly   531 LGDNDFICDC------------------------------HLRA--VVEVAAANNKDADCSY--- 560

  Fly   741 CPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMP 805

  Fly   561 ----------------------------------------------------------------- 560

  Fly   806 ELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELY 870

  Fly   561 ----------------------------------------------------------------- 560

  Fly   871 LHNNMLTHISNATFEPLVSL-EVLRLDNNRLSS--LPHLQYRHSLQGLTLGRNAWSCRCQQLREL 932
               .:|.:..||..|.::|| |.|.:|.....|  :|.||..:|                .:||.
  Fly   561 ---RLLNYSQNAVGEEVISLAESLIIDRKLWQSRYIPWLQRSYS----------------NIREF 606

  Fly   933 --------AQFVSDNAMVVR----DAHDIYCLDAGIKRELELIGNLANGPDC---SDLLDASASN 982
                    .:|.|::.||.:    ..:.:..||..:..:.:|:...|:...|   :|.|.....|
  Fly   607 NRANHIIKLRFSSEDYMVAKCSAAQPYHLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELN 671

  Fly   983 --ISSSQDLAGGYRLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHY------------GVRV 1033
              |.|..|||..........:.|:..||...|:.|:.  .::.|...:|            ..:.
  Fly   672 CQIRSMSDLAEELHHVTNTVIAVMGSLVGACILGFII--YLKRWHIHYYYSSLKSAALLSSASKE 734

  Fly  1034 CEPRF-----EDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHL-QL 1092
            ...:|     .|...:||..|.:.:.|..:|...:...:|. .....:|:.:||.....:.| .:
  Fly   735 SVNKFTNISQRDPSAVYDIFISYCQNDRTWVLNELLPNVEE-TGDVSICLHERDFQIGVTILDNI 798

  Fly  1093 VEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDV------- 1150
            :.....|..::|:::...|.:.|.:.|...|.|.......:.|:::       ..||:
  Fly   799 ISCMDRSYSLMLIISSKFLLSHWCQFEMYLAQHRIFEVSKEHLILV-------FLEDIPRRKRPK 856

  Fly  1151 -----AELSPYLK--SVPSNRLLTCDRYFWEKLRYAIPI 1182
                 .::..|:|  :...:|.|     ||::|:.::.:
  Fly   857 TLQYLMDVKTYIKWPTAKEDRKL-----FWKRLKRSLEV 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	13/48 (27%)
		leucine-rich repeat	116..146	CDD:275380	5/13 (38%)
		leucine-rich repeat	147..170	CDD:275380	5/22 (23%)
		leucine-rich repeat	171..201	CDD:275380	5/29 (17%)
		LRR_RI	210..464	CDD:238064	63/284 (22%)
		leucine-rich repeat	212..236	CDD:275380	6/38 (16%)
		LRR_8	235..295	CDD:290566	18/64 (28%)
		leucine-rich repeat	237..260	CDD:275380	9/27 (33%)
		leucine-rich repeat	261..284	CDD:275380	4/22 (18%)
		LRR_8	283..345	CDD:290566	12/66 (18%)
		leucine-rich repeat	285..308	CDD:275380	6/22 (27%)
		leucine-rich repeat	309..334	CDD:275380	3/27 (11%)
		LRR_8	334..393	CDD:290566	15/60 (25%)
		leucine-rich repeat	335..358	CDD:275380	3/24 (13%)
		leucine-rich repeat	359..382	CDD:275380	8/22 (36%)
		LRR_8	382..441	CDD:290566	13/59 (22%)
		leucine-rich repeat	383..406	CDD:275380	5/22 (23%)
		leucine-rich repeat	407..430	CDD:275380	0/22 (0%)
		LRR_8	431..488	CDD:290566	17/62 (27%)
		leucine-rich repeat	431..451	CDD:275380	8/25 (32%)
		leucine-rich repeat	454..477	CDD:275380	4/22 (18%)
		LRR_8	477..559	CDD:290566	22/89 (25%)
		leucine-rich repeat	478..499	CDD:275380	4/20 (20%)
		leucine-rich repeat	502..525	CDD:275380	7/22 (32%)
		leucine-rich repeat	526..548	CDD:275380	8/28 (29%)
		leucine-rich repeat	590..617	CDD:275380	1/26 (4%)
		leucine-rich repeat	618..641	CDD:275380	5/22 (23%)
		leucine-rich repeat	642..689	CDD:275380	13/46 (28%)
		LRRCT	679..736	CDD:214507	9/56 (16%)
		leucine-rich repeat	775..796	CDD:275380	0/20 (0%)
		LRR_8	797..852	CDD:290566	0/54 (0%)
		leucine-rich repeat	797..817	CDD:275380	0/19 (0%)
		leucine-rich repeat	818..841	CDD:275380	0/22 (0%)
		LRR_8	841..900	CDD:290566	9/59 (15%)
		leucine-rich repeat	842..865	CDD:275380	0/22 (0%)
		LRR_4	866..907	CDD:289563	11/43 (26%)
		leucine-rich repeat	866..889	CDD:275380	4/22 (18%)
		leucine-rich repeat	890..911	CDD:275380	8/23 (35%)
		TIR	1045..1183	CDD:214587	27/153 (18%)
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	9/27 (33%)
		LRR_8	262..322	CDD:290566	20/83 (24%)
		leucine-rich repeat	264..287	CDD:275380	8/22 (36%)
		leucine-rich repeat	288..311	CDD:275380	7/46 (15%)
		leucine-rich repeat	312..356	CDD:275380	14/51 (27%)
		LRR_8	<344..387	CDD:290566	11/50 (22%)
		leucine-rich repeat	357..381	CDD:275380	5/23 (22%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	6/24 (25%)
		LRR_8	431..488	CDD:290566	18/84 (21%)
		leucine-rich repeat	432..453	CDD:275380	4/23 (17%)
		LRR_RI	<449..536	CDD:238064	24/119 (20%)
		leucine-rich repeat	454..477	CDD:275380	8/47 (17%)
		LRR_8	477..536	CDD:290566	15/63 (24%)
		leucine-rich repeat	478..501	CDD:275380	5/22 (23%)
		leucine-rich repeat	502..525	CDD:275380	5/26 (19%)
		TIR	751..891	CDD:214587	27/153 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453681
Domainoid	1	1.000	44	1.000	Domainoid score	I4673
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24216
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
	6	5.850