DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 18w and CG4950

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	122/435 - (28%)
Similarity:	198/435 - (45%)	Gaps:	74/435 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 LQTLDVS-FNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLP 275
            |:||||| .|.|....:|:.|:  ..|..|:|.:||::::..:...|.:.|..|::|||.:.||.
  Fly    96 LKTLDVSNTNILELTRNAFSAA--SNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLS 158

  Fly   276 SEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNL 340
            ..||.|...:.:::|.||.|.||...:....|.|..:...||.|||  :....|..:.|:..:||
  Fly   159 VNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTS--IQPEVFRNMRRIKEVNL 221

  Fly   341 SNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLY 405
            |||.|..|...||.:...|:.|.:..|.:.:         :.|...|:. ::|| |||.
  Fly   222 SNNRLIFIHPDTFADAASLENLVLSYNELKN---------FQLTEKNIV-HQLH-LDNN------ 269

  Fly   406 VLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNN 470
            .||.||:|..                :.:..|.||::|:  .:.....::||||..|::|...|.
  Fly   270 YLTNLTINAT----------------RFVRASHNQISEL--FLHQSLHIETLDLSANKLSSISNI 316

  Fly   471 TFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNF 535
            |  |:..:..|.:.||.||.:.:..|..|.||..|||....|:.::.|.|.|...:|.:.|..|.
  Fly   317 T--NITHMLYLDVSDNPIGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNN 379

  Fly   536 LTDINGIFATLASLLWLNLSENHLVWFDYAFIP--SNLKWLDIHGNYI-EALGNYYKLQEEIRVT 597
            ||.:|           |::           |:|  :|||...|.||.: |..||....:...::.
  Fly   380 LTILN-----------LDM-----------FVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQ 422

  Fly   598 TLDASHNRI--TEIGAMSVPNSIELLFINNNIIGQIQANTFVDKT 640
            .|..|.||.  :.:..:.:|.|:.     .:::..|:.:|.:|:|
  Fly   423 KLGVSRNRFNCSYLHHLLIPPSLP-----ESVVLNIEPDTNLDET 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	74/252 (29%)
		leucine-rich repeat	212..236	CDD:275380	10/24 (42%)
		LRR_8	235..295	CDD:290566	19/59 (32%)
		leucine-rich repeat	237..260	CDD:275380	6/22 (27%)
		leucine-rich repeat	261..284	CDD:275380	10/22 (45%)
		LRR_8	283..345	CDD:290566	20/61 (33%)
		leucine-rich repeat	285..308	CDD:275380	6/22 (27%)
		leucine-rich repeat	309..334	CDD:275380	7/24 (29%)
		LRR_8	334..393	CDD:290566	15/58 (26%)
		leucine-rich repeat	335..358	CDD:275380	9/22 (41%)
		leucine-rich repeat	359..382	CDD:275380	3/22 (14%)
		LRR_8	382..441	CDD:290566	14/58 (24%)
		leucine-rich repeat	383..406	CDD:275380	7/22 (32%)
		leucine-rich repeat	407..430	CDD:275380	5/22 (23%)
		LRR_8	431..488	CDD:290566	16/56 (29%)
		leucine-rich repeat	431..451	CDD:275380	4/19 (21%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..559	CDD:290566	23/81 (28%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)
		leucine-rich repeat	502..525	CDD:275380	8/22 (36%)
		leucine-rich repeat	526..548	CDD:275380	6/21 (29%)
		leucine-rich repeat	590..617	CDD:275380	5/28 (18%)
		leucine-rich repeat	618..641	CDD:275380	4/23 (17%)
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	10/24 (42%)
		LRR_8	118..178	CDD:290566	19/59 (32%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	10/22 (45%)
		leucine-rich repeat	168..191	CDD:275380	6/22 (27%)
		LRR_8	192..250	CDD:290566	20/59 (34%)
		leucine-rich repeat	192..215	CDD:275380	7/24 (29%)
		LRR_RI	<207..432	CDD:238064	77/283 (27%)
		leucine-rich repeat	216..239	CDD:275380	9/22 (41%)
		leucine-rich repeat	240..299	CDD:275380	19/93 (20%)
		LRR_8	299..356	CDD:290566	21/58 (36%)
		leucine-rich repeat	300..321	CDD:275380	9/22 (41%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	344..405	CDD:290566	24/82 (29%)
		leucine-rich repeat	346..365	CDD:275380	6/18 (33%)
		leucine-rich repeat	370..394	CDD:275380	9/45 (20%)
		leucine-rich repeat	395..420	CDD:275380	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940