DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Toll-6

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster


Alignment Length:1438 Identity:524/1438 - (36%)
Similarity:788/1438 - (54%) Gaps:180/1438 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 AQQQCNWQ--YGLTTMDI--RCSVRALESGTGTP-LDLQVAEAAGRLDLQCSQELLHASELAPGL 85
            |...|::.  .||...:|  .|::|.:.|...|. ..:..||....|.:.|:.|::..|.|....
  Fly    77 APDDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQS 141

  Fly    86 FRQLQKLSELRIDACKLQRVPPNAFEGLMSLKRLTLESHNAVWGPGKTLELHGQSFQGLKELSEL 150
            |..|.:|.:|.|..|||.|:.....:||..|:.|||.:||.:| |....|:...:|...:.|..|
  Fly   142 FAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILW-PALNFEIEADAFSVTRRLERL 205

  Fly   151 HLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEK------------LCAGSALSNAN 203
            .|..|||..||:.::|::..|..||:::||::....|||.::            ....||..:::
  Fly   206 DLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSS 270

  Fly   204 GAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISY 268
            .:.|...:|:.||||.|:...|| |.|...||||:.||:.:|.||.:|..||:||.:|::||:|.
  Fly   271 SSTSCSLDLEYLDVSHNDFVVLP-ANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSS 334

  Fly   269 NHLVSLPSEAFAGN-KELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGL 332
            |.:|:||:|.||.. |.::|::||.|.:..|...|...|:||..||||.||:||..:|.:||.||
  Fly   335 NKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGL 399

  Fly   333 IRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLD 397
            |||::||||:|.||::..:.|.:||.||||::|:|.:.:|....|.|:.|||||.|:.|:|..||
  Fly   400 IRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLD 464

  Fly   398 NRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGEN 462
            ....||||||:.|:|:||.:..|...||||||.|::|:|:.|||..||.|::::..|:|:|||||
  Fly   465 AYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGEN 529

  Fly   463 QISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIE 527
            .|:..:::.|:.|..|.|||||.|.:.|||:..|:|||.|.:||||:|||..:|.|||:..:.|:
  Fly   530 MITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQ 594

  Fly   528 AIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQE 592
            |:|||.|.|.||||:|:.:.||||||:|:|.|..|||..:||.|:|||:|.|.:.:|.|.:.|..
  Fly   595 AVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDS 659

  Fly   593 EIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISL 657
            |:::.|||.|.|::..||..|:||||||||:|:|:|..:..:||:.||.|.|||||||.::.:.:
  Fly   660 ELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDI 724

  Fly   658 NALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPL 722
            .:||:.||...:.:||||:|||||.|||:::|||:||::|:||:|.::||..|.|.:.::|....
  Fly   725 KSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAY 789

  Fly   723 RPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALP 787
            .||.......|:|.|::||...|||||::.|:||:.||.||:||||.||:||||:|.....:.:|
  Fly   790 IPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMP 854

  Fly   788 NRIPQDVSDLYLDGNNMPELEVGH-LTGRRNLRALYLNASNLMTLQNGSLAQLVNLRVLHLENNK 851
            .|:|.|.|:||:||||..|| .|| ..||:||..||.|.||:..:.|.:.:.|..|.:||||:|.
  Fly   855 RRVPMDTSELYIDGNNFVEL-AGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNH 918

  Fly   852 LTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNR--------LSSLPHLQY 908
            :.:|||.||.:|..||||||.:|.:..|:|.:|:.|..|||||||.||        ||:.|:   
  Fly   919 IISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPY--- 980

  Fly   909 RHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCL---DAGIKRELELIGNLANGP 970
               |..::|..|.|||.|..|.....::..::..:.||..:.|:   ...:.||       .||.
  Fly   981 ---LVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLRE-------KNGT 1035

  Fly   971 DCSDLLDASASNISSSQDLAGGYRLP-LLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHYG---V 1031
            .|:  |....::...:.::.|  .|| ||.|....:....::..:|.:|..:::|  ||..   :
  Fly  1036 KCT--LRDGVAHYMHTNEIEG--LLPLLLVATCAFVAFFGLIFGLFCYRHELKIW--AHSTNCLM 1094

  Fly  1032 RVC--EPRFE---DAGKLYDAIILHSEKDYEFVCRNIAAELEH--GRPPFRLCIQQRDLPPQASH 1089
            ..|  .|||.   |..:..||...:|.:|..||.:.:|..||:  |   :|||:..||:...|..
  Fly  1095 NFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIG---YRLCLHYRDVNINAYI 1156

  Fly  1090 LQ-LVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAEL 1153
            .. |:|.|.::::.:|||::|.|..||:|.|:::|.||.:: ..:::|.|....:.....|: ::
  Fly  1157 TDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVK-RRKRVVFILYGDLPQRDIDM-DM 1219

  Fly  1154 SPYLKSVPSNRLLTC----DRYFWEKLRYAIPIELSPRGNN------------------YTLDHH 1196
            ..||      |..||    |:.||:|||.|:|:. :.||||                  |...|.
  Fly  1220 RHYL------RTSTCIEWDDKKFWQKLRLALPLP-NGRGNNNKRVVSGCLSGRTPSVNMYATSHE 1277

  Fly  1197 ERFKQPVSPGMIFRQAPPPPAYY--CTEEMEANYSSATTATPS-------PRPTRPGGAARIVDS 1252
               .|..:.|:|    |||.|.|  |...   ||::......:       |.||....||.....
  Fly  1278 ---YQAGNGGVI----PPPSARYADCGSN---NYATINECAAAGGGRGYKPIPTSASAAAAACKF 1332

  Fly  1253 MPMPMRPPSEHIYHSIESEYSAYDQHE-ALSMIPTGLMHQHQQQQLRLHQQQQQQQQQRLLQPQF 1316
            ..|              ::.|...|.: :::.:...|.|||.      |..|..::.|.      
  Fly  1333 NTM--------------NQLSKKQQRDLSVAGMAKTLEHQHH------HNHQANRRSQH------ 1371

  Fly  1317 RAMPQQAIPA--PSAPVHLRSGSGLSQASTSTQSTAQASTSAAAAQQQQQQQ----------QQQ 1369
                :.|:|:  |||                    |.|..|...|:||.:..          .::
  Fly  1372 ----EYAVPSYLPSA--------------------APAYDSVDYAKQQIRNNANCECVNLGTAKR 1412

  Fly  1370 AAGSEAAN 1377
            |||...|:
  Fly  1413 AAGKNPAS 1420

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 7/24 (29%)
leucine-rich repeat 92..115 CDD:275380 9/22 (41%)
LRR_8 115..181 CDD:404697 23/65 (35%)
leucine-rich repeat 116..146 CDD:275380 10/29 (34%)
leucine-rich repeat 147..170 CDD:275380 9/22 (41%)
leucine-rich repeat 171..201 CDD:275380 10/41 (24%)
LRR 210..592 CDD:443914 187/382 (49%)
leucine-rich repeat 212..236 CDD:275380 11/23 (48%)
leucine-rich repeat 237..260 CDD:275380 11/22 (50%)
leucine-rich repeat 261..284 CDD:275380 11/23 (48%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 14/24 (58%)
leucine-rich repeat 335..358 CDD:275380 10/22 (45%)
leucine-rich repeat 359..382 CDD:275380 9/22 (41%)
leucine-rich repeat 383..406 CDD:275380 12/22 (55%)
leucine-rich repeat 407..430 CDD:275380 11/22 (50%)
leucine-rich repeat 431..451 CDD:275380 9/19 (47%)
leucine-rich repeat 454..477 CDD:275380 10/22 (45%)
leucine-rich repeat 478..499 CDD:275380 11/20 (55%)
leucine-rich repeat 502..525 CDD:275380 12/22 (55%)
leucine-rich repeat 526..548 CDD:275380 12/21 (57%)
leucine-rich repeat 590..617 CDD:275380 11/26 (42%)
leucine-rich repeat 618..641 CDD:275380 11/22 (50%)
leucine-rich repeat 642..689 CDD:275380 24/46 (52%)
LRRCT 679..736 CDD:214507 23/56 (41%)
LRR <775..>920 CDD:443914 66/153 (43%)
leucine-rich repeat 775..796 CDD:275380 7/20 (35%)
leucine-rich repeat 797..817 CDD:275380 12/20 (60%)
leucine-rich repeat 818..841 CDD:275380 8/22 (36%)
leucine-rich repeat 842..865 CDD:275380 12/22 (55%)
leucine-rich repeat 866..889 CDD:275380 11/22 (50%)
leucine-rich repeat 890..911 CDD:275380 12/28 (43%)
TIR 1045..1183 CDD:214587 47/144 (33%)
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733 37/107 (35%)
leucine-rich repeat 148..171 CDD:275380 9/22 (41%)
leucine-rich repeat 172..201 CDD:275380 10/29 (34%)
LRR_8 200..>246 CDD:404697 17/45 (38%)
leucine-rich repeat 202..278 CDD:275380 20/75 (27%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
leucine-rich repeat 279..302 CDD:275380 11/23 (48%)
LRR 299..654 CDD:443914 175/354 (49%)
leucine-rich repeat 303..326 CDD:275380 11/22 (50%)
leucine-rich repeat 327..350 CDD:275380 11/22 (50%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 14/24 (58%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 9/22 (41%)
leucine-rich repeat 450..473 CDD:275380 12/22 (55%)
leucine-rich repeat 474..497 CDD:275380 11/22 (50%)
leucine-rich repeat 498..518 CDD:275380 9/19 (47%)
leucine-rich repeat 521..544 CDD:275380 10/22 (45%)
leucine-rich repeat 545..566 CDD:275380 11/20 (55%)
leucine-rich repeat 569..592 CDD:275380 12/22 (55%)
leucine-rich repeat 593..615 CDD:275380 12/21 (57%)
leucine-rich repeat 616..637 CDD:275380 12/20 (60%)
leucine-rich repeat 638..662 CDD:275380 10/23 (43%)
LRR_8 662..719 CDD:404697 31/56 (55%)
leucine-rich repeat 663..684 CDD:275380 9/20 (45%)
leucine-rich repeat 685..708 CDD:275380 11/22 (50%)
leucine-rich repeat 709..728 CDD:275380 8/18 (44%)
LRR <863..>990 CDD:443914 58/133 (44%)
leucine-rich repeat 885..908 CDD:275380 8/22 (36%)
leucine-rich repeat 909..932 CDD:275380 12/22 (55%)
leucine-rich repeat 933..956 CDD:275380 11/22 (50%)
TIR 1114..1247 CDD:214587 47/143 (33%)

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