DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 18w and CG42709

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001163434.1	Gene:	CG42709 / 39453	FlyBaseID:	FBgn0261674	Length:	458	Species:	Drosophila melanogaster

Alignment Length:	327	Identity:	71/327 - (21%)
Similarity:	135/327 - (41%)	Gaps:	65/327 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 GLSSLRVLNISYNHLVSLPSEAFAGNKE---LRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQ 318
            ||..:.:|::|.:|..:.|    ||::|   |.:.:...:|..|...|
  Fly     8 GLLLIFLLSVSISHTNAAP----AGSEEANPLEDFNYGDDDYSETATG----------------- 51

  Fly   319 LTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGH---------IEE 374
                  :.|......||:..:.|.:..|     ||:.::   .:..|:|.:..         :|:
  Fly    52 ------EESPETAENRLMPQSSSTSTTT-----TFRPIF---NIPRRSNHVLEPSCPRNCLCLED 102

  Fly   375 GAFLPLYNLH-------------TLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFR 426
            ..|:...|.|             .::|:.|.:..|....|..|....::.||:||:|.::...|:
  Fly   103 FKFVQCANAHLTHVPLDMPKTAAIIDLSHNVIAELRPEDFANLSRAVEINLNHNLISSIDKDVFQ 167

  Fly   427 NCSDLKELDLSSNQLTEV-PEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGN 490
            ....||.|.|::|:||:: |:.......|..|||..|.|::..:.:|.|...|.....::.....
  Fly   168 GSERLKRLRLANNRLTKIDPDTFAAAKELTLLDLSNNTITQRLDGSFLNQPDLVEFSCVNCSWTE 232

  Fly   491 ITVGMFQDLPRLSVLNLAKNRI-QSIERGAFDKNTEIEAIR---LDKNFLTDINGIFATLASLLW 551
            :....||::..|.||.|.||.. |.|...||...|:|..::   |::..:.::..:..::.::.:
  Fly   233 LPEQTFQNMSGLEVLRLNKNDFKQQINTKAFSPLTKIIKLKLPELEQQNIEELCSLLTSIDTISF 297

  Fly   552 LN 553
            ||
  Fly   298 LN 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	50/232 (22%)
		leucine-rich repeat	212..236	CDD:275380
		LRR_8	235..295	CDD:290566	10/40 (25%)
		leucine-rich repeat	237..260	CDD:275380	2/2 (100%)
		leucine-rich repeat	261..284	CDD:275380	6/22 (27%)
		LRR_8	283..345	CDD:290566	9/64 (14%)
		leucine-rich repeat	285..308	CDD:275380	4/22 (18%)
		leucine-rich repeat	309..334	CDD:275380	1/24 (4%)
		LRR_8	334..393	CDD:290566	14/80 (18%)
		leucine-rich repeat	335..358	CDD:275380	5/22 (23%)
		leucine-rich repeat	359..382	CDD:275380	4/31 (13%)
		LRR_8	382..441	CDD:290566	18/71 (25%)
		leucine-rich repeat	383..406	CDD:275380	6/35 (17%)
		leucine-rich repeat	407..430	CDD:275380	6/22 (27%)
		LRR_8	431..488	CDD:290566	17/57 (30%)
		leucine-rich repeat	431..451	CDD:275380	8/20 (40%)
		leucine-rich repeat	454..477	CDD:275380	8/22 (36%)
		LRR_8	477..559	CDD:290566	18/81 (22%)
		leucine-rich repeat	478..499	CDD:275380	3/20 (15%)
		leucine-rich repeat	502..525	CDD:275380	10/23 (43%)
		leucine-rich repeat	526..548	CDD:275380	2/24 (8%)
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
CG42709	NP_001163434.1	LRR_8	126..182	CDD:290566	16/55 (29%)
		leucine-rich repeat	128..147	CDD:275380	5/18 (28%)
		leucine-rich repeat	148..171	CDD:275380	6/22 (27%)
		LRR_RI	<150..225	CDD:238064	23/74 (31%)
		LRR_8	171..254	CDD:290566	25/82 (30%)
		leucine-rich repeat	172..195	CDD:275380	8/22 (36%)
		leucine-rich repeat	196..219	CDD:275380	8/22 (36%)
		leucine-rich repeat	220..243	CDD:275380	3/22 (14%)
		leucine-rich repeat	244..268	CDD:275380	10/23 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930