DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and ltl

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001261524.1 Gene:ltl / 38845 FlyBaseID:FBgn0268063 Length:817 Species:Drosophila melanogaster


Alignment Length:668 Identity:149/668 - (22%)
Similarity:266/668 - (39%) Gaps:180/668 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 IRCSVRALESGTGTPLDLQVAEAAGRLDLQCSQELLHASELAPGLFRQLQKLS--ELRIDACKLQ 103
            ::||||...|    |...:..:|...::|.| ::|...:.:...|..:|...:  :|:|...:|.
  Fly    14 LQCSVRPEIS----PCTCETGKAWNHVELSC-EKLESFNAVVDSLANKLNADTNIDLKITHSQLD 73

  Fly   104 RVPPNAFEGL-MSLKRLTLESHNAVWGPGKTL-ELHGQSFQGLKELSELHLGDNNIRQLPEGVWC 166
            .:...:|..: .:|.:|.::     |...|:| |:   .|:||..::.|.:|||::.::|:....
  Fly    74 DLEMRSFTDMNFNLYKLRMQ-----WNSLKSLPEV---PFRGLSNVTYLSIGDNDLDEIPKHALS 130

  Fly   167 SMPSLQLLNLTQNRIRSA---EFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDA 228
            .||||..|::.:.:||:.   :|.|                                        
  Fly   131 HMPSLLTLDIGRCKIRAVQQEDFRG---------------------------------------- 155

  Fly   229 WGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGN 293
                 ::|:..|.|..|.|:.|...:..  .||.:|::..|.|.||                   
  Fly   156 -----IQRVTNLILVSNIITRLDRGSFP--KSLLILHLGRNQLESL------------------- 194

  Fly   294 DLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYF 358
                  .|.||.|..|..|.::.|.:||.. |.....|.:||::.:  ||.|.|:.:        
  Fly   195 ------NGSLHDLHNLESLFINANNITSLD-DELPDGGQLRLLMAH--NNRLERLPA-------- 242

  Fly   359 LQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQ 423
                    |..|         :::|.|:::..|:|.:.| |:......|:::..:||.:..:...
  Fly   243 --------NMAG---------MHSLETVHIHCNQLRSFD-RVLRNAVNLSEVMADNNELEYLAQD 289

  Fly   424 AFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRI 488
            .|.:||.::.|.:..|.:..:..::..:..||..:...|.|.||      ::.:|.|||      
  Fly   290 EFASCSKVETLQMGCNHIKSLNSSLLPILKLKNANFSFNDIEEF------SMAELHGLR------ 342

  Fly   489 GNITVGMFQDLPRLSVLNLAKNRIQSI---ERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLL 550
                        .|..|.|:.||||.:   .||.  :...:..:.||.|.:..:||..|.|.:|.
  Fly   343 ------------SLKTLQLSSNRIQRLLPDPRGV--QELMLVNLDLDNNRIDSLNGALAGLGNLR 393

  Fly   551 WLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIG--AMS 613
            .|||:.|.|         .:|:..|..|              .||:..||.:.|::.|:.  .|:
  Fly   394 ILNLAGNRL---------EHLQVGDFDG--------------MIRLDILDLTGNQLAELKPLEMT 435

  Fly   614 VPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVP---EFY 675
            :..|:::|.:..|.|.:::.: |.....|.:.:|..|.:|.|| :.|..........||   |.:
  Fly   436 LLPSLKILKVAYNNITKLEQD-FKGLPVLCQANLTNNQISTIS-SELVTNTRCKNHNVPGKLEIH 498

  Fly   676 LGGNPFECDCSMEWLQRI 693
            |..||..||..:..|.|:
  Fly   499 LDDNPIMCDVGLNELCRL 516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 5/24 (21%)
leucine-rich repeat 92..115 CDD:275380 4/25 (16%)
LRR_8 115..181 CDD:290566 19/66 (29%)
leucine-rich repeat 116..146 CDD:275380 9/30 (30%)
leucine-rich repeat 147..170 CDD:275380 6/22 (27%)
leucine-rich repeat 171..201 CDD:275380 6/32 (19%)
LRR_RI 210..464 CDD:238064 49/253 (19%)
leucine-rich repeat 212..236 CDD:275380 0/23 (0%)
LRR_8 235..295 CDD:290566 13/59 (22%)
leucine-rich repeat 237..260 CDD:275380 5/22 (23%)
leucine-rich repeat 261..284 CDD:275380 6/22 (27%)
LRR_8 283..345 CDD:290566 15/61 (25%)
leucine-rich repeat 285..308 CDD:275380 4/22 (18%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
LRR_8 334..393 CDD:290566 11/58 (19%)
leucine-rich repeat 335..358 CDD:275380 5/22 (23%)
leucine-rich repeat 359..382 CDD:275380 2/22 (9%)
LRR_8 382..441 CDD:290566 14/58 (24%)
leucine-rich repeat 383..406 CDD:275380 6/22 (27%)
leucine-rich repeat 407..430 CDD:275380 5/22 (23%)
LRR_8 431..488 CDD:290566 12/56 (21%)
leucine-rich repeat 431..451 CDD:275380 2/19 (11%)
leucine-rich repeat 454..477 CDD:275380 6/22 (27%)
LRR_8 477..559 CDD:290566 25/84 (30%)
leucine-rich repeat 478..499 CDD:275380 4/20 (20%)
leucine-rich repeat 502..525 CDD:275380 9/25 (36%)
leucine-rich repeat 526..548 CDD:275380 7/21 (33%)
leucine-rich repeat 590..617 CDD:275380 7/28 (25%)
leucine-rich repeat 618..641 CDD:275380 4/22 (18%)
leucine-rich repeat 642..689 CDD:275380 15/49 (31%)
LRRCT 679..736 CDD:214507 6/15 (40%)
leucine-rich repeat 775..796 CDD:275380
LRR_8 797..852 CDD:290566
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
LRR_8 841..900 CDD:290566
leucine-rich repeat 842..865 CDD:275380
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
ltlNP_001261524.1 leucine-rich repeat 65..86 CDD:275380 4/20 (20%)
LRR_8 86..145 CDD:290566 19/66 (29%)
leucine-rich repeat 87..110 CDD:275380 9/30 (30%)
leucine-rich repeat 111..134 CDD:275380 6/22 (27%)
leucine-rich repeat 135..158 CDD:275380 6/67 (9%)
LRR_8 158..214 CDD:290566 20/82 (24%)
leucine-rich repeat 159..180 CDD:275380 5/22 (23%)
leucine-rich repeat 181..203 CDD:275380 10/46 (22%)
leucine-rich repeat 204..226 CDD:275380 6/22 (27%)
LRR_RI 226..451 CDD:238064 67/301 (22%)
leucine-rich repeat 227..249 CDD:275380 8/48 (17%)
leucine-rich repeat 250..272 CDD:275380 6/22 (27%)
leucine-rich repeat 273..296 CDD:275380 5/22 (23%)
leucine-rich repeat 297..315 CDD:275380 2/17 (12%)
LRR_8 319..402 CDD:290566 31/108 (29%)
leucine-rich repeat 320..335 CDD:275378 6/20 (30%)
leucine-rich repeat 344..366 CDD:275380 9/23 (39%)
leucine-rich repeat 367..391 CDD:275380 7/23 (30%)
LRR_8 369..426 CDD:290566 21/79 (27%)
leucine-rich repeat 392..415 CDD:275380 9/45 (20%)
leucine-rich repeat 416..439 CDD:275380 5/22 (23%)
LRR_8 438..>479 CDD:290566 11/42 (26%)
leucine-rich repeat 440..462 CDD:275380 4/22 (18%)
leucine-rich repeat 463..483 CDD:275380 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453796
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.840

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