DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr12

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_991392.1 Gene:Tlr12 / 384059 MGIID:3045221 Length:906 Species:Mus musculus


Alignment Length:1038 Identity:231/1038 - (22%)
Similarity:363/1038 - (34%) Gaps:345/1038 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 CAGSALSNANGAVSGGSELQTLDVSFNELRS----------LPDAWGASRLRRLQTLSLQHNNIS 248
            |..|.||.....:|..:..|||:|....:..          ||||:.|....::..|||   :::
Mouse    43 CRHSKLSFLAACLSVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSL---HLT 104

  Fly   249 TLAPNALAGLSSLRVLNISYNHL---VSLPSEAFAGNKELRELHLQGNDL-----YELPKGLLHR 305
            .|.|.||.||..|:.|:...:.|   :.||.:||:....|:.||:.|..|     ..||.||   
Mouse   105 QLLPGALRGLGQLQSLSFFDSPLRRSLFLPPDAFSDLISLQRLHISGPCLDKKAGIRLPPGL--- 166

  Fly   306 LEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIV-------------LNLSNNALTRIGSKTFKELY 357
              |.|.:.||..|      |....||:...:|             |:||:|...::.|....:..
Mouse   167 --QWLGVTLSCIQ------DVGELAGMFPDLVQGSSSRVSWTLQKLDLSSNWKLKMASPGSLQGL 223

  Fly   358 FLQILDMRNNSIGHIEEGAFLPLYNLHTLNL-----------AENRLHTLDNRIFNGLYVLTKLT 411
            .::|||:....:    :..:|....|..|::           ||...|          :.|..|.
Mouse   224 QVEILDLTRTPL----DAVWLKGLGLQKLDVLYAQTATAELAAEAVAH----------FELQGLI 274

  Fly   412 LNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEA-VQDLSMLKTLDLGENQISE--FKNNTFR 473
            :..:.:..:..:|..:|..||.|.|||..||::|.. :..:..|:.|:|..||:..  ...|...
Mouse   275 VKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVLCMNETG 339

  Fly   474 NLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTD 538
            :::.||.|.|..||:..:....|..||.|..|.|..|::.|:|...|.:..::|.::||.|.|..
Mouse   340 DVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPLLH 404

  Fly   539 I-NGIFATLASLLWLNLSENHL-------VWF-----------------DYAFIPSNLKWLDIHG 578
            : ....|.|.:|..|:|.:..:       .|.                 ...|:|..|..|::| 
Mouse   405 LGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAPAVLFLPMYLTSLELH- 468

  Fly   579 NYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLA 643
                             :.:....|..::.    ::..|:|.|.|:...:          |.:|.
Mouse   469 -----------------IASGTTEHWTLSP----AIFPSLETLTISGGGL----------KLKLG 502

  Fly   644 RVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDL- 707
                        |.||..|.|.     :.:..|..|..:..||    |..:||...|.|.:..| 
Mouse   503 ------------SQNASGVFPA-----LQKLSLLKNSLDAFCS----QGTSNLFLWQLPKLQSLR 546

  Fly   708 ----GNIE--CL---MPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNC 763
                ||..  ||   :|..|...|..|.|::.                                 
Mouse   547 VWGAGNSSRPCLITGLPSLRELKLASLQSITQ--------------------------------- 578

  Fly   764 SCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNL 828
                                       |:.|        .:.|| ||.|.   .|:||.|:::.|
Mouse   579 ---------------------------PRSV--------QLEEL-VGDLP---QLQALVLSSTGL 604

  Fly   829 MTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRE--------LY-LHNNMLTHISNATF 884
            .:|...:..:|.:|:||.||..|...|:.:       |||        :| |.:|:..|.:||..
Mouse   605 KSLSAAAFQRLHSLQVLVLEYEKDLMLQDS-------LREYSPQMPHYIYILESNLACHCANAWM 662

  Fly   885 EPLVSLEV---LRLDNNRL----------SSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFV 936
            ||.|....   :.:.:|||          .|||...:.|               |.|..||..|:
Mouse   663 EPWVKRSTKTYIYIRDNRLCPGQDRLSARGSLPSFLWDH---------------CPQTLELKLFL 712

  Fly   937 SDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAV 1001
            :.:|:|       :.|.|     |.|:....|.                        .:|.|.|:
Mouse   713 ASSALV-------FMLIA-----LPLLQEARNS------------------------WIPYLQAL 741

  Fly  1002 LVLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAGK--LYDAIILHSEKDYEFVCRNIA 1064
            .                   |:||   .|:|    ...|.||  |:|..:.|..:|..:|...:.
Mouse   742 F-------------------RVWL---QGLR----GKGDKGKRFLFDVFVSHCRQDQGWVIEELL 780

  Fly  1065 AELEHGRPP---FRLCIQQRDLPPQASHL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNA 1123
            ..||...|.   .|||:.:||..|....: .:|:...:||..:.||:...|.....|:|.|.|
Mouse   781 PALEGFLPAGLGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRLA 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 3/6 (50%)
LRR 210..592 CDD:443914 108/451 (24%)
leucine-rich repeat 212..236 CDD:275380 9/33 (27%)
leucine-rich repeat 237..260 CDD:275380 9/22 (41%)
leucine-rich repeat 261..284 CDD:275380 7/25 (28%)
leucine-rich repeat 285..308 CDD:275380 9/27 (33%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
leucine-rich repeat 335..358 CDD:275380 6/35 (17%)
leucine-rich repeat 359..382 CDD:275380 4/22 (18%)
leucine-rich repeat 383..406 CDD:275380 5/33 (15%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
leucine-rich repeat 431..451 CDD:275380 9/20 (45%)
leucine-rich repeat 454..477 CDD:275380 6/24 (25%)
leucine-rich repeat 478..499 CDD:275380 7/20 (35%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 7/22 (32%)
leucine-rich repeat 590..617 CDD:275380 1/26 (4%)
leucine-rich repeat 618..641 CDD:275380 4/22 (18%)
leucine-rich repeat 642..689 CDD:275380 10/46 (22%)
LRRCT 679..736 CDD:214507 18/66 (27%)
LRR <775..>920 CDD:443914 40/166 (24%)
leucine-rich repeat 775..796 CDD:275380 2/20 (10%)
leucine-rich repeat 797..817 CDD:275380 5/19 (26%)
leucine-rich repeat 818..841 CDD:275380 7/22 (32%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
leucine-rich repeat 866..889 CDD:275380 11/31 (35%)
leucine-rich repeat 890..911 CDD:275380 6/33 (18%)
TIR 1045..1183 CDD:214587 23/83 (28%)
Tlr12NP_991392.1 LRR 56..482 CDD:443914 110/475 (23%)
LRR 1 91..114 7/25 (28%)
leucine-rich repeat 94..116 CDD:275380 9/24 (38%)
LRR 2 115..140 7/24 (29%)
leucine-rich repeat 117..143 CDD:275380 7/25 (28%)
LRR 3 142..170 10/32 (31%)
leucine-rich repeat 144..191 CDD:275380 17/57 (30%)
LRR 4 198..222 5/23 (22%)
leucine-rich repeat 201..224 CDD:275380 5/22 (23%)
LRR 5 224..247 5/26 (19%)
leucine-rich repeat 225..247 CDD:275380 5/25 (20%)
leucine-rich repeat 248..293 CDD:275380 8/54 (15%)
LRR 6 267..290 4/32 (13%)
LRR 7 291..314 10/22 (45%)
leucine-rich repeat 294..317 CDD:275380 9/22 (41%)
LRR 8 316..338 6/21 (29%)
leucine-rich repeat 318..343 CDD:275380 6/24 (25%)
LRR 9 341..364 7/22 (32%)
leucine-rich repeat 344..367 CDD:275380 8/22 (36%)
LRR 10 366..388 8/21 (38%)
leucine-rich repeat 368..391 CDD:275380 7/22 (32%)
LRR 11 389..412 5/22 (23%)
leucine-rich repeat 392..415 CDD:275380 7/22 (32%)
LRR 12 414..436 3/21 (14%)
leucine-rich repeat 416..436 CDD:275380 3/19 (16%)
LRR 439..>625 CDD:443914 54/310 (17%)
leucine-rich repeat 440..512 CDD:275380 16/115 (14%)
LRR 13 462..484 4/43 (9%)
LRR 14 485..508 9/44 (20%)
LRR 15 510..533 6/31 (19%)
leucine-rich repeat 513..564 CDD:275380 14/54 (26%)
LRR 16 562..586 7/91 (8%)
leucine-rich repeat 565..593 CDD:275380 11/99 (11%)
LRR 17 591..614 7/25 (28%)
leucine-rich repeat 594..617 CDD:275380 7/22 (32%)
TIR 761..902 CDD:214587 23/83 (28%)
Blue background indicates that the domain is not in the aligned region.

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