DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Tlr12

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_991392.1 Gene:Tlr12 / 384059 MGIID:3045221 Length:906 Species:Mus musculus


Alignment Length:1038 Identity:231/1038 - (22%)
Similarity:363/1038 - (34%) Gaps:345/1038 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 CAGSALSNANGAVSGGSELQTLDVSFNELRS----------LPDAWGASRLRRLQTLSLQHNNIS 248
            |..|.||.....:|..:..|||:|....:..          ||||:.|....::..|||   :::
Mouse    43 CRHSKLSFLAACLSVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSL---HLT 104

  Fly   249 TLAPNALAGLSSLRVLNISYNHL---VSLPSEAFAGNKELRELHLQGNDL-----YELPKGLLHR 305
            .|.|.||.||..|:.|:...:.|   :.||.:||:....|:.||:.|..|     ..||.||   
Mouse   105 QLLPGALRGLGQLQSLSFFDSPLRRSLFLPPDAFSDLISLQRLHISGPCLDKKAGIRLPPGL--- 166

  Fly   306 LEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIV-------------LNLSNNALTRIGSKTFKELY 357
              |.|.:.||..|      |....||:...:|             |:||:|...::.|....:..
Mouse   167 --QWLGVTLSCIQ------DVGELAGMFPDLVQGSSSRVSWTLQKLDLSSNWKLKMASPGSLQGL 223

  Fly   358 FLQILDMRNNSIGHIEEGAFLPLYNLHTLNL-----------AENRLHTLDNRIFNGLYVLTKLT 411
            .::|||:....:    :..:|....|..|::           ||...|          :.|..|.
Mouse   224 QVEILDLTRTPL----DAVWLKGLGLQKLDVLYAQTATAELAAEAVAH----------FELQGLI 274

  Fly   412 LNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEA-VQDLSMLKTLDLGENQISE--FKNNTFR 473
            :..:.:..:..:|..:|..||.|.|||..||::|.. :..:..|:.|:|..||:..  ...|...
Mouse   275 VKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVLCMNETG 339

  Fly   474 NLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTD 538
            :::.||.|.|..||:..:....|..||.|..|.|..|::.|:|...|.:..::|.::||.|.|..
Mouse   340 DVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPLLH 404

  Fly   539 I-NGIFATLASLLWLNLSENHL-------VWF-----------------DYAFIPSNLKWLDIHG 578
            : ....|.|.:|..|:|.:..:       .|.                 ...|:|..|..|::| 
Mouse   405 LGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAPAVLFLPMYLTSLELH- 468

  Fly   579 NYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLA 643
                             :.:....|..::.    ::..|:|.|.|:...:          |.:|.
Mouse   469 -----------------IASGTTEHWTLSP----AIFPSLETLTISGGGL----------KLKLG 502

  Fly   644 RVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDL- 707
                        |.||..|.|.     :.:..|..|..:..||    |..:||...|.|.:..| 
Mouse   503 ------------SQNASGVFPA-----LQKLSLLKNSLDAFCS----QGTSNLFLWQLPKLQSLR 546

  Fly   708 ----GNIE--CL---MPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNC 763
                ||..  ||   :|..|...|..|.|::.                                 
Mouse   547 VWGAGNSSRPCLITGLPSLRELKLASLQSITQ--------------------------------- 578

  Fly   764 SCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNL 828
                                       |:.|        .:.|| ||.|.   .|:||.|:::.|
Mouse   579 ---------------------------PRSV--------QLEEL-VGDLP---QLQALVLSSTGL 604

  Fly   829 MTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRE--------LY-LHNNMLTHISNATF 884
            .:|...:..:|.:|:||.||..|...|:.:       |||        :| |.:|:..|.:||..
Mouse   605 KSLSAAAFQRLHSLQVLVLEYEKDLMLQDS-------LREYSPQMPHYIYILESNLACHCANAWM 662

  Fly   885 EPLVSLEV---LRLDNNRL----------SSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFV 936
            ||.|....   :.:.:|||          .|||...:.|               |.|..||..|:
Mouse   663 EPWVKRSTKTYIYIRDNRLCPGQDRLSARGSLPSFLWDH---------------CPQTLELKLFL 712

  Fly   937 SDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAV 1001
            :.:|:|       :.|.|     |.|:....|.                        .:|.|.|:
Mouse   713 ASSALV-------FMLIA-----LPLLQEARNS------------------------WIPYLQAL 741

  Fly  1002 LVLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAGK--LYDAIILHSEKDYEFVCRNIA 1064
            .                   |:||   .|:|    ...|.||  |:|..:.|..:|..:|...:.
Mouse   742 F-------------------RVWL---QGLR----GKGDKGKRFLFDVFVSHCRQDQGWVIEELL 780

  Fly  1065 AELEHGRPP---FRLCIQQRDLPPQASHL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNA 1123
            ..||...|.   .|||:.:||..|....: .:|:...:||..:.||:...|.....|:|.|.|
Mouse   781 PALEGFLPAGLGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRLA 843

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 3/6 (50%)
LRR_RI 210..464 CDD:238064 74/296 (25%)
leucine-rich repeat 212..236 CDD:275380 9/33 (27%)
LRR_8 235..295 CDD:290566 20/62 (32%)
leucine-rich repeat 237..260 CDD:275380 9/22 (41%)
leucine-rich repeat 261..284 CDD:275380 7/25 (28%)
LRR_8 283..345 CDD:290566 22/79 (28%)
leucine-rich repeat 285..308 CDD:275380 9/27 (33%)
leucine-rich repeat 309..334 CDD:275380 7/24 (29%)
LRR_8 334..393 CDD:290566 14/82 (17%)
leucine-rich repeat 335..358 CDD:275380 6/35 (17%)
leucine-rich repeat 359..382 CDD:275380 4/22 (18%)
LRR_8 382..441 CDD:290566 15/69 (22%)
leucine-rich repeat 383..406 CDD:275380 5/33 (15%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
LRR_8 431..488 CDD:290566 20/59 (34%)
leucine-rich repeat 431..451 CDD:275380 9/20 (45%)
leucine-rich repeat 454..477 CDD:275380 6/24 (25%)
LRR_8 477..559 CDD:290566 26/82 (32%)
leucine-rich repeat 478..499 CDD:275380 7/20 (35%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 7/22 (32%)
leucine-rich repeat 590..617 CDD:275380 1/26 (4%)
leucine-rich repeat 618..641 CDD:275380 4/22 (18%)
leucine-rich repeat 642..689 CDD:275380 10/46 (22%)
LRRCT 679..736 CDD:214507 18/66 (27%)
leucine-rich repeat 775..796 CDD:275380 2/20 (10%)
LRR_8 797..852 CDD:290566 17/54 (31%)
leucine-rich repeat 797..817 CDD:275380 5/19 (26%)
leucine-rich repeat 818..841 CDD:275380 7/22 (32%)
LRR_8 841..900 CDD:290566 20/70 (29%)
leucine-rich repeat 842..865 CDD:275380 7/22 (32%)
LRR_4 866..907 CDD:289563 18/62 (29%)
leucine-rich repeat 866..889 CDD:275380 11/31 (35%)
leucine-rich repeat 890..911 CDD:275380 6/33 (18%)
TIR 1045..1183 CDD:214587 23/83 (28%)
Tlr12NP_991392.1 LRR 1 91..114 7/25 (28%)
leucine-rich repeat 94..116 CDD:275380 9/24 (38%)
LRR 2 115..140 7/24 (29%)
leucine-rich repeat 117..143 CDD:275380 7/25 (28%)
LRR 3 142..170 10/32 (31%)
leucine-rich repeat 144..191 CDD:275380 17/57 (30%)
LRR 4 198..222 5/23 (22%)
leucine-rich repeat 201..224 CDD:275380 5/22 (23%)
LRR 5 224..247 5/26 (19%)
leucine-rich repeat 225..247 CDD:275380 5/25 (20%)
leucine-rich repeat 248..293 CDD:275380 8/54 (15%)
LRR 6 267..290 4/32 (13%)
LRR_8 269..328 CDD:290566 17/58 (29%)
LRR 7 291..314 10/22 (45%)
leucine-rich repeat 294..317 CDD:275380 9/22 (41%)
LRR 8 316..338 6/21 (29%)
leucine-rich repeat 318..343 CDD:275380 6/24 (25%)
LRR 9 341..364 7/22 (32%)
LRR_8 342..402 CDD:290566 20/59 (34%)
leucine-rich repeat 344..367 CDD:275380 8/22 (36%)
LRR_RI 364..625 CDD:238064 74/385 (19%)
LRR 10 366..388 8/21 (38%)
leucine-rich repeat 368..391 CDD:275380 7/22 (32%)
LRR 11 389..412 5/22 (23%)
leucine-rich repeat 392..415 CDD:275380 7/22 (32%)
LRR 12 414..436 3/21 (14%)
leucine-rich repeat 416..436 CDD:275380 3/19 (16%)
leucine-rich repeat 440..512 CDD:275380 16/115 (14%)
LRR 13 462..484 4/43 (9%)
LRR 14 485..508 9/44 (20%)
LRR 15 510..533 6/31 (19%)
leucine-rich repeat 513..564 CDD:275380 14/54 (26%)
LRR 16 562..586 7/91 (8%)
leucine-rich repeat 565..593 CDD:275380 11/99 (11%)
LRR 17 591..614 7/25 (28%)
leucine-rich repeat 594..617 CDD:275380 7/22 (32%)
TIR 761..902 CDD:214587 23/83 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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