DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and CG5819

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001246458.1 Gene:CG5819 / 37547 FlyBaseID:FBgn0034717 Length:915 Species:Drosophila melanogaster


Alignment Length:555 Identity:137/555 - (24%)
Similarity:216/555 - (38%) Gaps:148/555 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   209 GSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVS 273
            |..::.||:|.|:....|..:  :.:..|..|.|..|.||::....|.|.:|||.|.::.|.:.|
  Fly    53 GIPVEHLDLSGNKFLEFPTLY--ADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDS 115

  Fly   274 ----LPSEAFAGNKELRELHLQGNDLYELPKGLLHRL---EQLLVLDLS--------GNQLTSHH 323
                .|:|||.....|:.|.|.||.|.....|....|   ..|..|.||        |:|:.:. 
  Fly   116 WESLSPNEAFKYAPSLKRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQ- 179

  Fly   324 VDNSTFAGLIRLIVLNLSNNALTRIG---SKTFKELYFLQILDMRNNSIGHIEEGAFL-PLYNLH 384
                    |..|..|||:||.|.:|.   |:|      |::||:.|.||.:: .|.|| .:.||.
  Fly   180 --------LPNLERLNLANNQLAQIAALPSRT------LRVLDLSNCSIKNL-SGFFLDAMQNLE 229

  Fly   385 TLNLAEN-------------------RLH----TLDNRIFNGLYVLTKLTLNNNLVSIVESQAFR 426
            .|||:.|                   :|.    .||:...:||..||::.|..||:.:|:...|.
  Fly   230 ALNLSRNTELQFDSLSEDPILTYMLRKLDVSYCNLDSIELSGLPQLTEVRLQGNLLRVVDVNTFA 294

  Fly   427 NCSDLKELDLSSNQLTEV-PEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRIGN 490
            |.|.|:.:|||.|.|..: .:|...|..||.|:|..|:|:....|..||.:.|..|.|..|.:..
  Fly   295 NNSMLEVVDLSQNVLRHIGQDAFAKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQK 359

  Fly   491 ITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLLWLNLS 555
            :|             .:..|.:::|                                        
  Fly   360 LT-------------KIVSNSVRTI---------------------------------------- 371

  Fly   556 ENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIEL 620
                          |:.|.:|......||.:...:|:      ||.|:|.||::.......:::.
  Fly   372 --------------NMSWCEITSIESTALSSLSVIQK------LDLSNNLITDMPTFMRSETLQQ 416

  Fly   621 LFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPV-----SAEKPVPEFYLGGNP 680
            |.:.|..:..::.|||.:...||.:.|..|.|:         :|:     ...|.:.:.:||.||
  Fly   417 LNLANCRLTTVRNNTFREFPELADLHLNGNRLT---------SPIPPNYFDGNKFLDQLWLGDNP 472

  Fly   681 FECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMP 715
            :.|||.........:..|.:...:.|..::.|..|
  Fly   473 WICDCHSPLFVDFYDYLTAKPAKIKDRNHLRCAAP 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 90/296 (30%)
leucine-rich repeat 212..236 CDD:275380 5/23 (22%)
LRR_8 235..295 CDD:290566 23/63 (37%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 9/26 (35%)
LRR_8 283..345 CDD:290566 21/72 (29%)
leucine-rich repeat 285..308 CDD:275380 8/25 (32%)
leucine-rich repeat 309..334 CDD:275380 7/32 (22%)
LRR_8 334..393 CDD:290566 25/81 (31%)
leucine-rich repeat 335..358 CDD:275380 10/25 (40%)
leucine-rich repeat 359..382 CDD:275380 9/23 (39%)
LRR_8 382..441 CDD:290566 25/81 (31%)
leucine-rich repeat 383..406 CDD:275380 10/45 (22%)
leucine-rich repeat 407..430 CDD:275380 8/22 (36%)
LRR_8 431..488 CDD:290566 21/57 (37%)
leucine-rich repeat 431..451 CDD:275380 7/20 (35%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
LRR_8 477..559 CDD:290566 7/81 (9%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 2/22 (9%)
leucine-rich repeat 526..548 CDD:275380 0/21 (0%)
leucine-rich repeat 590..617 CDD:275380 7/26 (27%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 14/51 (27%)
LRRCT 679..736 CDD:214507 9/37 (24%)
leucine-rich repeat 775..796 CDD:275380
LRR_8 797..852 CDD:290566
leucine-rich repeat 797..817 CDD:275380
leucine-rich repeat 818..841 CDD:275380
LRR_8 841..900 CDD:290566
leucine-rich repeat 842..865 CDD:275380
LRR_4 866..907 CDD:289563
leucine-rich repeat 866..889 CDD:275380
leucine-rich repeat 890..911 CDD:275380
TIR 1045..1183 CDD:214587
CG5819NP_001246458.1 leucine-rich repeat 56..78 CDD:275380 5/23 (22%)
LRR_RI <58..236 CDD:238064 62/195 (32%)
LRR_8 78..141 CDD:290566 23/62 (37%)
leucine-rich repeat 79..102 CDD:275380 8/22 (36%)
leucine-rich repeat 103..130 CDD:275380 9/26 (35%)
leucine-rich repeat 131..155 CDD:275380 8/23 (35%)
LRR_8 156..214 CDD:290566 21/72 (29%)
leucine-rich repeat 158..182 CDD:275380 7/32 (22%)
LRR_8 202..285 CDD:290566 25/89 (28%)
leucine-rich repeat 204..227 CDD:275380 9/23 (39%)
leucine-rich repeat 254..274 CDD:275380 5/19 (26%)
LRR_8 273..333 CDD:290566 22/59 (37%)
leucine-rich repeat 275..298 CDD:275380 8/22 (36%)
LRR_RI 277..>471 CDD:238064 57/275 (21%)
leucine-rich repeat 299..322 CDD:275380 8/22 (36%)
LRR_8 321..402 CDD:290566 26/153 (17%)
leucine-rich repeat 323..346 CDD:275380 9/22 (41%)
leucine-rich repeat 347..391 CDD:275380 12/110 (11%)
leucine-rich repeat 392..413 CDD:275380 7/26 (27%)
LRR_8 393..448 CDD:290566 16/60 (27%)
leucine-rich repeat 414..437 CDD:275380 5/22 (23%)
LRRCT 471..517 CDD:214507 9/37 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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