DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and lbk

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_611091.2 Gene:lbk / 36788 FlyBaseID:FBgn0034083 Length:1252 Species:Drosophila melanogaster


Alignment Length:1132 Identity:252/1132 - (22%)
Similarity:397/1132 - (35%) Gaps:359/1132 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   210 SELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSL 274
            |.:|||.::.|:|.. ........|..|..:||:.|.:..: |..: |||.|:.|.::.||:.|:
  Fly   291 SYVQTLHLANNKLND-TTVLEIRNLLNLTKVSLKRNLLEVI-PKFI-GLSGLKHLVLANNHITSI 352

  Fly   275 PSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLN 339
            .||:.|....||.|.|..|.|:.:......:...|:.|.||.|::|  :|:..:||.|..|..|.
  Fly   353 SSESLAALPLLRTLDLSRNKLHTIELNSFPKSNNLVHLILSFNEIT--NVNEHSFATLNNLTDLE 415

  Fly   340 LSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGL 404
            ||||.|:.:..:.||.|..|:.|.:..|.: .|....|..|.::..|.|..|::..|.:.:|..:
  Fly   416 LSNNRLSTLPIRVFKNLNQLKKLALNFNQL-EINWSTFRGLESMKNLQLKSNKIRALQDGVFYVM 479

  Fly   405 YVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSM-LKTLDLGENQISEFK 468
            :.:..:.|..|.:|.:..|...|.:.|:.|:||.|.::.:.....:.:. |:.|||..|.|:|||
  Fly   480 HKIETIDLAMNQISSLSRQGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFK 544

  Fly   469 NNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFD--KNTEIEAIRL 531
            ......|:                        ||..||||.||:|.::...||  ||.|      
  Fly   545 PQHLDCLH------------------------RLKTLNLAHNRLQYLQENTFDCVKNLE------ 579

  Fly   532 DKNFLTDINGIFATLASLLWLNLSENHLVWF---DYAFIP----SNLKWLDIHGNYIEALGNYYK 589
                               .|||..|.|.|.   ..|..|    ..|:.||:|||.::.:..   
  Fly   580 -------------------ELNLRRNRLSWIIEDQSAAAPFKGLRKLRRLDLHGNNLKQIST--- 622

  Fly   590 LQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSK 654
                                .|||..|::|:|.:.:|.:..||.|.|....||       |.|..
  Fly   623 --------------------KAMSGLNNLEILNLGSNALASIQVNAFEHMLRL-------NKLVF 660

  Fly   655 ISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQR-INNLTTRQHPHVVDLGNIECLMPHSR 718
            .|||                      |.|||.:.|.|: :.|...:|..|.| .|..|.|:.   
  Fly   661 KSLN----------------------FICDCDLVWFQQWLKNRFPQQAEHAV-CGYPEHLLD--- 699

  Fly   719 SAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVICPGNCS--CFHDATWATNIVDCGR- 780
                |.|.|||:|:.|| .:|..|..    |.|..:...:...|.:  |...:..|.::..... 
  Fly   700 ----RHLKSLSSSELVC-VDSPKPRV----EQEPDDMLAVNAANITLECIASSPTAASLAAADEL 755

  Fly   781 -----------------QDLAALPNRIPQDVSDL------YLDGNNMP-------ELEVGHLTGR 815
                             .|.|:...:|..|:|..      ||...|:.       :..|.:..|.
  Fly   756 KIKWRHDNQHVQERPAVHDGASTETQIRHDLSTNQTSIYGYLRLTNVTYESAGRYQCVVSNAFGT 820

  Fly   816 R---------NLRALYLNASNLMTLQNGSLAQLV-NLRVLHLENNKLTALEGTEF-----RSLGL 865
            .         .:...:|...:.:||..|.:|:|| :..........|....|:||     |.|.:
  Fly   821 TYAQKFKISIGIHPTFLQVPSNLTLDAGEMARLVCSASGDPTPEIALQKFGGSEFPAATERRLQV 885

  Fly   866 LRE--LYLHNN---------MLTHIS-------NATFEPLVSLEVLRLDNNRLSSLPHLQYRHSL 912
            :||  .:|..|         ..|.:|       |||         |.:::....|:|.:.     
  Fly   886 IREENAFLITNAKPSDSGIYTCTALSAAGEIKVNAT---------LVVNDKPQPSIPLVH----- 936

  Fly   913 QGLTLGRNAWSCRCQQLRELA-----------QFVSDNAMV-----VRDAHDIYCLDAGIKRELE 961
            |.:.:||   :|..|.|.|.|           ::..:|..:     ..|....|           
  Fly   937 QEVVVGR---TCVLQCLSETANADFELEHPHREWFKENKPIHISPTAPDGDRYY----------- 987

  Fly   962 LIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPL-------------------LAAVLVLIFL 1007
                .:|..:...:|:|.:::       ||.:|..:                   |..|::|:.:
  Fly   988 ----FSNNKELLVILNAQSND-------AGHFRCEITDNSRTFTLQSELVVVKENLNWVVLLVGI 1041

  Fly  1008 VVVLIIVFVF------------RESVRMWLFAHYGVRVCEPR-FEDAGKLYDAIILHSEKDYEFV 1059
            :.|.:|..|.            ::.:||.|.|........|| ..|.|..||             
  Fly  1042 ITVTVICVVVDCCIIWCTLRYQKKKLRMSLAAERHSTQLRPRSLADLGCSYD------------- 1093

  Fly  1060 CRNIAAELEHGR-------PPFRLCIQ---------QRDLPPQASHLQLVEGARASRKIILVLTR 1108
                  |..|.|       |..:.|::         |.||..|..||...:....|...:   .|
  Fly  1094 ------EANHRRLTVMSTPPSEQRCLEQGLTLSYLRQTDLEAQQDHLSSKDSGTGSDAAV---KR 1149

  Fly  1109 NLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAEL-----SPYLKSVPSNRLLTC 1168
            .|     :..|.....|             :..:...|.|:|.|:     .||:|..        
  Fly  1150 TL-----DDFEVAMPSH-------------KHHTDDEEEEEVEEVYEENEPPYIKHT-------- 1188

  Fly  1169 DRYFWEKLRYAIPIE-LSPRGNNYTLD 1194
                 .::.||.|.: |..:.||:..|
  Fly  1189 -----YEVNYAEPEQHLFLQNNNHNYD 1210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 75/254 (30%)
leucine-rich repeat 212..236 CDD:275380 6/23 (26%)
LRR_8 235..295 CDD:290566 21/59 (36%)
leucine-rich repeat 237..260 CDD:275380 7/22 (32%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
LRR_8 283..345 CDD:290566 22/61 (36%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 10/24 (42%)
LRR_8 334..393 CDD:290566 19/58 (33%)
leucine-rich repeat 335..358 CDD:275380 10/22 (45%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
LRR_8 382..441 CDD:290566 15/58 (26%)
leucine-rich repeat 383..406 CDD:275380 5/22 (23%)
leucine-rich repeat 407..430 CDD:275380 5/22 (23%)
LRR_8 431..488 CDD:290566 15/57 (26%)
leucine-rich repeat 431..451 CDD:275380 5/19 (26%)
leucine-rich repeat 454..477 CDD:275380 10/22 (45%)
LRR_8 477..559 CDD:290566 18/83 (22%)
leucine-rich repeat 478..499 CDD:275380 0/20 (0%)
leucine-rich repeat 502..525 CDD:275380 12/24 (50%)
leucine-rich repeat 526..548 CDD:275380 0/21 (0%)
leucine-rich repeat 590..617 CDD:275380 3/26 (12%)
leucine-rich repeat 618..641 CDD:275380 7/22 (32%)
leucine-rich repeat 642..689 CDD:275380 10/46 (22%)
LRRCT 679..736 CDD:214507 20/57 (35%)
leucine-rich repeat 775..796 CDD:275380 4/38 (11%)
LRR_8 797..852 CDD:290566 12/77 (16%)
leucine-rich repeat 797..817 CDD:275380 5/41 (12%)
leucine-rich repeat 818..841 CDD:275380 7/23 (30%)
LRR_8 841..900 CDD:290566 16/81 (20%)
leucine-rich repeat 842..865 CDD:275380 6/27 (22%)
LRR_4 866..907 CDD:289563 12/58 (21%)
leucine-rich repeat 866..889 CDD:275380 9/40 (23%)
leucine-rich repeat 890..911 CDD:275380 3/20 (15%)
TIR 1045..1183 CDD:214587 28/158 (18%)
lbkNP_611091.2 LRR_RI <275..446 CDD:238064 52/160 (33%)
leucine-rich repeat 293..316 CDD:275380 6/23 (26%)
LRR_8 316..373 CDD:290566 21/58 (36%)
leucine-rich repeat 317..338 CDD:275380 7/22 (32%)
leucine-rich repeat 339..362 CDD:275380 8/22 (36%)
leucine-rich repeat 363..386 CDD:275380 6/22 (27%)
LRR_8 386..445 CDD:290566 23/60 (38%)
leucine-rich repeat 387..410 CDD:275380 10/24 (42%)
leucine-rich repeat 411..434 CDD:275380 10/22 (45%)
leucine-rich repeat 435..457 CDD:275380 6/22 (27%)
LRR_8 457..516 CDD:290566 15/58 (26%)
leucine-rich repeat 458..481 CDD:275380 5/22 (23%)
leucine-rich repeat 482..505 CDD:275380 5/22 (23%)
LRR_RI <498..669 CDD:238064 65/271 (24%)
LRR_8 504..564 CDD:290566 22/83 (27%)
leucine-rich repeat 506..529 CDD:275380 5/22 (23%)
leucine-rich repeat 530..553 CDD:275380 10/46 (22%)
leucine-rich repeat 554..577 CDD:275380 10/22 (45%)
LRR_8 576..641 CDD:290566 24/112 (21%)
leucine-rich repeat 578..604 CDD:275380 9/50 (18%)
leucine-rich repeat 607..630 CDD:275380 9/45 (20%)
leucine-rich repeat 631..652 CDD:275380 7/20 (35%)
LRRCT 665..712 CDD:214507 19/54 (35%)
IG 734..823 CDD:214652 13/88 (15%)
Ig 735..823 CDD:143165 12/87 (14%)
I-set 834..924 CDD:254352 23/98 (23%)
Ig 851..924 CDD:299845 19/81 (23%)
IG 936..1027 CDD:214652 17/120 (14%)
Ig 961..1020 CDD:143165 9/80 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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