DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and conv

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_610948.2 Gene:conv / 36588 FlyBaseID:FBgn0261269 Length:1092 Species:Drosophila melanogaster


Alignment Length:1068 Identity:253/1068 - (23%)
Similarity:430/1068 - (40%) Gaps:229/1068 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 LLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAFEG-----LMSLKRLTLESHNAVWGPGKTL 134
            |.|...|..|:   |.|..||.||....|::|.:.|.|     .:.:.|:|         .|...
  Fly   135 LSHVGLLGFGI---LGKAKELVIDGHAFQQLPKDLFAGQEIANSLGIIRVT---------NGNLS 187

  Fly   135 ELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSAL 199
            :|..::||.|::|..|.|..|                ||.||.:|:.::..              
  Fly   188 DLPIETFQPLRKLKTLDLHGN----------------QLENLKRNQFKNLR-------------- 222

  Fly   200 SNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVL 264
                       ||:.||:|.|:::.| :|...:.|.:|...::.||.:|.|:....|..|.|:||
  Fly   223 -----------ELEVLDISHNQIKKL-EAQHIADLTKLGWCNVSHNALSELSRGTFARNSVLKVL 275

  Fly   265 NISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTF 329
            ::|:|.:..|.:.:|.|.:.||.|.|..|.|.::.:|....:.::..:||:.|:|..  ::...|
  Fly   276 HLSHNQIARLDANSFRGMRFLRRLFLSDNVLTDIGRGTFGSIARIGTIDLARNRLKK--IEFQMF 338

  Fly   330 AGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLH 394
            ..:..:.:|:|:.|.:|:|...:||::| ..|:::.:|::..||..||....|:..|:|:.|||.
  Fly   339 TQMNYVELLDLAENNITKIEKNSFKDIY-QAIINVSHNALELIETAAFENCVNITVLDLSHNRLA 402

  Fly   395 TLDNRIFNGLYVLTKLTLN-NNLVSIVESQAFRNCSDLKELDLSSNQLTEVPE-AVQDLSMLKTL 457
            ....|.|:.....|...|: |||.::.:. ..:|.:.||.|:.|.|.:||:|: ....|..|.|:
  Fly   403 NFSRRSFDETTFATYFQLSYNNLTNLAQI-PIQNMTGLKVLNASYNSITEIPKNCFPKLYELHTI 466

  Fly   458 DLGENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDK 522
            |:..|.||...|..|:.|..|..:.|..|.:..|....|..||.|..::|:.|.:.|:.||:..|
  Fly   467 DVSHNNISSIFNGVFQTLFSLRSIDLSHNSMREIKSSTFGTLPTLLEMDLSHNELVSVVRGSLAK 531

  Fly   523 NTEIEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPS-------NLKWLDIHGNY 580
            .|.:..:.|:.|   .:..:|....||..|..|.|.|     ..|||       :|.:||:..|.
  Fly   532 LTSLRQLYLNNN---QLEKLFQLPISLNELYFSHNRL-----TNIPSGTWPVMNSLIYLDLSHNQ 588

  Fly   581 IEALGNYYKLQEEIRVTTLDASHNRITE--IGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLA 643
            :....|.......:.|..|...:|.|::  ..|::|.::::.|.:.||.|..::.:.|.....|.
  Fly   589 LGDTLNGESFTGLLVVQRLKLQNNGISQPPKDAVAVMSTLQYLHLENNNITTLERSAFGKLPVLF 653

  Fly   644 RVDLYANVLSKISLNA---------LRVAPVSAEKPVPEFYLG-GNPFECDCSMEWLQRINNLTT 698
            .::||.|.:..||..|         |.::....:....:.::| .:....|.|...|.:::|.| 
  Fly   654 ELNLYGNQVKDISKRAFEGLLQLLTLNLSSNGIQTLQNDIFVGLPSLRNLDLSFNSLTKLDNKT- 717

  Fly   699 RQHPHVVDLGNIECL-MPHSRSAPLRPLASLSASDFVCK--YESHCPPTCHCCEYEQCECEVICP 760
              :..:.||.::|.| :.|:|.:            ||.|  :.||        :|          
  Fly   718 --NGVLDDLLSLETLDLSHNRIS------------FVTKKTFPSH--------QY---------- 750

  Fly   761 GNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNA 825
                                         ||.::.:|.|..|.||.|......|.:.|..|.::.
  Fly   751 -----------------------------IPYNLRNLNLSYNLMPILTYDITFGTKKLVRLDVSH 786

  Fly   826 SNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTE--FRSLGLLRELYLHNNMLTHISNATFEPLV 888
            :.:..|:.|.::...:|:.|.:..|:|:.|:..|  |.....|..|.|.:|.:.|:..|....:.
  Fly   787 NQINDLRRGVISNFTSLQSLDMSYNELSNLKSEEHIFDLPQNLSWLDLSHNKIYHLPFANLVKVK 851

  Fly   889 SLEVLRLDNNRLSSLPHL---QYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIY 950
            ||:.:.|.||.|..:|..   ..|:..|.|..| |...|.| ..|.|..|:....:...|...||
  Fly   852 SLKYVDLTNNSLEDVPASIVGSMRNGSQVLLAG-NPLHCGC-NARPLKYFMLQQTIAGEDLKSIY 914

  Fly   951 CLDAGIKRELELIG-------------NLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVL 1002
            |....:.::.:||.             .:..|.|...|.|.....:.:::           |.:|
  Fly   915 CGTPALIKDKQLISLDDEYLHCAEDEQEMYKGIDYEQLTDVRFREVKTNK-----------AGML 968

  Fly  1003 VLIFLVVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAGKLYDAI------ILHSEKDYEFVCR 1061
            .|.:.|                           ..|.|....:..|      :|| :.||.:..|
  Fly   969 TLCWYV---------------------------SGFSDVSDFHVYIRSSSNDVLH-QSDYAYNNR 1005

  Fly  1062 NIAAELEH----GRPPFR---LCIQQRD 1082
            .....:|.    |....|   :||..||
  Fly  1006 TAQIPVEELSTLGEEKLRGAEICIVSRD 1033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 5/15 (33%)
leucine-rich repeat 92..115 CDD:275380 8/27 (30%)
LRR_8 115..181 CDD:404697 16/65 (25%)
leucine-rich repeat 116..146 CDD:275380 7/29 (24%)
leucine-rich repeat 147..170 CDD:275380 4/22 (18%)
leucine-rich repeat 171..201 CDD:275380 5/29 (17%)
LRR 210..592 CDD:443914 114/390 (29%)
leucine-rich repeat 212..236 CDD:275380 8/23 (35%)
leucine-rich repeat 237..260 CDD:275380 6/22 (27%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
leucine-rich repeat 285..308 CDD:275380 7/22 (32%)
leucine-rich repeat 309..334 CDD:275380 5/24 (21%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 6/22 (27%)
leucine-rich repeat 383..406 CDD:275380 7/22 (32%)
leucine-rich repeat 407..430 CDD:275380 6/23 (26%)
leucine-rich repeat 431..451 CDD:275380 8/20 (40%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
leucine-rich repeat 478..499 CDD:275380 5/20 (25%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 6/28 (21%)
leucine-rich repeat 618..641 CDD:275380 5/22 (23%)
leucine-rich repeat 642..689 CDD:275380 11/56 (20%)
LRRCT 679..736 CDD:214507 13/57 (23%)
LRR <775..>920 CDD:443914 37/149 (25%)
leucine-rich repeat 775..796 CDD:275380 2/20 (10%)
leucine-rich repeat 797..817 CDD:275380 7/19 (37%)
leucine-rich repeat 818..841 CDD:275380 4/22 (18%)
leucine-rich repeat 842..865 CDD:275380 7/24 (29%)
leucine-rich repeat 866..889 CDD:275380 6/22 (27%)
leucine-rich repeat 890..911 CDD:275380 7/23 (30%)
TIR 1045..1183 CDD:214587 13/51 (25%)
convNP_610948.2 leucine-rich repeat 125..148 CDD:275380 5/15 (33%)
leucine-rich repeat 150..175 CDD:275380 8/24 (33%)
leucine-rich repeat 176..199 CDD:275380 7/31 (23%)
PPP1R42 191..359 CDD:455733 53/211 (25%)
LRR_8 198..258 CDD:404697 21/101 (21%)
leucine-rich repeat 200..223 CDD:275380 9/63 (14%)
leucine-rich repeat 224..271 CDD:275380 14/47 (30%)
leucine-rich repeat 272..295 CDD:275380 8/22 (36%)
leucine-rich repeat 296..319 CDD:275380 7/22 (32%)
leucine-rich repeat 322..343 CDD:275380 5/22 (23%)
leucine-rich repeat 344..367 CDD:275380 8/23 (35%)
LRR 346..718 CDD:443914 103/384 (27%)
leucine-rich repeat 371..390 CDD:275380 5/18 (28%)
leucine-rich repeat 391..414 CDD:275380 7/22 (32%)
leucine-rich repeat 416..438 CDD:275380 6/22 (27%)
leucine-rich repeat 439..462 CDD:275380 9/22 (41%)
leucine-rich repeat 463..486 CDD:275380 9/22 (41%)
leucine-rich repeat 487..510 CDD:275380 6/22 (27%)
leucine-rich repeat 511..534 CDD:275380 7/22 (32%)
leucine-rich repeat 535..554 CDD:275380 3/21 (14%)
leucine-rich repeat 555..578 CDD:275380 8/27 (30%)
leucine-rich repeat 579..603 CDD:275380 5/23 (22%)
leucine-rich repeat 604..627 CDD:275380 6/22 (27%)
leucine-rich repeat 628..649 CDD:275380 5/20 (25%)
PPP1R42 631..849 CDD:455733 57/279 (20%)
leucine-rich repeat 652..672 CDD:275380 7/19 (37%)
leucine-rich repeat 700..726 CDD:275380 7/28 (25%)
leucine-rich repeat 727..745 CDD:275380 7/29 (24%)
leucine-rich repeat 779..802 CDD:275380 4/22 (18%)
leucine-rich repeat 829..852 CDD:275380 6/22 (27%)

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