DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr3

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_942086.2 Gene:Tlr3 / 364594 RGDID:735171 Length:905 Species:Rattus norvegicus


Alignment Length:1031 Identity:230/1031 - (22%)
Similarity:372/1031 - (36%) Gaps:296/1031 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   210 SELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSL 274
            |.:..|:::.|:||.||.| ..:|..:|..|....|:||.|.|.....|..|:|||:.:|.|..:
  Rat    52 SNITVLNLTHNQLRGLPPA-NFTRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQI 115

  Fly   275 PSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLN 339
            ..:.||....|.||||..|.:.::........:.|:.||||.|.|:|..:  .|...|..|..|.
  Rat   116 SDQTFAFCTNLTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKL--GTGVQLENLQELL 178

  Fly   340 LSNNALTRIGSKTFKELYF-----LQILDMRNNSIGHIEEGAF--------LPLYNLH-TLNLAE 390
            |:.|.:..:.|   :||.|     ||.||:.:|.:.....|.|        |.|.|.. .|||.|
  Rat   179 LAKNKIFALRS---EELDFLGNSSLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLNLNLTE 240

  Fly   391 NRLHTLDNRIFNGLYVLTKLTLNNNLVSIVESQAFRNC--SDLKELDLSSNQLTEV-PEAVQDLS 452
            .....|.|.      .:..|:|.||.:....:..|...  ::|..||||.|.|..| .:|...|.
  Rat   241 KLCWELSNT------SIQNLSLANNQLLATSNSTFSGLKQTNLTSLDLSYNSLRYVGNDAFSWLP 299

  Fly   453 MLKTLDLGENQISEFKNNTFRNLNQLTGLRLIDNRI-----------GNITVGMFQDLPRLSVLN 506
            .||.|.|..|.|.....::||.|:.|..|.|  .|.           .||....||.|..|..||
  Rat   300 HLKYLSLEYNNIQSLTPHSFRGLSNLRYLSL--KRAFTKQSVALASHPNIDDFSFQWLKCLEHLN 362

  Fly   507 LAKNRIQSIERGAFDKNTEIEAIRLDKNF-----LTDINGIFATLASLLWLNLSENHL------- 559
            :..|.|..|:...|.....::.:.|.|.|     ||:...:..|.:.||.|||::||:       
  Rat   363 MDDNTIPGIKSNTFTGLVSLKYLSLSKTFTGLQTLTNETFVSLTHSPLLTLNLTKNHISKIASGT 427

  Fly   560 -VWFDYAFIPSNLKWLDIHGNYIE---------ALGNYYKLQEEIRVTTLDASHNRITEIGAMSV 614
             .|.      ..|:.||:..|.||         .|||.::                         
  Rat   428 FSWL------GQLRILDLGLNEIEQELTGQEWRGLGNIFE------------------------- 461

  Fly   615 PNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGN 679
                  ::::.|...|:.:.:|.....|.|:     :|.:::|.::.::|               
  Rat   462 ------IYLSYNKYLQLTSKSFTLVPSLQRL-----MLRRVALKSVDISP--------------- 500

  Fly   680 PFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPT 744
                                                    :|.|||.:|:..|            
  Rat   501 ----------------------------------------SPFRPLYNLTILD------------ 513

  Fly   745 CHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEV 809
                                                                  |..||:..|..
  Rat   514 ------------------------------------------------------LSNNNIANLNE 524

  Fly   810 GHLTGRRNLRALYLNASNLMTLQNGS--------LAQLVNLRVLHLENNKLTALEGTEFRSLGLL 866
            ..|.|..||..|....:||..|...:        |..|.:|.:|:||:|.|..:....|::|..|
  Rat   525 DLLEGLENLEILDFQHNNLARLWKHANPGGPVNFLKGLSHLHILNLESNGLDEIPVKVFKNLFEL 589

  Fly   867 RELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPHLQYR---HSLQGLTLGRNAWSCRCQQ 928
            :.:.|..|.|..:..:.|:...||..|.|..|.::|:....:.   |:|..|.:..|.:.|.|:.
  Rat   590 KSINLGLNNLNTLLPSIFDDQTSLRSLNLQKNLITSVEKSVFGPAFHNLNSLDMSFNPFDCTCES 654

  Fly   929 LRELAQFVSDNAMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGY 993
            :.....:::.....:.:....|               |.|.|.....|.....:.||.:|.|...
  Rat   655 IAWFVTWLNQTHTNIPELSTHY---------------LCNTPQRYHGLPVKLFDTSSCKDSAPFQ 704

  Fly   994 RLPLLAAVLVLIFLVVVLIIVFVFRESVRMWLFAHY---------GVRVCE---PRFEDAGKLYD 1046
            .|.::....:|.|::.||:|.|      ..|..:.|         |.:..:   .:||     |.
  Rat   705 LLFIINTSTLLTFILAVLLIHF------EGWRISFYWNVSVHRILGFKEIDAQGEQFE-----YT 758

  Fly  1047 AIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQ-LVEGARASRKIILVLTRNL 1110
            |.|:|::||.::|..:. :.:|......:.|:::||.......|: :|...:.|||||.|:|.:|
  Rat   759 AYIIHAQKDRDWVWEHF-SPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHL 822

  Fly  1111 LATE-WNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRL 1165
            |... ..|.:..:|..:::......:::|                 :|:::|..:|
  Rat   823 LKDPLCRRFKVHHAVQQAIEQNLDSIILI-----------------FLQNIPDYKL 861

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380
LRR_RI 210..464 CDD:238064 85/270 (31%)
leucine-rich repeat 212..236 CDD:275380 8/23 (35%)
LRR_8 235..295 CDD:290566 22/59 (37%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 8/22 (36%)
LRR_8 283..345 CDD:290566 20/61 (33%)
leucine-rich repeat 285..308 CDD:275380 6/22 (27%)
leucine-rich repeat 309..334 CDD:275380 10/24 (42%)
LRR_8 334..393 CDD:290566 22/72 (31%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
leucine-rich repeat 359..382 CDD:275380 9/30 (30%)
LRR_8 382..441 CDD:290566 18/61 (30%)
leucine-rich repeat 383..406 CDD:275380 6/23 (26%)
leucine-rich repeat 407..430 CDD:275380 5/24 (21%)
LRR_8 431..488 CDD:290566 22/57 (39%)
leucine-rich repeat 431..451 CDD:275380 9/20 (45%)
leucine-rich repeat 454..477 CDD:275380 9/22 (41%)
LRR_8 477..559 CDD:290566 28/97 (29%)
leucine-rich repeat 478..499 CDD:275380 8/31 (26%)
leucine-rich repeat 502..525 CDD:275380 7/22 (32%)
leucine-rich repeat 526..548 CDD:275380 6/26 (23%)
leucine-rich repeat 590..617 CDD:275380 0/26 (0%)
leucine-rich repeat 618..641 CDD:275380 3/22 (14%)
leucine-rich repeat 642..689 CDD:275380 5/46 (11%)
LRRCT 679..736 CDD:214507 6/56 (11%)
leucine-rich repeat 775..796 CDD:275380 0/20 (0%)
LRR_8 797..852 CDD:290566 19/62 (31%)
leucine-rich repeat 797..817 CDD:275380 6/19 (32%)
leucine-rich repeat 818..841 CDD:275380 7/30 (23%)
LRR_8 841..900 CDD:290566 18/58 (31%)
leucine-rich repeat 842..865 CDD:275380 8/22 (36%)
LRR_4 866..907 CDD:289563 11/40 (28%)
leucine-rich repeat 866..889 CDD:275380 5/22 (23%)
leucine-rich repeat 890..911 CDD:275380 5/23 (22%)
TIR 1045..1183 CDD:214587 28/123 (23%)