DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Tlr12

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001102152.1 Gene:Tlr12 / 362604 RGDID:1559145 Length:904 Species:Rattus norvegicus


Alignment Length:1011 Identity:219/1011 - (21%)
Similarity:337/1011 - (33%) Gaps:327/1011 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 NANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLN 265
            |..|....|| :.||         ||||:.|....:...|:|   :::.|.|.||.||..||  |
  Rat    70 NVEGLCLSGS-VSTL---------LPDAFSAFPGLKFLGLNL---HLTRLLPGALRGLGQLR--N 119

  Fly   266 ISY------NHLVSLPSEAFAGNKELRELHLQGNDL-----YELPKGLLHRLEQLLVLDLSGNQL 319
            :|:      .:.:.||.:||.....|:.||..|..|     ..||..|     |.|.:.:|..| 
  Rat   120 LSFVDQPSGKNSLFLPPDAFGDLISLQRLHFCGPCLNKKAGVRLPSSL-----QWLSVTISCLQ- 178

  Fly   320 TSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYF------------------LQILDMRN 366
                 |:...||:...:|.|.|:.|     |.|.|:|..                  ::|||:|.
  Rat   179 -----DSGELAGIFPDLVQNSSSRA-----SWTLKKLDLSLNQKLKMATPGSLQGLQVEILDLRK 233

  Fly   367 NSIGHIEEGAFLPLYNLHTLNL-----------AENRLHTLDNRIFNGLYVLTKLTLNNNLVSIV 420
            .   .::.||...| .|..||:           ||...|          :.|..|.::.:.:..:
  Rat   234 T---QLDAGAVKGL-GLQKLNVLYAPTATAELAAETAAH----------FELQGLNVDRSKIGNI 284

  Fly   421 ESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLID 485
            ..:|..:|..|:.|.||...||::|.                                       
  Rat   285 SQEALASCHSLETLSLSDTGLTKLPP--------------------------------------- 310

  Fly   486 NRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLL 550
                    |....:|||..||||.|::||              ..|..|...|::|         
  Rat   311 --------GFLAAMPRLRRLNLAGNQLQS--------------TMLCMNETGDVSG--------- 344

  Fly   551 WLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMS-V 614
                                |..||:.||.:                       ||......| :
  Rat   345 --------------------LSTLDLSGNGL-----------------------RILPPATFSCL 366

  Fly   615 PNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGN 679
            |:..|||..:|.:: .::.:.|.|..:|..:.|..|.|..:..|.|...|.              
  Rat   367 PHLRELLLQDNQLL-SLEGHPFQDLQQLETLKLDRNPLLNLGKNCLAALPA-------------- 416

  Fly   680 PFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPL---ASLSASDFVCKYESHC 741
                      |..::.|.| |..|..|.|.......|:....|.||   |.||...::...|.|.
  Rat   417 ----------LTTLSLLDT-QILHSPDAGFWGARSLHTLHLSLPPLSAPAVLSLPMYLTSLELHV 470

  Fly   742 PPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPE 806
            .|                                   |.:.....||..| .:..|.::|.    
  Rat   471 TP-----------------------------------GLKHWTLSPNIFP-FLETLTINGR---- 495

  Fly   807 LEVGHLTGRRNLRALYLNASNLMTLQNG---------------SLAQLVNLRVLHLENNKLTALE 856
               |...|.:|...::....:|..|||.               .|.:|.:|:|....:|....| 
  Rat   496 ---GLKLGVQNASEVFPALQHLFLLQNSLDAFCSQDASSIFLWQLPKLQSLKVWGAGSNSRPCL- 556

  Fly   857 GTEFRSLGLLRELYLHN-NMLTHISNATFEPLV----SLEVLRLDNNRLSSLPHLQYR--HSLQG 914
               ...|..|:||.|.: ..:|...:...|.||    .|:.|:|.:..|.||....:|  ||||.
  Rat   557 ---ITGLPSLQELKLESLQSITQPRSVQLEELVGDLPQLQALQLSSTGLKSLSAAAFRRLHSLQA 618

  Fly   915 LTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDA----GIKRELELIGNLANGPDCSDL 975
            |.|...........|||.:..:.....:::......|.:|    .:|:..:...::.:|..|...
  Rat   619 LVLDSEKDLVLQDSLREYSPQMPRYVYILQSKLACQCANAWMELWVKQSTKTYVHIRDGHLCPGE 683

  Fly   976 LDASASNISSS-------QDLAGGYRLPLLAAVLVLIFLVVVLI-------IVFVFRESVRMWLF 1026
            :...|.:...|       |.|.  .:|.|.::.|||:.:|:.|:       |.:: |...|:||.
  Rat   684 VRVPARDSLISFLWDHCPQTLE--LKLFLASSALVLLLIVLPLLQGARNTWIPYL-RALFRIWLQ 745

  Fly  1027 AHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRPP---FRLCIQQRDLPPQAS 1088
            ...|......||     |:|..:.|..:|..:|...:...||...|.   .|||:.:||..|...
  Rat   746 GLRGQGNAGKRF-----LFDVFVSHCRQDQGWVLEELLPALEGFLPAGLGLRLCLPERDFEPGKD 805

  Fly  1089 HL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNA 1123
            .: .:|:...:||..:.||:...|......:|.|.|
  Rat   806 VVDNVVDSMVSSRVTLCVLSGPALCNPRCCLELRLA 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:290566
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 219/1011 (22%)
LRR_RI 210..464 CDD:238064 71/293 (24%)
leucine-rich repeat 212..236 CDD:275380 7/23 (30%)
LRR_8 235..295 CDD:290566 20/65 (31%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 8/28 (29%)
LRR_8 283..345 CDD:290566 18/66 (27%)
leucine-rich repeat 285..308 CDD:275380 8/27 (30%)
leucine-rich repeat 309..334 CDD:275380 6/24 (25%)
LRR_8 334..393 CDD:290566 20/87 (23%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 7/22 (32%)
LRR_8 382..441 CDD:290566 14/69 (20%)
leucine-rich repeat 383..406 CDD:275380 6/33 (18%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
LRR_8 431..488 CDD:290566 7/56 (13%)
leucine-rich repeat 431..451 CDD:275380 7/19 (37%)
leucine-rich repeat 454..477 CDD:275380 0/22 (0%)
LRR_8 477..559 CDD:290566 15/81 (19%)
leucine-rich repeat 478..499 CDD:275380 1/20 (5%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
leucine-rich repeat 526..548 CDD:275380 4/21 (19%)
leucine-rich repeat 590..617 CDD:275380 4/27 (15%)
leucine-rich repeat 618..641 CDD:275380 6/22 (27%)
leucine-rich repeat 642..689 CDD:275380 7/46 (15%)
LRRCT 679..736 CDD:214507 14/59 (24%)
leucine-rich repeat 775..796 CDD:275380 4/20 (20%)
LRR_8 797..852 CDD:290566 14/69 (20%)
leucine-rich repeat 797..817 CDD:275380 4/19 (21%)
leucine-rich repeat 818..841 CDD:275380 6/37 (16%)
LRR_8 841..900 CDD:290566 16/63 (25%)
leucine-rich repeat 842..865 CDD:275380 5/22 (23%)
LRR_4 866..907 CDD:289563 14/45 (31%)
leucine-rich repeat 866..889 CDD:275380 8/27 (30%)
leucine-rich repeat 890..911 CDD:275380 7/22 (32%)
TIR 1045..1183 CDD:214587 22/83 (27%)
Tlr12NP_001102152.1 leucine-rich repeat 71..93 CDD:275380 10/31 (32%)
leucine-rich repeat 94..116 CDD:275380 8/24 (33%)
leucine-rich repeat 117..144 CDD:275380 8/28 (29%)
leucine-rich repeat 202..225 CDD:275380 2/22 (9%)
leucine-rich repeat 226..270 CDD:275380 13/57 (23%)
leucine-rich repeat 246..259 CDD:275381 3/12 (25%)
LRR_8 270..329 CDD:290566 20/105 (19%)
leucine-rich repeat 271..294 CDD:275380 4/22 (18%)
LRR_4 294..331 CDD:289563 16/83 (19%)
leucine-rich repeat 295..318 CDD:275380 8/69 (12%)
leucine-rich repeat 319..344 CDD:275380 11/38 (29%)
LRR_8 343..403 CDD:290566 19/112 (17%)
LRR_RI 345..547 CDD:238064 56/293 (19%)
leucine-rich repeat 345..368 CDD:275380 8/45 (18%)
leucine-rich repeat 369..392 CDD:275380 6/23 (26%)
leucine-rich repeat 393..416 CDD:275380 6/22 (27%)
leucine-rich repeat 417..437 CDD:275380 7/20 (35%)
leucine-rich repeat 441..510 CDD:275380 19/111 (17%)
leucine-rich repeat 511..562 CDD:275380 11/54 (20%)
leucine-rich repeat 563..591 CDD:275380 8/27 (30%)
leucine-rich repeat 592..615 CDD:275380 7/22 (32%)
TIR 759..900 CDD:214587 22/83 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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