DRSC/TRiP Functional Genomics Resources

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Protein Alignment 18w and Tlr12

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_001102152.1 Gene:Tlr12 / 362604 RGDID:1559145 Length:904 Species:Rattus norvegicus


Alignment Length:1013 Identity:221/1013 - (21%)
Similarity:341/1013 - (33%) Gaps:331/1013 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   201 NANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLN 265
            |..|....|| :.||         ||||:.|....:...|:|   :::.|.|.||.||..||  |
  Rat    70 NVEGLCLSGS-VSTL---------LPDAFSAFPGLKFLGLNL---HLTRLLPGALRGLGQLR--N 119

  Fly   266 ISY------NHLVSLPSEAFAGNKELRELHLQGNDL-----YELPKGLLHRLEQLLVLDLSGNQL 319
            :|:      .:.:.||.:||.....|:.||..|..|     ..||..|     |.|.:.:|..| 
  Rat   120 LSFVDQPSGKNSLFLPPDAFGDLISLQRLHFCGPCLNKKAGVRLPSSL-----QWLSVTISCLQ- 178

  Fly   320 TSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYF------------------LQILDMRN 366
                 |:...||:...:|.|.|:.|     |.|.|:|..                  ::|||:|.
  Rat   179 -----DSGELAGIFPDLVQNSSSRA-----SWTLKKLDLSLNQKLKMATPGSLQGLQVEILDLRK 233

  Fly   367 NSIGHIEEGAFLPLYNLHTLNL-----------AENRLHTLDNRIFNGLYVLTKLTLNNNLVSIV 420
            .   .::.||...| .|..||:           ||...|          :.|..|.::.:.:..:
  Rat   234 T---QLDAGAVKGL-GLQKLNVLYAPTATAELAAETAAH----------FELQGLNVDRSKIGNI 284

  Fly   421 ESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQLTGLRLID 485
            ..:|..:|..|:.|.||...||::|.                                       
  Rat   285 SQEALASCHSLETLSLSDTGLTKLPP--------------------------------------- 310

  Fly   486 NRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKNFLTDINGIFATLASLL 550
                    |....:|||..||||.|::||              ..|..|...|::|         
  Rat   311 --------GFLAAMPRLRRLNLAGNQLQS--------------TMLCMNETGDVSG--------- 344

  Fly   551 WLNLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMS-V 614
                                |..||:.||.:                       ||......| :
  Rat   345 --------------------LSTLDLSGNGL-----------------------RILPPATFSCL 366

  Fly   615 PNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYLGGN 679
            |:..|||..:|.:: .::.:.|.|..:|..:.|..|.|..:..|.|...|.              
  Rat   367 PHLRELLLQDNQLL-SLEGHPFQDLQQLETLKLDRNPLLNLGKNCLAALPA-------------- 416

  Fly   680 PFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMPHSRSAPLRPL---ASLSASDFVCKYESHC 741
                      |..::.|.| |..|..|.|.......|:....|.||   |.||...::...|.|.
  Rat   417 ----------LTTLSLLDT-QILHSPDAGFWGARSLHTLHLSLPPLSAPAVLSLPMYLTSLELHV 470

  Fly   742 PPTCHCCEYEQCECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPE 806
            .|                                   |.:.....||..| .:..|.::|.    
  Rat   471 TP-----------------------------------GLKHWTLSPNIFP-FLETLTINGR---- 495

  Fly   807 LEVGHLTGRRNLRALYLNASNLMTLQNG---------------SLAQLVNLRVLHLENNKLTALE 856
               |...|.:|...::....:|..|||.               .|.:|.:|:|....:|....| 
  Rat   496 ---GLKLGVQNASEVFPALQHLFLLQNSLDAFCSQDASSIFLWQLPKLQSLKVWGAGSNSRPCL- 556

  Fly   857 GTEFRSLGLLRELYLHN-NMLTHISNATFEPLV----SLEVLRLDNNRLSSLPHLQYR--HSLQG 914
               ...|..|:||.|.: ..:|...:...|.||    .|:.|:|.:..|.||....:|  ||||.
  Rat   557 ---ITGLPSLQELKLESLQSITQPRSVQLEELVGDLPQLQALQLSSTGLKSLSAAAFRRLHSLQA 618

  Fly   915 LTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDIYCLDA----GIKRELELIGNLANGPDCSDL 975
            |.|...........|||.:..:.....:::......|.:|    .:|:..:...::.:|..|...
  Rat   619 LVLDSEKDLVLQDSLREYSPQMPRYVYILQSKLACQCANAWMELWVKQSTKTYVHIRDGHLCPGE 683

  Fly   976 LDASASNISSS-------QDLAGGYRLPLLAAVLVLIFLVVVLI-------IVFVFRESVRMWLF 1026
            :...|.:...|       |.|.  .:|.|.::.|||:.:|:.|:       |.:: |...|:|| 
  Rat   684 VRVPARDSLISFLWDHCPQTLE--LKLFLASSALVLLLIVLPLLQGARNTWIPYL-RALFRIWL- 744

  Fly  1027 AHYGVRVCEPRFEDAGK--LYDAIILHSEKDYEFVCRNIAAELEHGRPP---FRLCIQQRDLPPQ 1086
              .|:|    ...:|||  |:|..:.|..:|..:|...:...||...|.   .|||:.:||..|.
  Rat   745 --QGLR----GQGNAGKRFLFDVFVSHCRQDQGWVLEELLPALEGFLPAGLGLRLCLPERDFEPG 803

  Fly  1087 ASHL-QLVEGARASRKIILVLTRNLLATEWNRIEFRNA 1123
            ...: .:|:...:||..:.||:...|......:|.|.|
  Rat   804 KDVVDNVVDSMVSSRVTLCVLSGPALCNPRCCLELRLA 841

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380
leucine-rich repeat 92..115 CDD:275380
LRR_8 115..181 CDD:404697
leucine-rich repeat 116..146 CDD:275380
leucine-rich repeat 147..170 CDD:275380
leucine-rich repeat 171..201 CDD:275380 221/1013 (22%)
LRR 210..592 CDD:443914 91/421 (22%)
leucine-rich repeat 212..236 CDD:275380 7/23 (30%)
leucine-rich repeat 237..260 CDD:275380 8/22 (36%)
leucine-rich repeat 261..284 CDD:275380 8/28 (29%)
leucine-rich repeat 285..308 CDD:275380 8/27 (30%)
leucine-rich repeat 309..334 CDD:275380 6/24 (25%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 7/22 (32%)
leucine-rich repeat 383..406 CDD:275380 6/33 (18%)
leucine-rich repeat 407..430 CDD:275380 4/22 (18%)
leucine-rich repeat 431..451 CDD:275380 7/19 (37%)
leucine-rich repeat 454..477 CDD:275380 0/22 (0%)
leucine-rich repeat 478..499 CDD:275380 1/20 (5%)
leucine-rich repeat 502..525 CDD:275380 8/22 (36%)
leucine-rich repeat 526..548 CDD:275380 4/21 (19%)
leucine-rich repeat 590..617 CDD:275380 4/27 (15%)
leucine-rich repeat 618..641 CDD:275380 6/22 (27%)
leucine-rich repeat 642..689 CDD:275380 7/46 (15%)
LRRCT 679..736 CDD:214507 14/59 (24%)
LRR <775..>920 CDD:443914 41/166 (25%)
leucine-rich repeat 775..796 CDD:275380 4/20 (20%)
leucine-rich repeat 797..817 CDD:275380 4/19 (21%)
leucine-rich repeat 818..841 CDD:275380 6/37 (16%)
leucine-rich repeat 842..865 CDD:275380 5/22 (23%)
leucine-rich repeat 866..889 CDD:275380 8/27 (30%)
leucine-rich repeat 890..911 CDD:275380 7/22 (32%)
TIR 1045..1183 CDD:214587 22/83 (27%)
Tlr12NP_001102152.1 leucine-rich repeat 71..93 CDD:275380 10/31 (32%)
leucine-rich repeat 94..116 CDD:275380 8/24 (33%)
leucine-rich repeat 117..144 CDD:275380 8/28 (29%)
LRR <202..516 CDD:443914 90/509 (18%)
leucine-rich repeat 202..225 CDD:275380 2/22 (9%)
leucine-rich repeat 226..270 CDD:275380 13/57 (23%)
leucine-rich repeat 271..294 CDD:275380 4/22 (18%)
leucine-rich repeat 295..318 CDD:275380 8/69 (12%)
leucine-rich repeat 319..344 CDD:275380 11/38 (29%)
leucine-rich repeat 345..368 CDD:275380 8/45 (18%)
leucine-rich repeat 369..392 CDD:275380 6/23 (26%)
PPP1R42 390..645 CDD:455733 68/326 (21%)
leucine-rich repeat 393..416 CDD:275380 6/22 (27%)
leucine-rich repeat 417..437 CDD:275380 7/20 (35%)
leucine-rich repeat 441..510 CDD:275380 19/111 (17%)
leucine-rich repeat 511..562 CDD:275380 11/54 (20%)
leucine-rich repeat 563..591 CDD:275380 8/27 (30%)
leucine-rich repeat 592..615 CDD:275380 7/22 (32%)
TIR 759..900 CDD:214587 22/83 (27%)
Blue background indicates that the domain is not in the aligned region.

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