DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and rdo

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	847	Identity:	188/847 - (22%)
Similarity:	308/847 - (36%)	Gaps:	220/847 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 NNIRQLPEGVWCSMPSLQL---------LN--LTQNR----IRSAEFLGFSEKLCAGSALSNANG 204
            |..|:.|....|||..|..         ||  |:.|.    ::.....|....:..|.||...
  Fly    19 NTKRKCPTECQCSMDDLDRYQAICTKGGLNSLLSPNELDVDVKVIIIRGPRNSITIGPALRQF-- 81

  Fly   205 AVSGGSELQTLDVSFNELRSL--PDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNIS 267
                 .:|:.|.::.:.|.::  ...||   |:.|:.|.|..|||:.:..|...|..:|..|::|
  Fly    82 -----MKLEILRITDSNLPAIGAESFWG---LKYLRILDLSKNNITNITENNFRGQDNLLELDLS 138

  Fly   268 YNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGL 332
            .|.::.:.|..|....:||.|:|..|.:.||.:.....|.:|..||||||.|.....|  .|..:
  Fly   139 KNKVLRMASSTFRHLTDLRRLNLADNSIVELVQRNFFMLSRLKYLDLSGNPLQDLQPD--VFRDV 201

  Fly   333 IRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLD 397
            ..|.||...|..|.:|..:.:..|..|..||:..|....:::..|..:..|..:.|..|:|..:.
  Fly   202 PELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLDKDEFRDVKRLTKVLLDGNQLSVVV 266

  Fly   398 NRIFNGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEV-PEAVQDLSMLKTLDLGE 461
            :::|.....|..|.|:.|.::.|.:.:|...::|..||||.|:|..: |::::.||.|.||::..
  Fly   267 DQLFRMQKSLNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISG 331

  Fly   462 NQISEFK--NNTFRNL----------------NQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLA 508
            |.:.:.:  ..||..|                .|||.|.:.|  :|.:.||:.....:|..||::
  Fly   332 NVLMDLREMRETFEPLIYYFFLTCSKLFFQLIPQLTHLAIAD--MGTMPVGLLHPFKQLRYLNIS 394

  Fly   509 KNRIQSIERGAFDKNTEIEAIRLDKNFLTDIN-GIFATLASLLWLNLSENHLV------------ 560
            .|.:.:......|...|:|.:.|.:|.|..|: .....:..:..:.|..|.|:
  Fly   395 GNSLNNTALEVIDPCRELEFLDLSRNQLHGISEDTVLRIQGIRNVRLDNNPLICDECHMGKLINV 459

  Fly   561 -------WFDY--AFIPSNLKW-----LDIHG--------------------NYIE--------A 583
                   |..|  .|:|.:|:.     |||:|                    |::|        .
  Fly   460 VRQLQWKWDTYPICFLPKSLRGAEINNLDINGLHTCLTFITDEEQNAASTSYNFLEHGGLNTLAI 524

  Fly   584 LGNYYKLQEEIRVTTLDA--SHNRITEIGAMSVPNSIELLFINNNI-------IGQIQANTFVDK 639
            ||....:...:.:.:|.|  |.||..........|..|...:..|:       :|...:.|....
  Fly   525 LGGIIFVLIAVIILSLVACFSKNRARYYTREDHLNGSESKCLEKNLEATTITTLGNGSSPTTTTT 589

  Fly   640 TRLARVDLYANVLSKISLNALRVAPVSAEKPV--------PEFYLGGNPFECD---CSMEWLQRI 693
            ..||......|. .|.:...|.::|.:...||        .|...   .|..|   |:::.|...
  Fly   590 LTLATSPAAPNG-PKTNGQGLSLSPANGSTPVHGISDDKGKEINF---TFPVDDRVCTIDELMPS 650

  Fly   694 NNLTTRQHPHVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQCECEVI 758
            .....:|||| .::|::...:.||.:: ...||:::|:                       ..||
  Fly   651 PPPPPQQHPH-PNMGSLMYSVSHSPNS-ATTLAAVAAA-----------------------ATVI 690

  Fly   759 CPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYL 823
            .||..|  |.:              ...|...|.:...:.|....:|..:..|
  Fly   691 PPGAPS--HSS--------------MPTPTPTPAEAVVVVLPPPPLPPQQHHH------------ 727

  Fly   824 NASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLV 888
                   ..:||||.                           |||:   ...|.|:| :|.||||
  Fly   728 -------QMDGSLAS---------------------------LREV---QQQLVHLS-STLEPLV 754

  Fly   889 SL 890
            |:
  Fly   755 SV 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566	11/40 (28%)
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380	6/14 (43%)
		leucine-rich repeat	171..201	CDD:275380	9/44 (20%)
		LRR_RI	210..464	CDD:238064	75/256 (29%)
		leucine-rich repeat	212..236	CDD:275380	6/25 (24%)
		LRR_8	235..295	CDD:290566	19/59 (32%)
		leucine-rich repeat	237..260	CDD:275380	8/22 (36%)
		leucine-rich repeat	261..284	CDD:275380	6/22 (27%)
		LRR_8	283..345	CDD:290566	22/61 (36%)
		leucine-rich repeat	285..308	CDD:275380	8/22 (36%)
		leucine-rich repeat	309..334	CDD:275380	10/24 (42%)
		LRR_8	334..393	CDD:290566	15/58 (26%)
		leucine-rich repeat	335..358	CDD:275380	7/22 (32%)
		leucine-rich repeat	359..382	CDD:275380	5/22 (23%)
		LRR_8	382..441	CDD:290566	17/58 (29%)
		leucine-rich repeat	383..406	CDD:275380	5/22 (23%)
		leucine-rich repeat	407..430	CDD:275380	6/22 (27%)
		LRR_8	431..488	CDD:290566	22/75 (29%)
		leucine-rich repeat	431..451	CDD:275380	8/20 (40%)
		leucine-rich repeat	454..477	CDD:275380	7/40 (18%)
		LRR_8	477..559	CDD:290566	21/82 (26%)
		leucine-rich repeat	478..499	CDD:275380	7/20 (35%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		leucine-rich repeat	526..548	CDD:275380	5/22 (23%)
		leucine-rich repeat	590..617	CDD:275380	5/28 (18%)
		leucine-rich repeat	618..641	CDD:275380	4/29 (14%)
		leucine-rich repeat	642..689	CDD:275380	12/57 (21%)
		LRRCT	679..736	CDD:214507	14/59 (24%)
		leucine-rich repeat	775..796	CDD:275380	2/20 (10%)
		LRR_8	797..852	CDD:290566	7/54 (13%)
		leucine-rich repeat	797..817	CDD:275380	3/19 (16%)
		leucine-rich repeat	818..841	CDD:275380	4/22 (18%)
		LRR_8	841..900	CDD:290566	12/50 (24%)
		leucine-rich repeat	842..865	CDD:275380	0/22 (0%)
		LRR_4	866..907	CDD:289563	12/25 (48%)
		leucine-rich repeat	866..889	CDD:275380	10/22 (45%)
		leucine-rich repeat	890..911	CDD:275380	0/1 (0%)
		TIR	1045..1183	CDD:214587
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	6/25 (24%)
		leucine-rich repeat	108..131	CDD:275380	8/22 (36%)
		LRR_8	131..190	CDD:290566	21/58 (36%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		LRR_RI	151..422	CDD:238064	75/274 (27%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		LRR_8	178..262	CDD:290566	25/85 (29%)
		leucine-rich repeat	180..203	CDD:275380	10/24 (42%)
		leucine-rich repeat	204..251	CDD:275380	12/46 (26%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
		LRR_8	274..334	CDD:290566	20/59 (34%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR_4	298..342	CDD:289563	14/43 (33%)
		leucine-rich repeat	300..323	CDD:275380	9/22 (41%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740