DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment 18w and CG18480

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001285960.1	Gene:	CG18480 / 34920	FlyBaseID:	FBgn0028518	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	308	Identity:	80/308 - (25%)
Similarity:	127/308 - (41%)	Gaps:	65/308 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 LCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAG 257
            :|:...|.:||..:....||  ||:|:|::.::.|....:.: .|..|:|.||.|.||..:|...
  Fly    59 VCSAKRLISANIEIPTTVEL--LDLSYNDITTIDDDSFKTTI-HLLNLTLAHNAIHTLYGDAFVE 120

  Fly   258 LSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSH 322
            |:.||.|::|||.|..:.......|.:|..|:|:||.|..|.||.:.|...|.
  Fly   121 LTRLRYLDLSYNRLEQIDEHILESNNQLIHLNLEGNKLSTLGKGPILRSPSLR------------ 173

  Fly   323 HVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLN 387
                          .|||.|:.:.::|::....|..|:.||:..|.:..:..|.|....||.:||
  Fly   174 --------------SLNLRNSQVNQLGTQLLSALPQLRQLDLAQNLLLTLSPGDFHAPRNLASLN 224

  Fly   388 LAENRLHTLDNRIFNGLYVLTKLT--LNNNLVSIVESQAFRNCSDLKELDLSSN----------- 439
            :.||.        ||....|.|:.  |....|:|..|    ||.:.:..|...:
  Fly   225 VEENP--------FNCDRALAKVATGLRQRGVAIFMS----NCMEEEVQDHQDDAEAVNFPNKNE 277

  Fly   440 ---------QLTEVPEAVQDLSMLKTLDLGENQISEFKNNTFRNLNQL 478
                     ..|..|::|  ||:.:.||..|.|.|...:....:|:.:
  Fly   278 KFESMEYLEPSTRGPQSV--LSVWRDLDSSEEQNSSQDDEQMSSLSDV 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380	2/7 (29%)
		LRR_RI	210..464	CDD:238064	73/275 (27%)
		leucine-rich repeat	212..236	CDD:275380	6/23 (26%)
		LRR_8	235..295	CDD:290566	23/59 (39%)
		leucine-rich repeat	237..260	CDD:275380	10/22 (45%)
		leucine-rich repeat	261..284	CDD:275380	8/22 (36%)
		LRR_8	283..345	CDD:290566	15/61 (25%)
		leucine-rich repeat	285..308	CDD:275380	10/22 (45%)
		leucine-rich repeat	309..334	CDD:275380	1/24 (4%)
		LRR_8	334..393	CDD:290566	18/58 (31%)
		leucine-rich repeat	335..358	CDD:275380	6/22 (27%)
		leucine-rich repeat	359..382	CDD:275380	6/22 (27%)
		LRR_8	382..441	CDD:290566	17/80 (21%)
		leucine-rich repeat	383..406	CDD:275380	7/22 (32%)
		leucine-rich repeat	407..430	CDD:275380	8/24 (33%)
		LRR_8	431..488	CDD:290566	12/68 (18%)
		leucine-rich repeat	431..451	CDD:275380	4/39 (10%)
		leucine-rich repeat	454..477	CDD:275380	6/22 (27%)
		LRR_8	477..559	CDD:290566	0/2 (0%)
		leucine-rich repeat	478..499	CDD:275380	0/1 (0%)
		leucine-rich repeat	502..525	CDD:275380
		leucine-rich repeat	526..548	CDD:275380
		leucine-rich repeat	590..617	CDD:275380
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
CG18480	NP_001285960.1	LRR_8	74..134	CDD:290566	23/62 (37%)
		LRR_RI	<76..230	CDD:238064	54/190 (28%)
		leucine-rich repeat	76..99	CDD:275380	7/25 (28%)
		leucine-rich repeat	100..123	CDD:275380	10/22 (45%)
		LRR_8	122..182	CDD:290566	23/85 (27%)
		leucine-rich repeat	124..147	CDD:275380	8/22 (36%)
		leucine-rich repeat	148..171	CDD:275380	10/22 (45%)
		LRR_8	170..230	CDD:290566	19/93 (20%)
		leucine-rich repeat	172..195	CDD:275380	7/48 (15%)
		leucine-rich repeat	196..219	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468851
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930