DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and CG16974

DIOPT Version :10

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0287775 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_609610.2 Gene:CG16974 / 34713 FlyBaseID:FBgn0032479 Length:1257 Species:Drosophila melanogaster


Alignment Length:1476 Identity:288/1476 - (19%)
Similarity:475/1476 - (32%) Gaps:603/1476 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 ESGTGTPLD--------LQVAE----AAGRLD-------LQC--------SQELLHASELAPGLF 86
            :|..|..||        ::|.|    :.|.:|       |.|        :||||.         
  Fly    89 DSDEGLWLDAADAGSESVEVEEHELPSVGHVDPTGNVFKLNCEHVDLRRVNQELLS--------- 144

  Fly    87 RQLQKLSELRIDACKLQRVP-----PNAFEGLMSLKRLTLESHNAVWGPGKTL-ELHGQSFQGLK 145
               |:.|.:..:...|..||     |.....|.||:..:.:|...   ..:|| ||..:..:..:
  Fly   145 ---QRSSHINYNQLMLAHVPADRSNPLKLPQLESLREFSWQSSEL---KDETLMELFTRQPRSFE 203

  Fly   146 ELSELHLGDNNIRQLPEGVWCSMPSLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGS 210
            .:..|:|.:|.:..|...:..::..:::|.::.||:.:...|..                     
  Fly   204 YMERLNLAENRLECLHWAIPLAVRRVKVLEMSGNRLSNCSLLNL--------------------- 247

  Fly   211 ELQTLDVSFNELRSLPDAWGASRLRRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLP 275
                                 ..:::||.|.|..:.::.|....|..||.||:||:|.|.|..||
  Fly   248 ---------------------QYMKQLQELHLDRSELTYLPQRFLGELSELRMLNLSQNLLTELP 291

  Fly   276 SEAFAGNKELRELHLQGNDLYELPKGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNL 340
            .:.|.|..:|..|:|.||.|..||..|......|.|||||.|:|.|  ..::.||...:|..|:|
  Fly   292 RDIFVGALKLERLYLSGNRLSVLPFMLFQTAADLQVLDLSDNRLLS--FPDNFFARNGQLRQLHL 354

  Fly   341 SNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLY 405
            ..|.|..||..:...|..|:.||:..||:..|:..||..|.:|..||::.|.|..|.:.||..|:
  Fly   355 QRNQLKSIGKHSLYSLRELRQLDLSQNSLSVIDRKAFESLDHLLALNVSGNNLTLLSSIIFQSLH 419

  Fly   406 VLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAV-QDLSMLKTLDLGENQISEFKN 469
            .                        |::||||.||..::|..: |....|..|.:.|..|.:|.|
  Fly   420 A------------------------LRQLDLSRNQFKQLPSGLFQRQRSLVLLRIDETPIEQFSN 460

  Fly   470 NTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRLDKN 534
            ...|....     |:|.::          |.||..|::.:||          |.|.:.|.     
  Fly   461 WISRYDES-----LVDPQV----------LHRLRYLSVQQNR----------KLTYLPAT----- 495

  Fly   535 FLTDINGIFATLASLLWLNLSENHLVWFDYAFIP------SNLKWLDIHGNYIEALGNYYKLQEE 593
                   :||...::..|.|:||.|:.     :|      |.|:.|.:.||   :||        
  Fly   496 -------LFANTPNIRELLLAENGLLQ-----LPTQISGLSRLQRLSVRGN---SLG-------- 537

  Fly   594 IRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYANVLSKISLN 658
                               |:|.:|:.|                      |...|.|:|      
  Fly   538 -------------------SLPENIKEL----------------------RQLHYLNIL------ 555

  Fly   659 ALRVAPVSAEKPVPEFYLGGNPFECDCSMEWL------------------QRINNLTTRQHP--- 702
                               ||.::|||||.||                  |..:|.:|.|.|   
  Fly   556 -------------------GNEYQCDCSMYWLTAWLANTSTSLRHQMPQAQNHSNGSTNQTPLDS 601

  Fly   703 -----HVVDLGNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCH-CCEYEQCECEVICPG 761
                 |.:|.  ::|...: |...||.|:.|:.|  |........|..| .....:.||::    
  Fly   602 YESIDHQIDA--LKCQYGY-RGDMLRVLSKLNCS--VPTVVQFSEPKMHKLLSTAKLECQI---- 657

  Fly   762 NCSCFHDATWATNIVDCGRQDLA---ALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRAL-- 821
            :.|...|..|.|     .|..:.   |.|::.| .:.|...|.:..|..:        .|.||  
  Fly   658 SGSPVPDIIWVT-----PRNKILRHHADPDKRP-IIIDSKEDAHQPPSAQ--------ELAALMD 708

  Fly   822 --YLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATF 884
              |:.:.| .|.||    .||..||:.:||.                 .|.:||           
  Fly   709 ESYIQSLN-WTRQN----SLVGRRVVLVENG-----------------SLLVHN----------- 740

  Fly   885 EPLVSLEVLRLDNNRLSSLPHLQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDNAMVVRDAHDI 949
                   :.|:|:...:.     |..::.|..                                 
  Fly   741 -------ISRIDSGLYTC-----YAFNVMGKA--------------------------------- 760

  Fly   950 YCLDAGIKRELE-------LIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAVLVLIFL 1007
               .||::..::       .||::                              |....|...||
  Fly   761 ---SAGLRLYIDPIVFYRVKIGSI------------------------------LFGTALATAFL 792

  Fly  1008 VVVLIIVFVFRESVRMWLFAHYGVRVCEPRFEDAGKLYDAIILHSEKDYEFVCRNIAAELEHGRP 1072
            ::.||:               .|:|.|..|:.                   :|..          
  Fly   793 LLTLIV---------------QGLRSCLSRWG-------------------ICNR---------- 813

  Fly  1073 PFRLCIQQRDLPPQA----SHLQLVEGARASRKIILVLTRNLLATEWNRIEFRNAFHESLRGLAQ 1133
             |..|:.::...|:.    :.|..:|..::.:            .|..|..:....|......||
  Fly   814 -FYCCVNRKKKSPRKHQIYAMLDSIETYKSQQ------------LERLRENYTQQVHRIRENCAQ 865

  Fly  1134 KLVIIEETSVSAEAEDVAELSPYLKSVPSNRLLTC-DRYF--WEKLRYAIPIELSPRGNNYTLDH 1195
            ::..| ::|.:::|:.:.|    .:.:.||.|.|. |:|:  .:|:|.....:||....||....
  Fly   866 QVEWI-QSSYTSQAKHIRE----FRDIGSNHLTTLKDQYYDQVKKVRDYSTGQLSWVRENYVFQR 925

  Fly  1196 HE----------RFKQPVSPGMIFRQ------APPPPAYY-------CTEE-------------- 1223
            ::          |.::    |..::|      ....|::|       |.|:              
  Fly   926 NKIRKFSAHQVLRLRE----GYKYQQQTLNKVLENLPSFYFENCRGRCEEDIAEDIDCYFKGQMD 986

  Fly  1224 ---------------MEANYSSATTATPSPRPTRPGGAARIVDSMPMPMRPPSEHIYHSIESEYS 1273
                           :.||||::..:                    :...||.:.:.||.:    
  Fly   987 FGDSKELHIQKIKARLSANYSASKAS--------------------LYYTPPDDDLLHSSQ---- 1027

  Fly  1274 AYDQHEALSMIPTGLMHQHQQQQLRLHQQQQQQQQQRLLQPQFRAMPQQAIPAPSAPVHLRSGSG 1338
                   |::         |...:.::...:...||:.|:..|:..||         :.|.:.|.
  Fly  1028 -------LNL---------QNSPIHINYIDENLDQQKQLEHDFKMEPQ---------LLLYNASM 1067

  Fly  1339 LSQASTSTQSTAQASTSAAAA------------QQQQQQQQQQAAG 1372
            |........|:.||:..|||.            |:|:.|..::.:|
  Fly  1068 LYMNPEGASSSGQAAALAAAGALSQFISVEDNNQEQEMQPLRKISG 1113

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 7/39 (18%)
leucine-rich repeat 92..115 CDD:275380 6/27 (22%)
LRR_8 115..181 CDD:404697 13/66 (20%)
leucine-rich repeat 116..146 CDD:275380 6/30 (20%)
leucine-rich repeat 147..170 CDD:275380 4/22 (18%)
leucine-rich repeat 171..201 CDD:275380 4/29 (14%)
LRR 210..592 CDD:443914 107/388 (28%)
leucine-rich repeat 212..236 CDD:275380 0/23 (0%)
leucine-rich repeat 237..260 CDD:275380 7/22 (32%)
leucine-rich repeat 261..284 CDD:275380 11/22 (50%)
leucine-rich repeat 285..308 CDD:275380 9/22 (41%)
leucine-rich repeat 309..334 CDD:275380 11/24 (46%)
leucine-rich repeat 335..358 CDD:275380 8/22 (36%)
leucine-rich repeat 359..382 CDD:275380 9/22 (41%)
leucine-rich repeat 383..406 CDD:275380 9/22 (41%)
leucine-rich repeat 407..430 CDD:275380 0/22 (0%)
leucine-rich repeat 431..451 CDD:275380 9/20 (45%)
leucine-rich repeat 454..477 CDD:275380 7/22 (32%)
leucine-rich repeat 478..499 CDD:275380 2/20 (10%)
leucine-rich repeat 502..525 CDD:275380 5/22 (23%)
leucine-rich repeat 526..548 CDD:275380 3/21 (14%)
leucine-rich repeat 590..617 CDD:275380 2/26 (8%)
leucine-rich repeat 618..641 CDD:275380 2/22 (9%)
leucine-rich repeat 642..689 CDD:275380 11/46 (24%)
LRRCT 679..736 CDD:214507 23/82 (28%)
LRR <775..>920 CDD:443914 28/151 (19%)
leucine-rich repeat 775..796 CDD:275380 4/23 (17%)
leucine-rich repeat 797..817 CDD:275380 2/19 (11%)
leucine-rich repeat 818..841 CDD:275380 9/26 (35%)
leucine-rich repeat 842..865 CDD:275380 4/22 (18%)
leucine-rich repeat 866..889 CDD:275380 3/22 (14%)
leucine-rich repeat 890..911 CDD:275380 3/20 (15%)
TIR 1045..1183 CDD:214587 23/144 (16%)
CG16974NP_609610.2 leucine-rich repeat 206..228 CDD:275380 4/21 (19%)
leucine-rich repeat 229..252 CDD:275380 4/64 (6%)
LRR <230..531 CDD:443914 107/410 (26%)
leucine-rich repeat 253..276 CDD:275380 7/22 (32%)
leucine-rich repeat 277..300 CDD:275380 11/22 (50%)
leucine-rich repeat 301..324 CDD:275380 9/22 (41%)
leucine-rich repeat 325..348 CDD:275380 11/24 (46%)
leucine-rich repeat 349..372 CDD:275380 8/22 (36%)
leucine-rich repeat 373..396 CDD:275380 9/22 (41%)
leucine-rich repeat 397..420 CDD:275380 9/22 (41%)
leucine-rich repeat 421..444 CDD:275380 9/22 (41%)
leucine-rich repeat 478..502 CDD:275380 9/45 (20%)
leucine-rich repeat 503..526 CDD:275380 7/27 (26%)
Ig <714..761 CDD:472250 17/127 (13%)
Ig strand C 714..718 CDD:409358 1/4 (25%)
Ig strand E 734..738 CDD:409358 1/20 (5%)
Ig strand F 748..753 CDD:409358 0/9 (0%)

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