DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 18w and Tlr9

DIOPT Version :9

Sequence 1:NP_476814.1 Gene:18w / 37277 FlyBaseID:FBgn0004364 Length:1385 Species:Drosophila melanogaster
Sequence 2:NP_937764.1 Gene:Tlr9 / 338457 RGDID:631352 Length:1032 Species:Rattus norvegicus


Alignment Length:1278 Identity:303/1278 - (23%)
Similarity:466/1278 - (36%) Gaps:405/1278 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 CSQELLHASELAPGLFRQLQKLSELRIDACKLQRVPPNAF-------EGLMSLKRLTLES--HNA 126
            ||:.|...|     |..|...|:|    |..|..:|  ||       .||:....|.|:|  |.:
  Rat     4 CSRTLHPLS-----LLVQAAVLAE----ALALGTLP--AFLPCELKPHGLVDCNWLFLKSVPHFS 57

  Fly   127 VWGPGK---TLELHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMPSLQLLNLT-QNRIRSAEFL 187
            ...|..   :|.|.......|..|..:||  .|:|||.....|..|.|..|:.: :..|....||
  Rat    58 AAEPRSNITSLSLIANRIHHLHNLDFVHL--PNVRQLNLKWNCPPPGLSPLHFSCRMTIEPKTFL 120

  Fly   188 GFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRL-RRLQTLSLQHNNISTLA 251
            ..                    ..|:.|::|:|.:.::|      || ..|..|||.|.||..|.
  Rat   121 AM--------------------RMLEELNLSYNGITTVP------RLPSSLTNLSLSHTNILVLD 159

  Fly   252 PNALAGLSSLRVL----NISY----NHLVSLPSEAFAGNKELRELHLQGNDLYELPKGLLHRLEQ 308
            .::||||.|||||    |..|    |..|::..:||.|...|..|.|:.|:|.|:|:.|...||.
  Rat   160 ASSLAGLHSLRVLFMDGNCYYKNPCNGAVNVTPDAFLGLSNLTHLSLKYNNLTEVPRQLPPSLEY 224

  Fly   309 LLVLDLSGNQLTSHHVDNSTFAGLIRLIVLNLSNNALTRIGSKTFKELYFLQILDM--------- 364
            ||                             ||.|.:.::|.:....|..|::||:         
  Rat   225 LL-----------------------------LSYNLIVKLGPEDLANLTSLRVLDVGGNCRRCDH 260

  Fly   365 --------RNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFNGLYVLTKLTLNNNLV--SI 419
                    |..|: .:....|..|.:|..|.|.::.||:|:::.|.||..|:.|.|:.|.:  ||
  Rat   261 APDLCTECRQKSL-DLHPQTFHHLSHLEGLVLKDSSLHSLNSKWFQGLVNLSVLDLSENFLYESI 324

  Fly   420 VESQAFRNCSDLKELDLSSNQLTEVPEAVQDL-----SMLKTLDLGENQI--SEFKNNTFR---N 474
            .::.||:|.:.|::||||.|...:|..|...|     |::...:|..|.|  .....||.|   .
  Rat   325 NKTSAFQNLTRLRKLDLSFNYCKKVSFARLHLASSFKSLVSLQELNMNGIFFRLLNKNTLRWLAG 389

  Fly   475 LNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQ---SIERGAFDKNTEIE--------- 527
            |.:|..|.|..|.|....:.:|.....|..::|:.|||.   ::.|.|.:|..|.|         
  Rat   390 LPKLHTLHLQMNFINQAQLSVFSTFRALRFVDLSNNRISGPPTLSRVAPEKADEAEKGVPWPASL 454

  Fly   528 -----AIRLDKNFLTDINGI------------------FATLASLLWLNLSENHLVWF--DYAFI 567
                 :..:.|||:.....:                  |..|:.|..|:||.|.:...  ...|:
  Rat   455 TPALPSTPVSKNFMVRCKNLRFTMDLSRNNLVTIKPEMFVNLSHLQCLSLSHNCIAQAVNGSQFL 519

  Fly   568 P-SNLKWLDIHGNYIEALGNYYKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQI 631
            | :|||.||:..|.:: |.:.....|..::..||.|:|        |.|.|::.:..|.:.:..:
  Rat   520 PLTNLKVLDLSYNKLD-LYHSKSFSELPQLQALDLSYN--------SQPFSMQGIGHNFSFLANL 575

  Fly   632 QANTFVDKTRLARVDLYANVLSKISLNALRVAPVSAEKPVPEFYL--GGNPF-----ECDCSMEW 689
            ..   :....||..|:::.|.|       |:...|.|      ||  .||..     |.|..:.:
  Rat   576 SR---LQNLSLAHNDIHSRVSS-------RLYSTSVE------YLDFSGNGVGRMWDEEDLYLYF 624

  Fly   690 LQRINNLTTRQHPHVVDL--GNIECLMPHSRSAPLRPLASLSASDFVCKYESHCPPTCHCCEYEQ 752
            .|.:.:|.     | :||  ..:..|.|.:.:...:.|..||..|                    
  Rat   625 FQDLRSLI-----H-LDLSQNKLHILRPQNLNYLPKSLTKLSFRD-------------------- 663

  Fly   753 CECEVICPGNCSCFHDATWATNIVDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRN 817
                    .:.|.|:   |::         ||.|||     :.||.|.||.:..|..|       
  Rat   664 --------NHLSFFN---WSS---------LAFLPN-----LRDLDLAGNLLKALTNG------- 696

  Fly   818 LRALYLNASNLMTLQNGSLAQLVNLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNA 882
                        ||.||:|     |:.|.:.:|.:..:....|.....|:|:.|.:|:|..:..:
  Rat   697 ------------TLPNGTL-----LQKLDVSSNSIVFVVPAFFALAVELKEVNLSHNILKTVDRS 744

  Fly   883 TFEPLV-SLEVLRLDNNRL---SSLPH----LQYRHSLQGLTLGRNAWSCRCQQLRELAQFVSDN 939
            .|.|:| :|.||.:.:|.|   ...|.    |:.:..:.||..|....|.|  ||:..:.|..|.
  Rat   745 WFGPIVMNLTVLDVSSNPLHCACGAPFVDLLLEVQTKVPGLANGVKCGSPR--QLQGRSIFAQDL 807

  Fly   940 AMVVRDAHDIYCLDAGIKRELELIGNLANGPDCSDLLDASASNISSSQDLAGGYRLPLLAAV--- 1001
            .:         |||..:.|            ||..|         |...:|.|..||||..:   
  Rat   808 RL---------CLDDVLSR------------DCFGL---------SLLAVAVGTVLPLLQHLCGW 842

  Fly  1002 -------LVLIFLVVV-------------LIIVFVFRES-VRMWLFAHYGVRVCEPRFEDAGKLY 1045
                   |.|.:|.::             ..:||...:| |..|::....||:.|.|        
  Rat   843 DVWYCFHLCLAWLPLLTRGRRSAQALPYDAFVVFDKAQSAVADWVYNELRVRLEERR-------- 899

  Fly  1046 DAIILHSEKDYEFVCRNIAAELEHGRPPFRLCIQQRD-LPPQASHLQLVEGARASRKIILVLTRN 1109
                                    ||...|||::.|| ||.|.....|......|||.:.||   
  Rat   900 ------------------------GRRALRLCLEDRDWLPGQTLFENLWASIYGSRKTLFVL--- 937

  Fly  1110 LLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDV---------AELSPYLKSVPSNRL 1165
                         |..:.:.||.:...::.:..:..:.:||         |..|.|::.  ..||
  Rat   938 -------------AHTDKVSGLLRTSFLLAQQRLLEDRKDVVVLVILRPDAHRSRYVRL--RQRL 987

  Fly  1166 LTCDRYFWEKLRYAIPIELSPRGNNY-------TLDHHERFKQ 1201
            ......||       |.:.:.:|:.:       |.|:|..:.:
  Rat   988 CRQSVLFW-------PHQPNGQGSFWAQLSTALTRDNHHFYNR 1023

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
18wNP_476814.1 leucine-rich repeat 66..91 CDD:275380 6/19 (32%)
leucine-rich repeat 92..115 CDD:275380 9/29 (31%)
LRR_8 115..181 CDD:290566 19/71 (27%)
leucine-rich repeat 116..146 CDD:275380 8/34 (24%)
leucine-rich repeat 147..170 CDD:275380 8/22 (36%)
leucine-rich repeat 171..201 CDD:275380 5/30 (17%)
LRR_RI 210..464 CDD:238064 85/286 (30%)
leucine-rich repeat 212..236 CDD:275380 7/24 (29%)
LRR_8 235..295 CDD:290566 28/67 (42%)
leucine-rich repeat 237..260 CDD:275380 12/22 (55%)
leucine-rich repeat 261..284 CDD:275380 11/30 (37%)
LRR_8 283..345 CDD:290566 15/61 (25%)
leucine-rich repeat 285..308 CDD:275380 9/22 (41%)
leucine-rich repeat 309..334 CDD:275380 2/24 (8%)
LRR_8 334..393 CDD:290566 15/75 (20%)
leucine-rich repeat 335..358 CDD:275380 5/22 (23%)
leucine-rich repeat 359..382 CDD:275380 7/39 (18%)
LRR_8 382..441 CDD:290566 24/60 (40%)
leucine-rich repeat 383..406 CDD:275380 9/22 (41%)
leucine-rich repeat 407..430 CDD:275380 9/24 (38%)
LRR_8 431..488 CDD:290566 21/66 (32%)
leucine-rich repeat 431..451 CDD:275380 8/19 (42%)
leucine-rich repeat 454..477 CDD:275380 7/27 (26%)
LRR_8 477..559 CDD:290566 26/116 (22%)
leucine-rich repeat 478..499 CDD:275380 6/20 (30%)
leucine-rich repeat 502..525 CDD:275380 8/25 (32%)
leucine-rich repeat 526..548 CDD:275380 6/53 (11%)
leucine-rich repeat 590..617 CDD:275380 7/26 (27%)
leucine-rich repeat 618..641 CDD:275380 1/22 (5%)
leucine-rich repeat 642..689 CDD:275380 14/53 (26%)
LRRCT 679..736 CDD:214507 14/63 (22%)
leucine-rich repeat 775..796 CDD:275380 5/20 (25%)
LRR_8 797..852 CDD:290566 14/54 (26%)
leucine-rich repeat 797..817 CDD:275380 6/19 (32%)
leucine-rich repeat 818..841 CDD:275380 5/22 (23%)
LRR_8 841..900 CDD:290566 16/59 (27%)
leucine-rich repeat 842..865 CDD:275380 4/22 (18%)
LRR_4 866..907 CDD:289563 14/48 (29%)
leucine-rich repeat 866..889 CDD:275380 8/23 (35%)
leucine-rich repeat 890..911 CDD:275380 7/27 (26%)
TIR 1045..1183 CDD:214587 29/147 (20%)
Tlr9NP_937764.1 leucine-rich repeat 43..64 CDD:275380 5/20 (25%)
LRR_8 63..135 CDD:290566 21/93 (23%)
leucine-rich repeat 65..88 CDD:275380 6/24 (25%)
leucine-rich repeat 89..124 CDD:275380 10/54 (19%)
LRR_RI 123..373 CDD:238064 84/285 (29%)
leucine-rich repeat 125..144 CDD:275380 7/24 (29%)
LRR_8 143..211 CDD:290566 28/67 (42%)
leucine-rich repeat 145..168 CDD:275380 12/22 (55%)
leucine-rich repeat 169..200 CDD:275380 11/30 (37%)
LRR_8 199..254 CDD:290566 20/83 (24%)
leucine-rich repeat 201..221 CDD:275380 8/19 (42%)
leucine-rich repeat 222..245 CDD:275380 9/51 (18%)
leucine-rich repeat 246..285 CDD:275380 7/39 (18%)
LRR_8 284..344 CDD:290566 23/59 (39%)
leucine-rich repeat 286..309 CDD:275380 9/22 (41%)
LRR_RI 310..556 CDD:238064 65/246 (26%)
leucine-rich repeat 310..335 CDD:275380 9/24 (38%)
leucine-rich repeat 336..365 CDD:275380 10/28 (36%)
leucine-rich repeat 393..416 CDD:275380 6/22 (27%)
leucine-rich repeat 477..498 CDD:275380 2/20 (10%)
LRR_RI <490..692 CDD:238064 63/277 (23%)
LRR_8 497..556 CDD:290566 18/59 (31%)
leucine-rich repeat 499..523 CDD:275380 7/23 (30%)
leucine-rich repeat 524..547 CDD:275380 7/23 (30%)
leucine-rich repeat 548..577 CDD:275380 8/36 (22%)
leucine-rich repeat 578..630 CDD:275380 15/64 (23%)
leucine-rich repeat 601..618 CDD:275380 5/22 (23%)
LRR_8 629..690 CDD:290566 23/111 (21%)
leucine-rich repeat 631..655 CDD:275380 6/29 (21%)
leucine-rich repeat 656..679 CDD:275380 10/62 (16%)
leucine-rich repeat 680..703 CDD:275380 11/41 (27%)
LRR_8 704..763 CDD:290566 16/58 (28%)
leucine-rich repeat 704..727 CDD:275380 4/22 (18%)
leucine-rich repeat 728..746 CDD:275380 5/17 (29%)
leucine-rich repeat 753..774 CDD:275380 6/20 (30%)
TIR_2 870..1013 CDD:304906 39/199 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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